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ASSOCIATION OF RADIOGRAPHIC OUTCOMES WITH LOW DISEASE ACTIVITY AND REMISSION AND SUSTAINABILITY OF RESPONSE WITH SUBCUTANEOUS ABATACEPT OR ADALIMUMAB: 2-YEAR RESULTS FROM THE AMPLE TRIAL [Meeting Abstract]

Fleischmann, R; Schiff, M; Weinblatt, M; Maldonado, M; Massarotti, E; Fay, J; Yazici, Y
ISI:000346919802137
ISSN: 1468-2060
CID: 1598932

Anterior mediastinal bone-eroding mass with disseminated lung lesions [Case Report]

Siddaiah, Roopa; Weinblatt, Mark; Roberts, Jon; Cataletto, Mary
PMID: 22045883
ISSN: 1931-3543
CID: 3498592

Transient TTP in childhood [Case Report]

Moskowitz, Naomi P; Fligman, Igal; Scimeca, Philip; Weinblatt, Mark
Thrombotic thrombocytopenic purpura (TTP) is a type of microangiopathic hemolytic anemia that is uncommon in childhood. Adults with TTP have a high mortality rate unless they are treated with plasma exchange. There are few reports of children with acquired idiopathic TTP, and most of those children received some form of treatment. We describe a child with acquired idiopathic TTP who had severe thrombocytopenia and anemia that resolved over several months without the use of any medications. This case suggests that some children with acquired idiopathic TTP might be safely observed without ill effects.
PMID: 18989888
ISSN: 1545-5009
CID: 868442

Amyloid myopathy masquerading as polymyositis [Case Report]

Mandl, L A; Folkerth, R D; Pick, M A; Weinblatt, M E; Gravallese, E M
OBJECTIVE: It is not well appreciated that the clinical presentation of amyloid myopathy can mimic that of polymyositis. By retrospective clinicopathologic analysis we determined distinctive features of amyloid myopathy that differentiate the 2 diseases. METHODS: Two patients with clinical and histologic evidence of an inflammatory myopathy had fatal outcomes despite appropriate treatment for polymyositis. Their clinical course and original pathologic specimens were reviewed. In addition, original tissue samples were obtained and analyzed using Congo red staining and immunoperoxidase. RESULTS: The initial diagnosis of polymyositis was supported in both cases by muscle biopsies showing inflammatory infiltrates and elevations of creatine phosphokinase and by classic electromyography. Retrospective evaluation of the initial muscle biopsies disclosed subtle but incontrovertible evidence of vascular amyloid. Further analysis of the original specimens confirmed the presence of immunoglobin light chain (AL) amyloid. CONCLUSION: Amyloid myopathy can mimic polymyositis. Both can have similar clinical symptoms, as well as inflammatory infiltrates on muscle biopsy. Failure to recognize amyloid myopathy deprives patients of potentially life prolonging treatment. Congo red staining and immunohistochemical analysis of tissue could prevent misdiagnosis.
PMID: 10782821
ISSN: 0315-162x
CID: 2177442

Amyloid myopathy masquerading as polymyositis. [Meeting Abstract]

Mandl, LA; Folkerth, RD; Pick, MA; Weinblatt, ME; Gravallese, EM
ISI:000082936300597
ISSN: 0004-3591
CID: 2178212

Posttraumatic stress disorder and family functioning in adolescent cancer

Pelcovitz D; Libov BG; Mandel F; Kaplan S; Weinblatt M; Septimus A
Twenty three adolescents with a history of cancer, 27 physically abused adolescents, and 23 healthy, nonabused adolescents were administered structured posttraumatic stress disorder (PTSD) interviews and self-report questionnaires regarding family functioning. Thirty five percent of adolescent cancer subjects met criteria for lifetime PTSD as compared to only 7% of the abused adolescents: 17% of the cancer subjects and 11% of the abuse subjects met criteria for current PTSD. Adolescents with cancer viewed their mothers and fathers as significantly more caring and more protective than the comparison and abused adolescents. Cancer subjects who met criteria for lifetime PTSD saw their families as significantly more chaotic than those who did not have PTSD. Eighty three percent of cancer subjects who had lifetime PTSD also had mothers who had PTSD
PMID: 9565912
ISSN: 0894-9867
CID: 7738

Ovarian neoplasm and endometrioid carcinoma in a patient with Turcot syndrome

Shalon, L; Markowitz, J; Bialer, M; Kahn, E; Weinblatt, M; Giardiello, F M; Luce, M C; Daum, F
PMID: 9252914
ISSN: 0277-2116
CID: 147464

False-positive FDG-PET imaging of the thymus of a child with Hodgkin's disease [Case Report]

Weinblatt, M E; Zanzi, I; Belakhlef, A; Babchyck, B; Kochen, J
During the evaluation of a child who had completed treatment for Hodgkin's disease, a PET study strongly suggested recurrent disease in the mediastinum. Biopsies were obtained and revealed normal thymic tissue only, with no evidence of recurrent disease. The ongoing difficulty in establishing accurate disease status in patients treated for Hodgkin's disease is discussed, along with recommendations for treating pediatric patient populations.
PMID: 9189136
ISSN: 0161-5505
CID: 2313572

Chemotherapeutic treatment of malignant chordoma in children [Case Report]

Scimeca PG; James-Herry AG; Black KS; Kahn E; Weinblatt ME
PURPOSE: We describe the effect of multiagent chemotherapy for malignant chordoma. Previous reports of other patients with malignant chordoma treated with chemotherapy as well as other therapeutic interventions are reviewed. PATIENTS AND METHODS: We describe a 19-month-old girl with unresectable cervical chordoma metastatic to the lungs at diagnosis treated with multiagent systemic chemotherapy. CNS disease was diagnosed after one course of therapy, and intrathecal chemotherapy was then administered. CONCLUSIONS: Ifosfamide and doxorubicin were efficacious in a patient with advanced metastatic disease, producing significant disease regression. The addition of intrathecal or intraventricular therapy with hydrocortisone, ARA-C, and methotrexate was effective in controlling CNS disease due to chordoma. There was no apparent benefit from the use of actinomycin-D, cyclophosphamide and vincristine nor the combination of cisplatin and 5-fluorouracil or high-dose methotrexate
PMID: 8846149
ISSN: 1077-4114
CID: 21534

Atypical PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis, adenitis) in a young girl with Fanconi anemia [Case Report]

Scimeca PG; James-Herry AG; Weinblatt ME
PURPOSE: To describe a case of atypical, severe, periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA syndrome) in a patient with Fanconi anemia. Important aspects about the PFAPA syndrome and Fanconi anemia are reviewed. PATIENTS AND METHODS: An 8-year-old girl with Fanconi anemia was noted to have a pattern of periodic fever, stomatitis, and pharyngitis consistent with the diagnosis of PFAPA syndrome, a generally benign disorder. After prednisone treatment for the syndrome, life-threatening intestinal ulceration and perforation developed, which was successfully treated. CONCLUSION: In patients with underlying hematologic disease such as Fanconi anemia, PFAPA syndrome may be associated with severe clinical problems in contrast to otherwise normal children with the disorder
PMID: 8846129
ISSN: 1077-4114
CID: 21535