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Identifying bioethical issues in biostatistical consulting: findings from a US national pilot survey of biostatisticians

Wang, Min Qi; Yan, Alice F; Katz, Ralph V
OBJECTIVES: The overall purposes of this first US national pilot study were to (1) test the feasibility of online administration of the Bioethical Issues in Biostatistical Consulting (BIBC) Questionnaire to a random sample of American Statistical Association (ASA) members; (2) determine the prevalence and relative severity of a broad array of bioethical violations requests that are presented to biostatisticians by investigators seeking biostatistical consultations; and (3) establish the sample size needed for a full-size phase II study. DESIGN: A descriptive survey as approved and endorsed by the ASA. PARTICIPANTS: Administered to a randomly drawn sample of 112 professional biostatisticians who were ASA members. PRIMARY AND SECONDARY OUTCOME MEASURES: The 18 bioethical violations were first ranked by perceived severity scores, then categorised into three perceived severity subcategories in order to identify seven 'top tier concern violations' and seven 'second tier concern violations'. RESULTS: Methodologically, this phase I pilot study demonstrated that the BIBC Questionnaire, as administered online to a random sample of ASA members, served to identify bioethical violations that occurred during biostatistical consultations, and provided data needed to establish the sample size needed for a full-scale phase II study. The No. 1 top tier concern was 'remove or alter some data records in order to better support the research hypothesis'. The No. 2 top tier concern was 'interpret the statistical findings based on expectation, not based on actual results'. In total, 14 of the 18 BIBC Questionnaire items, as judged by a combination of 'severity of violation' and 'frequency of occurrence over past 5 years', were rated by biostatisticians as 'top tier' or 'second tier' bioethical concerns. CONCLUSION: This pilot study gives clear evidence that researchers make requests of their biostatistical consultants that are not only rated as severe violations, but further that these requests occur quite frequently.
PMCID:5695368
PMID: 29146653
ISSN: 2044-6055
CID: 2784232

Delayed tooth emergence in children infected with human immunodeficiency virus

Psoter, Walter J; Nelson, Evelyn M; Psoter, Kevin J; Dearing, Bianca A; Katz, Ralph V; Catalanotto, Frank
OBJECTIVE: There is limited evidence that early deficits in growth might be reflected in tooth emergence in children infected with human immunodeficiency virus (HIV). The purpose of this study was to prospectively evaluate tooth emergence timing between children positive and negative for HIV in the exposed and unexposed groups, respectively. STUDY DESIGN: A longitudinal study of children positive for HIV and HIV-negative household peers, aged 2 to 15 years was conducted between 1993 and 1996. Emergence status was determined for the maxillary and the mandibular permanent first molars and the central and lateral incisors. A multivariable, discrete time, proportional hazards model was fitted to the data. Median age of emergence for each of the six pairs of teeth was calculated using the parameter estimates from the regression model. RESULTS: A total of 116 participants (62 HIV positive, 54 HIV negative) completed six examinations over the 36-month study period. Statistical differences in tooth emergence timing were observed for five of the six tooth pairs, with children positive for HIV being less likely to have emergence of the corresponding tooth compared with the children negative for HIV. Age differences for each tooth pair ranged from 0.7 to 1.5 years, with a median emergence age difference of 1.03 years. CONCLUSIONS: Delayed tooth emergence of the permanent dentition was observed in children with HIV.
PMCID:5031531
PMID: 27554377
ISSN: 2212-4411
CID: 2221322

Assessment of readiness of dental faculty and students in Kuwait to implement a smoking cessation counseling curriculum

Khalaf, Mai E; Katz, Ralph V
AIMS AND OBJECTIVES: The goal of this study was to assess the readiness of both dental faculty and dental students in Kuwait to implement a smoking cessation counseling curriculum. MATERIALS AND METHODS: The study population included all faculty and students in their clinical training years at the Faculty of Dentistry, Kuwait University. The survey instrument was a 42-item questionnaire. Data analysis involved employing various methods of descriptive statistics. RESULTS: Students and faculty reported that their general knowledge of what to include in a cessation message was excellent. Students reported and anticipated more clinical barriers than did the faculty. Both students and faculty agreed strongly that they were willing to refer patients for cessation in their clinical practice, faculty were much less willing to prescribe medications for cessation as compared to students. The majority of students and faculty disagreed with the statement that performing cessation was easy. Responses showed that the use of the 5 A's has not penetrated well into clinical practice for either the students or the faculty. CONCLUSIONS: Clinical students and faculty members believe smoking cessation counseling to be effective; however, their activity was mostly limited to asking patients if they smoked and both reported their knowledge of cessation counseling to be only fair.
PMCID:4863480
PMID: 27195224
ISSN: 2231-0762
CID: 2111842

Psychosocial impact of anterior dental esthetics on periodontal health, dental caries, and oral hygiene practices in young adults

Solomon, Deborah; Katz, Ralph V; Bush, Anneke C; Farley, Victoria K; McGerr, Trevor J; Min, Hoon; Carbonella, Anthony M; Kayne, Joseph D
This study sought to determine whether the self-perceived image of a young adult's anterior dental esthetics is linked with periodontal health, dental caries, and oral hygiene practices. Two hundred subjects were assessed via a clinical examination, including intraoral photographs. The subjects were questioned about their demographics and oral hygiene practices and given the Psychosocial Impact of Dental Aesthetics Questionnaire (PIDAQ) to measure their self-perceived variables related to dental esthetics. A high PIDAQ score indicates a negative image of one's own dental esthetics, while a low PIDAQ score indicates a positive outlook. A self-perceived negative psychosocial impact of anterior dental esthetics was detected in subjects with higher levels of dental caries and visible gingival inflammation in the anterior region of the mouth.
PMID: 26943088
ISSN: 0363-6771
CID: 2068432

Was the development of the Mistrust-in-Research field of study yet another 'legacy' of the USPHS Syphilis Study at Tuskegee?

Katz, Ralph V; Conguista, A; Tien, TC; Chetcuti, MC; McGowan, Richard; Lee, J; Casgli, DB; Hill, KC; Dearing, Bianca A
ORIGINAL:0011189
ISSN: 2159-8800
CID: 2703022

Oral cancer in Libya and development of regional oral cancer registries: A review

BenNasir, E; El Mistiri, M; McGowan, R; Katz, R V
The aims of this paper are three-fold: (1) to summarize the current epidemiological data on oral cancer in Libya as reported in the published literature and as compared to other national oral cancer rates in the region; (2) to present both the history of the early development, and future goals, of population-based oral cancer tumor registries in Libya as they partner with the more established regional and international population-based cancer tumor registries; and, (3) to offer recommendations that will likely be required in the near future if these nascent, population-based Libyan oral cancer registries are to establish themselves as on-going registries for describing the oral cancer disease patterns and risk factors in Libya as well as for prevention and treatment. This comprehensive literature review revealed that the current baseline incidence of oral cancer in Libya is similar to those of other North Africa countries and China, but is relatively low compared to the United Kingdom, the United States, and India. The recently established Libyan National Cancer Registry Program, initiated in 2007, while envisioning five cooperating regional cancer registries, continues to operate at a relatively suboptimal level. Lack of adequate levels of national funding continue to plague its development...and the accompanying quality of service that could be provided to the Libyan people.
PMCID:4642192
PMID: 26644751
ISSN: 1013-9052
CID: 1870102

Revisiting the status of oral health services in adult PM&R programs: a 40-year follow-up survey

Katz, Ralph V; Tillman, Hilde H; Bloch, Rina M; Stojanovic, Maria; Kaira, Akanksha
PURPOSE: This survey compared the status of oral health service access and needs for adult Physical Medicine & Rehabilitation (PM&R) patients over a 40-year period. METHODS: This report compares two surveys (1974 vs. 2014) of Directors of PM&R residency programs in the United States. The same 14 survey questions used in 1974 survey were repeated in 2014, with four new questions added. RESULTS: The major comparative findings about oral health services were that while perceived need remained high and availability and adequacy of dental care remained low, program directors indicated a slightly lessened desirability, feasibility and overall support for the concept of integrating oral health services into their PM&R program in the 2014 survey. CONCLUSION: These findings show that 40 years has not brought better access to oral health care for adult PM&R patients, only a slightly lessened enthusiasm in the program directors. Future research should explore the reasons underlying these disappointing outcomes.
PMID: 26094713
ISSN: 1754-4505
CID: 1641152

Significant unmet oral health needs of homebound elderly adults

Ornstein, Katherine A; DeCherrie, Linda; Gluzman, Rima; Scott, Elizabeth S; Kansal, Jyoti; Shah, Tushin; Katz, Ralph; Soriano, Theresa A
OBJECTIVES: To assess the oral health status, use of dental care, and dental needs of homebound elderly adults and to determine whether medical diagnoses or demographic factors influenced perceived oral health. DESIGN: Cross-sectional analysis. SETTING: Participants' homes in New York City. PARTICIPANTS: Homebound elderly adults (N = 125). MEASUREMENTS: A trained dental research team conducted a comprehensive clinical examination in participants' homes and completed a dental use and needs survey and the Geriatric Oral Health Assessment Index. RESULTS: Participants who reported a high level of unmet oral health needs were more likely to be nonwhite, although this effect was not significant in multivariate analysis. Individual medical diagnoses and the presence of multiple comorbidities were not associated with unmet oral health needs. CONCLUSION: The oral health status of homebound elderly adults was poor regardless of their medical diagnoses. High unmet oral health needs combined with strong desire to receive dental care suggests there is a need to improve access to dental care for this growing population. In addition to improving awareness of geriatricians and primary care providers who care for homebound individuals, the medical community must partner with the dental community to develop home-based programs for older adults.
PMCID:4367536
PMID: 25537919
ISSN: 0002-8614
CID: 1477212

Skills in Assessing the Professional Literature (SAPL): A 7-year Analysis of Student EBD Performance

Katz, Ralph V; Shamia, Hebba A; Dearing, Bianca A; Kang, Paul D S; Li, Lin; Chang, Andy
PURPOSE: The primary goal of this project was to describe the level of knowledge acquisition using detailed test performance outcomes of the EBD SAPL curriculum over its first 7-years of implementation at the NYU College of Dentistry. A secondary goal was to compare performance outcomes impact of the full 60 h base SAPL curriculum as taught to 4-year DDS students vs an abbreviated 30 h base SAPL curriculum as taught to 3-year Advanced Placement DDS students. METHODS: The findings for the period 2004-2010 are reported for 1647 dental students (63.6% 4-year DDS students, 36.3% 3-year Advanced Placement DDS students). The database consisted of the score earned by each student on each individual question of the SAPL course's 4 h final examination in which each student read an original research article and answered all questions on the Literature Analysis Form. RESULTS: The major findings were overall high performance by both groups of students (SAPL exam scores of 85.8 vs 83.7, respectively) as well as very similar outcomes between these two student groups on: 1) recognizing research design elements and on interpreting those design elements for clinical application, 2) detailed performance of knowledge within the specific five traditional sections of research articles, and 3) detailed performance across 18 identified research design topics. CONCLUSION: In conclusion, both course formats appear to be highly effective for their respective student groups, but should not be interpreted as evidence favoring the shorter format given the different characteristics of the two student groups.
PMID: 25234208
ISSN: 1532-3382
CID: 1252022

Effect of early childhood protein-energy malnutrition on permanent dentition dental caries

Reyes-Perez, Elisandra; Borrell, Luisa N; Katz, Ralph V; Gebrian, Bette J; Prophete, Samuel; Psoter, Walter J
OBJECTIVES: The objective of this study is to determine the effect of early childhood protein-energy malnutrition (ECPEM) on decayed, missing, filled tooth (DMFT) scores in the permanent dentition of rural Haitian adolescents aged 11-19 years (n = 1,006). METHODS: We used data from a retrospective cohort that was developed from the Haitian Health Foundation database and merged records on weight-for-age covering the birth through 5-year-old period for all enrolled participants. Dental examinations and interviewer-administered structured questionnaires on demographic and socioeconomic status, and relative sugar consumption were completed in 1,058 participants aged 11-19 years. The ECPEM was defined based on weight-for-age of the subjects during their first 5 years of life that were converted to Z-scores based on the National Center for Health Statistics referent database. Descriptive statistics were calculated. DMFT was regressed on ECPEM adjusting for age, sex, current body mass index Z-score, socioeconomic status, relative sugar consumption, and number of permanent teeth present assuming a Poisson distribution. RESULTS: Questionable malnutrition [rate ratio (RR) = 0.72; 95 percent confidence interval (CI), 0.61-0.86] and malnutrition (RR = 0.58; 95 percent CI, 0.49-0.69) were associated with a statistically significant lower DMFT in Haitian adolescents. CONCLUSIONS: ECPEM status is inversely associated with DMFT in Haitian participants. Further follow-up of these same participants will be recommended to evaluate the potential caries catch-up effect.
PMCID:4029931
PMID: 24255941
ISSN: 0022-4006
CID: 667572