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Physical comorbidities in older adults receiving antidepressants in Asia

Zhong, Xiao-Mei; Dong, Min; Wang, Fei; Zhang, Qinge; Ungvari, Gabor S; Ng, Chee H; Chiu, Helen F K; Si, Tian-Mei; Sim, Kang; Avasthi, Ajit; Grover, Sandeep; Chong, Mian-Yoon; Chee, Kok-Yoon; Kanba, Shigenobu; Lee, Min-Soo; Yang, Shu-Yu; Udomratn, Pichet; Kallivayalil, Roy A; Tanra, Andi J; Maramis, Margarita M; Shen, Winston W; Sartorius, Norman; Mahendran, Rathi; Tan, Chay-Hoon; Shinfuku, Naotaka; Xiang, Yu-Tao
BACKGROUND:The present study explored the patterns of physical comorbidities and their associated demographic and clinical factors in older psychiatric patients prescribed with antidepressants in Asia. METHODS:Demographic and clinical information of 955 older adults were extracted from the database of the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD) project. Standardized data collection procedure was used to record demographic and clinical data. RESULTS:Proportion of physical comorbidities in this cohort was 44%. Multiple logistic regression analyses showed that older age (OR = 1.7, P < 0.001), higher number of depressive symptoms (OR = 1.09, P = 0.016), being treated in psychiatric hospital (OR = 0.5, P = 0.002), living in high income countries/territories (OR = 2.4, P = 0.002), use of benzodiazepines (OR = 1.4, P = 0.013) and diagnosis of 'other psychiatric disorders' (except mood, anxiety disorders and schizophrenia) (OR = 2.7, P < 0.001) were significantly associated with physical comorbidities. CONCLUSIONS:Physical comorbidities in older patients prescribed with antidepressants were common in Asia. Integrating physical care into the treatment of older psychiatric patients should be urgently considered.
PMID: 29989257
ISSN: 1479-8301
CID: 3199832

Postgraduate training in psychiatry in Asia

Isaac, Mohan; Ahmed, Helal U; Chaturvedi, Santosh K; Hopwood, Malcolm J; Javeed, Afzal; Kanba, Shigenobu; Mufti, Ali Ahsan; Maramiis, Albert; Samaniego, Rene M; Udomratn, Pichet; Yanling, He; Zainal, Nor Z; Sartorius, Norman
PURPOSE OF REVIEW/OBJECTIVE:To understand the current situation, needs and challenges in the area of postgraduate training in psychiatry in Asia and identify implementable solutions.Leaders in psychiatric education from nine Asia Pacific countries prepared country reports, based on a suggested list of items and met for a day to discuss and identify implementable solutions to improve the current unsatisfactory status of postgraduate training in psychiatry. RECENT FINDINGS/RESULTS:Except Japan, all the other countries have a very low number of psychiatrists per 100 000 population - far lower than the global target of 10 psychiatrist per 100 000 population. The undergraduate teaching in psychiatry in majority of the countries is restricted to 20 h of lectures given during the 4-6 semester and 2-3 weeks of clinical ward placements. The duration as well as the overall quality of postgraduate training and methods of assessment and accreditation varies widely across and within countries. SUMMARY/CONCLUSIONS:Numerous gaps that need to be addressed to enhance the quality of psychiatrists trained in Asia were identified. There is a need to have uniform minimum standards of training and mechanisms of mutual support, for not only training but also academics and research activities in Asia.
PMID: 30015670
ISSN: 1473-6578
CID: 3200642

Selected and non-selected non-communicable diseases [Letter]

Sartorius, Norman
PMID: 30152340
ISSN: 1474-547x
CID: 3255872

Polypharmacy and psychotropic drug loading in patients with schizophrenia in Asian countries: Fourth survey of Research on Asian Prescription Patterns on antipsychotics

Yang, Shu-Yu; Chen, Lian-Yu; Najoan, Eunice; Kallivayalil, Roy Abraham; Viboonma, Kittisak; Jamaluddin, Ruzita; Javed, Afzal; Hoa, Duong Thi Quynh; Iida, Hitoshi; Sim, Kang; Swe, Thiha; He, Yan-Ling; Park, Yongchon; Ahmed, Helal Uddin; De Alwis, Angelo; Chiu, Helen Fung-Kum; Sartorius, Norman; Tan, Chay-Hoon; Chong, Mian-Yoon; Shinfuku, Naotaka; Lin, Shih-Ku
AIM/OBJECTIVE:The aim of the present study was to survey the prevalence of antipsychotic polypharmacy and combined medication use across 15 Asian countries and areas in 2016. METHODS:By using the results from the fourth survey of Research on Asian Prescription Patterns on antipsychotics, the rates of polypharmacy and combined medication use in each country were analyzed. Daily medications prescribed for the treatment of inpatients or outpatients with schizophrenia, including antipsychotics, mood stabilizers, anxiolytics, hypnotics, and antiparkinson agents, were collected. Fifteen countries from Asia participated in this study. RESULTS:A total of 3744 patients' prescription forms were examined. The prescription patterns differed across these Asian countries, with the highest rate of polypharmacy noted in Vietnam (59.1%) and the lowest in Myanmar (22.0%). Furthermore, the combined use of other medications, expressed as highest and lowest rate, respectively, was as follows: mood stabilizers, China (35.0%) and Bangladesh (1.0%); antidepressants, South Korea (36.6%) and Bangladesh (0%); anxiolytics, Pakistan (55.7%) and Myanmar (8.5%); hypnotics, Japan (61.1%) and, equally, Myanmar (0%) and Sri Lanka (0%); and antiparkinson agents, Bangladesh (87.9%) and Vietnam (10.9%). The average psychotropic drug loading of all patients was 2.01 ± 1.64, with the highest and lowest loadings noted in Japan (4.13 ± 3.13) and Indonesia (1.16 ± 0.68), respectively. CONCLUSION/CONCLUSIONS:Differences in psychiatrist training as well as the civil culture and health insurance system of each country may have contributed to the differences in these rates. The concept of drug loading can be applied to other medical fields.
PMID: 29761577
ISSN: 1440-1819
CID: 3164652

United Nations convention on the rights of persons with disabilities needs to be interpreted on the basis of scientific evidence regarding psychiatry [Editorial]

Galderisi, Silvana; Gorwood, Philip; Gaebel, Wolfgang; Kurimay, Tamas; Dom, Geert; Beezhold, Julian; Wasserman, Danuta; Bailey, Sue; Hanon, Cecile; Heinz, Andreas; Sartorius, Norman; van der Gaag, Rutger Jan; Vavrusova, Livia; Wise, Jan
PMID: 29885750
ISSN: 1778-3585
CID: 3166872

Urban mental health: challenges and perspectives

Okkels, Niels; Kristiansen, Christina Blanner; Munk-Jørgensen, Povl; Sartorius, Norman
PURPOSE OF REVIEW/OBJECTIVE:To provide an update on urban mental health and highlight the challenges that require urgent attention. RECENT FINDINGS/RESULTS:The majority of the world's population live in towns and urbanization is expected to increase in all areas of the world. Challenges to mental health in urban areas include loneliness, violence, high crime rates, homelessness, noise and other pollutants, traffic accidents, drug abuse, and insufficiency of mental health services. SUMMARY/CONCLUSIONS:Urbanization is a global and growing phenomenon that pose significant challenges to mental health and mental health services. Fast and unstructured urbanization, such as that seen in many developing countries, further exacerbates these challenges. There are promising initiatives emerging including initiatives to end homelessness, to improve access to green areas in urban environments, to provide emergency psychiatric services, and to develop new forms of mental health services adjusted to urban settings. Regrettably there are no universally accepted guidelines that would help governments in structuring health services for people with mental illness in towns and help to prevent mental health problems related to rapid urbanization.
PMID: 29528897
ISSN: 1473-6578
CID: 2992512

Temporal order of cancers and mental disorders in an adult population

Cawthorpe, David; Kerba, Marc; Narendran, Aru; Ghuttora, Harleen; Chartier, Gabrielle; Sartorius, Norman
Background/UNASSIGNED:Population-based examination of comorbidity is an emerging field of study. Aims/UNASSIGNED:The purpose of the present population level study is to expand our understanding of how cancer and mental illness are temporally associated. Method/UNASSIGNED:A sample of 83 648 056 physician billing records for 664 838 (56% female) unique individuals over the age of 18 was stratified on ages 19-49 years and 50+ years, with temporal order of mental disorder and cancer forming the basis of comparison. Results/UNASSIGNED:Mental disorders preceded cancers for both genders within each age strata. The full range of cancers and mental disorders preceding or following each pivot ICD class are described in terms of frequency of diagnosis and duration in days, with specific examples illustrated. Conclusions/UNASSIGNED:The temporal comorbidity between specific cancers and mental disorders may be useful in screening or clinical planning and may represent indicators of disease mechanism that warrant further screening or investigation. Declaration of interest/UNASSIGNED:None.
PMCID:6020283
PMID: 29971152
ISSN: 2056-4724
CID: 3199422

Reliability and validity of the Spanish version of the IDEAL Schedule for assessing care needs in dementia: Cross-sectional, multicenter study

López-Antón, Raúl; Barrada, Juan Ramón; Santabárbara, Javier; Posadas-de Miguel, Mar; Agüera, Luís; Burillo, Carmen; Franco, Manuel; López-Álvarez, Jorge; Mesa, Pilar; Petidier, Roberto; Quintanilla, Miguel Ángel; Robles-Del Olmo, Bernabé; Ventura, Tirso; Semrau, Maya; Sartorius, Norman; Lobo, Antonio
OBJECTIVE:The IDEAL Schedule was developed for staging "care needs" in patients with dementia. We here aim to validate the Spanish version, further test its psychometric properties and explore a latent construct for "care needs". METHODS:A multicenter study was done in 8 dementia care facilities across Spain. Patients referred with a reliable ICD-10 diagnosis of dementia (n = 151) were assessed with the IDEAL Schedule by pairs of raters. Inter-rater reliability (intra-class correlation [ICC] coefficients), internal consistency (Cronbach's alpha), and factor analysis were calculated. Convergent validity for individual items was tested against validated Spanish versions of international instruments. RESULTS:Pilot testing with numerical scales supported the feasibility, face, and content validity of the schedule. The psychometric coefficients were good/clinically acceptable: inter-rater reliability (mean ICC = 0.861; 85% of the ICCs > 0.8), internal consistency (global alpha coefficient = 0.74 in 5 nuclear items), and concurrent validity (global score against the Clinical Dementia Rating schedule, r = 0.63; coefficients for individual items ranging from 0.40 to 0.84, all statistically significant, p < 0.05). Internal consistency was low for the "nonprofessional care" and "social support" dimensions. Factor analysis supported a unidimensional solution, suggesting a latent "care needs" construct. CONCLUSION/CONCLUSIONS:The Spanish version of the IDEAL Schedule confirms the main psychometric properties of the original version and documents for the first time the convergent validity of individual items. Factor analysis identified a latent construct consistent with the concept "care needs" although 2 dimensions need further psychometric research.
PMID: 28857260
ISSN: 1099-1166
CID: 2984592

Depression and diabetes

Sartorius, Norman
The comorbidity of mental and physical disorders is a major challenge for health care worldwide. Its prevalence is increasing and is likely to continue to grow due to the increase in life expectancy and a variety of other reasons. The comorbidity of depression and diabetes can be seen as a prototypical example of mental/physical comorbidity. The prevalence of both conditions is growing, and depression is twice as frequent in people with diabetes compared with those without diabetes. Health services are by and large inadequately prepared to deal with comorbid depression and diabetes, and the increasing specialization (and fragmentation) of medicine will probably make things worse. This paper reviews the epidemiology and risk factors of the comorbidity of depression and diabetes and describes areas that should be given attention in order to reduce problems arising as a result of the comorbidity of these two conditions.
PMCID:6016052
PMID: 29946211
ISSN: 1958-5969
CID: 3168442

Learning About the Management of Physical Illness During the Postgraduate Training to Become a Good Psychiatrist [Letter]

Horinouchi, Toru; Nishida, Keiichiro; Nakagami, Yukako; Nakamura, Itta; Aoki, Nobuatsu; Tanaka, Masuo; Suzuki, Muneyuki; Kuga, Hironori; Takeda, Masatoshi; Bhugra, Dinesh; Sartorius, Norman
PMID: 28875286
ISSN: 1545-7230
CID: 2984652