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Correction to: AI is a viable alternative to high throughput screening: a 318-target study (Scientific Reports, (2024), 14, 1, (7526), 10.1038/s41598-024-54655-z)
Giles, Ellie; Heifets, Abraham; Artia, Zoraima; Inde, Zintis; Liu, Zhongle; Zhang, Zhiguo; Wang, Zhenghe; Su, Zhengchen; Chung, Zara; Frangos, Zachary J.; Li, Yunlong; Yen, Yun; Sidorova, Yulia A.; Tse-Dinh, Yuk Ching; He, Yuan; Tang, Young; Li, Yong; Pérez-Pertejo, Yolanda; Gupta, Yogesh K.; Zhu, Yini; Sun, Ying; Li, Yihe; Chen, Yicheng; Aldhamen, Yasser Ali; Hu, Yanmei; Zhang, Yan Jessie; Zhang, Xu; Yuan, Xinrui; Wang, Xingyou; Qin, Xingping; Yu, Xinfang; Xu, Xin; Qi, Xin; Lu, Xin; Wu, Xiaoyang; Blanchet, Xavier; Foong, Wuen Ee; Bradshaw, William J.; Gerwick, William H.; Kerr, William G.; Hahn, William C.; Donaldson, William A.; Van Voorhis, Wesley C.; Zhang, Wenjun; Tang, Weiping; Li, Wei; Houry, Walid A.; Lowther, W. Todd; Clayton, W. Brent; Van Hung Le, Vuong; Ronchi, Virginia Paola; Woods, Virgil A.; Scoffone, Viola Camilla; Maltarollo, Vinicius Gonçalves; Dolce, Vincenza; Maranda, Vincent; Segers, Vincent F.M.; Namasivayam, Vigneshwaran; Gunasekharan, Vignesh; Robinson, Victoria L.; Banerji, Versha; Tandon, Vasudha; Thai, Van Chi; Pai, Vaibhav P.; Desai, Umesh R.; Baumann, Ulrich; Chou, Tsui Fen; Chou, Tristan; O"™Mara, Tracy A.; Banjo, Toshihiro; Su, Tong; Lan, Tong; Ogunwa, Tomisin Happy; Hermle, Tobias; Corson, Timothy W.; O"™Meara, Timothy R.; Kotzé, Timothy J.; Herdendorf, Timothy J.; Richardson, Timothy I.; Kampourakis, Thomas; Gillingwater, Thomas H.; Jayasinghe, Thilina D.; Teixeira, Thaiz Rodrigues; Ikegami, Tetsuro; Moreda, Teresa Lozano; Haikarainen, Teemu; Akopian, Tatos; Abaffy, Tatjana; Swart, Tarryn; Mehlman, Tamar; Teramoto, Tadahisa; Azeem, Syeda Maryam; Dallman, Sydney; Brady-Kalnay, Susann M.; Sarilla, Suryakala; Van Doren, Steven R.; Marx, Steven O.; Olson, Steven H.; Poirier, Steve; Waggoner, Stephen N.; Capuzzi, Stephen J.; Celano, Stephanie L.; Sainas, Stefano; Gustincich, Stefano; Espinoza, Stefano; Zahler, Stefan; Banerjee, Sourav; Xu, Sophia Q.; Park, Soonju; Byun, Soo Young; Chadni, Somaia Haque; Tsimbalyuk, Sofiya; Zhu, Siran; White, Simon J.; Garavaglia, Silvia; Buroni, Silvia; Conticello, Silvestro G.; Shyng, Show Ling; Ashkar, Shireen R.; Maruta, Shinsaku; Chauhan, Shefali; Chu, Shaoyou; Zhou, Shan; Li, Shan; Seo, Seung Yong; Dzhumaev, Sergei; Ammendola, Serena; Radhakrishnan, Senthil K.; Landfear, Scott M.; Legare, Scott; Wazir, Sarah; Johannsen, Sandra; Geden, Sandra E.; Shelburne, Samuel A.; Phadke, Sameer; Hossain, Sakib; Katyal, Sachin; Cullinane, Ryan T.; Gorgoglione, Ruggiero; do Monte-Neto, Rubens Lima; Uribe, Ruben Vazquez; Reguera, Rosa Maria; McCarthy, Ronan R.; Viola, Ronald E.; Gierse, Robin Matthias; Solano, Roberto; Blumenthal, Robert M.; Bradley, Robert K.; Lake, Robert J.; Kelm, Robert J.; Hickey, Robert J.; Vandenberg, Robert J.; Blelloch, Robert; Batey, Robert A.; Kejriwal, Rishabh; Yan, Riqiang; Angell, Richard M.; Ebright, Richard H.; Moore, Richard G.; Taylor, Richard E.; Austin, Richard C.; Douville, Renée N.; Dame, Remus T.; Koppisetti, Rama K.; Mazitschek, Ralph; Tiwari, Rakesh Kumar; Singh, Rakesh K.; Verma, Rajkumar; Ramachandran, Rajesh; Harijan, Rajesh K.; Agrawal, Rajendra K.; Ferreira, Rafaela Salgado; Guido, Rafael V.C.; Rocha, Rafael Eduardo Oliveira; Balaña-Fouce, Rafael; Rowswell-Turner, Rachael B.; Lee, Pil H.; von Hundelshausen, Philipp; Ip, Philbert; Toogood, Peter; Ngoi, Peter; Jones, Peter L.; Agogo-Mawuli, Percy; Wu, Pengpeng; Liu, Pengda; Zhou, Pei; Moreira, Paulo Otávio Lourenço; Fish, Paul V.; Mellor, Paul; Martin-Malpartida, Pau; O"™Connell, Patrick; Chuong, Patrick; Sobrado, Pablo; Iglesias, Pablo; Bishop, Ozlem Tastan; Silvennoinen, Olli; Escaffre, Olivier; Kandror, Olga; Rabal, Obdulia; Khalaf, Noureddine Ben; Anastasio, Noelle C.; Gumede, Njabulo Joyfull; Mahmoodi, Niusha; Rouzbeh, Nirvan; Bharambe, Nikhil; Longo, Nicola; Horstmann, Nicola; Matovic, Nick; Schneider, Nicholas O.; Trinh, Nguyen Mai; Chan, Nei Li; Gandhi, Neha S.; Singh, Neeraj; Kootstra, Neeltje A.; Singh, Nathanael; Merrill, Nathan M.; Van Pelt, Natascha; Zelinskaya, Natalia; Stec, Natalia; Christodoulides, Myron; Hussain, Muhammad Saddam; De Luise, Monica; Maksimainen, Mirko M.; Giardini, Miriam A.; Al-Yozbaki, Minnatallah; Paige, Mikell; Jackson, Michael R.; Mowat, Michael; Levin, Michael; Rizzi, Menico; Bedi, Mel; O"™Mara, Megan L.; Skorodinsky, Maxim; Champion, Matthew M.; Alteen, Matthew G.; Soellner, Matthew B.; Serafim, Mateus Sá Magalhães; Mehedi, Masfique; Pasquali, Marzia; McDowell, Mary Ann; Maurice, Martin St; Safo, Martin K.; Giorgis, Marta; Cerna, Mark Vincent C.dela; Ashton, Mark R.; Hannink, Mark; Wilson, Mark A.; Tye, Mark A.; Mellado, Mario; Barghash, Marim M.; Valli, Marilia; Macias, Maria J.; Caroleo, Maria Cristina; Vleminckx, Margot; Lolli, Marco Lucio; Lolicato, Marco; Windisch, Marc P.; Lussier, Marc P.; Ben-Johny, Manu; Kilkenny, Mairi Louise; Nagai, Maira Harume; Fathallah, M. Dahmani; Randall, Lia M.; Whitesell, Luke; Iommarini, Luisa; Antonelli, Lorenzo; Walensky, Loren D.; Hedstrom, Lizbeth; Zhuo, Ling; Malkas, Linda H.; Chen, Lifeng; Puchades-Carrasco, Leonor; Wert-Lamas, Leon; Su, Leila; Byrne, Lee J.; Cowen, Leah E.; Haupt, Larisa M.; Lehtio, Lari; Pusztai, Lajos; Lee, Kyung Hyeon; Kim, Kyu Kwang; Rohde, Kyle H.; Sarosiek, Kristopher; Smith, Kristiana S.; Liu, Koting; Korotkov, Konstantin V.; Mostert, Konrad J.; Nagamori, Kiyo; Faller, Kiterie M.E.; Musta, Kirsikka; McManus, Kirk James; Sugamori, Kim S.; Ghilarducci, Kim; Pham, Kien; Machaca, Khaled; Parang, Keykavous; Hopkins, Kevin M.; Lobb, Kevin A.; Lai, Kent; Wentworth, Kelly L.; Wong, Keith S.; Ojo, Kayode K.; Gadar, Kavita; Martin, Katie R.; Cunningham, Kathryn A.; Molyneaux, Kathleen A.; Hansen, Kasper B.; Francisco, Karol R.; Sishtla, Kamakshi; Abrahão, Jônatas Santos; Sistla, Jyothi C.; Liao, Junzhuo; Kee, Jung Min; Wang, Jun; Bogomolovas, Julijus; Lescar, Julien; Cools, Julie; Milosavljevic, Julian; Oyarzabal, Julen; Lasarte, Juan José; Arias, Juan Antonio Sanchez; Rodriguez-Frade, José Miguel; Watkins, Joshua; Finkelstein, Joshua M.; Gruber, Joshua J.; Nasburg, Joshua Alexander; Maciag, Joseph J.; Rayman, Joseph B.; Costoya, Jose A.; Pederick, Jordan L.; So, Jonathan; Pascal, John M.; Tanner, John J.; Coles, John G.; Bruning, John Burt; Bruning, John B.; Stetefeld, Joerg; Reis, Joana; Lee, Jiyoun; Lin, Jiusheng; Zhao, Jinshi; Xu, Jingyi; Liao, Jiayu; Zhu, Jiaqi; Wang, Jianghai; Xu, Jiake; Lin, Jiabei; Zhou, Jia; Jossart, Jennifer N.; MacKeigan, Jeffrey P.; Dickhout, Jeffrey; Evans, Jay D.; Maynes, Jason T.; Mousa, Jarrod J.; Chuah, Janelle; Gebauer, Jan M.; Voss, Jan Hendrik; Shorter, James; Ng, James; Granneman, James G.; Siqueira-Neto, Jair L.; Miner, Jaden; Kratz, Jadel Müller; Fries, Jacob; Ferreira, Jacob; Boorman, Jacob; Kwiatkowski, Jacek; Perry, J. Jefferson P.; Cakir, Isin; Lotsaris, Irina; Qureshi, Insaf Ahmed; Verhamme, Ingrid M.; Mungrue, Imran N.; Arozarena, Imanol; Corvo, Ileana; Caliandro, Ileana; Greig, Iain R.; Kim, Hyeong Jun; Zhou, Hui; Feng, Hui; Fan, Hua Ying; Jung, Hoyoung; Lieberman, Howard B.; Debonsi, Hosana Maria; Xu, Hongyang; Van Remmen, Holly; Tam, Heng Keat; Chaytow, Helena; Hoppe, Heinrich; Wulff, Heike; Shim, Heesung; Yuan, Haynes; Tilford, Hannah; Moore, Hannah P.; Zhou, Han; Jafar-Nejad, Hamed; Breton, Hairol E.; Li, Hai; Cildir, Gokhan; Lee, Gyeongeun; Rucinski, Gwennan; Alvarez, Guzmán; Caljon, Guy; Akk, Gustav; de Souza, Guilherme Eduardo; Veit, Guido; Popowicz, Grzegorz Maria; Bowman, Gregory R.; Stuchbury, Grant David; Conn, Graeme L.; Michlewski, Gracjan; Dahal, Gopal; Leuzzi, Giuseppe; Gasparre, Giuseppe; Fiermonte, Giuseppe; Girolimetti, Giulia; Roti, Giovanni; Cortopassi, Gino; De Keulenaer, Gilles; Colotti, Gianni; Parico, Gian Carlo G.; Prikler, Gergely; Lukacs, Gergely L.; Garcia, George A.; Greene, Geoffrey L.; Mayer, Gaétan; Eitzen, Gary; Dempsey, Garrett; Zhang, Gang; Lembo, Gaia; Bognár, Gabriella; Rodriguez, G. Marcela; Svensson, Fredrik; Bdira, Fredj Ben; Vizeacoumar, Frederick S.; Buckner, Frederick S.; Luh, Frank; Vizeacoumar, Franco J.; Borriello, Francesco; van den Akker, Focco; Ingoglia, Filippo; Wang, Feng; Leng, Fenfei; Xiang, Fei; Yu, Fang; Gavathiotis, Evripidis; Glukhov, Evgenia; Garcia-Cuesta, Eva M.; Jo, Eunji; Kroon, Erna Geessien; Fan, Erkang; Lisabeth, Erika Mathes; Cione, Erika; Thompson, Erik W.; Strauss, Erick; Rubin, Eric J.; Trakhtenberg, Ephraim F.; Petretto, Enrico; Mason, Emily R.; Christensen, Emily M.; Leung, Elisa; Mameli, Eleonora; Lama, Eleonora; Abraham, Elena Theres; Lenci, Elena; Aguilera, Elena; Silva, Elany Barbosa; Lynn, Edward G.; Hsiao, Edward C.; Gelardi, Edoardo Luigi Maria; Glubb, Dylan M.; Duncan, Dustin; Krishnamurthy, Durga; Zochodne, Douglas William; Shoue, Douglas A.; Dirksen, Dorian; Lee, Donghan; Ronning, Donald R.; Slotboom, Dirk J.; Chaudhuri, Dipayan; Zhang, Dingqiang; Alramadhani, Dina; Ortiz, Diana; Hu, Di; Welsbie, Derek S.; Coombe, Deirdre R.; Anderson, Deborah H.; Ferraris, Davide Maria; Riches, David W.H.; Krist, David T.; Shum, David; Siderovski, David P.; Moreira, David; Smith, David M.; Hosfield, David J.; Dowling, David J.; Drewry, David H.; Hildeman, David A.; Trader, Darci J.; Manor, Danny; Chen, Daniel; Lawrence, Daniel A.; Keedy, Daniel A.; Tumes, Damon J.; Luo, Dahai; Santiago, César; Paulino, Cristina; Arrigoni, Cristina; Myhr, Courtney; Wilson, Cornelia M.; Loy, Cody A.; Reglero, Clara; Alkan, Cigdem; Morisseau, Christophe; Muli, Christine S.; Zeina, Christina M.; Weber, Christian; Müller, Christa E.; Kemet, Chinyere Maat; Mantri, Chinmay Kumar; Peltier, Cheryl; Liu, Chen; Huimei, Chen; Dieck, Chelsea L.; Keller, Charles; Karan, Charles; Kahler, Charlene M.; Yang, Chao Yie; Huang, Chang; Chaton, Catherine T.; Partch, Carrie L.; Chapman, Carly J.; Bon, Carlotta; Ballatore, Carlo; Torner, Carles; Novina, Carl D.; Lempicki, Camille; Fraser, Cameron; Dickinson, Bryan C.; Mota, Bruno Eduardo Fernandes; Hammock, Bruce D.; Morten, Brianna C.; Dymock, Brian W.; Geisbrecht, Brian V.; Duggan, Brendan M.; Salas, Brenda P.Medellin; Pressly, Brandon; Agianian, Bogos; Gong, Bin; Balakrishnan, Bijina; Englinger, Bernhard; Kováts, Benjámin; Chua, Benjamin Soon Kai; Perry, Benjamin; Liou, Benjamin; Edelman, Benjamin L.; Bailey-Elkin, Ben A.; Ribeiro, Beatriz Murta Rezende Moraes; Diallo, Bakary N"™tji; O"™Dea, Austin; Colomba, Audrey; Apfel, Athena Marie; ElSheikh, Assmaa; Prince, Ashutosh; John, Ashley L.St; Paparella, Ashleigh S.; Haas, Arthur L.; Chatterjee, Arnab K.; Samantha, Ariela; Panganiban, Antonito T.; Pineda-Lucena, Antonio; Garmendia, Antonio E.; Del Rio Flores, Antonio; O"™Donoghue, Anthony J.; Virtanen, Anniina; Fiorillo, Annarita; Müller, Anna; Montanaro, Anna; Minakova, Anna; Porcelli, Anna Maria; Hirsch, Anna K.H.; D"™Antuono, Anna; Borowska, Anna; Motyl, Anna A.L.; Cathcart, Ann M.; Ojha, Anil K.; Taglialatela, Angelo; White, Andrew; Cuddihy, Andrew R.; Lam, Andrew; Reidenbach, Andrew G.; Freywald, Andrew; Berti, Andrew; Herr, Andrew B.; Stahl, Andreas; Trabocchi, Andrea; Foote, Andrea Talbot; Mattevi, Andrea; Ilari, Andrea; Chini, Andrea; Caporali, Andrea; Battistoni, Andrea; Matheeussen, An; Rangarajan, Amith Vikram; Patel, Amit K.; Caflisch, Amedeo; Bryant-Friedrich, Amanda; Garaeva, Alisa A.; Vrielink, Alice; Tomilov, Alexey; Degterev, Alexei; Gingras, Alexandre R.; Statsyuk, Alexander V.; Freiberg, Alexander N.; Kushnir, Alexander; Agoulnik, Alexander I.; de Sousa, Alessandra Mara; Sverzhinsky, Aleksandr; de Oliveira, Aldo Sena; Ciccia, Alberto; Smrcka, Alan V.; Toh, Alan Kie Leong; Shaqra, Ala M.; Mushtaq, Aisha; Ayachi, Aicha Gharbi; Ghosh, Agnidipta; Andricopulo, Adriano D.; Ferrando, Adolfo A.; Presser, Adam G.; Mysore, Venkatesh; Gupta, Tushita; Abramyan, Tigran M.; Schroedl, Stefan; Pemberton, Ryan P.; DeHaan, Nicholas; Young, Matthew A.; Goldenberg, Joshua M.; Sorenson, Jon M.; Warrington, Jeffrey M.; Cox, Bryan D.; Anderson, Brandon M.; Bergman, Bastiaan; Cann, Andrew B.; Lee, Andreia H.; Kenyon, Victor; Chern, Ting Rong; Williams, Tiffany; Van Grack, Tessa; O"™Brien, Terrence E.; Palazzo, Teresa; Hare, Stephanie; Contreras, Stephanie; Shek, Stefani; PrasadPrasad, Srimukh Veccham Krishna; Suterwala, Shabbir; de Oliveira, Saulo; Eckert, Sam; Gniewek, Pawel; Henriksen, Niel; Anthis, Nicholas J.; Ahmed, Mostafa; Mysinger, Michael; Ngo, Lien; Giesler, Kyle; Sarangapani, Krishna; Stafford, Kate; Ng, Ho Leung; van den Bedem, Henry; Truong, Ha; Friedland, Greg; Moharreri, Ehsan; Thayer, Desiree; Laggner, Christian; Butler, Brittany; Worley, Brad; Thomas, Bill; Samudio, Ben; Davtyan, Aram; O"™Sullivan, Ann Marie; Rosnik, Andreana; Stecula, Adrian; Morrison, Adrian; Ho, Gregory; Nguyen, Kong; Bernard, Denzil; Wallach, Izhar
Correction to: Scientific Reportshttps://doi.org/10.1038/s41598-024-54655-z, published online 02 April 2024 The original version of this Article contained errors. In the original version of this article, Ellie Giles was omitted from the Author list. Additionally, the following Affiliation information has been updated: 1. Affiliation 25 was incorrect. Affiliation 25 "˜Queensland University of Technology, Brisbane, USA."™ now reads, "˜Queensland University of Technology, Brisbane, Australia."™ 2. Marta Giorgis was incorrectly affiliated with the "˜University of Aberdeen, Aberdeen, UK."™ The correct Affiliation is listed below: "˜University of Turin, Turin, Italy."™ 3. Affiliations 52, 125 and 261 were duplicated. As a result, the correct Affiliation for Andrew B. Herr, Benjamin Liou, David A. Hildeman, Joseph J. Maciag, Ying Sun, Durga Krishnamurthy, and Stephen N. Waggoner is: "˜Cincinnati Children"™s Hospital Medical Center, Cincinnati, USA."™ Furthermore, an outdated version of Figure 1 was typeset. The original Figure 1 and accompanying legend appear below. (Figure presented.) Pairs of representative compounds extracted from AI patents (right) and corresponding prior patents (left) for clinical-stage programs (CDK792,93, A2Ar-antagonist94,95, MALT196,97, QPCTL98,99, USP1100,101, and 3CLpro102,103). The identical atoms between the chemical structures are highlighted in red. Lastly, The Acknowledgements section contained an error. "See Supplementary section S1." now reads, "See Supplementary section S2." The original Article has been corrected.
SCOPUS:85204723078
ISSN: 2045-2322
CID: 5714322
AI is a viable alternative to high throughput screening: a 318-target study
Wallach, Izhar; Bernard, Denzil; Nguyen, Kong; Ho, Gregory; Morrison, Adrian; Stecula, Adrian; Rosnik, Andreana; O"™Sullivan, Ann Marie; Davtyan, Aram; Samudio, Ben; Thomas, Bill; Worley, Brad; Butler, Brittany; Laggner, Christian; Thayer, Desiree; Moharreri, Ehsan; Friedland, Greg; Truong, Ha; van den Bedem, Henry; Ng, Ho Leung; Stafford, Kate; Sarangapani, Krishna; Giesler, Kyle; Ngo, Lien; Mysinger, Michael; Ahmed, Mostafa; Anthis, Nicholas J.; Henriksen, Niel; Gniewek, Pawel; Eckert, Sam; de Oliveira, Saulo; Suterwala, Shabbir; PrasadPrasad, Srimukh Veccham Krishna; Shek, Stefani; Contreras, Stephanie; Hare, Stephanie; Palazzo, Teresa; O"™Brien, Terrence E.; Van Grack, Tessa; Williams, Tiffany; Chern, Ting Rong; Kenyon, Victor; Lee, Andreia H.; Cann, Andrew B.; Bergman, Bastiaan; Anderson, Brandon M.; Cox, Bryan D.; Warrington, Jeffrey M.; Sorenson, Jon M.; Goldenberg, Joshua M.; Young, Matthew A.; DeHaan, Nicholas; Pemberton, Ryan P.; Schroedl, Stefan; Abramyan, Tigran M.; Gupta, Tushita; Mysore, Venkatesh; Presser, Adam G.; Ferrando, Adolfo A.; Andricopulo, Adriano D.; Ghosh, Agnidipta; Ayachi, Aicha Gharbi; Mushtaq, Aisha; Shaqra, Ala M.; Toh, Alan Kie Leong; Smrcka, Alan V.; Ciccia, Alberto; de Oliveira, Aldo Sena; Sverzhinsky, Aleksandr; de Sousa, Alessandra Mara; Agoulnik, Alexander I.; Kushnir, Alexander; Freiberg, Alexander N.; Statsyuk, Alexander V.; Gingras, Alexandre R.; Degterev, Alexei; Tomilov, Alexey; Vrielink, Alice; Garaeva, Alisa A.; Bryant-Friedrich, Amanda; Caflisch, Amedeo; Patel, Amit K.; Rangarajan, Amith Vikram; Matheeussen, An; Battistoni, Andrea; Caporali, Andrea; Chini, Andrea; Ilari, Andrea; Mattevi, Andrea; Foote, Andrea Talbot; Trabocchi, Andrea; Stahl, Andreas; Herr, Andrew B.; Berti, Andrew; Freywald, Andrew; Reidenbach, Andrew G.; Lam, Andrew; Cuddihy, Andrew R.; White, Andrew; Taglialatela, Angelo; Ojha, Anil K.; Cathcart, Ann M.; Motyl, Anna A.L.; Borowska, Anna; D"™Antuono, Anna; Hirsch, Anna K.H.; Porcelli, Anna Maria; Minakova, Anna; Montanaro, Anna; Müller, Anna; Fiorillo, Annarita; Virtanen, Anniina; O"™Donoghue, Anthony J.; Del Rio Flores, Antonio; Garmendia, Antonio E.; Pineda-Lucena, Antonio; Panganiban, Antonito T.; Samantha, Ariela; Chatterjee, Arnab K.; Haas, Arthur L.; Paparella, Ashleigh S.; John, Ashley L.St; Prince, Ashutosh; ElSheikh, Assmaa; Apfel, Athena Marie; Colomba, Audrey; O"™Dea, Austin; Diallo, Bakary N"™tji; Ribeiro, Beatriz Murta Rezende Moraes; Bailey-Elkin, Ben A.; Edelman, Benjamin L.; Liou, Benjamin; Perry, Benjamin; Chua, Benjamin Soon Kai; Kováts, Benjámin; Englinger, Bernhard; Balakrishnan, Bijina; Gong, Bin; Agianian, Bogos; Pressly, Brandon; Salas, Brenda P.Medellin; Duggan, Brendan M.; Geisbrecht, Brian V.; Dymock, Brian W.; Morten, Brianna C.; Hammock, Bruce D.; Mota, Bruno Eduardo Fernandes; Dickinson, Bryan C.; Fraser, Cameron; Lempicki, Camille; Novina, Carl D.; Torner, Carles; Ballatore, Carlo; Bon, Carlotta; Chapman, Carly J.; Partch, Carrie L.; Chaton, Catherine T.; Huang, Chang; Yang, Chao Yie; Kahler, Charlene M.; Karan, Charles; Keller, Charles; Dieck, Chelsea L.; Huimei, Chen; Liu, Chen; Peltier, Cheryl; Mantri, Chinmay Kumar; Kemet, Chinyere Maat; Müller, Christa E.; Weber, Christian; Zeina, Christina M.; Muli, Christine S.; Morisseau, Christophe; Alkan, Cigdem; Reglero, Clara; Loy, Cody A.; Wilson, Cornelia M.; Myhr, Courtney; Arrigoni, Cristina; Paulino, Cristina; Santiago, César; Luo, Dahai; Tumes, Damon J.; Keedy, Daniel A.; Lawrence, Daniel A.; Chen, Daniel; Manor, Danny; Trader, Darci J.; Hildeman, David A.; Drewry, David H.; Dowling, David J.; Hosfield, David J.; Smith, David M.; Moreira, David; Siderovski, David P.; Shum, David; Krist, David T.; Riches, David W.H.; Ferraris, Davide Maria; Anderson, Deborah H.; Coombe, Deirdre R.; Welsbie, Derek S.; Hu, Di; Ortiz, Diana; Alramadhani, Dina; Zhang, Dingqiang; Chaudhuri, Dipayan; Slotboom, Dirk J.; Ronning, Donald R.; Lee, Donghan; Dirksen, Dorian; Shoue, Douglas A.; Zochodne, Douglas William; Krishnamurthy, Durga; Duncan, Dustin; Glubb, Dylan M.; Gelardi, Edoardo Luigi Maria; Hsiao, Edward C.; Lynn, Edward G.; Silva, Elany Barbosa; Aguilera, Elena; Lenci, Elena; Abraham, Elena Theres; Lama, Eleonora; Mameli, Eleonora; Leung, Elisa; Christensen, Emily M.; Mason, Emily R.; Petretto, Enrico; Trakhtenberg, Ephraim F.; Rubin, Eric J.; Strauss, Erick; Thompson, Erik W.; Cione, Erika; Lisabeth, Erika Mathes; Fan, Erkang; Kroon, Erna Geessien; Jo, Eunji; Garcia-Cuesta, Eva M.; Glukhov, Evgenia; Gavathiotis, Evripidis; Yu, Fang; Xiang, Fei; Leng, Fenfei; Wang, Feng; Ingoglia, Filippo; van den Akker, Focco; Borriello, Francesco; Vizeacoumar, Franco J.; Luh, Frank; Buckner, Frederick S.; Vizeacoumar, Frederick S.; Bdira, Fredj Ben; Svensson, Fredrik; Rodriguez, G. Marcela; Bognár, Gabriella; Lembo, Gaia; Zhang, Gang; Dempsey, Garrett; Eitzen, Gary; Mayer, Gaétan; Greene, Geoffrey L.; Garcia, George A.; Lukacs, Gergely L.; Prikler, Gergely; Parico, Gian Carlo G.; Colotti, Gianni; De Keulenaer, Gilles; Cortopassi, Gino; Roti, Giovanni; Girolimetti, Giulia; Fiermonte, Giuseppe; Gasparre, Giuseppe; Leuzzi, Giuseppe; Dahal, Gopal; Michlewski, Gracjan; Conn, Graeme L.; Stuchbury, Grant David; Bowman, Gregory R.; Popowicz, Grzegorz Maria; Veit, Guido; de Souza, Guilherme Eduardo; Akk, Gustav; Caljon, Guy; Alvarez, Guzmán; Rucinski, Gwennan; Lee, Gyeongeun; Cildir, Gokhan; Li, Hai; Breton, Hairol E.; Jafar-Nejad, Hamed; Zhou, Han; Moore, Hannah P.; Tilford, Hannah; Yuan, Haynes; Shim, Heesung; Wulff, Heike; Hoppe, Heinrich; Chaytow, Helena; Tam, Heng Keat; Van Remmen, Holly; Xu, Hongyang; Debonsi, Hosana Maria; Lieberman, Howard B.; Jung, Hoyoung; Fan, Hua Ying; Feng, Hui; Zhou, Hui; Kim, Hyeong Jun; Greig, Iain R.; Caliandro, Ileana; Corvo, Ileana; Arozarena, Imanol; Mungrue, Imran N.; Verhamme, Ingrid M.; Qureshi, Insaf Ahmed; Lotsaris, Irina; Cakir, Isin; Perry, J. Jefferson P.; Kwiatkowski, Jacek; Boorman, Jacob; Ferreira, Jacob; Fries, Jacob; Kratz, Jadel Müller; Miner, Jaden; Siqueira-Neto, Jair L.; Granneman, James G.; Ng, James; Shorter, James; Voss, Jan Hendrik; Gebauer, Jan M.; Chuah, Janelle; Mousa, Jarrod J.; Maynes, Jason T.; Evans, Jay D.; Dickhout, Jeffrey; MacKeigan, Jeffrey P.; Jossart, Jennifer N.; Zhou, Jia; Lin, Jiabei; Xu, Jiake; Wang, Jianghai; Zhu, Jiaqi; Liao, Jiayu; Xu, Jingyi; Zhao, Jinshi; Lin, Jiusheng; Lee, Jiyoun; Reis, Joana; Stetefeld, Joerg; Bruning, John B.; , ; Coles, John G.; Tanner, John J.; Pascal, John M.; So, Jonathan; Pederick, Jordan L.; Costoya, Jose A.; Rayman, Joseph B.; Maciag, Joseph J.; Nasburg, Joshua Alexander; Gruber, Joshua J.; Finkelstein, Joshua M.; Watkins, Joshua; Rodriguez-Frade, José Miguel; Arias, Juan Antonio Sanchez; Lasarte, Juan José; Oyarzabal, Julen; Milosavljevic, Julian; Cools, Julie; Lescar, Julien; Bogomolovas, Julijus; Wang, Jun; Kee, Jung Min; Kee, Jung Min; Liao, Junzhuo; Sistla, Jyothi C.; Abrahão, Jônatas Santos; Sishtla, Kamakshi; Francisco, Karol R.; Hansen, Kasper B.; Molyneaux, Kathleen A.; Cunningham, Kathryn A.; Martin, Katie R.; Gadar, Kavita; Ojo, Kayode K.; Wong, Keith S.; Wentworth, Kelly L.; Lai, Kent; Lobb, Kevin A.; Hopkins, Kevin M.; Parang, Keykavous; Machaca, Khaled; Pham, Kien; Ghilarducci, Kim; Sugamori, Kim S.; McManus, Kirk James; Musta, Kirsikka; Faller, Kiterie M.E.; Nagamori, Kiyo; Mostert, Konrad J.; Korotkov, Konstantin V.; Liu, Koting; Smith, Kristiana S.; Sarosiek, Kristopher; Rohde, Kyle H.; Kim, Kyu Kwang; Lee, Kyung Hyeon; Pusztai, Lajos; Lehtio, Lari; Haupt, Larisa M.; Cowen, Leah E.; Byrne, Lee J.; Su, Leila; Wert-Lamas, Leon; Puchades-Carrasco, Leonor; Chen, Lifeng; Malkas, Linda H.; Zhuo, Ling; , ; Hedstrom, Lizbeth; Walensky, Loren D.; Antonelli, Lorenzo; Iommarini, Luisa; Whitesell, Luke; Randall, Lia M.; Fathallah, M. Dahmani; Nagai, Maira Harume; Kilkenny, Mairi Louise; Ben-Johny, Manu; Lussier, Marc P.; Windisch, Marc P.; Lolicato, Marco; Lolli, Marco Lucio; Vleminckx, Margot; Caroleo, Maria Cristina; Macias, Maria J.; Valli, Marilia; Barghash, Marim M.; Mellado, Mario; Tye, Mark A.; Wilson, Mark A.; Hannink, Mark; Ashton, Mark R.; Cerna, Mark Vincent C.dela; Giorgis, Marta; Safo, Martin K.; Maurice, Martin St; McDowell, Mary Ann; Pasquali, Marzia; Mehedi, Masfique; Serafim, Mateus Sá Magalhães; Soellner, Matthew B.; Alteen, Matthew G.; Champion, Matthew M.; Skorodinsky, Maxim; O"™Mara, Megan L.; Bedi, Mel; Rizzi, Menico; Levin, Michael; Mowat, Michael; Jackson, Michael R.; Paige, Mikell; Al-Yozbaki, Minnatallah; Giardini, Miriam A.; Maksimainen, Mirko M.; De Luise, Monica; Hussain, Muhammad Saddam; Christodoulides, Myron; Stec, Natalia; Zelinskaya, Natalia; Van Pelt, Natascha; Merrill, Nathan M.; Singh, Nathanael; Kootstra, Neeltje A.; Singh, Neeraj; Gandhi, Neha S.; Chan, Nei Li; Trinh, Nguyen Mai; Schneider, Nicholas O.; Matovic, Nick; Horstmann, Nicola; Longo, Nicola; Bharambe, Nikhil; Rouzbeh, Nirvan; Mahmoodi, Niusha; Gumede, Njabulo Joyfull; Anastasio, Noelle C.; Khalaf, Noureddine Ben; Rabal, Obdulia; Kandror, Olga; Escaffre, Olivier; Silvennoinen, Olli; Bishop, Ozlem Tastan; Iglesias, Pablo; Sobrado, Pablo; Chuong, Patrick; O"™Connell, Patrick; Martin-Malpartida, Pau; Mellor, Paul; Fish, Paul V.; Moreira, Paulo Otávio Lourenço; Zhou, Pei; , ; Liu, Pengda; Wu, Pengpeng; Agogo-Mawuli, Percy; Jones, Peter L.; Ngoi, Peter; Toogood, Peter; Ip, Philbert; von Hundelshausen, Philipp; Lee, Pil H.; Rowswell-Turner, Rachael B.; Balaña-Fouce, Rafael; Rocha, Rafael Eduardo Oliveira; Guido, Rafael V.C.; Ferreira, Rafaela Salgado; Agrawal, Rajendra K.; Harijan, Rajesh K.; Ramachandran, Rajesh; Verma, Rajkumar; Singh, Rakesh K.; Tiwari, Rakesh Kumar; Mazitschek, Ralph; Koppisetti, Rama K.; Dame, Remus T.; Douville, Renée N.; Austin, Richard C.; Taylor, Richard E.; Moore, Richard G.; Ebright, Richard H.; Angell, Richard M.; Yan, Riqiang; Kejriwal, Rishabh; Batey, Robert A.; Blelloch, Robert; Vandenberg, Robert J.; Hickey, Robert J.; Kelm, Robert J.; Lake, Robert J.; Bradley, Robert K.; Blumenthal, Robert M.; Solano, Roberto; Gierse, Robin Matthias; Viola, Ronald E.; McCarthy, Ronan R.; Reguera, Rosa Maria; Uribe, Ruben Vazquez; do Monte-Neto, Rubens Lima; Gorgoglione, Ruggiero; Cullinane, Ryan T.; Katyal, Sachin; Hossain, Sakib; Phadke, Sameer; Shelburne, Samuel A.; Geden, Sandra E.; Johannsen, Sandra; Wazir, Sarah; Legare, Scott; Landfear, Scott M.; Radhakrishnan, Senthil K.; Ammendola, Serena; Dzhumaev, Sergei; Seo, Seung Yong; Li, Shan; Zhou, Shan; Chu, Shaoyou; Chauhan, Shefali; Maruta, Shinsaku; Ashkar, Shireen R.; Shyng, Show Ling; Conticello, Silvestro G.; Buroni, Silvia; Garavaglia, Silvia; White, Simon J.; Zhu, Siran; Tsimbalyuk, Sofiya; Chadni, Somaia Haque; Byun, Soo Young; Park, Soonju; Xu, Sophia Q.; Banerjee, Sourav; Zahler, Stefan; Espinoza, Stefano; Gustincich, Stefano; Sainas, Stefano; Celano, Stephanie L.; Capuzzi, Stephen J.; Waggoner, Stephen N.; Poirier, Steve; Olson, Steven H.; Marx, Steven O.; Van Doren, Steven R.; Sarilla, Suryakala; Brady-Kalnay, Susann M.; Dallman, Sydney; Azeem, Syeda Maryam; Teramoto, Tadahisa; Mehlman, Tamar; Swart, Tarryn; Abaffy, Tatjana; Akopian, Tatos; Haikarainen, Teemu; Moreda, Teresa Lozano; Ikegami, Tetsuro; Teixeira, Thaiz Rodrigues; Jayasinghe, Thilina D.; Gillingwater, Thomas H.; Kampourakis, Thomas; Richardson, Timothy I.; Herdendorf, Timothy J.; Kotzé, Timothy J.; O"™Meara, Timothy R.; Corson, Timothy W.; Hermle, Tobias; Ogunwa, Tomisin Happy; Lan, Tong; Su, Tong; Banjo, Toshihiro; O"™Mara, Tracy A.; Chou, Tristan; Chou, Tsui Fen; Baumann, Ulrich; Desai, Umesh R.; Pai, Vaibhav P.; Thai, Van Chi; Tandon, Vasudha; Banerji, Versha; Robinson, Victoria L.; Gunasekharan, Vignesh; Namasivayam, Vigneshwaran; Segers, Vincent F.M.; Maranda, Vincent; Dolce, Vincenza; Maltarollo, Vinicius Gonçalves; Scoffone, Viola Camilla; Woods, Virgil A.; Ronchi, Virginia Paola; Van Hung Le, Vuong; Clayton, W. Brent; Lowther, W. Todd; Houry, Walid A.; Li, Wei; Tang, Weiping; Zhang, Wenjun; Van Voorhis, Wesley C.; Donaldson, William A.; Hahn, William C.; Kerr, William G.; Gerwick, William H.; Bradshaw, William J.; Foong, Wuen Ee; Blanchet, Xavier; Wu, Xiaoyang; Lu, Xin; Qi, Xin; Xu, Xin; Yu, Xinfang; Qin, Xingping; Wang, Xingyou; Yuan, Xinrui; Zhang, Xu; Zhang, Yan Jessie; Hu, Yanmei; Aldhamen, Yasser Ali; Chen, Yicheng; Li, Yihe; Sun, Ying; Zhu, Yini; Gupta, Yogesh K.; Pérez-Pertejo, Yolanda; Li, Yong; Tang, Young; He, Yuan; Tse-Dinh, Yuk Ching; Sidorova, Yulia A.; Yen, Yun; Li, Yunlong; Frangos, Zachary J.; Chung, Zara; Su, Zhengchen; Wang, Zhenghe; Zhang, Zhiguo; Liu, Zhongle; Inde, Zintis; Artia, Zoraima; Heifets, Abraham
High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery.
SCOPUS:85191821387
ISSN: 2045-2322
CID: 5658952
Personalized Ablation Strategies Optimize First Pass Isolation and Minimize Pulmonary Vein Reconnection During Paroxysmal Atrial Fibrillation Ablation
Junarta, Joey; Qiu, Jessica; Cheng, Austin V; Barbhaiya, Chirag R; Jankelson, Lior; Holmes, Douglas; Kushnir, Alexander; Knotts, Robert J; Yang, Felix; Bernstein, Scott A; Park, David S; Chinitz, Larry A; Aizer, Anthony
PMID: 39447812
ISSN: 1556-3871
CID: 5740132
Catheter ablation compared to medical therapy for ventricular tachycardia in sarcoidosis: nationwide outcomes and hospital readmissions
Gurin, Michael I; Xia, Yuhe; Tarabanis, Constantine; Goldberg, Randal I; Knotts, Robert J; Donnino, Robert; Reyentovich, Alex; Bernstein, Scott; Jankelson, Lior; Kushnir, Alexander; Holmes, Douglas; Spinelli, Michael; Park, David S; Barbhaiya, Chirag R; Chinitz, Larry A; Aizer, Anthony
BACKGROUND/UNASSIGNED:Catheter ablation (CA) for ventricular tachycardia (VT) can be a useful treatment strategy, however, few studies have compared CA to medical therapy (MT) in the sarcoidosis population. OBJECTIVE/UNASSIGNED:To assess in-hospital outcomes and unplanned readmissions following CA for VT compared to MT in patients with sarcoidosis. METHODS/UNASSIGNED:Data was obtained from the Nationwide Readmissions Database between 2010 and 2019 to identify patients with sarcoidosis admitted for VT either undergoing CA or MT during elective and non-elective admission. Primary endpoints were a composite endpoint of inpatient mortality, cardiogenic shock, cardiac arrest and 30-day hospital readmissions. Procedural complications at index admission and causes of readmission were also identified. RESULTS/UNASSIGNED: = 0.343). The most common cause of readmission were ventricular arrhythmias (VA) in both groups, however, those undergoing elective CA were less likely to be readmitted for VA compared to non-elective CA. The most common complication in the CA group was cardiac tamponade (4.8 %). CONCLUSION/UNASSIGNED:VT ablation is associated with similar rates of 30-day readmission compared to MT and does not confer increased risk of harm with respect to inpatient mortality, cardiogenic shock or cardiac arrest. Further research is warranted to determine if a subgroup of sarcoidosis patients admitted with VT are better served with an initial conservative management strategy followed by VT ablation.
PMCID:11279686
PMID: 39070127
ISSN: 2666-6022
CID: 5731242
Conduction velocity is reduced in the posterior wall of hypertrophic cardiomyopathy patients with normal bipolar voltage undergoing ablation for paroxysmal atrial fibrillation
Zahid, Sohail; Malik, Tahir; Peterson, Connor; Tarabanis, Constantine; Dai, Matthew; Katz, Moshe; Bernstein, Scott A; Barbhaiya, Chirag; Park, David S; Knotts, Robert J; Holmes, Douglas S; Kushnir, Alexander; Aizer, Anthony; Chinitz, Larry A; Jankelson, Lior
OBJECTIVES/OBJECTIVE:We investigated characteristics of left atrial conduction in patients with HCM, paroxysmal AF and normal bipolar voltage. BACKGROUND:Patients with hypertrophic cardiomyopathy (HCM) exhibit abnormal cardiac tissue arrangement. The incidence of atrial fibrillation (AF) is increased fourfold in patients with HCM and confers a fourfold increased risk of death. Catheter ablation is less effective in HCM, with twofold increased risk of AF recurrence. The mechanisms of AF perpetuation in HCM are poorly understood. METHODS:We analyzed 20 patients with HCM and 20 controls presenting for radiofrequency ablation of paroxysmal AF normal left atrial voltage(> 0.5 mV). Intracardiac electrograms were extracted from the CARTO mapping system and analyzed using Matlab/Python code interfacing with Core OpenEP software. Conduction velocity maps were calculated using local activation time gradients. RESULTS: = 0.13, p = 0.03). CONCLUSIONS:Atrial conduction velocity is significantly reduced in patients with HCM and paroxysmal AF, possibly contributing to arrhythmia persistence after catheter ablation.
PMID: 36952090
ISSN: 1572-8595
CID: 5523872
Comparison of combined substrate-based mapping techniques to identify critical sites for ventricular tachycardia ablation
Khan, Hassan; Bonvissuto, Matthew R; Rosinski, Elizabeth; Shokr, Mohamed; Metcalf, Kara; Jankelson, Lior; Kushnir, Alexander; Park, David S; Bernstein, Scott A; Spinelli, Michael A; Aizer, Anthony; Holmes, Douglas; Chinitz, Larry A; Barbhaiya, Chirag R
BACKGROUND:Established electroanatomic mapping techniques for substrate mapping for ventricular tachycardia (VT) ablation includes voltage mapping, isochronal late activation mapping (ILAM), and fractionation mapping. Omnipolar mapping (Abbott Medical, Inc.) is a novel optimized bipolar electrogram creation technique with integrated local conduction velocity annotation. The relative utilities of these mapping techniques are unknown. OBJECTIVE:The purpose of this study was to evaluate the relative utility of various substrate mapping techniques for the identification of critical sites for VT ablation. METHODS:Electroanatomic substrate maps were created and retrospectively analyzed in 27 patients in whom 33 VT critical sites were identified. RESULTS:. CONCLUSION/CONCLUSIONS:ILAM, fractionation, and CV mapping each identified distinct critical sites and provided a smaller area of interest than did voltage mapping alone. The sensitivity of novel mapping modalities improved with greater local point density.
PMID: 36863636
ISSN: 1556-3871
CID: 5462332
Catheter ablation of atrioventricular nodal reentrant tachycardia with an irrigated contact-force sensing radiofrequency ablation catheter
Panday, Priya; Holmes, Douglas; Park, David S; Jankelson, Lior; Bernstein, Scott A; Knotts, Robert; Kushnir, Alexander; Aizer, Anthony; Chinitz, Larry A; Barbhaiya, Chirag R
INTRODUCTION/BACKGROUND:Radiofrequency ablation (RFA) slow pathway modification for catheter ablation of atrioventricular nodal reentrant tachycardia (AVNRT) is traditionally performed using a 4-mm nonirrigated (NI) RF ablation catheter. Slow pathway modification using irrigated, contact-force sensing (ICFS) RFA catheters has been described in case reports, but the outcomes have not been systematically evaluated. METHODS:Acute procedural outcomes of 200 consecutive patients undergoing slow pathway modification for AVNRT were analyzed. A 3.5-mm ICFS RFA catheter (ThermoCool SmartTouch STSF, Biosense Webster, Inc.) was utilized in 134 patients, and a 4-mm NI RFA catheter (EZ Steer, Biosense Webster, Inc.) was utilized in 66 patients. Electroanatomic maps were retrospectively analyzed in a blinded fashion to determine the proximity of ablation lesions to the His region. RESULTS:The baseline characteristics of patients in both groups were similar. Total RF time was significantly lower in the ICFS group compared to the NI group (5.53 ± 4.6 vs. 6.24 ± 4.9 min, p = 0.03). Median procedure time was similar in both groups (ICFS, 108.0 (87.5-131.5) min vs. NI, 100.0 (85.0-125.0) min; p = 0.2). Ablation was required in closer proximity to the His region in the NI group compared to the ICFS group (14.4 ± 5.9 vs. 16.7 ± 6.4 mm, respectively, p = 0.01). AVNRT was rendered noninducible in all patients, and there was no arrhythmia recurrence during follow-up in both groups. Catheter ablation was complicated by AV block in one patient in the NI group. CONCLUSION/CONCLUSIONS:Slow pathway modification for catheter ablation of AVNRT using an ICFS RFA catheter is feasible, safe, and may facilitate shorter duration ablation while avoiding ablation in close proximity to the His region.
PMID: 36738141
ISSN: 1540-8167
CID: 5420642
Temporal trends in atrial fibrillation ablation procedures at an academic medical center: 2011-2021
Kushnir, Alexander; Barbhaiya, Chirag R; Aizer, Anthony; Jankelson, Lior; Holmes, Douglas; Knotts, Robert; Park, David; Spinelli, Michael; Bernstein, Scott; Chinitz, Larry A
INTRODUCTION/BACKGROUND:Radiofrequency ablation technology for treating atrial fibrillation (AF) has evolved rapidly over the past decade. We investigated the impact of technological and procedural advances on procedure times and ablation outcomes at a major academic medical center over a 10-year period. METHODS:Clinical data was collected from patients who presented to NYU Langone Health between 2011 and 2021 for a first-time AF ablation. Time to redo AF ablation or direct current cardioversion (DCCV) for recurrent AF during a 3-year follow-up period was determined and correlated with ablation technology and practices, antiarrhythmic medications, and patient comorbid conditions. RESULTS:From 2011 to 2021, the cardiac electrophysiology lab adopted irrigated-contact force ablation catheters, high-power short duration ablation lesions, steady-pacing, jet ventilation, and eliminated stepwise linear ablation for AF ablation. During this time the number of first time AF ablations increased from 403 to 1074, the percentage of patients requiring repeat AF-related intervention within 3-years of the index procedure dropped from 22% to 14%, mean procedure time decreased from 271 ± 65 to 135 ± 36 min, and mean annual major adverse event rate remained constant at 1.1 ± 0.5%. Patient comorbid conditions increased during this time period and antiarrhythmic use was unchanged. CONCLUSION/CONCLUSIONS:Rates of redo-AF ablation or DCCV following an initial AF ablation at a single center decreased 36% over a 10-year period. Procedural and technological changes likely contributed to this improvement, despite increased AF related comorbidities.
PMID: 36738147
ISSN: 1540-8167
CID: 5420652
Outcomes and atrial substrate analysis in patients with HIV undergoing atrial fibrillation ablation
Cheng, Austin; Qiu, Jessica; Barbhaiya, Chirag; Garber, Leonid; Holmes, Douglas; Jankelson, Lior; Kushnir, Alexander; Knotts, Robert; Bernstein, Scott; Park, David; Spinelli, Michael; Chinitz, Larry; Aizer, Anthony
INTRODUCTION/BACKGROUND:Patients with HIV infection have increased risk of atrial fibrillation, but the pathophysiologic mechanisms and the utility of catheter ablation in this population are not well-studied. We aimed to characterize outcomes of atrial fibrillation ablation and left atrial substrate in patients with HIV. METHODS:The study was a retrospective propensity score-matched analysis of patients with and without HIV undergoing atrial fibrillation ablation. A search was performed in the electronic medical record for all patients with HIV who received initial atrial fibrillation ablation from 2011 to 2020. After calculating propensity scores for HIV, matching was performed with patients without HIV by using nearest-neighbor matching without replacement in a 1:2 ratio. The primary outcome was freedom from atrial arrhythmia and secondary outcomes were freedom from atrial fibrillation, freedom from atrial tachycardia, and freedom from repeat ablation, compared by log-rank analysis. The procedures of patients with HIV who underwent repeat ablation at our institution were further analyzed for etiology of recurrence. To further characterize the left atrial substrate, a subsequent case-control analysis was then performed for a set of randomly chosen 10 patients with HIV matched with 10 without HIV to compare minimum and maximum voltage at nine pre-specified regions of the left atrium. RESULTS:Twenty-seven patients with HIV were identified. All were prescribed antiretroviral therapy at time of ablation. These patients were matched with 54 patients without HIV by propensity score. 86.4% of patients with HIV and 76.9% of controls were free of atrial fibrillation or atrial tachycardia at 1 year (p = .509). Log-rank analysis showed no difference in freedom from atrial arrhythmia (p value .971), atrial fibrillation (p-value .346), atrial tachycardia (p value .306), or repeat ablation (p value .401) after initial atrial fibrillation ablation in patients with HIV compared to patients without HIV. In patients with HIV with recurrent atrial fibrillation, the majority had pulmonary vein reconnection (67%). There were no significant differences in minimum or maximum voltage at any of the nine left atrial regions between the matched patients with and without HIV. CONCLUSIONS:Ablation to treat atrial fibrillation in patients with HIV, but without overt AIDS is frequently successful therapy. The majority of patients with recurrence of atrial fibrillation had pulmonary vein reconnection, suggesting infrequent nonpulmonary vein substrate. In this population, the left atrial voltage in patients with HIV is similar to that of patients without HIV. These findings suggest that the pulmonary veins remain a critical component to the initiation and maintenance of atrial fibrillation in patients with HIV.
PMID: 36511474
ISSN: 1540-8167
CID: 5382032
Repetitive nonreentrant ventriculoatrial synchrony inducing atrial fibrillation in setting of dofetilide [Case Report]
Garber, Leonid; Shulman, Eric; Kushnir, Alexander; Saraon, Tajinderpal; Park, David S; Chinitz, Larry A
PMCID:9123322
PMID: 35607350
ISSN: 2214-0271
CID: 5232852
