Searched for: in-biosketch:true
person:fabbrn01
A modified Delphi consensus on tenosynovial giant cell tumour and giant cell tumour of bone : a report from the Birmingham Orthopaedic Oncology Meeting (BOOM)
Jeys, Lee M; Botello, Eduardo; Boyle, Richard; Ebeid, Walid; Hilton, Thomas; Houdek, Matthew T; Hosking, Keith; Kurisunkal, Vineet J; Laubscher, Maritz; Morris, Guy V; Puri, Ajay; Ruggieri, Pietro; ,; Laitinen, Minna K; Abdul Bari, Yunus; Abood, Ahmed; Abraham, John A; Acosta Marin, Marthelena; Agarwal, Manish; Agarwal, Rishi; Aguirre, Marcela; Ajit Singh, Vivek; Akiyama, Toru; Al Farii, Humaid; Alaqeel, Motaz; Alaseem, Abdulrahman; Aldosari, Omar; Alexander, Kate; Alfaro, Patricio; Aljuhani, Wazzan; Allison, Daniel C; Almashahedi, Mohammed; Alotaibi, Abdullah; Alpan, Bugra; Alshaygy, Ibrahim S; Althunayan, Turki; Andreani, Lorenzo; Andreou, Dimosthenis; Andriandi, Andriandi; Annabelle, Lucas; Aponte-Tinao, Luis; Ardelt, Melanie; Armas, Selma; Aston, William; Aycan, Osman Emre; Baad-Hansen, Thomas; Baeza, Pablo; Baird, Charles; Balach, Tessa; Banse, Xavier; Barriga, Juan; Barry, Janie; Basile, Georges; Bastoni, Stefano; Basuki, Mohammad Hardian; Bauer, Henrik C; Baydar, Semay; Bayliss, Lee; Becker, Ricardo; Bedi, Angad; Benevenia, Joseph; Bengoa, Francisco; Berger, Christina; Bernthal, Nicholas; Binitie, Odion; Bird, Justin; Bobseit, Abdulrahman; Bodian, Caitlin; Boffano, Michele; Bonilla Huertas, Patricia; Bramer, Jos; Broadhead, Matthew; Broekhuis, Demien; Broida, Samuel Earl; Brown, Danielle; Bruschi, Alessandro; Budny, Tymoteusz; Buist, Mirka; Burke, Zachary; Busse, Tilmann; Cabrolier, Jorge; Calvo-Haro, Jose Antonio; Campanacci, Domenico A; Cardoso, Rodrigo; Carey Smith, Richard; Carrasco, María G; Casales, Nicolas; Castan, Ashley; Ceballos, Oscar; Chan, Chung Ming; Chan, Lester; Chang, Liang Zhen; Charoenlap, Chris; Chaustre Florez, Juan Fernando; Chin, Janet; Choong, Peter; Chrobok, Adam; Chung, Yang-Guk; Ciechanowicz, Dawid; Clara-Altamirano, Miguel Angel; Consuegra Guzman, Luis Alfonso; Cornu, Olivier; Coubeau, Laurent; Courtot, Louis; Crawford, Brooke; Cribb, Gillian; Cuervo-Lozano, Carlos Eduardo; Dammerer, Dietmar; de la Rosa, Pablo; de Lima Corvino, Daniela; De Paolis, Massimiliano; De Santos de la Fuente, Francisco Javier; de Vaal, Marieke; Deisenhofer, Julian M; Delgado Obando, Javier; Demir, Eren; Deo, Shaneel; Deventer, Niklas; Di Bella, Claudia; Dierselhuis, Edwin; Docquier, Pierre-Louis; Domson, Gregory; Donati, Davide M; Doshi, Arpan; Duivenvoorden, Myléne J C; Duran-Ciarrochi, Rodolfo; Dürr, Hans Roland; Ehlers, Pierre J; El Ghoneimy, Ahmed Mohamed; El Motassime, Alessandro; Eloi Pinto, Fabio Fernando; Endo, Makoto; Epstein, Gadi; Eralp, Levent; Etaiwi, Mahmoud; Eward, Will; Fabbri, Nicola; Faimali, Martina; Farman, Ullah; Farooq, Arbab; Farooque, Khalil; Farris, Clayton; Ferguson, Peter; Ferreira, Nando; Fiorenza, Fabrice; Flint, Michael; Forsberg, Jonathan A; Franks, Daniel; Freitas, Joao Paolo; Fuchs, Bruno; Fujiwara, Tomohiro; Funovics, Philipp T; Fuzy, Edward; Galli Serra, Marcos; Gamie, Zakareya; Garcia-Carrasco, Maria; García-Huidobro, Gabriel; Gaston, Czar Louie; Gazendam, Aaron; Georges, Basile; Ghert, Michelle; Ghosh, Kanishka Milton; Giardina, Fabio Luca; Gibbs, C Parker; Golovina, Yanina; Gomez Mier, Luis Carlos; Gomez-Mascard, Anne; Gomez-Sierra, Maria Antonia; González-Browne, Catalina; Gonzalez-Saldivar, Juan; González-Motta, Alejandro; Gortzak, Yair; Gosheger, Georg; Gouin, Francois; Goulding, Krista; Gracia, Isidro; Graydon, Andrew; Green, Natalie; Griffin, Anthony; Guedes, Alex; Gulia, Ashish; Gupta, Sanjay; Guzman, Maurice; Hardes, Jendrik; Hasan, Yusuf O; Hashim, Ahmad Munir; Havard, Hel; Haydon, Rex; Hegde, Prateek; Hernandez Lopez, Adriana; Herrera, David; Hesham, Amr; Hesla, Asle; Hess, Matthew; Hirschmann, Adam; Hobusch, Gerhard; Hohensteiner, Anna; Hongsaprabhas, Chindanai; Hornicek, Francis; Hsu, Megan; Idowu, Oluwaseyi K; Idulhaq, Mujaddid; Igbinoba, Bright; Ippolito, Joseph A; Iwata, Shintaro; Jagiello, Jakub; Johan, Muhammad P; Johnson, Luke; Johnston, Andy; Joo, Min Wook; Joyce, David; Jung, Beatrice; Jungels, Christiane; Jutte, Paul; Jutte, Willem; Jääskeläinen, Anna-Stina; Kaldas, Kadri; Kapanci, Bilal; Karaca, Mustafa Onur; Kawai, Akira; Kemp, Alysia; Khal, Adyb-Adrian; Khan, Zeeshan; Khan, Zainab Aqeel; Khaouam, Nader; Kim, Han-Soo; Klopper, Schalk; Kobayashi, Eisuke; Kobayashi, Hiroshi; Kontogeorgakos, Vasileios; Kotrych, Daniel; Krebbekx, Gitte G J; Krishnamurthy, Anjan Venkataraman; Kunisada, Toshiyuki; Kyte, Richard; Lacroix, Valérie; Lazarides, Alexander; Le Nail, Louis-Romee; Lee, Francis Y; Lee, Jewoo; Lee, Minpyo; Legosz, Pawel; Lehner, Burkhard; Leithner, Andreas; Leone, Gianpaolo; Letson, Douglas; Lewis, Valerae O; Li, Binghao; Liikanen, Hanna; Lin, Peng; Linda, Zwelithini; Lindsay, Sarah; Lozano Calderon, Santiago; Lutomia Lumbasi, Mark; Macdonald, Jonathan; Machado, Pau; Majirija, Edgar; Malina, Mario; Malyk, Roman; Marais, Leonard; Mascard, Eric; Mattei, Jean Camille; McCullough, Louise; McMahon, Samuel; Medellin Rincon, Manuel Ricardo; Mediavilla Santos, Lydia; Meijer, Diederik; Meijer, Johannes Gerard; Miller, Benjamin; Molloy, Allan; Moriel Garcesco, Diego Jesus; Morris, Carol D; Morse-Sanyal, Ashlyn; Mottard, Sophie; Mthethwa, Phakamani G; Muñoz-Montecinos, Carlos; Murcia, Miguel; Müller, Michelle; Nakayama, Robert; Narhari, Prashant; Nasar, Ali; Nayak, Prakash; Neugebauer, Johannes; Nieminen, Jyrki; Ntombela, Philani; Nystrom, Lukas; O'Reilly-Harbidge, Sarah; O'Toole, Gary; Ogura, Koichi; Oktayana, Made Dolly; Oliveira, Vania; Olivier, André; Olson, Daniel; Olusunmade, Opeyemi; Omar, Mohamed; Omran Hasan, Yusuf; Ortiz-Cruz, Eduardo J; Ozaki, Shuhei; Ozaki, Toshifumi; Ozkan, Korhan; Pala, Elisa; Palmerini, Emanuela; Panchwagh, Yogesh; Pang, Grant; Papagelopoulos, Panayiotis; Papagelopoulos, Dimitra P; Paraliticci, Giovanni; Parizzia, Walter; Parry, Michael; Pate, Matthew; Peiró, Ana; Perera, Jonathan; Petersen, Michael M; Phakathi, Oatile; Phimolsarnti, Rapin; Phiri, Tshepang; Pinheiro, Rafael; Pinto Santander, Nicolas; Ploegmakers, Joris; Pollock, Robin; Powell, Gerard; Prabowo, Yuni; Pruthi, Manish; Puhaindran, Mark; Quirion, Julia; Quirland, Camila; Rabin, Eden; Rachbauer, Anna; Radhakrishnan, Sanjeevan; Raja, Anand; Rajalbandi, Rohit; Rajani, Rajiv; Rajasekaran, Raja Bhaskara; Rajasekaran, Shanmuganthan; Rajkovic, Stanislav; Ramirez, Maria Teresa; Ramkumar, Dipak B; Rankin, Kenneth S; Ras El Abiad, Alejandro; Rasappan, Kumaran; Redl, Malena; Rizzo, Arianna; Rose, Peter S; Rosenberg, Andrew; Russell, Michael; Salcedo Rodriguez, German; Saleh, Ahmad; Sambri, Andrea; Samy, Ahmed; Sánchez-Maldonado, Maria; Saputra, Rhyan Darma; Scanferla, Roberto; Scharschmidt, Tom; Schubert, Thomas; Scoccianti, Guido; Segura, Florencio; Sellevold, Simen; Shehadeh, Ahmad; Shreemal, Bhim; Shumelinsky, Félix; Siddiqi, Ather M; Silveri, Claudio; Sinnaeve, Friedl; Smolle, Maria A; Snyman, Franz; Solomons, Michael; Sommerville, Scott; Sood, Sahil Sood; Spense, Mariel E; Spiegel, Christian; Spiguel, Andre; Staals, Eric L; Stavropoulos, Nikolaos A; Steadman, Peter; Stern, Sydney; Stevenson, Jonathan; Stoppiello, Pablo; Stubbe, Chris; Sullivan, Mikaela H; Sundin, Nathalia; Suntaxi Basantes, Felipe Martín; Szostakowski, Bartlomiej; Szostakowski, Bartek; Tandon, Nikhil; Tang, Xiaodong; Tepper, Sarah; Terrarossa, Bruno; Thippeswamy, Pushpa B; Thorkildsen, Joachim; Tootsi, Kaspar; Torner-Rubies, Ferran; Tosyali, Koray; Traub, Frank; Trent, Jonathan; Triganjananun, Chanonta; Trikoupis, Ioannis; Trullols, Laura; Tsagkozis, Panagiotis; Tsoi, Kim; Tuntarattanapong, Pakjai; Ulrich, Marisa N; Vainio, Veli-Matti; Valencia, Juan D; van de Sande, Michiel; van der Geest, Ingrid; van der Wal, Robert Jp; van Langevelde, Kirsten; Velez, Roberto; Verbeke, Léonie; Verspoor, Floortje G M; Versteeg, Anne; Vicatos, George; Virk, Jagandeep Singh; Visgauss, Julia; Vyrva, Oleg; Wafa, Hazem; Wan Faisham, Wan Ismail; Wang, Patrick Qi; Wei, Ran; Wennergren, David; Werier, Joel; Weschenfelder, Wolfram; Williams, Nadine; Wunder, Jay; Yildiz, Huseyin Yusuf; Yonamine, Eduardo S; Yonezawa, Hirotaka; Yousuf, Maitham; Zaghloul, Ahmed; Zainul-Abidin, Suraya; Zamora, Tomas; Zuckerman, Lee; Zumarraga, Juan Pablo; Özger, Harzem
AIMS/UNASSIGNED:The aim of this study was to achieve consensus on important topics related to tenosynovial giant cell tumour (TGCT) and giant cell tumour of bone (GCTB), and to identify areas for future research. METHODS/UNASSIGNED:In January 2026, a consensus meeting, The Birmingham Orthopaedic Oncology Meeting (BOOM), held in Cape Town, South Africa, gathered 314 delegates from 59 countries to debate 21 consensus statements on tenosynovial giant cell tumour (TGCT) and giant cell tumour of bone (GCTB) through a modified Delphi process. RESULTS/UNASSIGNED:Of the 21 statements, two achieved unanimous consensus, 18 strong consensus, and one moderate consensus. Unanimous consensus was reached for prioritizing joint-preserving intralesional curettage in GCTB when feasible, and for supporting non-surgical approaches in anatomically challenging cases, particularly sacral lesions. The statement addressing the role of denosumab in GCTB achieved only moderate consensus. The use of adjuvants in GCTB, as well as the management of recurrent and systemic GCTB, including long-term use of denosumab, reached strong consensus. Strong consensus was achieved in the surgical and non-surgical management for both primary and recurrent TGCT. Surveillance strategies for both TGCT and GCTB generated substantial discussion despite strong consensus, reflecting ongoing uncertainty and lack in evidence. CONCLUSION/UNASSIGNED:This international consensus provides practical guidance for the management of TGCT and GCTB while identifying important gaps in evidence. Joint-preserving surgery remains central to the treatment of GCTB, with selective integration of systemic therapies and individualized surveillance. The consensus framework highlights priorities for future collaborative research in orthopaedic oncology.
PMID: 42261942
ISSN: 2049-4408
CID: 6048272
Complications of PI to PIII hemipelvic resections for intermediate and malignant tumours : a systematic review and meta-analysis
Smolle, Maria A; Wenzl, Florian A; Laitinen, Minna K; Jeys, Lee M; ,; Leithner, Andreas; Abdul Bari, Yunus; Abood, Ahmed; Abraham, John; Acosta, Marthelena; Agarwal, Rishi; Agarwal, Manish; Ajit Singh, Vivek; Akiyama, Toru; Al Farii, Humaid; Aldosari Omar, A; Alfaro, Patricio; Aljuhani, Wazzan; Allison, Daniel; Almashahedi, Mohammed; Alotaibi, Abdullah; Alpan, Bugra; Alshaygy Ibrahim, S; Althunayan, Turki; Andreani, Lorenzo; Andreou, Dimosthenis; Andriandi, Andriandi; Annabell, Lucas; Aponte-Tinao, Luis; Armas, Selma; Aston, William; Aycan Osman, Emre; Baad-Hansen, Thomas; Baird, Charles; Balach, Tessa; Barriga Juan, Alfonso; Barry, Janie; Basile, Georges; Bastoni, Stefano; Basuki Mohammad, Hardian; Bauer, Henrik; Bayliss, Lee; Becker, Ricardo; Bedi, Angad; Benevenia, Joseph; Bengoa, Francisco; Berger, Christina; Bernthal, Nicholas; Binitie, Odion; Bird, Justin E; Bobseit, Abdulrahman; Bodian, Caitlin; Boffano, Michele; Bonilla Huertas, Patricia; Botello, Eduardo; Boyle, Richard; Bramer, Jos; Broekhuis, Demien; Broida, Samuel E; Brown, Danielle; Budny, Tymoteusz; Burke, Zachary; Cabrolier, Jorge; Calvo Haro Jose, Antonio; Campanacci, Domenico Andrea; Cardoso, Rodrigo; Carey Smith, Richard; Casales Fresenga, Nicolas; Ceballos, Oscar; Chan Chung, Ming; Chan, Lester; Choong, Peter; Chrobok, Adam; Chung, Yang-Guk; Ciechanowicz, Dawid; Clara-Altamirano Miguel, Angel; Consuegra, Luis; Courtot, Louis; Crawford, Brooke; Cribb, Gillian; Cuervo-Lozano Carlos, Eduardo; Dammerer, Dietmar; de la Rosa, Pablo; De Paolis, Massimiliano; De Santos de la Fuente Francisco, Javier; de Vaal, Marieke; Deisenhofer, Julian; Delgado, Javier; Deo, Shaneel; Deventer, Niklas; Di Bella, Claudia; Dierselhuis, Edwin; Domson, Gregory; Donati, Davide Maria; Duran-Ciarrochi, Rodolfo; Durr Hans, Roland; Ebeid, Walid; Ehlers, Pierre; El Ghoneimy Ahmed, Mohamed; El Motassime, Alessandro; Eloi Pinto Fabio, Fernando; Endo, Makoto; Epstein, Gadi; Eralp, Levent; Etaiwi, Mahmoud; Eward, Will; Fabbri, Nicola; Faimali, Martina; Farooq, Arbab; Farooque, Khalil; Ferguson, Peter; Ferreira, Nando; Fiorenza, Fabrice; Fonseca de Freitas, Joao; Forsberg Jonathan, A; Fuchs, Bruno; Fujiwara, Tomohiro; Funovics, P T; Fuzy, Edward; Galli Serra, Marcos; Gamie, Zakareya; Garcia Carrasco, Maria; Gaston Czar, Louie; Georges, Basile; Ghert, Michelle; Ghert, Michelle; Ghosh, Kanishka; Giardina Fabio, Luca; Gomez Mier Luis, Carlos; Gomez-Mascard, Anne; Gomez-Sierra, Maria Antonia; Goodman Mthethwa, Phakamani; Gortzak, Yair; Goulding, Krista; Gracia, Isidro; Green, Natalie; Griffin, Anthony; Guedes, Alex; Gulia, Ashish; Gupta, Sanjay; Guzman, Maurice; Hardes, Jendrik; Hasan Yusuf, O; Havard, Hel; Haydon, Rex; Hegde, Prateek; Hernandez Lopez, Adriana; Herrera, David; Hesla, Asle; Hess, Matthew; Hilton, Thomas; Hirschmann, Adam; Hobusch, Gerhard; Hongsaprabhas, Chindanai; Hornicek, Francis; Hosking, Keith; Houdek, Matthew T; Hsu, Megan; Idowu, Oluwaseyi; Idulhaq, Mujaddid; Ippolito, Joseph; Iwata, Shintaro; Jagiello, Jake; Jeys, Lee; Johan, Muhammad Phetrus; Johnson, Luke; Johnston, Andy; Joo, Min Wook; Jutte, Paul; Jääskeläinen, Anna-Stina; Kaldas, Kadri; Kapanci, Bilal; Karaca Mustafa, Onur; Kawai, Akira; Kemp, Alysia; Khal Adyb-, Adrian; Khan, Zeeshan; Khan Zainab, Aqeel; Kim, Han-Soo; Klopper, Schalk; Kobayashi, Eisuke; Kobayashi, Hiroshi; Kontogeorgakos, Vasileios; Kotrych, Daniel; Krishnamurthy Anjan, Venkataraman; Kunisada, Toshiyuki; Kurisunkal, Vineet; Kyte, Richard; Laitinen, Minna; Laubscher, Maritz; Lazarides, Alexander; Le Nail, Louis-Romee; Lee Francis, Y; Legosz, Pawel; Lehner, Burkhard; Leithner, Andreas; Leone, Gianpaolo; Lewis Valerae, O; Li, Binghao; Liikanen, Hanna; Lin, Peng; Linda, Zwelithini; Lindsay, Sarah; Lozano Calderon, Santiago; Lutomia Lumbasi, Mark; MacDonald, Jonathan; Malina, Mario; Marais, Len; Mascard, Eric; Mattei, Jean-Camille; McCullough, Louise; McMahon, Sam; Medellin Rincon Manuel, Ricardo; Mediavilla Santos, Lidya; Meijer, Diederik; Meijer Johannes, Gerard; Miller, Ben; Molloy, Allan; Moriel Garcesco Diego, Jesus; Morris, Guy; Morris Carol, D; Morse-Sanyal, Ashlyn; Mottard, Sophie; Munir Hashim, Ahmad; Murcia, Miguel; Müller, Michelle; Nakayama, Robert; Narhari, Prashant; Nasar, Ali; Nayak, Prakash; Neugebauer, Johannes; Nieminen, Jyrki; Ntombela, Philani; Nystrom, Lukas; O'Toole, Gary; Ogura, Koichi; Oliveira, Vania; Olivier, André; Omar, Mohamed; Omran Hasan, Yusuf; Ortiz-Cruz, Eduardo; Ozaki, Shuhei; Ozaki, Toshifumi; Pala, Elisa; Palmerini, Emanuela; Panchwagh, Yogesh; Papagelopoulos, Panayiotis; Papagelopoulos, Dimitra; Paraliticci, Giovanni; Gibbs C, Parker; Parry, Michael; Peiró, Ana; Perera, Jonathan; Petersen, Michael Moerk; Phakathi, Oatile; Phimolsarnti, Rapin; Phiri, Tshepang; Pinto Santander, Nicolas; Ploegmakers, Joris; Pollock, Robin; Powell, Gerard; Pruthi, Manish; Puhaindran, Mark; Puri, Ajay; Quirion, Julia; Rabin, Eden; Rachbauer, Anna; Radhakrishnan, Sanjeevan; Raja, Anand; Rajalbandi, Rohit; Rajani, Rajiv; Rajasekaran Raja, Bhaskara; Rajkovic, Stanislav; Ramkumar, Dipak; Rankin, Kenneth; Ras El Abiad Mejia, Alejandro; Rasappan, Kumaran; Redl, Malena; Rose Peter, S; Rosenberg, Andrew; Ruggieri, Pietro; Russell, Michael; Salcedo, German; Saleh, Ahmad; Sambri, Andrea; Saputra Rhyan, Darma; Scanferia, Roberto; Scharschmidt, Thomas; Schubert, Thomas; Scoccianti, Guido; Segura, Florencio; Sellevold, Simen; Rajasekaran, Shanmuganthan; Shehadeh, Ahmad; Shreemal, Bhim; Shumelinsky, Félix; Siddiqi Muhammad, Ather; Silveri, Claudio; Sinnaeve, Friedl; Smolle, Maria Anna; Snyman, Franz; Solomons, Michael; Sommerville, Scott; Sood Sahil, Sood; Spense Mariel, Eliana; Spiegel, Christian; Spiguel, Andre; Staals, Eric; Stavropoulos, Nikolaos; Steadman, Peter; Stern, Sydney; Stevenson, Jonathan; Stoppiello, Pablo; Sullivan Mikaela, H; Szostakowski, Bartlomiej; Szostakowski, Bartek; Tang, Xiaodong; Thippesamy Pushpa, B; Thorkildsen, Joachim; Tootsi, Kaspar; Torner Rubies, Ferran; Tosyali, Koray; Traub, Frank; Trent Jonathan, C; Trikoupis, Ioannis; Tsagkozis, Panagiotis; Tuntarattanapong, Pakjai; Ullah, Farman; Ulrich, Marisa N; Vainio, Veli-Matti; Valencia, Juan; van de Sande, Michiel; Van Der Geest, Ingrid; van der Wal, Robert; Velez Villa, Roberto; Verbeke, Léonie; Verspoor Floortje, G M; Versteeg, Anne; Vicatos, George; Virk Jagandeep, Singh; Visgauss, Julia; Vyrva, Oleg; Wafa, Hazem; Wan Faisham Numan Wan, Ismail; Wang Patrick, Qi; Wei, Ran; Wennergren, David; Werier, Joel; Weschenfelder, Wolfram; Williams, Nadine; Wunder, Jay; Yildiz Huseyin, Yusuf; Yonamine, Eduardo; Yonezawa, Hirotaka; Yousuf, Maitham; Zainul Abidin, Suraya; Zamora, Tomas; Zuckerman, Lee; Zumarraga Juan, Pablo; Özger, Harzem; Özkan, Korhan; Triganjananun, Chanonta; Aguirre, Marcela; Alaqeel, Motaz; Alaseem, Abdulrahman; Alexander, Kate; Ardelt, Melanie; Baeza, Pablo; Banse, Xavier; Franks, Daniel; Baydar, Semay; Doshi, Arpan; Bruschi, Alessandro; Buist, Mirka; Busse, Tilmann; Carrasco, María; Castan, Ashley; Chang, Liang; Charoenlap, Chris; Chaustre, Florez; Chin, Janet; Pate, Matthew; Olson, Daniel; Cornu, Olivier; Farris, Clayton; de, Lima; Demir, Eren; Docquier, Pierre-Louis; Duivenvoorden, Myléne; Farman, Ullah; Flint, Michael; García-Huidobro, Gabriel; Gazendam, Aaron; Golovina, Yanina; Gomez M Luis, Carlos; González-Browne, Catalina; Gonzalez-Saldivar, Juan Carlos; González-Motta, Alejandro; Gosheger, Georg; Gouin, Francois; Graydon, Andrew; Hesham, Amr; Hohensteiner, Anna; Igbinoba, Bright; Joyce, David; Letson, Douglas; Tepper, Sarah; Jung, Beatrice; Jungels, Christiane; Jutte, Willem; Khan Zainab, Aqeel; Khaouam, Nader; Krebbekx, Gitte; Lacroix, Valérie; Lee, Jewoo; Lee, Minpyo; Machado, Pau; Majirija, Edgar; Malyk, Roman; Mthethwa Phakamani, G; Muñoz-Montecinos, Carlos; Quirland, Camila; Ramirez, Maria; O'Reilly-Harbidge, Sarah; Oktayana, Made Dolly; Olusunmade, Opeyemi; Pang, Grant; Stubbe, Chris; Parizzia, Walter; Pinheiro, Rafael; Prabowo, Yuni; Ramkumar Dipak, B; Rizzo, Arianna; Samy, Ahmed; Sánchez-Maldonado, Maria; Sundin, Nathalia; Suntaxi, Basantes; Tandon, Nikhil; Terrarossa, Bruno; Trullols, Laura; Tsoi, Kim; Zaghloul, Ahmed
AIMS/UNASSIGNED:Surgical management of intermediate and malignant tumours in the pelvis is complex. Complications are frequent and either related to the surgery itself or to post-surgical failure of the reconstruction technique. This systematic review and meta-analysis aims at analyzing all reported complications following PI to PIII pelvic resections for intermediate and malignant tumours. METHODS/UNASSIGNED:Based on a systematic literature search on PubMed adhering to the PRISMA guidelines, 1,683 study records were identified, of which we included 90 original studies published until 22 July 2025. Overall complication rates were assessed with random-effects meta-analysis. Differences in complication rates between reconstruction types (i.e. megaprosthetic, mostly biological, none) were evaluated with meta regression analysis. RESULTS/UNASSIGNED:Data on 2,199 patients (1,250 males (57%)) with mainly PI to PIII pelvic resections were analyzed. The most common reconstruction types were custom-made implants (21%; n = 451) and ice-cream cone prostheses (14%; n = 312). Pooled rates of infections, wound healing problems, nerve injuries, and deep vein thrombosis (DVT) amounted to 15% (95% CI 12% to 18%), 13% (95% CI 10% to 15%), 7% (95% CI 5% to 9%), and 4% (95% CI 2% to 6%), respectively. Further, pooled implant revision/removal and secondary external hemipelvectomy rates were 14% (95% CI 11% to 17%) and 4% (95% CI 3% to 5%). Mostly biological reconstructions were associated with higher rates of nerve injuries (p < 0.001), construct failures (p = 0.010), and secondary implant revision/removal (p = 0.003) compared to megaprosthetic reconstruction. Further, biological reconstructions were associated with increased secondary external hemipelvectomy rates compared to megaprosthetic reconstructions (p = 0.005) or no reconstructions (p = 0.001). CONCLUSION/UNASSIGNED:Treatment of pelvic malignancies is challenging, with technically demanding resections and complex reconstructions. Across all reconstruction techniques following sacrum-sparing pelvic resections, infections and wound healing problems are the most common complications, yet there is also a considerable proportion of patients with neurovascular complications and DVTs.
PMCID:13222729
PMID: 42219227
ISSN: 2633-1462
CID: 6043392
Collision Tumor of Metastatic Lung Adenocarcinoma to Lower Limb Leiomyosarcoma: Case Report and Literature Review
Strong, Mark; Frazzette, Nicholas; Zhou, Fang; Fabbri, Nicola; Hoda, Syed T
BackgroundCollision tumors, composed of 2 histologically distinct neoplasms at the same site, are rare. They encompass a variety of subtypes, where either lesion may be benign or malignant and where they may "collide" by direct invasion or metastasis. Carcinoma-sarcoma collisions are especially uncommon, and so-called tumor-to-tumor metastasis is even rarer. Tumor-to-tumor metastasis involving lung adenocarcinoma has only been reported within benign mesenchymal tumors; no such report to date has described metastasis into a malignant soft tissue sarcoma.Patient PresentationA 90-year-old man presented with a rapidly growing soft tissue mass on the anterolateral aspect of the right knee. Biopsy revealed high-grade leiomyosarcoma. Imaging also identified a dominant pulmonary nodule. The soft tissue mass was resected, revealing not only leiomyosarcoma but also a distinct glandular proliferation. Subsequent lung biopsy confirmed adenocarcinoma. Immunohistochemistry demonstrated that the glandular component within the sarcoma shared an identical profile with the lung tumor, consistent with metastatic lung adenocarcinoma into the primary sarcoma.DiscussionThis is the first reported example of lung adenocarcinoma metastasizing into a malignant soft-tissue tumor, representing a rare tumor-to-tumor metastasis resulting in a carcinoma-sarcoma collision tumor. A review of the literature identified 12 comparable reports, none involving both a malignant donor and a malignant mesenchymal recipient. This report underscores the importance of distinguishing such lesions from carcinosarcoma using histology and immunophenotyping.ConclusionThis unique example of carcinoma-to-sarcoma metastasis expands the differential diagnosis of biphasic soft-tissue tumors. Accurate classification is critical for guiding treatment, which may require tailored oncologic strategies addressing both tumor types.
PMID: 41873473
ISSN: 1940-2465
CID: 6017942
Automating the Referral of Bone Metastases Patients With and Without the Use of Large Language Models
Sangwon, Karl L; Han, Xu; Becker, Anton; Zhang, Yuchong; Ni, Richard; Zhang, Jeff; Alber, Daniel Alexander; Alyakin, Anton; Nakatsuka, Michelle; Fabbri, Nicola; Aphinyanaphongs, Yindalon; Yang, Jonathan T; Chachoua, Abraham; Kondziolka, Douglas; Laufer, Ilya; Oermann, Eric Karl
BACKGROUND AND OBJECTIVES/OBJECTIVE:Bone metastases, affecting more than 4.8% of patients with cancer annually, and particularly spinal metastases require urgent intervention to prevent neurological complications. However, the current process of manually reviewing radiological reports leads to potential delays in specialist referrals. We hypothesized that natural language processing (NLP) review of routine radiology reports could automate the referral process for timely multidisciplinary care of spinal metastases. METHODS:We assessed 3 NLP models-a rule-based regular expression (RegEx) model, GPT-4, and a specialized Bidirectional Encoder Representations from Transformers (BERT) model (NYUTron)-for automated detection and referral of bone metastases. Study inclusion criteria targeted patients with active cancer diagnoses who underwent advanced imaging (computed tomography, MRI, or positron emission tomography) without previous specialist referral. We defined 2 separate tasks: task of identifying clinically significant bone metastatic terms (lexical detection), and identifying cases needing a specialist follow-up (clinical referral). Models were developed using 3754 hand-labeled advanced imaging studies in 2 phases: phase 1 focused on spine metastases, and phase 2 generalized to bone metastases. Standard McRae's line performance metrics were evaluated and compared across all stages and tasks. RESULTS:In the lexical detection, a simple RegEx achieved the highest performance (sensitivity 98.4%, specificity 97.6%, F1 = 0.965), followed by NYUTron (sensitivity 96.8%, specificity 89.9%, and F1 = 0.787). For the clinical referral task, RegEx also demonstrated superior performance (sensitivity 92.3%, specificity 87.5%, and F1 = 0.936), followed by a fine-tuned NYUTron model (sensitivity 90.0%, specificity 66.7%, and F1 = 0.750). CONCLUSION/CONCLUSIONS:An NLP-based automated referral system can accurately identify patients with bone metastases requiring specialist evaluation. A simple RegEx model excels in syntax-based identification and expert-informed rule generation for efficient referral patient recommendation in comparison with advanced NLP models. This system could significantly reduce missed follow-ups and enhance timely intervention for patients with bone metastases.
PMID: 40823772
ISSN: 1524-4040
CID: 5908782
IlluminOss photodynamic bone stabilization system improves pain and function in the treatment of humeral metastatic disease
Terek, Richard M; ,; McGough, Richard; Fabbri, Nicola; Cheung, Felix; Brigman, Brian; Wittig, James; Emory, Cynthia; Aboulafia, Albert; Avedian, Raffi; Mayerson, Joel; Henshaw, Robert; Reimer, Nickolas; Eward, William; Weiss, Kurt; Healey, John; Mohler, David; Adams, Brock
AIMS/UNASSIGNED:The aim of the LightFix Trial was to evaluate the clinical outcomes for one year after the treatment of impending and completed pathological fractures of the humerus using the IlluminOss System (IS), and to analyze the performance of this device. METHODS/UNASSIGNED:A total of 81 patients with an impending or completed pathological fracture were enrolled in a multicentre, open label single cohort study and treated with IS. Inclusion criteria were visual analogue scale (VAS) Pain Scores > 60 mm/100 mm and Mirels' Score ≥ 8. VAS pain, Musculoskeletal Tumor Society (MSTS) Upper Limb Function, and The European Organization for Research and Treatment of Cancer QoL Group Bone Metastases Module (QLQ-BM22) scores were all normalized to 100, and radiographs were obtained at baseline and at 14, 30, 90, 180, and 360 days postoperatively. RESULTS/UNASSIGNED:The mean VAS pain score decreased significantly from 84 (SD 15) to 50 (SD 29), 38 (SD 30), 31 (SD 29), 31 (SD 29), and 21 (SD 23) between the baseline and follow-up times (p < 0.001). The mean MSTS function scores significantly increased from 27 (SD 19) to 52 (SD 22), 60 (23), 67 (SD 23), 72 (SD 26), and 83 (SD 14) (p < 0.001). The pain and functional subscales of the QLQ-BM22 also significantly improved at most times. A total of 12 devices broke, giving an unadjusted device fracture rate of 15%. CONCLUSION/UNASSIGNED:Stabilization with the IS decreased pain and improved function with consistent results during the first postoperative year. IS is a new, minimally invasive type of internal fixation. The use of the IS alone may be better for impending rather than completed pathological fractures, and may be better in completed fractures if an added plate or more than the usual number of locking screws is required. Caution is warranted regarding its use alone in patients with a completed pathological fracture due to the rate of breakage of the device.
PMID: 39615527
ISSN: 2049-4408
CID: 5763652
The Role of Distraction Osteogenesis in Limb Salvage for Tumors
Jejurikar, Neha; Herrero, Christina; Fabbri, Nicola
Modern technology and advances in medicine have facilitated increasing rates of limb salvage in the treatment of sarcomas. Orthopedic oncologists have a wide array of reconstruction options for limb salvage, ranging from allografts to endoprosthesis reconstruction. Limb lengthening is another option available to an orthopedic oncologist faced with bony defects and limb length discrepancies following resection. This review provides a brief history of limb lengthening, the principles of distraction osteogenesis, and current applications in orthopedic oncology. Considering the complications and challenges associated with the lengthening process, appropriate patient selection and thorough patient counseling is key to optimizing outcomes.
PMID: 38431976
ISSN: 2328-5273
CID: 5691792
Real-time indocyanine green imaging to aid in closure of radiated wounds [Letter]
Shahzad, Farooq; Fabbri, Nicola
PMID: 38134627
ISSN: 1878-0539
CID: 5611902
Distinct IDH1/2-associated Methylation Profile and Enrichment of TP53 and TERT Mutations Distinguish Dedifferentiated Chondrosarcoma from Conventional Chondrosarcoma
Dermawan, Josephine Kam Tai; Nafa, Khedoujia; Mohanty, Abhinita; Xu, Yingjuan; Rijo, Ivelise; Casanova, Jacklyn; Villafania, Liliana; Benhamida, Jamal; Kelly, Ciara M; Tap, William D; Boland, Patrick J; Fabbri, Nicola; Healey, John H; Ladanyi, Marc; Lu, Chao; Hameed, Meera
UNLABELLED:-associated methylation and transcriptional profiles as early events in DDCS, which may underlie the pathogenesis of dedifferentiation in chondrosarcomas. SIGNIFICANCE:DDCS is a rare, high-grade chondrosarcoma with a dismal prognosis. About 50%-80% of DDCS harbor IDH1/IDH2 mutations. We uncover a significant alteration of IDH-associated methylation profile in DDCS, which we propose is key to the progression to dedifferentiation. In this context, the potential effect of the use of IDH inhibitors is unclear but important to address, as clinical trials of selective IDH1 inhibitors showed worse outcome in DDCS.
PMCID:10013202
PMID: 36926116
ISSN: 2767-9764
CID: 5594502
ASO Visual Abstract: Sentinel Lymph Node Biopsy for Extremity and Truncal Soft Tissue Sarcomas-A Systematic Review of the Literature
Keung, Emily Z; Krause, Kate J; Maxwell, Jessica; Morris, Carol D; Crago, Aimee M; Houdek, Matthew T; Kane, John; Lewis, Valerae; Callegaro, Dario; Miller, Benjamin; Lazar, Alexander J; Gladdy, Rebecca; Raut, Chandrajit P; Fabbri, Nicola; Al-Refaie, Waddah; Fairweather, Mark; Wong, Sandra L; Roland, Christina L
PMID: 36323987
ISSN: 1534-4681
CID: 5354412
Sentinel Lymph Node Biopsy for Extremity and Truncal Soft Tissue Sarcomas: A Systematic Review of the Literature
Keung, Emily Z; Krause, Kate J; Maxwell, Jessica; Morris, Carol D; Crago, Aimee M; Houdek, Matthew T; Kane, John; Lewis, Valerae; Callegaro, Dario; Miller, Benjamin; Lazar, Alexander J; Gladdy, Rebecca; Raut, Chandrajit P; Fabbri, Nicola; Al-Refaie, Waddah; Fairweather, Mark; Wong, Sandra L; Roland, Christina L
BACKGROUND:Regional lymph node metastasis (RLNM) occurs infrequently in patients with soft tissue sarcoma (STS), although certain STS subtypes have a higher propensity for RLNM. The identification of RLNM has significant implications for staging and prognosis; however, the precise impact of node-positive disease on patient survival remains a topic of controversy. Although the benefits of sentinel lymph node biopsy (SLNB) are well documented in patients with melanoma and breast cancer, whether this procedure offers a benefit in STS is controversial. METHODS:A systematic literature search was performed and articles reviewed to determine if SLNB in patients with extremity/truncal STS impacts disease-free or overall survival. RESULTS:Six studies were included. Rates of sentinel lymph node positivity were heterogeneous (range 4.3-50%). The impact of SLNB on patient outcomes remains unclear. The overall quality of available evidence was low, as assessed by the Grading of Recommendations, Assessment, Development, and Evaluation system. CONCLUSIONS:The literature addressing the impact of nodal basin evaluation on the staging and management of patients with extremity/truncal STS is confounded by heterogeneous patient cohorts and clinical practices. Multicenter prospective studies are warranted to determine the true incidence of RLNM and whether SLNB could benefit patients with clinically occult RLNM at diagnosis.
PMID: 36307665
ISSN: 1534-4681
CID: 5354402
