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Global insights on diversity, equity, and inclusion-perspectives and experiences from musculoskeletal radiologists of the International Skeletal Society DEI Committee

Chhabra, Avneesh; Alaia, Erin F; Bucknor, Matthew D; Choi, Jung-Ah; Forster, Bruce B; Gyftopoulos, Soterios; Hayashi, Daichi; Isaac, Amanda; Matrawy, Khaled; McGill, Kevin C; Motamedi, Kambiz; Prakash, Mahesh; Serfaty, Aline; Smith, Stacy E; Stevens, Kathryn J; Bredella, Miriam A
Diversity, equity, and inclusion (DEI) is important for delivering high-quality, culturally competent care and ensuring equal access to resources and opportunities in healthcare. However, the implementation of DEI has been met with unique challenges and successes across the globe. The International Skeletal Society (ISS), a multidisciplinary musculoskeletal society, made a conscious effort to promote DEI. This article discusses advantages and controversies of DEI approaches, DEI initiatives implemented by the ISS, and experiences of the ISS DEI committee members from their respective continents. The ISS DEI committee implemented educational webinars with expert panel discussions, revising membership criteria and policies for enhancing inclusiveness, advising on programing and speakers for the annual meeting, and fostering mentorship. From a global perspective, in North America, DEI has improved health outcomes and patient care, but anti-DEI legislation has posed significant challenges. Europe relies on international recruitment but faces challenges in staff retention. South America's cultural diversity necessitates culturally sensitive approaches, but discussions about DEI are scarce, and gender inequalities persist in leadership. In Africa, DEI principles are underdeveloped, with limited engagement among stakeholders. In Asia, DEI is emerging, with more women being appointed to faculty positions and leadership roles in academic societies. The implementation of meaningful DEI initiatives requires long-term institutional buy-in and the global participation and commitment of employees and institutional leaders at all levels.
PMID: 40220144
ISSN: 1432-2161
CID: 5824482

Musculoskeletal infection reporting and data system (MSKI-RADS): multi-institutional wider generalizability study

Chhabra, Avneesh; He, Angela; Chalian, Majid; Pandey, Tarun; Alaia, Erin; Wong, Philip K; Lee, Kenneth S; Colucci, Philip G; Subhawong, Ty; Vossen, Josephina A; Samet, Jonathan; Chen, Eric; Dayan, Etan; Chang, Yu-Cherng Channing; Driessen, Rebecca; Rich, Natalie; Cummings, Ryan; Radder, Nivedita; Zemianschi, Razwan; Mohanan, Shilpa; Zech, John; Sanders, Alison Esteva; Qiao, Yujie; Brisk, Brody; Kim, Junman; Igbinoba, Zenas; Tan, Nicholas; Venugopal, Nitin; Laucis, Nicholas; Eacobacci, Katherine; Shaqdan, Ayman; Napolitano, Alex; Davis-Hayes, Cecilia; Taneja, Atul Kumar; Iancau, Alex; Zhu, Alex; Xi, Yin; Silva, Flavio Duarte
OBJECTIVE:To determine inter-reader reliability and diagnostic accuracy of MSKI-RADS among early-career radiologists with different experience levels. MATERIALS AND METHODS/METHODS:This is a retrospective multicenter study of MRIs of proven musculoskeletal (MSK) infections. MSKI-RADS categories included: 0-incomplete imaging, I-negative for infection, II-superficial soft tissue infection, III-deeper soft tissue infection, IV-possible osteomyelitis (OM), V-highly suggestive of OM, VI-known OM, and NOS-nonspecific bony lesions unrelated to infection. There were 22 readers from 9 institutions with 1-8 years of radiology experience, including radiology residents, MSK radiology clinical fellows, and junior MSK attendings. After initial training with expert readers, a dataset of 210 cases across a spectrum of extremity infections from a single institution was evaluated. The readers recorded the following for each case: MSKI-RADS score, final qualitative diagnosis, and confidence levels for both. Inter-reader agreements (ICC) and accuracy were obtained. RESULTS:Among 210 cases, there were 17 negative, 32 superficial soft tissue infections, 39 deeper soft tissue infections, 24 possible OM, 41 highly suggestive of OM, 18 known OM, and 39 NOS cases. A moderate inter-reader agreement was seen for 22 readers (ICC: 0.57 (CI = 0.52, 0.67)). The average true positive rates for non-infectious cases (I and NOS), soft tissue infection (II and III), and bony infection (IV and V) were 70% (95% CI: 67-73%), 66% (95% CI: 63-68%), and 82% (95% CI: 80-84%), respectively. Average true positive rates for classes V and VI were 80% (95% CI: 77-82%) and 86% (95% CI: 82-89%), respectively. Overall, MSKI-RADS reader accuracy was 66 ± 10%, higher than the qualitative diagnosis accuracy of 59 ± 11% (p < 0.05). Average confidence levels for MSKI-RADS score and final qualitative diagnosis were 3.56 ± 0.91 and 3.52 ± 0.92, respectively (p > 0.05). CONCLUSION/CONCLUSIONS:MSKI-RADS is an accurate and reliable MRI-based classification system for the diagnosis of a spectrum of musculoskeletal infections among early-career radiologists, like expert readers. KEY POINTS/CONCLUSIONS:Question What is the inter-reader reliability and diagnostic accuracy of the musculoskeletal infection reporting and data system (MSKI-RADS) among early-career radiologists with different experience levels? Findings Overall reader accuracy using MSKI-RADS was significantly higher than the accuracy for final qualitative diagnoses, like the results of the initial validation study with expert readers. Clinical relevance MSKI-RADS is valid and reliable for diagnosis and grading of a spectrum of extremity musculoskeletal infections for early career radiologists of different experience levels, like expert readers.
PMID: 40875018
ISSN: 1432-1084
CID: 5910492

A Prospective Single-Arm Trial of Genicular Artery Embolization for Symptomatic Knee Osteoarthritis: Clinical and Biomarker Outcomes

Taslakian, Bedros; Mabud, Tarub; Attur, Mukundan; Alaia, Erin F; Samuels, Jonathan; Macaulay, William; Ramos, Danibel; Salame, Christiana; Liu, Shu; Morris, Elizabeth M; Hickey, Ryan
PURPOSE/OBJECTIVE:To evaluate the safety and efficacy of genicular artery embolization and its longitudinal effects on biomarkers implicated in knee osteoarthritis (KOA) pathogenesis.. MATERIALS AND METHODS/METHODS:This is a prospective, single-arm clinical trial of patients with symptomatic KOA resistant to conservative therapy for greater than 3 months. Twenty-five patients who underwent GAE using 250-μm microspheres were included. Patient reported outcome measures were evaluated at baseline and 1-, 3-, and 12-months following GAE. Blood samples were collected for biomarker analysis. Magnetic resonance imaging was obtained at baseline and 3 months post GAE. The primary endpoint was the clinical success rate at 12 months. Baseline and follow-up outcomes were analyzed using the Wilcoxon matched-pairs signed-rank test. RESULTS:The technical success was 100%, with no significant adverse events. The clinical success rate was 62%. The mean VAS pain score for the target knee decreased by 48.5% at 1 month, 50.8% at 3 months, and 55.4% at 12 months (p < .001). WOMAC pain scores improved by 39.6% at 1 month, 50.1% at 3 months, and 43.7% at 12 months (p < .001). There was a statistically significant decrease in the serum levels of vascular endothelial growth factor (VEGF) and Interleukin-1 receptor antagonist (IL-1Ra) at 12 months. The remaining biomarkers showed no significant change. CONCLUSIONS:GAE is a safe treatment for symptomatic KOA, providing clinically significant pain relief for a subset of patients. The observed reductions in serum VEGF and IL-1Ra levels following GAE may contribute to local pain relief and decreased inflammation in the knee joints.
PMID: 40812531
ISSN: 1535-7732
CID: 5907702

Artificial Intelligence Large Language Models Improve Patient Comprehension of Radiologist MRI Reports

Berzolla, Emily; Gosnell, Griffith G; Chen, Larry; Vonck, Caroline; Alaia, Erin; Meislin, Robert
PURPOSE/OBJECTIVE:To assess whether an Artificial Intelligence (AI) translation of a magnetic resonance imaging (MRI) report improved patient understanding of the information presented in the radiology report and to evaluate patient preferences for these translations over traditional radiology reports. METHODS:Patients presenting to an orthopedic surgery clinic were prospectively enrolled and randomized into two groups. The "standard MRI group" received a traditional MRI report written by a radiologist of a multi-ligament knee injury, while the "AI group" received an AI- translated version of the same report, generated using ChatGPT 4. All patients completed a standardized quiz to assess comprehension of their respective reports. Following the quiz, participants were provided with both reports and asked to rate their preferences between the two. Demographic information including age, sex, race, education level, area deprivation index, and previous orthopedic history was collected from all patients. RESULTS:A total of 64 patients (32 in each group) with an average age of 51.9 ± 15.5 years were enrolled and randomized. No significant differences in demographics were identified between the two groups. Patients in the AI group scored 20% higher than those in the standard MRI group on the comprehension quiz (74.7% vs 54.7%, p<.001). 87.5% of patients preferred the AI translation while 4.7% preferred the standard version. Patients rated the AI translation as significantly clearer than the standard (4.5/5 vs. 2.2/5, p<.001), although they had less trust in the AI translation compared to the standard report (4.1/5 vs 4.5/5, p=.003). A higher education level was predictive of comprehension. CONCLUSION/CONCLUSIONS:AI-translated MRI reports significantly improved patient comprehension and were preferred for their clarity, despite lower trust levels compared to standard radiology reports. CLINICAL RELEVANCE/CONCLUSIONS:AI-translated MRI reports have the potential to enhance patient understanding of radiologic findings in orthopedic care. However, given the low quality and low level of trust in AI-generated content observed in this study, physician oversight remains essential to ensure accuracy and sustain patient confidence.
PMID: 40288466
ISSN: 1526-3231
CID: 5832962

Zone specific bone density evaluation of the acromion may predict postoperative acromion stress fracture in patients undergoing a reverse total shoulder arthroplasty

Colasanti, Christopher A; Lin, Charles C; Levin, Jay M; Shen, Michelle S; Ben-Ari, Erel; Alaia, Erin; Simovitch, Ryan W; Zuckerman, Joseph D
BACKGROUND:The goal of this study was to utilize preoperative computed-tomography(CT) scans to identify differences in the Hounsfield units(HU) of the acromion in patients who did and did not develop a postoperative acromial and scapular-spine fracture(ASF) after primary reverse total shoulder arthroplasty (rTSA). METHODS:A retrospective analysis was performed at a single institution. All patients undergoing a rTSA with either a 135° neck/shaft angle(NSA) humeral inlay design combined with a lateralized center-of-rotation(COR) glenosphere or a 145° NSA onlay combined with a medialized COR glenosphere design between 2011-2021 with a minimum follow-up of 24-months were included. Demographic characteristics and clinical outcome metric scores were recorded. Preoperative CT scans were analyzed to obtain acromion trabecular bone density measurements in HU in each zone of the scapula based on the Levy classification. Radiographic parameters were evaluated to determine their association with ASF. RESULTS:In total 263-patients were included, 140-patients with a 135° NSA humeral-inlay design;123-patients with a 145° NSA humeral-onlay design. There were no significant differences in baseline demographics between cohorts. The rate of ASF was 6.4%(9/140) for the 135° NSA-inlay-design versus 2.4%(3/123) in the 145° NSA-onlay design. In the non-fracture cohort there was a linear increase in bone density from zone-1(173.9HU)→zone-3(396.5HU)(lateral→medial). In the fracture cohort there was a decrease in bone density from zone-1(282.6HU)→zone-3(154.5HU). Measuring preoperative bone density in all Levy specific fracture-zones resulted in an AUC of 0.96 correlating to excellent predictive value. A threshold cutoff of 99.9 resulted in a sensitivity of 91.6% and specificity of 75.3%. A HU of 99.9 in any of the three-zones resulted in OR 5.1(p<0.0001) for sustaining an ASF postoperatively. A threshold of<50HU was associated with an 8-times higher-likelihood of developing a fracture in that specific zone. Greater than 5° of superior tilt in combination with ≥24mm of distalization was associated with an OR 6.4(p=0.0004) of sustaining an ASF. CONCLUSION/CONCLUSIONS:The current study demonstrates an accurate method of measuring HU at each of the described Levy fracture zones with excellent predictability of patients who are at risk of an ASF following rTSA. Additionally, we found that a HU threshold of <50 HU at any of the three Levy zones was associated with a nearly 8 times higher likelihood of developing a fracture in that specific zone. Lastly, we found that >5° of superior tilt in combination with ≥24mm of distalization was associated with 6.4 times higher likelihood of sustaining an ASF agnostic to prosthesis design.
PMID: 40089016
ISSN: 1532-6500
CID: 5812842

Pre- and Postoperative Imaging: What the Surgeon Wants to Know

Alaia, Erin; Atinga, Angela
PMID: 39933536
ISSN: 1098-898x
CID: 5793372

Imaging of Reparable and Irreparable Rotator Cuff Tears

Murthy, Sindhoora; Shen, Michelle; Lemos, Diego F; Alaia, Michael J; Alaia, Erin F
This review offers a comprehensive discussion of magnetic resonance imaging (MRI) for the assessment of rotator cuff tendon repair and joint-preserving surgical options for patients with irreparable rotator cuff tears. Deciding to proceed with arthroscopic repair of a rotator cuff tendon tear is impacted both by clinical factors and morphological imaging features. Preoperative clinical and imaging features also predict the likelihood of success of a rotator cuff tendon repair and are important to recognize. In patients with irreparable rotator cuff tears and relatively preserved glenohumeral cartilage, various joint-preserving surgical options are available and seen increasingly in clinical practice.The acceptable range of postoperative imaging findings correlating with a functionally intact rotator cuff repaired tendon, and MRI findings that are either suggestive of or definitive for rotator cuff tendon repair failure are discussed in detail, with attention to the Sugaya classification. Ancillary features, such as progressive retraction of the myotendinous junction and the degree of muscle fatty atrophy, can be used as problem-solving tools in cases equivocal for rotator cuff retear. Finally, this review discusses in detail the most common joint-preserving treatment options for patients with irreparable rotator cuff tears, including an in-depth focus on superior capsular reconstruction.
PMID: 39933546
ISSN: 1098-898x
CID: 5793402

Magnetic Resonance Imaging of Thumb Carpometacarpal Arthroplasty: Preoperative Evaluation and Postoperative Imaging

Lemos, Diego F; Kanner, Christopher D; Geeslin, Matthew G; Lack, Mark E; Benoit, Michel Y; Alaia, Erin F
In this review we discuss the magnetic resonance imaging (MRI) appearance of thumb carpometacarpal (CMC) arthroplasty, both the preoperative evaluation and particularly the postoperative MRI of different surgical options for patients with advanced degenerative disease of the basal joint of the thumb. The first CMC joint is one of the most frequently involved articulations in the hand and wrist in the setting of degenerative osteoarthrosis and certainly a pain generator and important cause of disability due to its significant impact on hand function. It is the most common joint for which surgery is sought in the wrist. Radiologists interpreting imaging studies of patients with first CMC joint arthroplasty must be familiar with the normal and abnormal preoperative appearance of the thumb basal joint. Moreover, knowledge of the normal postoperative MRI findings, as well as the appearance of patterns of failure and complications, is of paramount importance.
PMID: 39933543
ISSN: 1098-898x
CID: 5793392

Clinical outcomes following transtibial medial meniscal root repair are maintained at long-term follow-up

Moore, Michael; Levitt, Sarah; Lin, Charles C; Wolfe, Isabel; Alaia, Erin; Meislin, Robert; Strauss, Eric J; Jazrawi, Laith; Alaia, Michael J; Kaplan, Daniel
PURPOSE/OBJECTIVE:To evaluate long-term outcomes of patients treated with posterior medial meniscal root tear (PMMRT) repair through assessment of functional outcome scores and to identify patient surgical and magnetic resonance imaging (MRI) characteristics associated with improved outcomes. METHODS:This was a single-centre, retrospective study evaluating patients who had undergone a PMMR repair using a transtibial suture pullout technique with two locking cinch sutures. This was performed as a follow-up to previously published 2-year and 5-year outcome studies, using the same cohort. All patients from the prior short-term and midterm studies were invited to participate. Patient-reported outcome (PROs) scores, including the International Knee Documentation Committee (IKDC) and Lysholm scores, were collected. Previously collected demographic data were updated based on review of the electronic medical record. Patient outcomes were assessed preoperatively, as well as at 2-year, 5-year and 8-year postoperatively. MRI outcome measurements were assessed at 2-year and 5-year follow-ups. All statistical analysis was performed using SPSS version 26. RESULTS:Seventeen patients of the original 18 patients (94.4%) were included in the final analysis. Additionally, three patients who had additional ipsilateral surgery were excluded from the analysis of PROs. The IKDC score significantly increased from 44.7 ± 11.6 at preoperative baseline to 71.2 ± 21.3 at 8-year post-operation (p = 0.001). There were no significant differences in IKDC score between 2-year and 8-year follow-ups (p = n.s.) or 5-year and 8-year follow-ups (p = n.s.). The Lysholm score significantly increased from 49.6 ± 7.3 at preoperative baseline to 76.4 ± 17.2 at 8-year follow-up (p < 0.001). There was no significant difference in Lysholm scores between 2-year and 8-year follow-ups (p = n.s.) or 5-year and 8-year follow-ups (p = n.s.). A linear regression analysis found that 5-year IKDC scores were significantly correlated with 8-year IKDC scores (β = 0.681, p = 0.038). At 8-year follow-up, four (23.5%) patients required additional procedures on their operative knee (one total knee arthroplasty conversion). CONCLUSION/CONCLUSIONS:Patients treated with repair of PMMRT had maintenance of clinical outcome improvements at long-term follow-up despite worsening MRI outcomes at short-term and medium-term follow-ups. While a high proportion of patients required additional procedures on their operative knee at 8-year follow-up, few of these patient's additional procedures were related to failure of their primary surgery. Providers and patients may expect durable clinical outcomes following the repair of PMMRT, irrespective of radiographic appearance. LEVEL OF EVIDENCE/METHODS:Level IV.
PMID: 38923098
ISSN: 1433-7347
CID: 5733142

Utilization of Hip or Knee MRI in Patients 50 Years and Older With Atraumatic Pain: An Analysis of the National Ambulatory Medical Care Survey

Alaia, Erin F; Ross, Andrew B; Chen, Bangyan; Gyftopoulos, Soterios
PURPOSE/OBJECTIVE:The aim of this study was to use the National Ambulatory Medical Care Survey database to assess MRI utilization in patients 50 years and older with atraumatic hip or knee pain. METHODS:National Ambulatory Medical Care Survey weighted survey data (2007-2019) were obtained for ambulatory visits in patients 50 years and older with atraumatic hip or knee pain. The outcome variable was MRI ordering status, and analyzed characteristics included patient age, race/ethnicity, payer, physician specialty, metropolitan statistical area, and a coexistent radiography order. Multivariable logistic regressions were conducted to assess the association between MRI ordering status and the analyzed patient characteristics. All tests were two sided, and P values ≤.05 were considered to indicate statistical significance. RESULTS:In total, 88,978,804 knee pain and 28,675,725 hip pain patient visits (survey weighted) were analyzed, with 4,690,943 (5.3%) and 2,023,226 (7.1%) having knee or hip MRI orders, respectively. Overall, 2,454,433 knee pain visits (2.8%) and 575,155 hip pain visits (2.0%) had orders for both MRI and radiographs. Black patients (P = .03) and patients 80 years and older (P = .04) were less likely to have knee MRI ordered, whereas uninsured patients were less likely to have hip MRI ordered (P = .01). Patients with hip pain were more likely to have hip MRI ordered if seen by a surgical subspecialist (P = .01). CONCLUSIONS:A low proportion of MRI examinations were ordered for visits in patients 50 years and older with atraumatic hip or knee pain. Groups with lower health care access were less likely to have an MRI order, highlighting known disparities in health care equity.
PMID: 39122200
ISSN: 1558-349x
CID: 5730962