Faculty Bibliography

A detailed study of fluoroscopic spot film systems and the methodology developed for achieving optimal clinical image quality at minimum patient exposure are reported. The procedure developed for the complete examination of spot film imaging equipment and the means for assuring their optimal performance are described. Clinical films made on a series of image intensifiers are compared with the physical imaging properties and patient dose rates of these systems. A simple method for the daily check of spot film image quality is presented. The wide variation in the imaging ability of new spot film systems is also discussed

The contrast agent for biliary tract visualization, iodipamide, is strongly bound to serum albumin. The relationship between the affinity of the contrast agent for albumin and its preferential uptake and excretion by the liver has been unclear. The role of serum albumin on hepatic uptake and excretion of iodipamide therefore was investigated on the isolated perfused rabbit liver. With the perfusate containing fully reconstituted rabbit plasma protein or 3.5 g/100 ml rabbit albumin alone, the iodipamide excretion is initially extremely slow. It then increases gradually to about 6 mug/gm liver per min by 60 minutes and thereafter remains constant. The half-time of transfer to the bile is about 130 min. Without albumin in the perfusate the initial clearance rate of iodipamide is rapid, with half-time transfer to the bile of about 40 min. Rabbit serum globulins have no effect on iodipamide excretion. Thus, binding of iodipamide to albumin retards the transfer of iodipamide from plasma to the bile, probably due to competition between albumin and the anion binding protein of the liver

Electronic stimulation of the external and sphincter muscle was successful in preventing premature evacuation of barium in 28 of 30 patients. All of them were unable on 1 or more occasions to retain the barium during previously attempted studies by conventional methods. None of the patients had an underlying neurologic problem affecting the anal sphincter. No adverse reactions were noted