Searched for: person:silvej03
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Diffusion tensor imaging and mild traumatic brain injury in soldiers: abnormal findings, uncertain implications
Silver, Jonathan M
PMID: 23212052
ISSN: 0002-953x
CID: 210222
Thalamus and cognitive impairment in Mild Traumatic Brain Injury: A Diffusional Kurtosis Imaging Study
Grossman EJ; Ge Y; Jensen JH; Babb JS; Miles L; Reaume J; Silver JM; Grossman RI; Inglese M
Conventional imaging is unable to detect damage that accounts for permanent cognitive impairment in patients with mild traumatic brain injury (MTBI). While diffusion tensor imaging (DTI) can help to detect diffuse axonal injury (DAI), it is a limited indicator of tissue complexity. It has also been suggested that the thalamus may play an important role in the development of clinical sequelae in MTBI. The purpose of this study was to determine if diffusional kurtosis imaging (DKI), a novel quantitative magnetic resonance imaging (MRI) technique, can provide early detection of damage in the thalamus and white matter (WM) of MTBI patients and if thalamic injury is associated with cognitive impairment. Twenty-two MTBI patients and 14 controls underwent MRI and neuropsychological testing. Mean kurtosis (MK), fractional anisotropy (FA), and mean diffusivity (MD) were measured in the thalamus and several WM regions classically identified with DAI. Compared to controls, patients examined within one year after injury exhibited variously altered DTI and DKI derived measures in the thalamus and the internal capsule while, in addition to these regions, patients examined more than one year after injury also showed similar differences in the splenium of the corpus callosum and the centrum semiovale. Cognitive impairment was correlated to MK in the thalamus and the internal capsule. These findings suggest that combined use of DTI and DKI provides a more sensitive tool for identifying brain injury. In addition, MK in the thalamus might be useful for early prediction of permanent brain damage and cognitive outcome
PMCID:3430483
PMID: 21639753
ISSN: 1557-9042
CID: 135641
Effort, exaggeration and malingering after concussion
Silver, Jonathan M
Although most individuals who suffer a mild traumatic brain injury have complete recovery, a number experience persistent symptoms that appear inconsistent with the severity of the injury. Symptoms may be ascribed to malingering, exaggeration or poor effort on cognitive testing. The purpose of this paper is to propose that previously unconsidered factors, informed by social psychology and behavioural economics, can appear as 'symptom magnification' or 'poor effort', which are incorrectly interpreted as the result of a conscious process. These are complex and multi-determined behaviours with a unique differential diagnosis which have important implications for research, evaluation and treatment.
PMID: 22696584
ISSN: 0022-3050
CID: 171560
Pharmacotherapy of cognitive impairment
Chapter by: Acriniegas, DB; Silver, JM
in: Brain Injury Medicine by Zasler, Nathan; Katz, Douglas; Zafonte, Ross [Eds]
New York : Demos Medical Publishing, 2012
pp. 1215-1226
ISBN: 1617050571
CID: 427192
Pharmacotherapy of neuropsychiatric disturbances
Chapter by: Arciniegas, DB; Silver, JM
in: Brain Injury Medicine by Zasler, Nathan; Katz, Douglas; Zafonte, Ross [Eds]
New York : Demos Medical Publishing, 2012
pp. 1227-1244
ISBN: 1617050571
CID: 427202
Neuropsychiatry of traumatic brain injury
Chapter by: Silver, JM; Hayes, RE; Yudofsky, SC
in: Clinical manual of neuropsychiatry by Yudofsky, Stuart C; Hales, Robert E [Eds]
Washington, DC : American Psychiatric Pub., c2012
pp. 119-179
ISBN: 1585624292
CID: 427272
Traumatic brain injury
Chapter by: Silver, JM; Yudofsky, SC; Hales, RE
in: ASCP Model Psychopharmacology Curriculum by
[S.l.] : American Society of Clinical Psychopharmacology, 2012
pp. 212-?
ISBN: n/a
CID: 428332
The 'unexplained' illness: costly, but is it treatable?
Silver, Jonathan M
PMID: 21429901
ISSN: 1468-330x
CID: 134439
Whistling Vivaldi and other clues to how stereotypes affect us [Book Review]
Silver, JM
ORIGINAL:0008333
ISSN: 0002-953x
CID: 426792
Aggressive disorders
Chapter by: Silver, Jonathan M; Yudofsky, Stuart C; Anderson, Karen E
in: Textbook of traumatic brain injury by Silver, Jonathan M.; McAllister, Thomas W; Yudofsky, Stuart C [Eds]
Washington, DC : American Psychiatric Pub., c2011
pp. 225-238
ISBN: 1585623571
CID: 426882