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295


Imaging the Vasculitides

Younger, David S
"Neuroimaging plays a vital role in the diagnosis of primary and secondary vasculitic disorders. There multiple neuroimaging options available to accurately describe the underlying clinical deficits of involved cases. Noninvasive neuroimaging modalities provide less risk and when interdigitated, form the basis for a more conclusive understanding of the disease process. There are instances in which invasive cerebral angiography may be needed to image the intricate and at times, small involved vessels. Neuroradiologists should be included in the multidisciplinary team of physicians caring for patients with vasculitides and in research to provide more sensitive and safe modalities for accurate diagnosis."
PMID: 30952408
ISSN: 1557-9875
CID: 3789722

The Blood-Brain Barrier: Implications for Vasculitis

Younger, David S
There has been extraordinary research in the blood-brain barrier. Once considered a static anatomic barrier to the traffic of molecules in and out of the central nervous system when fully developed in adults, the blood-brain barrier is now known to be not only fully functional in development but also vital in cerebrovascular angiogenesis. Blood-brain barrier breakdown has been recognized as an important factor in a variety of primary neurologic diseases; however, such disturbances have yet to be critically analyzed. This article reviews the history, neurodevelopment, ultrastructure, function, and clinicopathologic correlation and relevance to central nervous system vasculitis.
PMID: 30952407
ISSN: 1557-9875
CID: 3789712

Neuroophthalmologic Aspects of the Vasculitides

Younger, David S
There have been significant advances in the understanding of the vasculitides in the past several years, leading to more precise classification and nosology. Ophthalmologic manifestations may be the presenting feature of and a clue to the diagnosis of vasculitis, or develop in the course of the illness owing to a common disease mechanism. Precise diagnosis and prompt treatment prevents short- and long-term ophthalmologic sequela.
PMID: 30952415
ISSN: 1557-9875
CID: 3789742

Central Nervous System Vasculitis Due to Substance Abuse

Younger, David S
Illicit drug abuse is a common differential diagnosis of acquired central nervous system vasculitis even though there are only a handful of histopathologically confirmed patients in the literature from among the many potential classes of abused drugs traditionally implicated in this disease. This article considers the major classes of illicit drugs in those with and without human immunodeficiency virus type-1 infection and acquired immune deficiency syndrome.
PMID: 30952417
ISSN: 1557-9875
CID: 3789752

Dermatologic Aspects of Systemic Vasculitis

Younger, David S; Carlson, Andrew
Systemic and localized vasculitis affects the skin and subcutis, due to large vascular beds and hemodynamic factors, such as stasis in lower extremities, and environmental influences, as occur in cold exposure. Initial cutaneous manifestations of vasculitides include diverse and dynamic patterns of discoloration, swelling, hemorrhage, and necrosis. One-half of affected patients present with localized, self-limited disease to the skin without any known trigger or associated systemic disease, known as idiopathic cutaneous leukocytoclastic vasculitis. Skin biopsy and dermatopathology contribute relevant information; however, they require correlation with clinical history, physical examination, and laboratory findings to reach an accurate diagnosis.
PMID: 30952419
ISSN: 1557-9875
CID: 3789762

Vasculitis of the Nervous System [Editorial]

Younger, David S
PMID: 30952420
ISSN: 1557-9875
CID: 3858202

Autonomic dysfunction in cancer

Chapter by: Younger, DS
in: Cancer Rehabilitation: Principles and Practice by
pp. 703-709
ISBN: 9780826121646
CID: 3784222

Motor neuron disease in cancer

Chapter by: Younger, DS
in: Cancer Rehabilitation: Principles and Practice by
pp. 696-702
ISBN: 9780826121646
CID: 3784232

Public Health, Neuroepidemiology, and Health Systems Preface [Editorial]

Younger, David S.
ISI:000386545000001
ISSN: 0733-8619
CID: 3588882

Health Care in China

Younger, David S
China has recently emerged as an important global partner. However, like other developing nations, China has experienced dramatic demographic and epidemiologic changes in the past few decades. Population discontent with the health care system has led to major reforms. China's distinctive health care system, including its unique history, vast infrastructure, the speed of health reform, and economic capacity to make important advances in health care, nonetheless, has incomplete insurance coverage for urban and rural dwellers, uneven access, mixed quality of health care, increasing costs, and risk of catastrophic health expenditures.
PMID: 27719993
ISSN: 1557-9875
CID: 2278052