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Arthroscopy-validated diagnostic performance of sub-5-min deep learning super-resolution 3T knee MRI in children and adolescents
Vosshenrich, Jan; Breit, Hanns-Christian; Donners, Ricardo; Obmann, Markus M; Harder, Dorothee; Ahlawat, Shivani; Walter, Sven S; Serfaty, Aline; Cantarelli Rodrigues, Tatiane; Recht, Michael; Stern, Steven E; Fritz, Jan
OBJECTIVE:This study aims to determine the diagnostic performance of sub-5-min combined sixfold parallel imaging (PIx3)-simultaneous multislice (SMSx2)-accelerated deep learning (DL) super-resolution 3T knee MRI in children and adolescents. MATERIALS AND METHODS/METHODS:Children with painful knee conditions who underwent PIx3-SMSx2-accelerated DL super-resolution 3T knee MRI and arthroscopy between October 2022 and December 2023 were retrospectively included. Nine fellowship-trained musculoskeletal radiologists independently scored the MRI studies for image quality and the presence of artifacts (Likert scales, range: 1 = very bad/severe, 5 = very good/absent), as well as structural abnormalities. Interreader agreements and diagnostic performance testing was performed. RESULTS:Forty-four children (mean age: 15 ± 2 years; range: 9-17 years; 24 boys) who underwent knee MRI and arthroscopic surgery within 22 days (range, 2-133) were evaluated. Overall image quality was very good (median rating: 5 [IQR: 4-5]). Motion artifacts (5 [5-5]) and image noise (5 [4-5]) were absent. Arthroscopy-verified abnormalities were detected with good or better interreader agreement (κ ≥ 0.74). Sensitivity, specificity, accuracy, and AUC values were 100%, 84%, 93%, and 0.92, respectively, for anterior cruciate ligament tears; 71%, 97%, 93%, and 0.84 for medial meniscus tears; 65%, 100%, 86%, and 0.82 for lateral meniscus tears; 100%, 100%, 100%, and 1.00 for discoid lateral menisci; 100%, 95%, 96%, and 0.98 for medial patellofemoral ligament tears; and 55%, 100%, 98%, and 0.77 for articular cartilage defects. CONCLUSION/CONCLUSIONS:Clinical sub-5-min PIx3-SMSx2-accelerated DL super-resolution 3T knee MRI provides excellent image quality and high diagnostic performance for diagnosing internal derangement in children and adolescents.
PMID: 40493057
ISSN: 1432-2161
CID: 5869102
Image-guided injections for facet joint pain: evidence-based Delphi conjoined consensus paper from the European Society of Musculoskeletal Radiology and European Society of Neuroradiology
Sconfienza, Luca Maria; Dalili, Danoob; Adriaensen, Miraude; Albano, Domenico; Allen, Georgina; Aparisi Gomez, Maria Pilar; Aringhieri, Giacomo; Arrigoni, Francesco; Bazzocchi, Alberto; Oliveira Castro, Miguel; Cazzato, Roberto Luigi; De Dea, Miriam; De Vivo, Aldo Eros; Drakonaki, Elena; Facal de Castro, Fernando; Filippiadis, Dimitrios; Fritz, Jan; Gil, Inês; Gitto, Salvatore; Gruber, Hannes; Gupta, Harun; Isaac, Amanda; Klauser, Andrea S; Le Corroller, Thomas; Loizides, Alexander; Marsico, Salvatore; Mauri, Giovanni; McNally, Eugene; Melaki, Kalliopi; Messina, Carmelo; Mirón Mombiela, Rebeca; Olchowy, Cyprian; Orlandi, Davide; Moutinho, Ricardo; Picasso, Riccardo; Prakash, Mahesh; Theumann, Nicolas; Vasilevska Nikodinovska, Violeta; Vassalou, Evangelia E; Vucetic, Jelena; Wilson, David; Zaottini, Federico; Zappia, Marcello; Zini, Chiara; Snoj, Žiga
OBJECTIVES/OBJECTIVE:To perform a Delphi-based consensus on published evidence on image-guided injections for facet joint pain (FJP) and provide clinical indications. METHODS:We report the results of an evidence-based Delphi consensus of 38 experts from the European Society of Musculoskeletal Radiology and the European Society of Neuroradiology, who reviewed the published literature for evidence on image-guided injections for FJP. Experts drafted a list of statements and graded them according to the Oxford Centre for evidence-based medicine levels of evidence. Consensus was considered strong when ≥ 95% of experts agreed with the statement or broad when > 80% but < 95% agreed. The results of the consensus were used to write the paper. RESULTS:Twenty statements on image-guided FJP treatment have been drafted. Eighteen statements received strong consensus, while two received broad consensus. Three statements reached the highest level of evidence, all of them regarding the lumbar spine. All radiological methods are used for image-guided injections for FJP, and regardless of the radiological method used, all show good safety and efficacy. Facet joint injections and medial branch blocks are used in all spinal regions to treat FJP, and both show similar clinical outcomes. Advanced technological solutions have been studied in the field of lumbar FJP; however, the level of evidence for these is low. CONCLUSION/CONCLUSIONS:Despite promising results reported by published papers on image-guided injections for FJP, there is still a lack of evidence on injection efficacy, appropriateness of imaging methods, and optimal medication. KEY POINTS/CONCLUSIONS:Question Image-guided injections to treat facet joint pain (FJP) are performed throughout the spine; however, the highest level of evidence exists for the lumbar spine. Findings Regardless of the imaging method used, image-guided injections for facet joint pain treatment are safe, with only minor adverse events in rare cases. Clinical relevance All imaging methods are used for injection guidance to treat FJP, each with advantages and disadvantages. These statements on image-guided injections for FJP provide a concise and up to date overview on the topic, serving as a list of clinical indications.
PMID: 40338342
ISSN: 1432-1084
CID: 5839382
[Adhesive capsulitis (frozen shoulder): MR-characteristics]
Heckl, Stefan; Fritz, Jan; Gohla, Georg; Horger, Marius
PMID: 40623434
ISSN: 1438-9010
CID: 5890512
Real-world diagnostic performance of knee MRI protocols accelerated using simultaneous multi-slice acquisition and deep learning reconstruction
Johnson, Patricia M; Dogra, Siddhant; Westerhoff, Malte; Fritz, Jan; Lin, Dana J; Recht, Michael P
OBJECTIVE:To assess whether accelerated knee MRI protocols using simultaneous multi-slice (SMS) and deep learning reconstruction (DLR) are non-inferior to a conventional parallel imaging protocol for detecting internal derangement injuries. METHODS:This retrospective cohort study included 1055 patients who underwent knee MRI followed by arthroscopy within 180 days. Patients were scanned using either a conventional protocol (n = 226), an accelerated SMS protocol (n = 406), or a SMS with DLR protocol (n = 423). Each group included consecutive exams. Imaging was performed on 3 T MRI using five standardized two-dimensional turbo spin echo sequences. Radiology interpretations were compared with arthroscopy (reference standard) for anterior cruciate ligament (ACL), medial meniscus (MM), and lateral meniscus (LM) tears. Sensitivity and specificity were calculated with 95% confidence intervals using non-parametric bootstrapping. Non-inferiority was concluded if the upper bound of the 95% confidence interval for the difference in sensitivity and specificity was ≤ 0.05. RESULTS:Among all patients, 666 had MM tears, 417 had LM tears, and 220 had ACL tears. Sensitivity for ACL tears was higher with accelerated protocols (0.96 and 0.98) than the conventional (0.85), with non-inferiority confirmed. Specificity was ≥ 0.98 across all protocols. MM sensitivity (0.94-0.95) met non-inferiority criteria. MM specificity (0.88-0.91) and LM sensitivity (0.63-0.68) were not statistically different across protocols but did not meet the non-inferiority margin. LM specificity (0.94) met non-inferiority criteria. CONCLUSION/CONCLUSIONS:Accelerated MRI protocols using SMS and DLR demonstrated comparable diagnostic performance to the reference protocol. Although not all metrics met the strict non-inferiority margin, none showed statistically significant reductions in sensitivity or specificity. These findings support the clinical adoption of accelerated protocols for faster, high-throughput knee imaging.
PMID: 41109866
ISSN: 1432-2161
CID: 5955482
[Mucoid degeneration of the anterior and posterior cruciate ligament: MR-Imaging findings and differential diagnoses]
Horger, Marius; Fritz, Jan; Gohla, Georg; Ruff, Christer; Heckl, Stefan
PMID: 40669505
ISSN: 1438-9010
CID: 5897252
[Macrodystrophia lipomatosa with fibrolipomatous hamartoma of the median nerve, sciatic nerve and brachial plexus]
Horger, Marius; Fritz, Jan; Gohla, Georg; Heckl, Stefan
PMID: 40972641
ISSN: 1438-9010
CID: 5935642
[Intraneural ganglion cysts at the superior tibiofibular joint]
Heckl, Stefan; Gohla, Georg; Fritz, Jan; Ruff, Christer; Horger, Marius
PMID: 40669504
ISSN: 1438-9010
CID: 5897242
MR Neurography of the Foot and Ankle Nerves
Leonhardt, Yannik; Fritz, Jan
MR neurography offers a specialized approach for detailed nerve imaging when clinical symptoms indicate involvement. Imaging peripheral nerves in the foot and ankle is demanding due to their small size and challenging anatomy. This article provides an overview of foot and ankle nerve assessment, highlighting the importance of technical expertise and anatomic knowledge for accurate diagnosis.
PMID: 40610164
ISSN: 1557-9786
CID: 5888392
mapping near metallic implants using turbo spin echo pulse sequences
Khodarahmi, Iman; Bruno, Mary; Schwarzkopf, Ran; Fritz, Jan; Keerthivasan, Mahesh B
PURPOSE/OBJECTIVE:mapping technique for imaging of body parts containing metal hardware, based on magnitude images acquired with turbo spin echo (TSE) pulse sequences. THEORY AND METHODS/METHODS:values were validated against gradient-recalled and spin echo dual angle methods, as well as a vendor-provided TurboFLASH-based mapping sequence, in gel phantoms and human subjects without and with metal implants. RESULTS:shimming. CONCLUSION/CONCLUSIONS:values in regions near metal hardware, overcoming susceptibility-related and narrow-range limitations of standard mapping techniques.
PMID: 40079274
ISSN: 1522-2594
CID: 5808662
MRI grading using the neuropathy score-reporting and data system with electrodiagnostic correlation in radial neuropathy around the elbow: a 13-year retrospective review
Abiri, Benjamin; Kopylov, David; Samim, Mohammad; Walter, William; Fritz, Jan; Khodarahmi, Iman; Burke, Christopher J
OBJECTIVE:To evaluate the Neuropathy Score-Reporting and Data System (NS-RADS) MRI grading system in conjunction with electrodiagnostic (EDx) testing for radial neuropathy at the elbow. MATERIALS AND METHODS/METHODS:Patients presenting between 2010 and 2023 with suspected radial neuropathy who underwent both EDx testing in the form of electromyography and nerve conduction studies and MRI within a 12-month period were evaluated. Three blinded radiologists used the NS-RADS grading system to evaluate nerve entrapment (E grades), muscle denervation (M grades) proximally within the supinator/extensor carpi radialis brevis (ECRB), and more distally within the forearm extensor muscles. These grades and the presence of lateral epicondylitis were then correlated with EDx abnormalities. RESULTS:Forty-nine participants were included. Inter-reader reliability for M grades in the forearm extensor muscles was good (ICC = 0.90 [95% CI = 0.83 - 0.94], p < 0.001), as was reliability for the supinator/ECRB muscles (ICC = 0.91 [95% CI = 0.86-0.95], p < 0.001). Inter-reader reliability for E grades was moderate (ICC = 0.83 [95% CI = 0.69-0.90], p < 0.001). Patients with positive EDx studies had a significantly different distribution of M grades for the forearm extensors and supinator/ECRB than those with negative studies (all p values < 0.001). However, overall consensus reads showed no significant difference in the distribution of E grades between patients with positive and negative EDx studies. CONCLUSION/CONCLUSIONS:Muscle grading strongly correlated with EDx positivity, with a high level of inter-reader agreement for muscle denervation-related alterations. Nerve grading, however, did not show a statistical correlation.
PMID: 39760931
ISSN: 1432-2161
CID: 5804892