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42


Scalp nodule in a 59-year-old female What is your diagnosis? [Editorial]

Wilken, Reason; Carucci, John A.; Brinster, Nooshin K.; Stevenson, Mary L.
ISI:000546107300001
ISSN: 0011-9059
CID: 4526612

Single-center retrospective review of the use of checkpoint inhibitors in merkel cell carcinoma patients [Meeting Abstract]

Babadzhanov, M.; Doudican, N.; Ovits, C.; Canavan, T.; Stevenson, M.; Pavlick, A.; Carucci, J.
ISI:000554564400420
ISSN: 0022-202x
CID: 4562172

Skin Cancer in Transplant Recipients: Scientific Retreat of The International Immunosuppression and Transplant Skin Cancer Collaborative and Skin Care in Organ Transplant Patients-Europe

Stevenson, Mary L; Carucci, John; Colegio, Oscar R
The International Immunosuppression and Transplant Skin Cancer Collaborative (ITSCC) is an organization of more than 500 physicians and scientists focused on the treatment of cutaneous malignancies following solid organ transplantation and in other forms of immunosuppression. It is well known that solid organ transplant recipients (SOTRs) have an approximate 100-fold increase in the risk of developing skin cancer with consensus guidelines recommending these patients be managed as high risk for local recurrence and metastasis associated with poor outcomes. In September 2018, ITSCC and its European counterpart, the Skin Care in Organ Transplant Patients-Europe (SCOPE), held their biennial scientific retreat in Essex, MA to discuss novel findings in the pathogenesis of cutaneous malignancy including new treatment and prevention strategies in this at risk population for significant morbidity and mortality from their cutaneous disease. This meeting report is a summary of the novel findings discussed.
PMID: 31628869
ISSN: 1399-0012
CID: 4140842

Stratification of Poor Outcomes for Cutaneous Squamous Cell Carcinoma in Immunosuppressed Patients Using the American Joint Committee on Cancer Eighth Edition and Brigham and Women's Hospital Staging Systems

Blechman, Adam B; Carucci, John A; Stevenson, Mary L
BACKGROUND:Staging systems for cutaneous squamous cell carcinoma (CSCC) include Brigham and Women's Hospital (BWH) and American Joint Committee on Cancer staging system, eighth edition (AJCC-8). OBJECTIVE:To evaluate and compare AJCC-8 and BWH staging systems for CSCC in immunosuppressed patients. MATERIALS AND METHODS/METHODS:A retrospective cohort study of immunosuppressed patients diagnosed with primary CSCC from 2012 to 2016. The main end point was any poor outcome (PO), which included local recurrence, nodal metastasis, and disease-specific death. RESULTS:Fifty-eight immunosuppressed patients had 263 CSCCs. Fifty percent of tumors were AJCC-8 T1, 44.7% T2, and 4.8% T3. Fifty percent of tumors were BWH T1, 48.5% T2a, 1.3% T2b, and 0.4% T3. Risk of PO for AJCC-8 was 1.7%, 8.8%, and 36.4% for T1, T2, and T3, respectively (p < .01). Risk of PO for BWH was 1.8%, 9.9%, 33.3%, and 100.0% for T1, T2a, T2b, and T3, respectively (p < .01). Thirty-six percent of AJCC-8 T3/T4 tumors had POs compared with 5.1% in low T1/T2 stages (p = .002). Fifty percent of BWH T2b/T3 tumors had POs compared with 5.3% in low T1/T2a stages (p = .01). CONCLUSION/CONCLUSIONS:AJCC-8 and BWH staging systems stratify CSCC with similar distinctiveness, homogeneity, and monotonicity for immunosuppressed patients.
PMID: 30640779
ISSN: 1524-4725
CID: 3595182

Expertise in Head and Neck Cutaneous Reconstructive Surgery

Deng, Min; Higgins, H William; Lesiak, Kendra; Decker, Ashley B; Regula, Christie G; Stevenson, Mary L; Raphael, Brian; Depry, Jennifer; Scott, Jeffrey F; Bangash, Haider; Ochoa, Shari A; Ibrahimi, Omar A; Shafai, Aria; Bordeaux, Jeremy S; Carucci, John A; Cook, Jonathan L; Goldman, Glenn D; Rohrer, Thomas E; Lawrence, Naomi
BACKGROUND:The management of skin cancers has evolved with the development of Mohs micrographic surgery and a greater emphasis on surgical training within dermatology. It is unclear whether these changes have translated into innovations and contributions to the reconstructive literature. OBJECTIVE:To assess contributions from each medical specialty to the cutaneous head and neck oncologic reconstructive literature. METHODS:The authors conducted a systematic review of the head and neck reconstructive literature from 2000 through 2015 based on a priori search terms relating to suture technique, linear closure, advancement, rotation, transposition and interpolation flaps, and identified the specialty of the senior authors. RESULTS:The authors identified 74,871 articles, of which 1,319 were relevant. Under suture technique articles, the senior authors were primarily dermatologists (58.2%) and plastic surgeons (20.3%). Under linear closure, the authors were dermatologists (48.1%), plastic surgeons (22.2%), and otolaryngologists (20.4%). Under advancement and rotation flaps, the senior authors were plastic surgeons (40.5%, 38.9%), dermatologists (38.1%, 34.2%), and otolaryngologists (14.4%, 21.6%). Under transposition and interpolation flaps, the senior authors were plastic surgeons (47.3%, 39.4%), dermatologists (32.3%, 27.0%), and otolaryngologists (15.3%, 23.4%). CONCLUSION/CONCLUSIONS:The primary specialties contributing to the cutaneous head and neck reconstructive literature are plastic surgery, dermatology, and otolaryngology.
PMID: 30829776
ISSN: 1524-4725
CID: 3722632

Repair of a Large Defect Involving the Nose, Cheek, and Upper Cutaneous Lip

Blechman, Adam B; Stevenson, Mary L; Carucci, John A
PMID: 30199429
ISSN: 1524-4725
CID: 3278132

Dermatologist Practices During Total Body Skin Examinations: A Survey Study

Rieder, Evan A; Mu, Euphemia W; Wang, Jenny; Cohen, David E; Rigel, Darrell S; Stevenson, Mary L
Though screening for skin cancer is an essential practice in dermatology, limited data are published on dermatologists' total body skin examination (TBSE) behaviors. We surveyed 6500 dermatologists on their TBSE practices, including questions about less commonly examined body sites. We found varied TBSE practices among all dermatologists and discrepancies in examinations between dermatologists of opposite genders. J Drugs Dermatol. 2018;17(5):516-520.
PMID: 29742182
ISSN: 1545-9616
CID: 3164102

Laser treatments of active acne

Wiznia, Lauren E; Stevenson, Mary L; Nagler, Arielle R
The utility of laser therapy is increasingly being recognized in the treatment of active acne vulgaris. We aimed to perform a narrative review of the medical literature on the use of laser therapy for the treatment of active acne vulgaris. We performed a PubMed literature search on September 1, 2016 using the search terms "active acne," "acne," "laser therapy," and "laser surgery." Case reports, case series, cohort, and controlled trials were included. Studies of lasers in the treatment of acne, including erbium glass, Nd:YAG, pulse dye laser (PDL), potassium titanyl phosphate (KTP) laser, and laser-based photodynamic therapy, have been published. While treatment of active acne with lasers has been successful, many studies are limited by small patient number and lack of control populations and comparison to standard therapies for active acne. Laser therapies are increasingly becoming part of or an adjunct to the medical treatment of active acne and are a useful treatment modality.
PMID: 28776112
ISSN: 1435-604x
CID: 2655972

Line scanning, stage scanning confocal microscope (LSSSCM)

Gareau, Daniel S; Krueger, James G; Hawkes, Jason E; Lish, Samantha R; Dietz, Michael P; Mulberger, Alba Guembe; Mu, Euphemia W; Stevenson, Mary L; Lewin, Jesse M; Meehan, Shane A; Carucci, John A
For rapid pathological assessment of large surgical tissue excisions with cellular resolution, we present a line scanning, stage scanning confocal microscope (LSSSCM). LSSSCM uses no scanning mirrors. Laser light is focused with a single cylindrical lens to a line of diffraction-limited width directly into the (Z) sample focal plane, which is parallel to and near the flattened specimen surface. Semi-confocal optical sections are derived from the linear array distribution (Y) and a single mechanical drive that moves the sample parallel to the focal plane and perpendicular to the focused line (X). LSSSCM demonstrates cellular resolution in the conditions of high nuclear density within micronodular basal cell carcinoma.
PMCID:5560842
PMID: 28856051
ISSN: 2156-7085
CID: 2764432

V-Y Advancement Flap for Defects of the Lid-Cheek Junction

Quatrano, Nicola A; Stevenson, Mary L; Sclafani, Anthony P; Carucci, John
PMID: 28571071
ISSN: 1098-8793
CID: 2589632