Faculty Bibliography

BACKGROUND:Buckling of a transesophageal echocardiography (TEE) probe is a rare but potentially life-threatening complication that carries a significant risk of esophageal perforation. CASE SUMMARY/METHODS:We report 3 cases of buckled TEE probes that were promptly recognized, diagnosed, and managed using multimodal imaging. In each instance, the location of the buckled probe was confirmed with bedside imaging. Subsequently, the patient was taken to the interventional suite for advancement of the probe to the stomach under fluoroscopic guidance. Finally, the buckled TEE probe was straightened and removed successfully from the patient without difficulty. DISCUSSION/CONCLUSIONS:Early recognition of buckled TEE probes and employment of a structured, algorithmic management approach are essential to optimizing outcomes and preventing associated morbidity and mortality. TAKE HOME MESSAGES/CONCLUSIONS:Buckling of the TEE probe requires a high index of suspicion and prompt diagnosis to prevent catastrophic complications such as esophageal perforation. Advancement of the TEE probe in the stomach under fluoroscopic guidance facilitates straightening and removal of the probe without the risk of esophageal perforation.

UNLABELLED:Oral anticoagulation (OAC) remains the primary means of stroke prevention in patients with atrial fibrillation (AF). However, there are patients at greater risk of bleeding or who have experienced major bleeding, whereby long term OAC is relatively contraindicated. Additionally, up to 55% of eligible AF patients do not utilize OAC. Thus, transcatheter left atrial appendage occlusion devices (LAAOD) present an attractive alternative to mitigate stroke risk. Randomized trials have demonstrated the noninferiority of LAAOD to OAC in reducing stroke risk. However, treatment with LAAODs presents its own risks, including the risk of device-related thrombus (DRT). In this report, we describe an unusual case of a patient with a small DRT initially identified on transesophageal echocardiography (TEE) 6 weeks after implantation of a Watchman FLX (Boston Scientific, Marlborough, MA, USA) LAAOD that was appropriately treated and resolved on TEE 6 months after implantation. However, a massive late DRT recurred 2 years after implantation. This case highlights the importance of continued device monitoring for unfavorable evolution of DRT beyond the currently recommended 45-day to 1-year monitoring period, and especially after suspected thrombus resolution. Furthermore, it underlines the importance of developing newer generation LAAOD that reduces DRT risk. LEARNING OBJECTIVE/UNASSIGNED:Left atrial appendage occlusion devices can mitigate stroke risk in atrial fibrillation patients with contraindications to oral anticoagulation. However, these devices present with their own risks, including the risk of device-related thrombus (DRT). This case highlights the importance of continued device monitoring for unfavorable evolution of DRT beyond the recommended 45-day to 1-year monitoring period.

PURPOSE OF REVIEW:This review summarizes the current and evolving landscape of multimodality imaging for percutaneous endocardial left atrial appendage occlusion (LAAO) across three phases: preprocedural planning, periprocedural guidance, and postprocedural follow-up. RECENT FINDINGS:Transesophageal echocardiography (TEE) remains the primary imaging modality to assess the left atrial appendage (LAA) in all three phases of clinical care surrounding LAAO, though many innovations have led to the rise of cardiac computed tomography (CCT) and intracardiac echocardiography (ICE) as powerful adjuncts and alternatives to TEE. Advances in CCT technology such as fusion imaging and three-dimensional (3D) modeling have contributed to the emergence of CCT as an alternative to TEE for preprocedural evaluation. Intraprocedurally, real-time 3D ICE offers similar real-time guidance to TEE with similar procedural efficacy while employing a simplified workflow that can reduce procedural times and staffing needs. Post-procedural assessment with TEE or CCT is essential for evaluating device stability and complications such as peridevice leak or device-related thrombus. SUMMARY:Multimodality imaging of LAAO is a rapidly evolving field, and thoughtful integration of TEE, CCT, and ICE is critical to optimize LAAO outcomes and minimize procedural complications.

• Less-invasive interventions for moderate-to-severe, symptomatic MR are emerging. • Direct measures of MR are unreliable after intervention due to the altered orifice. • Indirect measures of MR when used together can assess procedural success. • 2D, color, and spectral Doppler indirectly evaluate MR postop. • More validation is needed to link these indirect markers to long-term outcomes.

BACKGROUND:Diagnosis and management of multivalve disease could be challenging for clinicians. Rheumatic heart disease is a well-known etiology of multivalve disease. CASE SUMMARY/METHODS:A 51-year-old male with a history of rheumatic heart disease was referred to rule out infectious endocarditis. Three-dimensional (3D) transesophageal echocardiography (TEE) showed significant stenosis of the tricuspid valve, moderate tricuspid regurgitation, rheumatic mitral valve disease, and a bicuspid aortic valve. DISCUSSION/CONCLUSIONS:Transthoracic echocardiography is the modality of choice for evaluation of cardiac valves and quantification of cardiac chambers. However, due to the complex nature of multivalve disease, using a complementary imaging technique such as 3D TEE becomes crucial in many patients. Tricuspid stenosis as the dominant valvular lesion in rheumatic heart disease is rare and almost always occurs in the presence of mitral valve disease. We present a unique case of rheumatic heart disease with the involvement of mitral and tricuspid valves in the presence of a bicuspid aortic valve, in which tricuspid stenosis is the predominant lesion. We also discuss the important role of cardiac imaging and 3D TEE in patient decision making. TAKE-HOME MESSAGES/CONCLUSIONS:Tricuspid stenosis as the dominant valvular lesion in rheumatic heart disease is rare and almost always occurs in the presence of mitral valve disease. Transthoracic echocardiography remains the modality of choice for evaluation of the tricuspid valve. 3D TEE can play an important role in reaching a final management decision.

• LAAO devices are used for patients with AF intolerant of anticoagulation. • Periprocedural multimodality imaging is crucial for successful device deployment. • LAAs with bifid morphologies are uncommon and pose procedural challenges. • We describe closure of a bifid LAA using 2 side-by-side lobe-and-disk devices.

PURPOSE OF REVIEW/OBJECTIVE:Although rare, the development of mechanical complications following an acute myocardial infarction is associated with a high morbidity and mortality. Here, we review the clinical features, diagnostic strategy, and treatment options for each of the mechanical complications, with a focus on the role of echocardiography. RECENT FINDINGS/RESULTS:The growth of percutaneous structural interventions worldwide has given rise to new non-surgical options for management of mechanical complications. As such, select patients may benefit from a novel use of these established treatment methods. A thorough understanding of the two-dimensional, three-dimensional, color Doppler, and spectral Doppler findings for each mechanical complication is essential in recognizing major causes of hemodynamic decompensation after an acute myocardial infarction. Thereafter, echocardiography can aid in the selection and maintenance of mechanical circulatory support and potentially facilitate the use of a percutaneous intervention.

• Paracardiac cysts (located adjacent to or inside the heart) are rarely detected. • There is a broad differential diagnosis for cysts encountered with echocardiography. • Multimodality imaging is crucial for comprehensively evaluating paracardiac cysts.

• Precise LAA anatomy must be established for LAA occlusion device selection. • We have developed the TUPLE maneuver, an acronym for “tilt up and turn left”. • The TUPLE maneuver facilitates LAA device selection and intraprocedural guidance.

Genetically modified xenografts are one of the most promising solutions to the discrepancy between the numbers of available human organs for transplantation and potential recipients. To date, a porcine heart has been implanted into only one human recipient. Here, using 10-gene-edited pigs, we transplanted porcine hearts into two brain-dead human recipients and monitored xenograft function, hemodynamics and systemic responses over the course of 66 hours. Although both xenografts demonstrated excellent cardiac function immediately after transplantation and continued to function for the duration of the study, cardiac function declined postoperatively in one case, attributed to a size mismatch between the donor pig and the recipient. For both hearts, we confirmed transgene expression and found no evidence of cellular or antibody-mediated rejection, as assessed using histology, flow cytometry and a cytotoxic crossmatch assay. Moreover, we found no evidence of zoonotic transmission from the donor pigs to the human recipients. While substantial additional work will be needed to advance this technology to human trials, these results indicate that pig-to-human heart xenotransplantation can be performed successfully without hyperacute rejection or zoonosis.