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Streamlining the Journey of Research Into Clinical Practice: Making Your Patients and Practice Flourish Understanding and Setting Treatment Expectations for Patients With Metastatic Spine Tumors
Reynolds, Jeremy J; Charest-Morin, Raphaële; Versteeg, Annemarie L; Galgano, Michael; Lubelski, Daniel; Newman, W Christopher; Patel, Shalin S; Sullivan, Patricia L Z; Dea, Nicolas; Gasbarrini, Alessandro; Lazary, Aron; Rhines, Laurence D; Sahgal, Arjun; Verlaan, Jorrit-Jan; Fisher, Charles G; Laufer, Ilya
STUDY DESIGN/METHODS:Literature review with clinical recommendation. OBJECTIVE:A concise curation of the latest spine literature exploring the relationship between expectations and satisfaction for patients with metastatic spinal disease (MSD). Deliver recommendations to practicing clinicians regarding interpretation and utilisation of this evidence. METHODS:The latest spine literature in the topic of factors affecting the expectations of patients with MSD was reviewed and clinical recommendations were formulated. Recommendations are graded as strong or Conditional. RESULTS:recommendation to incorporate this questionnaire in clinical and research MSD practice. CONCLUSION/CONCLUSIONS:Patients with MSD are approaching end of life care and high levels of treatment satisfaction are crucial at this juncture. The role of expectation management and comprehensive counselling is critical.
PMCID:11418664
PMID: 39052928
ISSN: 2192-5682
CID: 5723692
Digital Preoperative Huddle Platform Use Leads to Decreased Surgical Cost
Eremiev, Alexander; London, Dennis; Ber, Roee; Kurland, David B; Sheerin, Kathleen; Dennett, Haleigh; Pacione, Donato; Laufer, Ilya
BACKGROUND AND OBJECTIVES/OBJECTIVE:Communication has a well-established effect on improving outcomes. The current study evaluated the effect of multidisciplinary preoperative team communication using a digital huddle software platform on operating room costs. METHODS:A digital huddle software platform was implemented in March 2022 for neurosurgical procedures performed at a single tertiary care center. Surgeons were encouraged, but not required, to participate. General linear models were used to test the association between participation and the difference in supply-related cost and case length, using intergroup comparison and historical controls. RESULTS:A total of 29626 cases (performed by 97 surgeons), conducted between March 2021 and June 2023, were included in our analysis. Cases from participating neurosurgeons (12 surgeons, 4064 cases) were compared with cases from nonparticipating neurosurgeons (6 surgeons, 2452 cases), non-neurosurgery cases carried out by the same operating room staff (20 orthopedic spine surgeons, 6073 cases), and non-neurosurgery cases performed in a different operating room unit (59 surgeons, 21 996 cases). In aggregate, operating room (OR) costs increased by 7.3% (95% CI: 0.9-14.1, P = .025) in the postintervention period. In the same period, participation in the digital huddle platform was associated with an OR utilization and supply-related cost decrease of 16.3% (95% CI: 8.3%-23.6%, P < .001). Among neurosurgeons specifically, participation was associated with a supply-related cost decrease of 17.5% (95% CI: 6.0%-27.5%, P = .0037). There was no change in case length (median case length 171 minutes, change: +2.7% increase, 95% CI:-2.2%-7.9%, P = .28). CONCLUSION/CONCLUSIONS:The implementation of a digital huddle software platform resulted in an OR utilization and supply cost decrease among participants during a period when the overall nonparticipating control cohort experienced an increase in cost.
PMID: 38842337
ISSN: 1524-4040
CID: 5665602
Patient-Reported and Clinical Outcomes of Surgically Treated Patients With Symptomatic Spinal Metastases: Results From Epidemiology, Process, and Outcomes of Spine Oncology (EPOSO), a Prospective, Multi-Institutional and International Study
Barzilai, Ori; Sahgal, Arjun; Rhines, Laurence D; Versteeg, Anne L; Sciubba, Daniel M; Lazary, Aron; Weber, Michael H; Schuster, James M; Boriani, Stefano; Bettegowda, Chetan; Arnold, Paul M; Clarke, Michelle J; Laufer, Ilya; Fehlings, Michael G; Gokaslan, Ziya L; Fisher, Charles G; ,
BACKGROUND AND OBJECTIVES/OBJECTIVE:The palliative impact of spine surgery for metastatic disease is evolving with improvements in surgical technique and multidisciplinary cancer care. The goal of this study was to prospectively evaluate long-term clinical outcomes including health-related quality-of-life (HRQOL) measures, using spine cancer-specific patient-reported-outcome (PRO) measures, in patients with symptomatic spinal metastases who underwent surgical management. METHODS:The Epidemiology, Process, and Outcomes of Spine Oncology (EPOSO, ClinicalTrials.gov identifier: NCT01825161) trial is a prospective-observational cohort study that included 10 specialist centers in North America and Europe. Patients aged 18 to 75 years who underwent surgery for spinal metastases were included. Prospective assessments included both spine tumor-specific and generic PRO tools which were collected for a minimum of 2 years post-treatment or until death. RESULTS:Two hundred and eighty patients (51.8% female, mean age 57.9 years) were included. At presentation, the mean Charlson Comorbidity Index was 6.0, 35.7% had neurological deficits as defined by the American Spinal Cord Injury Association scores, 47.2% had high-grade epidural spinal cord compression (2-3), and 89.6% had impending or frank instability as measured by a Spinal Instability Neoplastic Score of ≥7. The most common primary tumor sites were breast (20.2%), lung (18.8%), kidney (16.2%), and prostate (6.5%). The median overall survival postsurgery was 501 days, and the 2-year progression-free-survival rate was 38.4%. Compared with baseline, significant and durable improvements in HRQOL were observed at the 6-week, 12-week, 26-week, 1-year, and 2-year follow-up assessments from a battery of PRO questionnaires including the spine cancer-specific, validated, Spine Oncology Study Group Outcomes Questionnaire v2.0, the Short Form 36 version 2, EuroQol-5 Dimension (3L), and pain numerical rating scale score. CONCLUSION/CONCLUSIONS:Multi-institutional, prospective-outcomes data confirm that surgical decompression and/or stabilization provides meaningful and durable improvements in multiple HRQOL domains, including spine-specific outcomes based on the Spine Oncology Study Group Outcomes Questionnaire v2.0, for patients with metastatic spine disease.
PMID: 38832791
ISSN: 1524-4040
CID: 5665162
Reliability of a Smartphone App to Objectively Monitor Performance Outcomes in Degenerative Cervical Myelopathy: Observational Study
Yanez Touzet, Alvaro; Houhou, Tatiana; Rahic, Zerina; Kolias, Angelos; Yordanov, Stefan; Anderson, David B; Laufer, Ilya; Li, Maggie; Grahovac, Gordan; Kotter, Mark Rn; Davies, Benjamin M; ,
BACKGROUND:Developing new clinical measures for degenerative cervical myelopathy (DCM) is an AO Spine RECODE-DCM Research, an international and multi-stakeholder partnership, priority. Difficulties in detecting DCM and its changes cause diagnostic and treatment delays in clinical settings and heightened costs in clinical trials due to elevated recruitment targets. Digital outcome measures can tackle these challenges due to their ability to measure disease remotely, repeatedly, and more economically. OBJECTIVE:The aim of this study is to assess the reliability of the MoveMed battery of performance outcome measures. METHODS:A prospective observational study in decentralized secondary care was performed in England, United Kingdom. The primary outcome was to determine the test-retest reliability of the MoveMed performance outcomes using the intraclass correlation (ICC) of agreement . The secondary outcome was to determine the measurement error of the MoveMed performance outcomes using both the SE of the mean (SEM) of agreement and the smallest detectable change (SDC) of agreement . Criteria from the Consensus-Based Standards for the Selection of Health Measurement Instruments (COSMIN) manual were used to determine adequate reliability (ie, ICC of agreement ≥0.7) and risk of bias. Disease stability was controlled using 2 minimum clinically important difference (MCID) thresholds obtained from the literature on the patient-derived modified Japanese Orthopaedic Association (p-mJOA) score, namely, MCID ≤1 point and MCID ≤2 points. RESULTS:In total, 7 adults aged 59.5 (SD 12.4) years who live with DCM and possess an approved smartphone participated in the study. All tests demonstrated moderate to excellent test-retest coefficients and low measurement errors. In the MCID ≤1 group, ICC of agreement values were 0.84-0.94 in the fast tap test, 0.89-0.95 in the hold test, 0.95 in the typing test, and 0.98 in the stand and walk test. SEM of agreement values were ±1 tap, ±1%-3% stability score points, ±0.06 keys per second, and ±10 steps per minute, respectively. SDC of agreement values were ±3 taps, ±4%-7% stability score points, ±0.2 keys per second, and ±27 steps per minute, respectively. In the MCID ≤2 group, ICC of agreement values were 0.61-0.91, 0.75-0.77, 0.98, and 0.62, respectively; SEM of agreement values were ±1 tap, ±2%-4% stability score points, ±0.06 keys per second, and ±10 steps per minute, respectively; and SDC of agreement values were ±3-7 taps, ±7%-10% stability score points, ±0.2 keys per second, and ±27 steps per minute, respectively. Furthermore, the fast tap, hold, and typing tests obtained sufficient ratings (ICC of agreement ≥0.7) in both MCID ≤1 and MCID ≤2 groups. No risk of bias factors from the COSMIN Risk of Bias checklist were recorded. CONCLUSIONS:The criteria from COSMIN provide "very good" quality evidence of the reliability of the MoveMed tests in an adult population living with DCM.
PMID: 38787602
ISSN: 2561-326x
CID: 5655152
Safety and Efficacy of Surgical Implantation of Intrathecal Drug Delivery Pumps in Patients With Cancer With Refractory Pain
Winston, Graham M; Zimering, Jeffrey H; Newman, Christopher W; Reiner, Anne S; Manalil, Noel; Kharas, Natasha; Gulati, Amitabh; Rakesh, Neal; Laufer, Ilya; Bilsky, Mark H; Barzilai, Ori
BACKGROUND AND OBJECTIVES/OBJECTIVE:Pain management in patients with cancer is a critical issue in oncology palliative care as clinicians aim to enhance quality of life and mitigate suffering. Most patients with cancer experience cancer-related pain, and 30%-40% of patients experience intractable pain despite maximal medical therapy. Intrathecal pain pumps (ITPs) have emerged as an option for achieving pain control in patients with cancer. Owing to the potential benefits of ITPs, we sought to study the long-term outcomes of this form of pain management at a cancer center. METHODS:We retrospectively reviewed medical records of all adult patients with cancer who underwent ITP placement at a tertiary comprehensive cancer center between 2013 and 2021. Baseline characteristics, preoperative and postoperative pain control, and postoperative complication rate data were collected. RESULTS:A total of 193 patients were included. We found that the average Numerical Rating Scale (NRS) score decreased significantly by 4.08 points (SD = 2.13, P < .01), from an average NRS of 7.38 (SD = 1.64) to an average NRS of 3.27 (SD = 1.66). Of 185 patients with preoperative and follow-up NRS pain scores, all but 9 experienced a decrease in NRS (95.1%). The median overall survival from time of pump placement was 3.62 months (95% CI: 2.73-4.54). A total of 42 adverse events in 33 patients were reported during the study period. The 1-year cumulative incidence of any complication was 15.6% (95% CI: 10.9%-21.1%) and for severe complication was 5.7% (95% CI: 3.0%-9.7%). Eleven patients required reoperation during the study period, with a 1-year cumulative incidence of 4.2% (95% CI: 2.0%-7.7%). CONCLUSION/CONCLUSIONS:Our study demonstrates that ITP implantation for the treatment of cancer-related pain is a safe and effective method of pain palliation with a low complication rate. Future prospective studies are required to determine the optimal timing of ITP implantation.
PMID: 38700319
ISSN: 1524-4040
CID: 5734282
A Clinical Practice Guideline for Prevention, Diagnosis and Management of Intraoperative Spinal Cord Injury: Recommendations for Use of Intraoperative Neuromonitoring and for the Use of Preoperative and Intraoperative Protocols for Patients Undergoing Spine Surgery
Fehlings, Michael G; Alvi, Mohammed Ali; Evaniew, Nathan; Tetreault, Lindsay A; Martin, Allan R; McKenna, Stephen L; Rahimi-Movaghar, Vafa; Ha, Yoon; Kirshblum, Steven; Hejrati, Nader; Srikandarajah, Nisaharan; Quddusi, Ayesha; Moghaddamjou, Ali; Malvea, Anahita; Pinto, Ricardo Rodrigues; Marco, Rex A W; Newcombe, Virginia F J; Basu, Saumayajit; Strantzas, Samuel; Zipser, Carl M; Douglas, Sam; Laufer, Ilya; Chou, Dean; Saigal, Rajiv; Arnold, Paul M; Hawryluk, Gregory W J; Skelly, Andrea C; Kwon, Brian K
STUDY DESIGN/METHODS:Development of a clinical practice guideline following the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) process. OBJECTIVE:The objectives of this study were to develop guidelines that outline the utility of intraoperative neuromonitoring (IONM) to detect intraoperative spinal cord injury (ISCI) among patients undergoing spine surgery, to define a subset of patients undergoing spine surgery at higher risk for ISCI and to develop protocols to prevent, diagnose, and manage ISCI. METHODS:All systematic reviews were performed according to PRISMA standards and registered on PROSPERO. A multidisciplinary, international Guidelines Development Group (GDG) reviewed and discussed the evidence using GRADE protocols. Consensus was defined by 80% agreement among GDG members. A systematic review and diagnostic test accuracy (DTA) meta-analysis was performed to synthesize pooled evidence on the diagnostic accuracy of IONM to detect ISCI among patients undergoing spinal surgery. The IONM modalities evaluated included somatosensory evoked potentials (SSEPs), motor evoked potentials (MEPs), electromyography (EMG), and multimodal neuromonitoring. Utilizing this knowledge and their clinical experience, the multidisciplinary GDG created recommendations for the use of IONM to identify ISCI in patients undergoing spine surgery. The evidence related to existing care pathways to manage ISCI was summarized and based on this a novel AO Spine-PRAXIS care pathway was created. RESULTS:Our recommendations are as follows: (1) We recommend that intraoperative neurophysiological monitoring be employed for high risk patients undergoing spine surgery, and (2) We suggest that patients at "high risk" for ISCI during spine surgery be proactively identified, that after identification of such patients, multi-disciplinary team discussions be undertaken to manage patients, and that an intraoperative protocol including the use of IONM be implemented. A care pathway for the prevention, diagnosis, and management of ISCI has been developed by the GDG. CONCLUSION/CONCLUSIONS:We anticipate that these guidelines will promote the use of IONM to detect and manage ISCI, and promote the use of preoperative and intraoperative checklists by surgeons and other team members for high risk patients undergoing spine surgery. We welcome teams to implement and evaluate the care pathway created by our GDG.
PMCID:10964898
PMID: 38526921
ISSN: 2192-5682
CID: 5644482
Treatment of intramedullary spinal cord tumors: a modified Delphi technique of the North American Spine Society Section of Spine Oncology
Hersh, Andrew M; Pennington, Zach; Lubelski, Daniel; Elsamadicy, Aladine A; Dea, Nicolas; Desai, Atman; Gokaslan, Ziya L; Goodwin, C Rory; Hsu, Wesley; Jallo, George I; Krishnaney, Ajit; Laufer, Ilya; Lo, Sheng-Fu Larry; Macki, Mohamed; Mehta, Ankit I; Ozturk, Ali; Shin, John H; Soliman, Hesham; Sciubba, Daniel M
OBJECTIVE:Intramedullary spinal cord tumors (IMSCTs) are rare tumors with heterogeneous presentations and natural histories that complicate their management. Standardized guidelines are lacking on when to surgically intervene and the appropriate aggressiveness of resection, especially given the risk of new neurological deficits following resection of infiltrative tumors. Here, the authors present the results of a modified Delphi method using input from surgeons experienced with IMSCT removal to construct a framework for the operative management of IMSCTs based on the clinical, radiographic, and tumor-specific characteristics. METHODS:A modified Delphi technique was conducted using a group of 14 neurosurgeons experienced in IMSCT resection. Three rounds of written correspondence, surveys, and videoconferencing were carried out. Participants were queried about clinical and radiographic criteria used to determine operative candidacy and guide decision-making. Members then completed a final survey indicating their choice of observation or surgery, choice of resection strategy, and decision to perform duraplasty, in response to a set of patient- and tumor-specific characteristics. Consensus was defined as ≥ 80% agreement, while responses with 70%-79% agreement were defined as agreement. RESULTS:Thirty-six total characteristics were assessed. There was consensus favoring surgical intervention for patients with new-onset myelopathy (86% agreement), chronic myelopathy (86%), or progression from mild to disabling numbness (86%), but disagreement for patients with mild numbness or chronic paraplegia. Age was not a determinant of operative candidacy except among frail patients, who were deemed more suitable for observation (93%). Well-circumscribed (93%) or posteriorly located tumors reaching the surface (86%) were consensus surgical lesions, and participants agreed that the presence of syringomyelia (71%) and peritumoral T2 signal change (79%) were favorable indications for surgery. There was consensus that complete loss of transcranial motor evoked potentials with a 50% decrease in the D-wave amplitude should halt further resection (93%). Preoperative symptoms seldom influenced choice of resection strategy, while a distinct cleavage plane (100%) or visible tumor-cord margins (100%) strongly favored gross-total resection. CONCLUSIONS:The authors present a modified Delphi technique highlighting areas of consensus and agreement regarding surgical management of IMSCTs. Although not intended as a substitute for individual clinical decision-making, the results can help guide care of these patients. Additionally, areas of controversy meriting further investigation are highlighted.
PMID: 37856379
ISSN: 1547-5646
CID: 5625762
Canadian Spine Society: 24th Annual Scientific Conference, Wednesday, February 28 - Saturday, March 2, Fairmont Chateau Whistler, Whistler, B.C., Canada
Dionne, Antoine; Al-Zakri, Majeed; Labelle, Hubert; Joncas, Julie; Parent, Stefan; Mac-Thiong, Jean-Marc; Miyanji, Firoz; Lonner, Baron; Eren, Ali; Cahill, Patrick; Parent, Stefan; Newton, Peter; Dermott, Jennifer A; Jaakkimainen, Liisa; To, Teresa; Bouchard, Maryse; Howard, Andrew; Lebel, David E; Hardy, Sarah; Malhotra, Armaan K; Dermott, Jennifer; Thevarajah, Dilani; Mathias, Karen D A; Yoon, Samuel; Sakhrekar, Rajendra; Lebel, David E; Kim, Dorothy J; Hadi, Ayesha; Doria, Andrea; Mitani, Aya; Dermott, Jennifer; Howard, Andrew; Lebel, David; Yoon, Samuel; Mathias, Karen; Dermott, Jennifer; Lebel, David; Miyanji, Firoz; Newton, Peter; Lonner, Baron; Bastrom, Tracey; Samdani, Amer; Roy-Beaudry, Marjolaine; Beauséjour, Marie; Imbeault, Rachelle; Dufresne, Justin; Parent, Stefan; Romeo, Jessica; Livock, Holly; Smit, Kevin; Jarvis, James; Tice, Andrew; Chan, Vivien K; Cho, Robert; Poon, Selina; Skaggs, David L; Shumilak, Geoffrey K; Rocos, Brett; Sardi, Juan P; Charalampidis, Anastasios; Gum, Jeff; Lewis, Stephen J; Tretiakov, Peter S; Onafowokan, Oluwatobi; Mir, Jamshaid; Das, Ankita; Williamson, Tyler; Dave, Pooja; Imbo, Bailey; Lebovic, Jordan; Jankowski, Pawel; Passias, Peter G; Lewis, Stephen; Aljamaan, Yousef; Lenke, Lawrence G; Smith, Justin; Varshney, Vishal P; Sahjpaul, Ramesh; Paquette, Scott; Osborn, Jill; Pelletier-Roy, Rémi; Asmussen, Michael; Birk, Manjot; Ludwig, Taryn; Nicholls, Fred; Zohar, Ariel; Loomans, Janneke; Pellise, Ferran; Smith, Justin S; Kato, So; Sardar, Zeeshan; Lenke, Lawrence; Lewis, Stephen J; Abbas, Aazad; Toor, Jay; Sahi, Gurjovan; Kovacevic, Dusan; Lex, Johnathan; Miyanji, Firoz; Rampersaud, Raja; Perruccio, Anthony V; Mahomed, Nizar; Canizares, Mayilee; ,; Rizkallah, Maroun; Lebreton, Michel Alexandre; Boubez, Ghassan; Shen, Jesse; AlShakfa, Fidaa; Kamel, Yousef; Osman, Galil; Wang, Zhi; Koegl, Nikolaus; Herrington, Brandon; Fernandes, Renan R; Urquhart, Jennifer C; Rampersaud, Yoga R; Bailey, Chris S; Hakimjavadi, Ramtin; Zhang, Tinghua; DeVries, Zachary; Wai, Eugene K; Kingwell, Stephen P; Stratton, Alexandra; Tsai, Eve; Wang, Zhi; Phan, Philippe; ,; Rampersaud, Raja; Fine, Noah; Stone, Laura; Kapoor, Mohit; Chênevert, Alexandre; Bédard, Sonia; McIntosh, Greg; Goulet, Julien; Couture, Jérome; Investigators, Csorn; LaRue, Bernard; Rosenstein, Brent; Rye, Meaghan; Roussac, Alexa; Naghdi, Neda; Macedo, Luciana G; Elliott, James; DeMont, Richard; Weber, Michael H; Pepin, Véronique; Dover, Geoffrey; Fortin, Maryse; Wang, Zhi; Rizkallah, Maroun; Shen, Jesse; Lebreton, Michel Alexandre; Florial, Edisond; AlShakfa, Fidaa; Boubez, Ghassan; Raj, Aditya; Amin, Prarthan; McIntosh, Greg; Rampersaud, Yoga Raja; AlDuwaisan, Abdullah A S M; Hakimjavadi, Ramtin; Zhang, Tinghua; Phan, Kim; Stratton, Alexandra; Tsai, Eve; Kingwell, Stephen; Wai, Eugene; Phan, Philippe; ,; Hebert, Jeffrey; Nowell, Sarah; Wedderkopp, Niels; Vandewint, Amanda; Manson, Neil; Abraham, Edward; Small, Christopher; Attabib, Najmedden; Bigney, Erin; Koegl, Nikolaus; Craig, Michael; Al-Shawwa, Abdul; Ost, Kalum; Tripathy, Saswati; Evaniew, Nathan; Jacobs, Bradley; Cadotte, David; Malhotra, Armaan K; Evaniew, Nathan; Dea, Nicolas; Investigators, Csorn; McIntosh, Greg; Wilson, Jefferson R; Evaniew, Nathan; Bailey, Christopher S; Rampersaud, Y Raja; Jacobs, W Bradley; Phan, Philippe Phan; Nataraj, Andrew; Cadotte, David W; Weber, Michael H; Thomas, Kenneth C; Manson, Neil; Attabib, Najmedden; Paquet, Jerome; Christie, Sean D; Wilson, Jefferson R; Hall, Hamilton; Fisher, Charles G; McIntosh, Greg; Dea, Nicolas; Liu, Eva Y; Persad, Amit R L; Baron, Nathan; Fourney, Daryl; Shakil, Husain; Investigators, Csorn; Evaniew, Nathan; Wilson, Jefferson R; Dea, Nicolas; Phan, Philippe; Huang, Jingyi; Fallah, Nader; Dandurand, Charlotte; ,; Alfawaz, Thamer; Zhang, Tinghua; Stratton, Alexandra; Tsai, Eve; Wai, Eugene; Kingwell, Stephen; Wang, Zhi; Phan, Philippe; Investigators, Csorn; Zaldivar-Jolissaint, Julien Francisco; Charest-Morin, Raphaële; McIntosh, Greg; Fehlings, Michael G; Pedro, Karlo M; Alvi, Mohammed Ali; Wang, Jessica C W; Charest-Morin, Raphaële; Dea, Nicolas; Fisher, Charles; Dvorak, Marcel; Kwon, Brian; Ailon, Tamir; Paquette, Scott; Street, John; Dandurand, Charlotte; Mumtaz, Rohail; Skaik, Khaled; Wai, Eugene K; Kingwell, Stephen; Stratton, Alexandra; Tsai, Eve; Phan, Philippe Tran Nhut; Wang, Zhi; Investigators, Csorn; Manoharan, Ragavan; McIntosh, Greg; Rampersaud, Yoga R; Smith-Forrester, Jenna; Douglas, JoAnne E; Nemeth, Evan; Alant, Jacob; Barry, Sean; Glennie, Andrew; Oxner, William; Weise, Lutz; Christie, Sean; Liu, Eva Y; Persad, Amit R L; Saeed, Sabahat; Toyota, Patrick; Su, Jack; Newton, Braeden; Coote, Nicole; Fourney, Daryl; Rachevits, Maria S; Razmjou, Helen; Robarts, Susan; Yee, Albert; Finkelstein, Joel; Almojuela, Alysa; Zeiler, Frederick; Logsetty, Sarvesh; Dhaliwal, Perry; Abdelnour, Mark; Zhang, Yuxin; Wai, Eugene; Kingwell, Stephen P; Stratton, Alexandra; Tsai, Eve; Phan, Philippe T; Investigators, Csorn; Smith, Taylor A; Small, Christopher; Bigney, Erin; Richardson, Eden; Kearney, Jillian; Manson, Neil; Abraham, Edward; Attabib, Najmedden; Bond, Michael; Dombrowski, Stephan; Price, Gwyneth; GarcÃa-Moreno, Jose Manuel; Hebert, Jeffrey; Qiu, Steven; Surendran, Vithushan; Cheung, Victoria Shi Emily; Ngana, Sophie; Qureshi, Muhammad A; Sharma, Sunjay V; Pahuta, Markian; Guha, Daipayan; Essa, Ahmad; Shakil, Husain; Malhotra, Armaan; Byrne, James; Badhiwala, Jetan; Yuan, Eva; He, Yingshi; Jack, Andrew; Mathieu, Francois; Wilson, Jefferson R; Witiw, Christopher D; Shakil, Husain; Malhotra, Armaan K; Yuan, Eva; Smith, Christopher W; Harrington, Erin M; Jaffe, Rachel H; Wang, Alick P; Ladha, Karim; Nathens, Avery B; Wilson, Jefferson R; Witiw, Christopher D; Sandarage, Ryan V; Galuta, Ahmad; Tsai, Eve C; Rotem-Kohavi, Naama; Dvorak, Marcel F; Xu, Jijie; Fallah, Nader; Waheed, Zeina; Chen, Melody; Dea, Nicolas; Evaniew, Nathan; Noonan, Vanessa; Kwon, Brian; Kwon, Brian K; Malomo, Toluyemi; Charest-Morin, Raphaële; Paquette, Scott; Ailon, Tamir; Dandurand, Charlotte; Street, John; Fisher, Charles G; Dea, Nicolas; Heran, Manraj; Dvorak, Marcel; Jaffe, Rachael; Coyte, Peter; Chan, Brian; Malhotra, Armaan; Hancock-Howard, Rebecca; Wilson, Jefferson; Witiw, Christopher; Cho, Newton; Squair, Jordan; Aureli, Viviana; James, Nicholas; Bole-Feysot, Lea; Dewany, Inssia; Hankov, Nicolas; Baud, Laetitia; Leonhartsberger, Anna; Sveistyte, Kristina; Skinnider, Michael; Gautier, Matthieu; Galan, Katia; Goubran, Maged; Ravier, Jimmy; Merlos, Frederic; Batti, Laura; Pagès, Stéphane; Bérard, Nadia; Intering, Nadine; Varescon, Camille; Carda, Stefano; Bartholdi, Kay; Hutson, Thomas; Kathe, Claudia; Hodara, Michael; Anderson, Mark; Draganski, Bogdan; Demesmaeker, Robin; Asboth, Leonie; Barraud, Quentin; Bloch, Jocelyne; Courtine, Grégoire; Christie, Sean D; Greene, Ryan; Nadi, Mustafa; Alant, Jacob; Barry, Sean; Glennie, Andrew; Oxner, Bill; Weise, Lutz; Julien, Lisa; Lownie, Clara; Dvorak, Marcel F; Öner, Cumhur F C; Dandurand, Charlotte; Joeris, Alexander; Schnake, Klaus; Phillips, Mark; Vaccaro, Alexander R; Bransford, Richard; Popescu, Eugen Cezar; El-Sharkawi, Mohammed; Rajasekaran, Shanmuganathan; Benneker, Lorin M; Schroeder, Greg D; Tee, Jin W; France, John; Paquet, Jérôme; Allen, Richard; Lavelle, William F; Vialle, Emiliano; Dea, Nicolas; Dionne, Antoine; Magnuson, David; Richard-Denis, Andréane; Petit, Yvan; Bernard, Francis; Barthélémy, Dorothy; Mac-Thiong, Jean-Marc; Grassner, Lukas; Garcia-Ovejero, Daniel; Beyerer, Evelyn; Mach, Orpheus; Leister, Iris; Maier, Doris; Aigner, Ludwig; Arevalo-Martin, Angel; MacLean, Mark Alexander; Charles, Antoinette; Georgiopoulos, Miltiadis; Charest-Morin, Raphaële; Goodwin, Rory; Weber, Michael; Brouillard, Emile; Richard-Denis, Andréane; Dionne, Antoine; Laassassy, Ismail; Khoueir, Paul; Bourassa-Moreau, Étienne; Maurais, Gilles; Mac-Thiong, Jean-Marc; Zaldivar-Jolissaint, Julien Francisco; Dea, Nicolas; Brown, Aysha Allard; So, Kitty; Manouchehri, Neda; Webster, Megan; Ethridge, Jay; Warner, Audrey; Billingsley, Avril; Newsome, Rochelle; Bale, Kirsten; Yung, Andrew; Seneviratne, Mehara; Cheng, Jimmy; Wang, Jing; Basnayake, Shenani; Streijger, Femke; Heran, Manraj; Kozlowski, Piotr; Kwon, Brian K; Golan, Jeff D; Elkaim, Lior M; Alrashidi, Qais; Georgiopoulos, Miltiadis; Lasry, Oliver J; Bednar, Drew A; Love, Alyson; Nedaie, Soroush; Gandhi, Pranjan; Amin, Prarthan C; Raj, Aditya; McIntosh, Greg; Neilsen, Christopher J; Swamy, Ganesh; Rampersaud, Raja; ,; Vandewint, Amanda; Rampersaud, Y Raja; Hebert, Jeffrey; Bigney, Erin; Manson, Neil; Attabib, Najmedden; Small, Chris; Richardson, Eden; Kearney, Jill; Abraham, Edward; Rampersaud, Raja; Raj, Aditya; Marathe, Nanadan; McIntosh, Greg; ,; Dhiman, Manmeet; Bader, Taylor J; Hart, David; Swamy, Ganesh; Duncan, Neil; Dhiman, Manmeet; Bader, Taylor J; Ponjevic, Dragana; Matyas, John R; Hart, David; Swamy, Ganesh; Duncan, Neil; O'Brien, Connor P; Hebert, Jeffrey; Bigney, Erin; Kearney, Jillian; Richardson, Eden; Abraham, Edward; Manson, Neil; Attabib, Najmedden; Small, Christopher; LaRochelle, Luke; Rivas, Gabriella; Lawrence, James; Ravinsky, Robert; Kim, Dorothy; Dermott, Jennifer; Mitani, Aya; Doria, Andrea; Howard, Andrew; Lebel, David; Dermott, Jennifer A; Switzer, Lily S; Kim, Dorothy J; Lebel, David E; Montpetit, Chanelle; Vaillancourt, Nicolas; Rosenstein, Brent; Fortin, Maryse; Nadler, Emma; Dermott, Jennifer; Kim, Dorothy; Lebel, David E; Wolfe, Daniel; Rosenstein, Brent; Fortin, Maryse; Wolfe, Daniel; Dover, Geoffrey; Boily, Mathieu; Fortin, Maryse; Shakil, Husain; Malhotra, Armaan K; Badhiwala, Jetan H; Karthikeyan, Vishu; He, Yingshi; Fehlings, Michael G; Sahgal, Arjun; Dea, Nicolas; Kiss, Alex; Witiw, Christopher D; Redelmeier, Donald R; Wilson, Jefferson R; Caceres, Marco Pérez; Freire, Véronique; Shen, Jesse; Al-Shakfa, Fidaa; Ahmed, Omer; Wang, Zhi; Kwan, William Chu; Zuckerman, Scott L; Fisher, Charles G; Laufer, Ilya; Chou, Dean; O'Toole, John E; Schultheiss, Markus; Weber, Michael H; Sciubba, Daniel M; Pahuta, Markian; Shin, John H; Fehlings, Michael G; Versteeg, Anne; Goodwin, Matthew L; Boriani, Stefano; Bettegowda, Chetan; Lazary, Aron; Gasbarrini, Alessandro; Reynolds, Jeremy J; Verlaan, Jorrit-Jan; Sahgal, Arjun; Gokaslan, Ziya L; Rhines, Laurence D; Dea, Nicolas; Truong, Van Tri; Dang, The Khanh; Osman, Galil; Al-Shakfa, Fidaa; Boule, Danielle; Shen, Jesse; Wang, Zhi; Rizkallah, Maroun; Boubez, Ghassan; Shen, Jesse; Phan, Philippe; Alshakfa, Fidaa; Boule, Danielle; Belguendouz, Celine; Kafi, Rayane; Yuh, Sung-Joo; Shedid, Daniel; Wang, Zhi; Wang, Zhi; Shen, Jesse; Boubez, Ghassan; Alshakfa, Fidaa; Boulé, Daniele; Belguendouz, Celine; Kafi, Rayane; Phan, Philippe; Shedid, Daniel; Yuh, Sung-Joo; Rizkallah, Maroun; Silva, Yan Gabriel Morais David; Weber, Luis; Leão, Felipe; Essa, Ahmad; Malhotra, Armaan K; Shakil, Husain; Byrne, James; Badhiwala, Jetan; Nathens, Avery B; Azad, Tej D; Yuan, Eva; He, Yingshi; Jack, Andrew S; Mathieu, Francois; Wilson, Jefferson R; Witiw, Christopher D; Craig, Michael; Guenther, Nick; Valosek, Jan; Bouthillier, Maxime; Enamundram, Naga Karthik; Rotem-Kohavi, Naama; Humphreys, Suzanne; Christie, Sean; Fehlings, Michael; Kwon, Brian; Mac-Thiong, Jean-Marc; Phan, Philippe; Paquet, Jerome; Guay-Paquet, Mathieu; Cohen-Adad, Julien; Cadotte, David; Dionne, Antoine; Mac-Thiong, Jean-Marc; Hong, Heather; Kurban, Dilnur; Xu, Jijie; Barthélémy, Dorothy; Christie, Sean; Fourney, Daryl; Linassi, Gary; Sanchez, Adalberto Loyola; Paquet, Jérôme; Sreenivasan, Vidya; Townson, Andrea; Tsai, Eve C; Richard-Denis, Andréane; Kwan, William Chu; Laghaei, Pedram; Kahlon, Harsh; Ailon, Tamir; Charest-Morin, Raphael; Dandurand, Charlotte; Paquette, Scott; Dea, Nicholas; Street, John; Fisher, Charles G; Dvorak, Marcel F; Kwon, Brian K; Thibault, Jérémie; Dionne, Antoine; Al-Sofyani, Mohamed; Pelletier-Roy, Rémi; Richard-Denis, Andréane; Bourassa-Moreau, Étienne; Mac-Thiong, Jean-Marc; Bouthillier, Maxime; ValoÅ¡ek, Jan; Enamundram, Naga Karthik; Guay-Paquet, Mathieu; Guenther, Nick; Rotem-Kohavi, Naama; Humphreys, Suzanne; Christie, Sean; Fehlings, Michael; Kwon, Brian K; Mac-Thiong, Jean Marc; Phan, Philippe; Cadotte, David; Cohen-Adad, Julien; Reda, Luke; Kennedy, Colton; Stefaniuk, Stephanie; Eftekhar, Parvin; Robinson, Larry; Craven, Cathy; Dengler, Jana; Kennedy, Colton; Reda, Luke; Stefaniuk, Stephanie; Eftekhar, Parvin; Robinson, Larry; Craven, Cathy; Dengler, Jana; Roukerd, Maryam Rezaeezadeh; Patel, Maitreya; Tsai, Eve; Galuta, Ahmad; Jagadeesan, Sasi; Sandarage, Ryan Vimukthie; Phan, Philippe; Michalowski, Wojtek; Van Woensel, William; Vig, Khushdeep; Kazley, Jillian; Arain, Abdul; Rivas, Gabriella; Ravinsky, Robert; Lawrence, James; Gupta, Shaurya; Patel, Jibrahn; Turkstra, Isaac; Pustovetov, Kirill; Yang, Victor; Jacobs, W Bradley; Mariscal, Gonzalo; Witiw, Christopher D; Harrop, James S; Essa, Ahmed; Witiw, Christopher D; Mariscal, Gonzalo; Jacobs, W Bradley; Harrop, James S; Essa, Ahmed; Du, Jin Tong; Cherry, Ahmed; Kumar, Rajesh; Jaber, Nadia; Fehlings, Michael; Yee, Albert; Dukkipati, Siril Teja; Driscoll, Mark; Byers, Elizabeth; Brown, Justin L; Gallagher, Michelle; Sugar, James; Rockall, Shannon; Hektner, James; Donia, Scott; Chernesky, John; Noonan, Vanessa K; Varga, Aaron A; Slomp, Flo; Thiessen, Emily; Lastivnyak, Nataliya; Maclean, Linda Slater; Ritchie, Vanessa; Hockley, Aaron; Weise, Lutz M; Potvin, Christine; Flynn, Peggy; Christie, Sean; Turkstra, Isaac; Oppermann, Bruno; Oppermann, Marcelo; Gupta, Shaurya; Patel, Jibrahn; Pustovetov, Kirill; Lee, Kenneth; Chen, ChaoLiang; Rastgarjazi, Mohammadmahdi; Yang, Victor; Hardy, Sarah; Strantzas, Samuel; Anthony, Alison; Dermott, Jennifer; Vandenberk, Mike; Hassan, Samer; Lebel, David; Silva, Yan Gabriel Morais David; LaRue, Bernard; Couture, Jerome; Pimenta, Newton; Blanchard, Jocelyn; Chenevert, Alexandre; Goulet, Julien; Greene, Ryan; Christie, Sean D; Hall, Amanda; Etchegary, Holly; Althagafi, Alwalaa; Han, Jae; Greene, Ryan; Christie, Sean; Pickett, Gwynedd; Witiw, Christopher; Harrop, James; Jacobs, W Bradley; Mariscal, Gonzalo; Essa, Ahmed; Jacobs, W Bradley; Mariscal, Gonzalo; Witiw, Christopher; Harrop, James S; Essa, Ahmed; Lasswell, Timothy; Rasoulinejad, Parham; Hu, Richard; Bailey, Chris; Siddiqi, Fawaz; Hamdoon, Abdulrahman; Soliman, Mohamed Amin; Maraj, Juhi; Jhawar, Deven; Jhawar, Balraj; Schuler, Kirsten A; Orosz, Lindsay D; Yamout, Tarek; Allen, Brandon J; Lerebo, Wondwossen T; Roy, Rita T; Schuler, Thomas C; Good, Christopher R; Haines, Colin M; Jazini, Ehsan; Ost, Kalum J; Al-Shawwa, Abdul; Anderson, David; Evaniew, Nathan; Jacobs, Bradley W; Lewkonia, Peter; Nicholls, Fred; Salo, Paul T; Thomas, Kenneth C; Yang, Michael; Cadotte, David; Sarraj, Mohamed; Rajapaksege, Nathasha; Dea, Nicolas; Evaniew, Nathan; McIntosh, Greg; Pahuta, Markian; ,; Alharbi, Hani Nouran; Skaik, Khaled; Wai, Eugene K; Kingwell, Stephen; Stratton, Alexandra; Tsai, Eve; Phan, Philippe Tran Nhut; Wang, Zhi; Investigators, Csorn; Zaldivar-Jolissaint, Julien Francisco; Gustafson, Sara; Polyzois, Ian; Gascoyne, Trevor; Goytan, Michael; Bednar, Drew Alexander; Sarra, Mohamed; Rocos, Brett; Sardi, Juan P; Charalampidis, Anastasios; Gum, Jeff; Lewis, Stephen J; Ghag, Ravi; Kirk, Samuel; Shirley, Otis; Bone, Jeffrey; Morrison, Andrew; Miyanji, Firoz; Parekh, Amit; Sanders, Ethan; Birk, Manjot; Nicholls, Fred; Smit, Kevin; Livock, Holly; Romeo, Jessica; Jarvis, James; Tice, Andrew; Frank, SofÃa; Labelle, Hubert; Parent, Stephan; Barchi, Soraya; Joncas, Julie; Mac-Thiong, Jean-Marc; Thibault, Jérémie; Joncas, Julie; Barchi, Soraya; Parent, Stefan; Beausejour, Marie; Mac-Thiong, Jean-Marc; Dionne, Antoine; Mac-Thiong, Jean-Marc; Parent, Stefan; Shen, Jesse; Joncas, Julie; Barchi, Soraya; Labelle, Hubert; Birk, Manjot S; Nicholls, Fred; Pelletier-Roy, Rémi; Sanders, Ethan; Lewis, Stephen; Aljamaan, Yousef; Lenke, Lawrence G; Smith, Justin; Sardar, Zeeshan; Mullaj, Elen; Lebel, David; Dermott, Jennifer; Bath, Natasha; Mathias, Karen; Kattail, Deepa; Zohar, Ariel; Loomans, Janneke; Pellise, Ferran; Smith, Justin S; Kato, So; Sardar, Zeeshan; Lenke, Lawrence; Lewis, Stephen J; Bader, Taylor J; Dhiman, Manmeet; Hart, David; Duncan, Neil; Salo, Paul; Swamy, Ganesh; Lewis, Stephen Joel; Lawrence, Peyton Lloyd; Smith, Justin; Pellise, Ferran; Sardar, Zeeshan; Lawrence, Peyton Lloyd; Lewis, Stephen Joel; Smith, Justin; Pellise, Ferran; Sardar, Zeeshan; Levett, Jordan J; Alnasser, Abdulrhman; Barak, Uri; Elkaim, Lior M; Hoang, Thien Sa; Alotaibi, Naif M; Guha, Daipayan; Moss, Isaac L; Weil, Alexander G; Weber, Michael H; de Muelenaere, Phillip; Parvez, Kashif; Sun, John; Iorio, Olivia C; Rosenstein, Brent; Naghdi, Neda; Fortin, Maryse; Manocchio, Felicia; Ankory, Ran; Stallwood, Lisa; Ahn, Henry; Mahdi, Hamza; Naeem, Abdul; Jhawar, Deven; Moradi, Milad; Jhawar, Balraj; Qiu, Steven; Surendran, Vithushan; Shi, Victoria; Cheung, Emily; Ngana, Sophie; Qureshi, Muhammad A; Sharma, Sunjay V; Pahuta, Markian; Guha, Daipayan
PMID: 39537311
ISSN: 1488-2310
CID: 5753252
Canadian Spine Society: 24th Annual Scientific Conference, Wednesday, February 28 - Saturday, March 2, Fairmont Chateau Whistler, Whistler, B.C., Canada
Dionne, Antoine; Al-Zakri, Majeed; Labelle, Hubert; Joncas, Julie; Parent, Stefan; Mac-Thiong, Jean-Marc; Miyanji, Firoz; Lonner, Baron; Eren, Ali; Cahill, Patrick; Parent, Stefan; Newton, Peter; Dermott, Jennifer A; Jaakkimainen, Liisa; To, Teresa; Bouchard, Maryse; Howard, Andrew; Lebel, David E; Hardy, Sarah; Malhotra, Armaan K; Dermott, Jennifer; Thevarajah, Dilani; Mathias, Karen D A; Yoon, Samuel; Sakhrekar, Rajendra; Lebel, David E; Kim, Dorothy J; Hadi, Ayesha; Doria, Andrea; Mitani, Aya; Dermott, Jennifer; Howard, Andrew; Lebel, David; Yoon, Samuel; Mathias, Karen; Dermott, Jennifer; Lebel, David; Miyanji, Firoz; Newton, Peter; Lonner, Baron; Bastrom, Tracey; Samdani, Amer; Roy-Beaudry, Marjolaine; Beauséjour, Marie; Imbeault, Rachelle; Dufresne, Justin; Parent, Stefan; Romeo, Jessica; Livock, Holly; Smit, Kevin; Jarvis, James; Tice, Andrew; Chan, Vivien K; Cho, Robert; Poon, Selina; Skaggs, David L; Shumilak, Geoffrey K; Rocos, Brett; Sardi, Juan P; Charalampidis, Anastasios; Gum, Jeff; Lewis, Stephen J; Tretiakov, Peter S; Onafowokan, Oluwatobi; Mir, Jamshaid; Das, Ankita; Williamson, Tyler; Dave, Pooja; Imbo, Bailey; Lebovic, Jordan; Jankowski, Pawel; Passias, Peter G; Lewis, Stephen; Aljamaan, Yousef; Lenke, Lawrence G; Smith, Justin; Varshney, Vishal P; Sahjpaul, Ramesh; Paquette, Scott; Osborn, Jill; Pelletier-Roy, Rémi; Asmussen, Michael; Birk, Manjot; Ludwig, Taryn; Nicholls, Fred; Zohar, Ariel; Loomans, Janneke; Pellise, Ferran; Smith, Justin S; Kato, So; Sardar, Zeeshan; Lenke, Lawrence; Lewis, Stephen J; Abbas, Aazad; Toor, Jay; Sahi, Gurjovan; Kovacevic, Dusan; Lex, Johnathan; Miyanji, Firoz; Rampersaud, Raja; Perruccio, Anthony V; Mahomed, Nizar; Canizares, Mayilee; ,; Rizkallah, Maroun; Lebreton, Michel Alexandre; Boubez, Ghassan; Shen, Jesse; AlShakfa, Fidaa; Kamel, Yousef; Osman, Galil; Wang, Zhi; Koegl, Nikolaus; Herrington, Brandon; Fernandes, Renan R; Urquhart, Jennifer C; Rampersaud, Yoga R; Bailey, Chris S; Hakimjavadi, Ramtin; Zhang, Tinghua; DeVries, Zachary; Wai, Eugene K; Kingwell, Stephen P; Stratton, Alexandra; Tsai, Eve; Wang, Zhi; Phan, Philippe; ,; Rampersaud, Raja; Fine, Noah; Stone, Laura; Kapoor, Mohit; Chênevert, Alexandre; Bédard, Sonia; McIntosh, Greg; Goulet, Julien; Couture, Jérome; Investigators, Csorn; LaRue, Bernard; Rosenstein, Brent; Rye, Meaghan; Roussac, Alexa; Naghdi, Neda; Macedo, Luciana G; Elliott, James; DeMont, Richard; Weber, Michael H; Pepin, Véronique; Dover, Geoffrey; Fortin, Maryse; Wang, Zhi; Rizkallah, Maroun; Shen, Jesse; Lebreton, Michel Alexandre; Florial, Edisond; AlShakfa, Fidaa; Boubez, Ghassan; Raj, Aditya; Amin, Prarthan; McIntosh, Greg; Rampersaud, Yoga Raja; AlDuwaisan, Abdullah A S M; Hakimjavadi, Ramtin; Zhang, Tinghua; Phan, Kim; Stratton, Alexandra; Tsai, Eve; Kingwell, Stephen; Wai, Eugene; Phan, Philippe; ,; Hebert, Jeffrey; Nowell, Sarah; Wedderkopp, Niels; Vandewint, Amanda; Manson, Neil; Abraham, Edward; Small, Christopher; Attabib, Najmedden; Bigney, Erin; Koegl, Nikolaus; Craig, Michael; Al-Shawwa, Abdul; Ost, Kalum; Tripathy, Saswati; Evaniew, Nathan; Jacobs, Bradley; Cadotte, David; Malhotra, Armaan K; Evaniew, Nathan; Dea, Nicolas; Investigators, Csorn; McIntosh, Greg; Wilson, Jefferson R; Evaniew, Nathan; Bailey, Christopher S; Rampersaud, Y Raja; Jacobs, W Bradley; Phan, Philippe Phan; Nataraj, Andrew; Cadotte, David W; Weber, Michael H; Thomas, Kenneth C; Manson, Neil; Attabib, Najmedden; Paquet, Jerome; Christie, Sean D; Wilson, Jefferson R; Hall, Hamilton; Fisher, Charles G; McIntosh, Greg; Dea, Nicolas; Liu, Eva Y; Persad, Amit R L; Baron, Nathan; Fourney, Daryl; Shakil, Husain; Investigators, Csorn; Evaniew, Nathan; Wilson, Jefferson R; Dea, Nicolas; Phan, Philippe; Huang, Jingyi; Fallah, Nader; Dandurand, Charlotte; ,; Alfawaz, Thamer; Zhang, Tinghua; Stratton, Alexandra; Tsai, Eve; Wai, Eugene; Kingwell, Stephen; Wang, Zhi; Phan, Philippe; Investigators, Csorn; Zaldivar-Jolissaint, Julien Francisco; Charest-Morin, Raphaële; McIntosh, Greg; Fehlings, Michael G; Pedro, Karlo M; Alvi, Mohammed Ali; Wang, Jessica C W; Charest-Morin, Raphaële; Dea, Nicolas; Fisher, Charles; Dvorak, Marcel; Kwon, Brian; Ailon, Tamir; Paquette, Scott; Street, John; Dandurand, Charlotte; Mumtaz, Rohail; Skaik, Khaled; Wai, Eugene K; Kingwell, Stephen; Stratton, Alexandra; Tsai, Eve; Phan, Philippe Tran Nhut; Wang, Zhi; Investigators, Csorn; Manoharan, Ragavan; McIntosh, Greg; Rampersaud, Yoga R; Smith-Forrester, Jenna; Douglas, JoAnne E; Nemeth, Evan; Alant, Jacob; Barry, Sean; Glennie, Andrew; Oxner, William; Weise, Lutz; Christie, Sean; Liu, Eva Y; Persad, Amit R L; Saeed, Sabahat; Toyota, Patrick; Su, Jack; Newton, Braeden; Coote, Nicole; Fourney, Daryl; Rachevits, Maria S; Razmjou, Helen; Robarts, Susan; Yee, Albert; Finkelstein, Joel; Almojuela, Alysa; Zeiler, Frederick; Logsetty, Sarvesh; Dhaliwal, Perry; Abdelnour, Mark; Zhang, Yuxin; Wai, Eugene; Kingwell, Stephen P; Stratton, Alexandra; Tsai, Eve; Phan, Philippe T; Investigators, Csorn; Smith, Taylor A; Small, Christopher; Bigney, Erin; Richardson, Eden; Kearney, Jillian; Manson, Neil; Abraham, Edward; Attabib, Najmedden; Bond, Michael; Dombrowski, Stephan; Price, Gwyneth; GarcÃa-Moreno, Jose Manuel; Hebert, Jeffrey; Qiu, Steven; Surendran, Vithushan; Cheung, Victoria Shi Emily; Ngana, Sophie; Qureshi, Muhammad A; Sharma, Sunjay V; Pahuta, Markian; Guha, Daipayan; Essa, Ahmad; Shakil, Husain; Malhotra, Armaan; Byrne, James; Badhiwala, Jetan; Yuan, Eva; He, Yingshi; Jack, Andrew; Mathieu, Francois; Wilson, Jefferson R; Witiw, Christopher D; Shakil, Husain; Malhotra, Armaan K; Yuan, Eva; Smith, Christopher W; Harrington, Erin M; Jaffe, Rachel H; Wang, Alick P; Ladha, Karim; Nathens, Avery B; Wilson, Jefferson R; Witiw, Christopher D; Sandarage, Ryan V; Galuta, Ahmad; Tsai, Eve C; Rotem-Kohavi, Naama; Dvorak, Marcel F; Xu, Jijie; Fallah, Nader; Waheed, Zeina; Chen, Melody; Dea, Nicolas; Evaniew, Nathan; Noonan, Vanessa; Kwon, Brian; Kwon, Brian K; Malomo, Toluyemi; Charest-Morin, Raphaële; Paquette, Scott; Ailon, Tamir; Dandurand, Charlotte; Street, John; Fisher, Charles G; Dea, Nicolas; Heran, Manraj; Dvorak, Marcel; Jaffe, Rachael; Coyte, Peter; Chan, Brian; Malhotra, Armaan; Hancock-Howard, Rebecca; Wilson, Jefferson; Witiw, Christopher; Cho, Newton; Squair, Jordan; Aureli, Viviana; James, Nicholas; Bole-Feysot, Lea; Dewany, Inssia; Hankov, Nicolas; Baud, Laetitia; Leonhartsberger, Anna; Sveistyte, Kristina; Skinnider, Michael; Gautier, Matthieu; Galan, Katia; Goubran, Maged; Ravier, Jimmy; Merlos, Frederic; Batti, Laura; Pagès, Stéphane; Bérard, Nadia; Intering, Nadine; Varescon, Camille; Carda, Stefano; Bartholdi, Kay; Hutson, Thomas; Kathe, Claudia; Hodara, Michael; Anderson, Mark; Draganski, Bogdan; Demesmaeker, Robin; Asboth, Leonie; Barraud, Quentin; Bloch, Jocelyne; Courtine, Grégoire; Christie, Sean D; Greene, Ryan; Nadi, Mustafa; Alant, Jacob; Barry, Sean; Glennie, Andrew; Oxner, Bill; Weise, Lutz; Julien, Lisa; Lownie, Clara; Dvorak, Marcel F; Öner, Cumhur F C; Dandurand, Charlotte; Joeris, Alexander; Schnake, Klaus; Phillips, Mark; Vaccaro, Alexander R; Bransford, Richard; Popescu, Eugen Cezar; El-Sharkawi, Mohammed; Rajasekaran, Shanmuganathan; Benneker, Lorin M; Schroeder, Greg D; Tee, Jin W; France, John; Paquet, Jérôme; Allen, Richard; Lavelle, William F; Vialle, Emiliano; Dea, Nicolas; Dionne, Antoine; Magnuson, David; Richard-Denis, Andréane; Petit, Yvan; Bernard, Francis; Barthélémy, Dorothy; Mac-Thiong, Jean-Marc; Grassner, Lukas; Garcia-Ovejero, Daniel; Beyerer, Evelyn; Mach, Orpheus; Leister, Iris; Maier, Doris; Aigner, Ludwig; Arevalo-Martin, Angel; MacLean, Mark Alexander; Charles, Antoinette; Georgiopoulos, Miltiadis; Charest-Morin, Raphaële; Goodwin, Rory; Weber, Michael; Brouillard, Emile; Richard-Denis, Andréane; Dionne, Antoine; Laassassy, Ismail; Khoueir, Paul; Bourassa-Moreau, Étienne; Maurais, Gilles; Mac-Thiong, Jean-Marc; Zaldivar-Jolissaint, Julien Francisco; Dea, Nicolas; Brown, Aysha Allard; So, Kitty; Manouchehri, Neda; Webster, Megan; Ethridge, Jay; Warner, Audrey; Billingsley, Avril; Newsome, Rochelle; Bale, Kirsten; Yung, Andrew; Seneviratne, Mehara; Cheng, Jimmy; Wang, Jing; Basnayake, Shenani; Streijger, Femke; Heran, Manraj; Kozlowski, Piotr; Kwon, Brian K; Golan, Jeff D; Elkaim, Lior M; Alrashidi, Qais; Georgiopoulos, Miltiadis; Lasry, Oliver J; Bednar, Drew A; Love, Alyson; Nedaie, Soroush; Gandhi, Pranjan; Amin, Prarthan C; Raj, Aditya; McIntosh, Greg; Neilsen, Christopher J; Swamy, Ganesh; Rampersaud, Raja; ,; Vandewint, Amanda; Rampersaud, Y Raja; Hebert, Jeffrey; Bigney, Erin; Manson, Neil; Attabib, Najmedden; Small, Chris; Richardson, Eden; Kearney, Jill; Abraham, Edward; Rampersaud, Raja; Raj, Aditya; Marathe, Nanadan; McIntosh, Greg; ,; Dhiman, Manmeet; Bader, Taylor J; Hart, David; Swamy, Ganesh; Duncan, Neil; Dhiman, Manmeet; Bader, Taylor J; Ponjevic, Dragana; Matyas, John R; Hart, David; Swamy, Ganesh; Duncan, Neil; O'Brien, Connor P; Hebert, Jeffrey; Bigney, Erin; Kearney, Jillian; Richardson, Eden; Abraham, Edward; Manson, Neil; Attabib, Najmedden; Small, Christopher; LaRochelle, Luke; Rivas, Gabriella; Lawrence, James; Ravinsky, Robert; Kim, Dorothy; Dermott, Jennifer; Mitani, Aya; Doria, Andrea; Howard, Andrew; Lebel, David; Dermott, Jennifer A; Switzer, Lily S; Kim, Dorothy J; Lebel, David E; Montpetit, Chanelle; Vaillancourt, Nicolas; Rosenstein, Brent; Fortin, Maryse; Nadler, Emma; Dermott, Jennifer; Kim, Dorothy; Lebel, David E; Wolfe, Daniel; Rosenstein, Brent; Fortin, Maryse; Wolfe, Daniel; Dover, Geoffrey; Boily, Mathieu; Fortin, Maryse; Shakil, Husain; Malhotra, Armaan K; Badhiwala, Jetan H; Karthikeyan, Vishu; He, Yingshi; Fehlings, Michael G; Sahgal, Arjun; Dea, Nicolas; Kiss, Alex; Witiw, Christopher D; Redelmeier, Donald R; Wilson, Jefferson R; Caceres, Marco Pérez; Freire, Véronique; Shen, Jesse; Al-Shakfa, Fidaa; Ahmed, Omer; Wang, Zhi; Kwan, William Chu; Zuckerman, Scott L; Fisher, Charles G; Laufer, Ilya; Chou, Dean; O'Toole, John E; Schultheiss, Markus; Weber, Michael H; Sciubba, Daniel M; Pahuta, Markian; Shin, John H; Fehlings, Michael G; Versteeg, Anne; Goodwin, Matthew L; Boriani, Stefano; Bettegowda, Chetan; Lazary, Aron; Gasbarrini, Alessandro; Reynolds, Jeremy J; Verlaan, Jorrit-Jan; Sahgal, Arjun; Gokaslan, Ziya L; Rhines, Laurence D; Dea, Nicolas; Truong, Van Tri; Dang, The Khanh; Osman, Galil; Al-Shakfa, Fidaa; Boule, Danielle; Shen, Jesse; Wang, Zhi; Rizkallah, Maroun; Boubez, Ghassan; Shen, Jesse; Phan, Philippe; Alshakfa, Fidaa; Boule, Danielle; Belguendouz, Celine; Kafi, Rayane; Yuh, Sung-Joo; Shedid, Daniel; Wang, Zhi; Wang, Zhi; Shen, Jesse; Boubez, Ghassan; Alshakfa, Fidaa; Boulé, Daniele; Belguendouz, Celine; Kafi, Rayane; Phan, Philippe; Shedid, Daniel; Yuh, Sung-Joo; Rizkallah, Maroun; Silva, Yan Gabriel Morais David; Weber, Luis; Leão, Felipe; Essa, Ahmad; Malhotra, Armaan K; Shakil, Husain; Byrne, James; Badhiwala, Jetan; Nathens, Avery B; Azad, Tej D; Yuan, Eva; He, Yingshi; Jack, Andrew S; Mathieu, Francois; Wilson, Jefferson R; Witiw, Christopher D; Craig, Michael; Guenther, Nick; Valosek, Jan; Bouthillier, Maxime; Enamundram, Naga Karthik; Rotem-Kohavi, Naama; Humphreys, Suzanne; Christie, Sean; Fehlings, Michael; Kwon, Brian; Mac-Thiong, Jean-Marc; Phan, Philippe; Paquet, Jerome; Guay-Paquet, Mathieu; Cohen-Adad, Julien; Cadotte, David; Dionne, Antoine; Mac-Thiong, Jean-Marc; Hong, Heather; Kurban, Dilnur; Xu, Jijie; Barthélémy, Dorothy; Christie, Sean; Fourney, Daryl; Linassi, Gary; Sanchez, Adalberto Loyola; Paquet, Jérôme; Sreenivasan, Vidya; Townson, Andrea; Tsai, Eve C; Richard-Denis, Andréane; Kwan, William Chu; Laghaei, Pedram; Kahlon, Harsh; Ailon, Tamir; Charest-Morin, Raphael; Dandurand, Charlotte; Paquette, Scott; Dea, Nicholas; Street, John; Fisher, Charles G; Dvorak, Marcel F; Kwon, Brian K; Thibault, Jérémie; Dionne, Antoine; Al-Sofyani, Mohamed; Pelletier-Roy, Rémi; Richard-Denis, Andréane; Bourassa-Moreau, Étienne; Mac-Thiong, Jean-Marc; Bouthillier, Maxime; ValoÅ¡ek, Jan; Enamundram, Naga Karthik; Guay-Paquet, Mathieu; Guenther, Nick; Rotem-Kohavi, Naama; Humphreys, Suzanne; Christie, Sean; Fehlings, Michael; Kwon, Brian K; Mac-Thiong, Jean Marc; Phan, Philippe; Cadotte, David; Cohen-Adad, Julien; Reda, Luke; Kennedy, Colton; Stefaniuk, Stephanie; Eftekhar, Parvin; Robinson, Larry; Craven, Cathy; Dengler, Jana; Kennedy, Colton; Reda, Luke; Stefaniuk, Stephanie; Eftekhar, Parvin; Robinson, Larry; Craven, Cathy; Dengler, Jana; Roukerd, Maryam Rezaeezadeh; Patel, Maitreya; Tsai, Eve; Galuta, Ahmad; Jagadeesan, Sasi; Sandarage, Ryan Vimukthie; Phan, Philippe; Michalowski, Wojtek; Van Woensel, William; Vig, Khushdeep; Kazley, Jillian; Arain, Abdul; Rivas, Gabriella; Ravinsky, Robert; Lawrence, James; Gupta, Shaurya; Patel, Jibrahn; Turkstra, Isaac; Pustovetov, Kirill; Yang, Victor; Jacobs, W Bradley; Mariscal, Gonzalo; Witiw, Christopher D; Harrop, James S; Essa, Ahmed; Witiw, Christopher D; Mariscal, Gonzalo; Jacobs, W Bradley; Harrop, James S; Essa, Ahmed; Du, Jin Tong; Cherry, Ahmed; Kumar, Rajesh; Jaber, Nadia; Fehlings, Michael; Yee, Albert; Dukkipati, Siril Teja; Driscoll, Mark; Byers, Elizabeth; Brown, Justin L; Gallagher, Michelle; Sugar, James; Rockall, Shannon; Hektner, James; Donia, Scott; Chernesky, John; Noonan, Vanessa K; Varga, Aaron A; Slomp, Flo; Thiessen, Emily; Lastivnyak, Nataliya; Maclean, Linda Slater; Ritchie, Vanessa; Hockley, Aaron; Weise, Lutz M; Potvin, Christine; Flynn, Peggy; Christie, Sean; Turkstra, Isaac; Oppermann, Bruno; Oppermann, Marcelo; Gupta, Shaurya; Patel, Jibrahn; Pustovetov, Kirill; Lee, Kenneth; Chen, ChaoLiang; Rastgarjazi, Mohammadmahdi; Yang, Victor; Hardy, Sarah; Strantzas, Samuel; Anthony, Alison; Dermott, Jennifer; Vandenberk, Mike; Hassan, Samer; Lebel, David; Silva, Yan Gabriel Morais David; LaRue, Bernard; Couture, Jerome; Pimenta, Newton; Blanchard, Jocelyn; Chenevert, Alexandre; Goulet, Julien; Greene, Ryan; Christie, Sean D; Hall, Amanda; Etchegary, Holly; Althagafi, Alwalaa; Han, Jae; Greene, Ryan; Christie, Sean; Pickett, Gwynedd; Witiw, Christopher; Harrop, James; Jacobs, W Bradley; Mariscal, Gonzalo; Essa, Ahmed; Jacobs, W Bradley; Mariscal, Gonzalo; Witiw, Christopher; Harrop, James S; Essa, Ahmed; Lasswell, Timothy; Rasoulinejad, Parham; Hu, Richard; Bailey, Chris; Siddiqi, Fawaz; Hamdoon, Abdulrahman; Soliman, Mohamed Amin; Maraj, Juhi; Jhawar, Deven; Jhawar, Balraj; Schuler, Kirsten A; Orosz, Lindsay D; Yamout, Tarek; Allen, Brandon J; Lerebo, Wondwossen T; Roy, Rita T; Schuler, Thomas C; Good, Christopher R; Haines, Colin M; Jazini, Ehsan; Ost, Kalum J; Al-Shawwa, Abdul; Anderson, David; Evaniew, Nathan; Jacobs, Bradley W; Lewkonia, Peter; Nicholls, Fred; Salo, Paul T; Thomas, Kenneth C; Yang, Michael; Cadotte, David; Sarraj, Mohamed; Rajapaksege, Nathasha; Dea, Nicolas; Evaniew, Nathan; McIntosh, Greg; Pahuta, Markian; ,; Alharbi, Hani Nouran; Skaik, Khaled; Wai, Eugene K; Kingwell, Stephen; Stratton, Alexandra; Tsai, Eve; Phan, Philippe Tran Nhut; Wang, Zhi; Investigators, Csorn; Zaldivar-Jolissaint, Julien Francisco; Gustafson, Sara; Polyzois, Ian; Gascoyne, Trevor; Goytan, Michael; Bednar, Drew Alexander; Sarra, Mohamed; Rocos, Brett; Sardi, Juan P; Charalampidis, Anastasios; Gum, Jeff; Lewis, Stephen J; Ghag, Ravi; Kirk, Samuel; Shirley, Otis; Bone, Jeffrey; Morrison, Andrew; Miyanji, Firoz; Parekh, Amit; Sanders, Ethan; Birk, Manjot; Nicholls, Fred; Smit, Kevin; Livock, Holly; Romeo, Jessica; Jarvis, James; Tice, Andrew; Frank, SofÃa; Labelle, Hubert; Parent, Stephan; Barchi, Soraya; Joncas, Julie; Mac-Thiong, Jean-Marc; Thibault, Jérémie; Joncas, Julie; Barchi, Soraya; Parent, Stefan; Beausejour, Marie; Mac-Thiong, Jean-Marc; Dionne, Antoine; Mac-Thiong, Jean-Marc; Parent, Stefan; Shen, Jesse; Joncas, Julie; Barchi, Soraya; Labelle, Hubert; Birk, Manjot S; Nicholls, Fred; Pelletier-Roy, Rémi; Sanders, Ethan; Lewis, Stephen; Aljamaan, Yousef; Lenke, Lawrence G; Smith, Justin; Sardar, Zeeshan; Mullaj, Elen; Lebel, David; Dermott, Jennifer; Bath, Natasha; Mathias, Karen; Kattail, Deepa; Zohar, Ariel; Loomans, Janneke; Pellise, Ferran; Smith, Justin S; Kato, So; Sardar, Zeeshan; Lenke, Lawrence; Lewis, Stephen J; Bader, Taylor J; Dhiman, Manmeet; Hart, David; Duncan, Neil; Salo, Paul; Swamy, Ganesh; Lewis, Stephen Joel; Lawrence, Peyton Lloyd; Smith, Justin; Pellise, Ferran; Sardar, Zeeshan; Lawrence, Peyton Lloyd; Lewis, Stephen Joel; Smith, Justin; Pellise, Ferran; Sardar, Zeeshan; Levett, Jordan J; Alnasser, Abdulrhman; Barak, Uri; Elkaim, Lior M; Hoang, Thien Sa; Alotaibi, Naif M; Guha, Daipayan; Moss, Isaac L; Weil, Alexander G; Weber, Michael H; de Muelenaere, Phillip; Parvez, Kashif; Sun, John; Iorio, Olivia C; Rosenstein, Brent; Naghdi, Neda; Fortin, Maryse; Manocchio, Felicia; Ankory, Ran; Stallwood, Lisa; Ahn, Henry; Mahdi, Hamza; Naeem, Abdul; Jhawar, Deven; Moradi, Milad; Jhawar, Balraj; Qiu, Steven; Surendran, Vithushan; Shi, Victoria; Cheung, Emily; Ngana, Sophie; Qureshi, Muhammad A; Sharma, Sunjay V; Pahuta, Markian; Guha, Daipayan
PMID: 39537311
ISSN: 1488-2310
CID: 5753262
Gender and Sex Differences in Health-related Quality of Life, Clinical Outcomes and Survival after Treatment of Metastatic Spine Disease
Goodwin, C Rory; Price, Meghan; Goodwin, Andrea N; Dalton, Tara; Versteeg, Anne L; Sahgal, Arjun; Rhines, Laurence D; Schuster, James M; Weber, Michael H; Lazary, Aron; Boriani, Stefano; Bettegowda, Chetan; Fehlings, Michael G; Arnold, Paul M; Dea, Nicolas; Charest-Morin, Raphaele; Shin, John; Laufer, Ilya; Chou, Dean; Gokaslan, Ziya L; Clarke, Michelle J; Fisher, Charles G; Sciubba, Daniel M; ,
STUDY DESIGN/METHODS:Retrospective review of prospective, multicenter and international cohort study. OBJECTIVE:To describe the effect of gender on HRQoL, clinical outcomes and survival for patients with spinal metastases treated with either surgery and/or radiation. SUMMARY OF BACKGROUND DATA/BACKGROUND:Gender differences in health-related outcomes are demonstrated in numerous studies, with women experiencing worse outcomes and receiving lower standards of care than men, however, the influence that gender has on low health-related quality of life (HRQoL) and clinical outcomes after spine surgery remains unclear. METHODS:Patient demographic data, overall survival, treatment details, perioperative complications, and HRQoL measures including EQ-5D, pain NRS, the short form 36 version 2 (SF-36v2) and the Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ2.0) were reviewed. Patients were stratified by sex, and a separate sensitivity analysis that excluded gender-specific cancers (i.e., breast, prostate, etc.) was performed. RESULTS:The study cohort included 207 female and 183 male patients, with age, smoking status, and site of primary cancer being significantly different between the two cohorts (P<0.001). Both males and females experienced significantly improved SOSGOQ2.0, EQ-5D, and pain NRS scores at all study time points from baseline (P<0.001). Upon sensitivity analysis, (gender-specific cancers removed from analysis), the significant improvement in SOSGOQ physical, mental, and social subdomains and on SF-36 domains disappeared for females. Males experienced higher rates of postoperative complications. Kaplan-Meier survival analysis of both the overall and sensitivity analysis cohorts showed females lived longer than males after treatment (P=0.001 and 0.043, respectively). CONCLUSION/CONCLUSIONS:Both males and females experienced significantly improved HRQoL scores after treatment, but females demonstrated longer survival and a lower complication rate. This study suggests that gender may be a prognostic factor in survival and clinical outcomes for patients undergoing treatment for spine metastases and should be taken into consideration when counseling patients accordingly.
PMID: 38149519
ISSN: 1528-1159
CID: 5623572
