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Vasoplegic Syndrome in Cardiac Surgery: A Narrative Review of Etiologic Mechanisms and Therapeutic Options

Polyak, Paul; Kwak, Jenny; Kertai, Miklos D; Anton, James M; Assaad, Sherif; Dacosta, Michelle E; Dimitrova, Galina; Gao, Wei Dong; Henderson, Reney A; Hollon, McKenzie M; Jones, Nathan; Kucharski, Donna; Low, Yinghui; Moriarty, Allison; Neuburger, Peter; Ngai, Jennie Y; Cole, Sheela Pai; Rhee, Amanda; Richter, Ellen; Shapeton, Alexander; Sutherland, Lauren; Turner, Katja; Wanat-Hawthorne, Alycia M; Wu, Isaac Y; Shore-Lesserson, Linda
Vasoplegic syndrome, a form of distributive shock that may manifest during or after cardiopulmonary bypass, is a serious complication that increases morbidity and mortality after cardiac surgery. No consensus definition exists, but vasoplegic syndrome is generally described as a state of pathologic vasodilation causing hypotension refractory to fluid resuscitation and vasopressor therapy, and resulting in organ malperfusion despite a normal or increased cardiac output. Diagnosis can be complex as there is a broad differential diagnosis for low systemic vascular resistance in the cardiac surgical patient. Interpretation of hemodynamic data can also be challenging in the setting of mixed shock states and mechanical support. This narrative review summarizes the pathophysiology of vasoplegic syndrome, the literature concerning its incidence and risk factors, the hemodynamic parameters important to the diagnosis of vasoplegic syndrome, a consensus definition of the syndrome, and a proposed goal-directed treatment framework.
PMID: 40157894
ISSN: 1532-8422
CID: 5818102

A Call for Diversity: Underrepresented Minorities and Cardiothoracic Anesthesiology Professional Development

Sumler, Michele L; Capdeville, Michelle; Ngai, Jennie; Biney, Barbara; Oakes, Daryl
The presence of underrepresented minorities (URMs) in cardiothoracic anesthesiology is underwhelming, and progress toward diversity has been slow at best. Despite decades of efforts, change seems hard to achieve. For example, it took more than 30 years for women to make up 50% of medical school matriculants. However, women continue to be underrepresented in our professional subspecialty and notably. This slow movement is not idiosyncratic to women but also applies to equity related to race and ethnicity. Given this current state, this article seeks to bring attention to the lack of diversity in cardiac anesthesiology and is a call to action to accelerate efforts and the pace of change toward greater equity both in our field and in medicine in general. This piece is the final part of a 4-part series exploring opportunities for improving diversity in cardiac anesthesiology. The authors focus specifically on the professional experience of URMs in medicine in our subspecialty and the opportunities for improving diversity. While many barriers for URM physicians reflect those of women, the experience of URM practicing physicians is unique and solutions need to incorporate.
PMID: 39721920
ISSN: 1532-8422
CID: 5767552

New postoperative atrial fibrillation after in OR extubation after cardiac surgery - A response to a letter to the editor [Letter]

Gupta, Ragini G; Ngai, Jennie Y
PMID: 39708561
ISSN: 1873-4529
CID: 5765072

In operating room extubation after cardiac surgery is associated with decreased incidence of in hospital new postoperative atrial fibrillation

Gupta, Ragini G; Patel, Shreya; Wang, Anke; Ngai, Jennie Y
OBJECTIVES/OBJECTIVE:This study aims to characterize the risks and benefits of in-OR extubation after cardiac surgery. DESIGN/METHODS:This is a retrospective chart review. SETTING/METHODS:Single tertiary care hospital. PARTICIPANTS/METHODS:Cardiac surgical patients >18 years. Exclusion criteria included patients extubated after 6 h in the ICU, those with a history of congenital heart disease (CHD), those intubated prior to arrival to the OR, procedures including circulatory arrest and/or selective cerebral perfusion, cardiothoracic transplantation, and intraoperative death. De-identified data was collected via the hospital's electronic medical record. INTERVENTIONS/METHODS:None. MEASUREMENTS AND MAIN RESULTS/RESULTS:Perioperative data was collected for 726 patients, of which 303 (42 %) were extubated in the OR. Multivariable regression models were derived with covariates based on expert clinical reasoning. When compared to fast track extubation, in-OR extubation was independently associated with decreased index hospitalization length of stay (-1.74, 95 % CI [-2.22, -1.08], p < 0.001) and decreased incidence of in-hospital new post-operative atrial fibrillation (OR 0.56 95 % CI [0.37, 0.86], p < 0.01). There were no differences in persistent vasoactive therapy requirement, postoperative mechanical circulatory support or extubation failure. CONCLUSIONS:In-OR extubation is associated with decreased index hospitalization length of stay and decreased new onset in-hospital atrial fibrillation.
PMID: 39393343
ISSN: 1873-4529
CID: 5706332

Development and Publication of Clinical Practice Parameters, Reviews, and Meta-analyses: A Report From the Society of Cardiovascular Anesthesiologists Presidential Task Force

Kertai, Miklos D; Makkad, Benu; Bollen, Bruce A; Grocott, Hilary P; Kachulis, Bessie; Boisen, Michael L; Raphael, Jacob; Perry, Tjorvi E; Liu, Hong; Grant, Michael C; Gutsche, Jacob; Popescu, Wanda M; Hensley, Nadia B; Mazzeffi, Michael A; Sniecinski, Roman M; Teeter, Emily; Pal, Nirvik; Ngai, Jennie Y; Mittnacht, Alexander; Augoustides, Yianni G T; Ibekwe, Stephanie O; Martin, Archer Kilbourne; Rhee, Amanda J; Walden, Rachel L; Glas, Kathryn; Shaw, Andrew D; Shore-Lesserson, Linda
The Society of Cardiovascular Anesthesiologists (SCA) is committed to improving the quality, safety, and value that cardiothoracic anesthesiologists bring to patient care. To fulfill this mission, the SCA supports the creation of peer-reviewed manuscripts that establish standards, produce guidelines, critically analyze the literature, interpret preexisting guidelines, and allow experts to engage in consensus opinion. The aim of this report, commissioned by the SCA President, is to summarize the distinctions among these publications and describe a novel SCA-supported framework that provides guidance to SCA members for the creation of these publications. The ultimate goal is that through a standardized and transparent process, the SCA will facilitate up-to-date education and implementation of best practices by cardiovascular and thoracic anesthesiologists to improve patient safety, quality of care, and outcomes.
PMID: 37788388
ISSN: 1526-7598
CID: 5639592

Cardiothoracic Anesthesiology Fellowship Programs Website Assessment and Recommendations for Fellowship Web-based Platforms [Editorial]

Zhitny, Vladislav Pavlovich; Lopez Mora, Edgar; Kawana, Eric; Vachirakorntong, Benjamin; Wajda, Michael C; Kim, Sunny; Foley, Adam; Nihalani, Aditya; Rehe, David; Pospishil, Liliya; Ngai, Jennie
PMCID:10954042
PMID: 38516147
ISSN: 2333-0406
CID: 5640802

Donation After Circulatory Death Heart Transplants: Doing More and Waiting Less [Editorial]

Ngai, Jennie; Jankowska, Anna
PMID: 37743133
ISSN: 1532-8422
CID: 5609522

I, Robot: Healthcare Decisions Made With Artificial Intelligence [Editorial]

Jankowska, Anna; Ngai, Jennie
PMID: 37500370
ISSN: 1532-8422
CID: 5593852

Intraoperative Considerations and Management of Simultaneous Heart Kidney Transplantation

Ngai, Jennie; Keny, Nikhil; James, Les; Katz, Simon; Moazami, Nader
PMID: 37210325
ISSN: 1532-8422
CID: 5508212

Are Ventricular Assist Devices Leading the Way in Patients With Advanced Heart Failure? [Editorial]

Desai, Krupa; Ngai, Jennie
PMID: 37120326
ISSN: 1532-8422
CID: 5465792