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Management and Outcomes of Pediatric Lymphatic Malformations: A Systematic Review From the APSA Outcomes and Evidence-Based Practice Committee

Huerta, Carlos Theodore; Beres, Alana L; Englum, Brian R; Gonzalez, Katherine; Levene, Tamar; Wakeman, Derek; Yousef, Yasmine; Gulack, Brian C; Chang, Henry L; Christison-Lagay, Emily R; Ham, Phillip Benson; Mansfield, Sara A; Kulaylat, Afif N; Lucas, Donald J; Rentea, Rebecca M; Pennell, Christopher P; Sulkowski, Jason P; Russell, Katie W; Ricca, Robert L; Kelley-Quon, Lorraine I; Tashiro, Jun; Rialon, Kristy L; ,
BACKGROUND:Significant variation in management strategies for lymphatic malformations (LMs) in children persists. The goal of this systematic review is to summarize outcomes for medical therapy, sclerotherapy, and surgery, and to provide evidence-based recommendations regarding the treatment. METHODS:Three questions regarding LM management were generated according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Publicly available databases were queried to identify articles published from January 1, 1990, to December 31, 2021. A consensus statement of recommendations was generated in response to each question. RESULTS:The initial search identified 9326 abstracts, each reviewed by two authors. A total of 600 abstracts met selection criteria for full manuscript review with 202 subsequently utilized for extraction of data. Medical therapy, such as sirolimus, can be used as an adjunct with percutaneous treatments or surgery, or for extensive LM. Sclerotherapy can achieve partial or complete response in over 90% of patients and is most effective for macrocystic lesions. Depending on the size, extent, and location of the malformation, surgery can be considered. CONCLUSION/CONCLUSIONS:Evidence supporting best practices for the safety and effectiveness of management for LMs is currently of moderate quality. Many patients benefit from multi-modal treatment determined by the extent and type of LM. A multidisciplinary approach is recommended to determine the optimal individualized treatment for each patient.
PMID: 38914511
ISSN: 1531-5037
CID: 5689642

Classification and Surgical Management of Anorectal Malformations: A Systematic Review and Evidence-based Guideline From the APSA Outcomes and Evidence-based Practice Committee

Smith, Caitlin A; Rialon, Kristy L; Kawaguchi, Akemi; Dellinger, Matthew B; Goldin, Adam B; Acker, Shannon; Kulaylat, Afif N; Chang, Henry; Russell, Katie; Wakeman, Derek; Derderian, S Christopher; Englum, Brian R; Polites, Stephanie F; Lucas, Donald J; Ricca, Robert; Levene, Tamar L; Sulkowski, Jason P; Kelley-Quon, Lorraine I; Tashiro, Jun; Christison-Lagay, Emily R; Mansfield, Sara A; Beres, Alana L; Huerta, Carlos T; Ben Ham, P; Yousef, Yasmine; Rentea, Rebecca M; ,
OBJECTIVE:Treatment of neonates with anorectal malformations (ARMs) can be challenging due to variability in anatomic definitions, multiple approaches to surgical management, and heterogeneity of reported outcomes. The purpose of this systematic review is to summarize existing evidence, identify treatment controversies, and provide guidelines for perioperative care. METHODS:The American Pediatric Surgical Association Outcomes and Evidence Based Practice Committee (OEBP) drafted five consensus-based questions regarding management of children with ARMs. These questions were related to categorization of ARMs and optimal methods and timing of surgical management. A comprehensive search strategy was performed, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to perform the systematic review to attempt to answer five questions related to surgical care of ARM. RESULTS:A total of 10,843 publications were reviewed, of which 90 were included in final recommendations, and some publications addressed more than one question (question: 1 n = 6, 2 n = 63, n = 15, 4 n = 44). Studies contained largely heterogenous groups of ARMs, making direct comparison for each subtype challenging and therefore, no specific recommendation for optimal surgical approach based on outcomes can be made. Both loop and divided colostomy may be acceptable methods of fecal diversion for patients with a diagnosis of anorectal malformation, however, loop colostomies have higher rates of prolapse in the literature reviewed. In terms of timing of repair, there did not appear to be significant differences in outcomes between early and late repair groups. Clear and uniform definitions are needed in order to ensure similar populations of patients are compared moving forward. Recommendations are provided based primarily on A-D levels of evidence. CONCLUSIONS:Evidence-based best practices for ARMs are lacking for many aspects of care. Multi-institutional registries have made progress to address some of these gaps. Further prospective and comparative studies are needed to improve care and provide consensus guidelines for this complex patient population.
PMID: 38997855
ISSN: 1531-5037
CID: 5689682

Evaluation and Management of Biliary Dyskinesia in Children and Adolescents: A Systematic Review From the APSA Outcomes and Evidence-Based Committee

Kulaylat, Afif N; Lucas, Donald J; Chang, Henry L; Derderian, S Christopher; Beres, Alana L; Ham, P Benson; Huerta, Carlos T; Sulkowski, Jason P; Wakeman, Derek; Englum, Brian R; Gulack, Brian C; Acker, Shannon N; Gonzalez, Katherine W; Levene, Tamar L; Christison-Lagay, Emily; Mansfield, Sara A; Yousef, Yasmine; Pennell, Christopher P; Russell, Katie W; Rentea, Rebecca M; Tashiro, Jun; Diesen, Diana L; Alemayehu, Hanna; Ricca, Robert; Kelley-Quon, Lorraine; Rialon, Kristy L
INTRODUCTION/BACKGROUND:The diagnosis and management of biliary dyskinesia in children and adolescents remains variable and controversial. The American Pediatric Surgical Association Outcomes and Evidence-Based Practice Committee (APSA OEBP) performed a systematic review of the literature to develop evidence-based recommendations. METHODS:Through an iterative process, the membership of the APSA OEBP developed five a priori questions focused on diagnostic criteria, indications for cholecystectomy, short and long-term outcomes, predictors of success/benefit, and outcomes of medical management. A systematic review was conducted, and articles were selected for review following Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) guidelines. Risk of bias was assessed using Methodologic Index for Non-Randomized Studies (MINORS) criteria. The Oxford Levels of Evidence and Grades of Recommendation were utilized. RESULTS:The diagnostic criteria for biliary dyskinesia in children and adolescents are not clearly defined. Cholecystectomy may provide long-term partial or complete relief in some patients; however, there are no reliable predictors of symptom relief. Some patients may experience resolution of symptoms with non-operative management. CONCLUSIONS:Pediatric biliary dyskinesia remains an ill-defined clinical entity. Pediatric-specific guidelines are necessary to better characterize the condition, guide work-up, and provide management recommendations. Prospective studies are necessary to more reliably identify patients who may benefit from cholecystectomy. LEVEL OF EVIDENCE/METHODS:Level 3-4. TYPE OF STUDY/METHODS:Systematic Review of Level 3-4 Studies.
PMID: 39227244
ISSN: 1531-5037
CID: 5687842

The impact of parental bariatric surgery and patient age on laparoscopic sleeve gastrectomy outcomes in adolescents

Tashiro, Jun; McKenna, Elise; Alberto, Emily C; Mackey, Eleanor R; Nadler, Evan P
BACKGROUND:Adolescent obesity is multifactorial, but parental history is the most significant risk factor. Laparoscopic sleeve gastrectomy (LSG) is part of the multidisciplinary approach to adolescent weight loss. OBJECTIVE:We aimed to evaluate the effects of parental history of bariatric surgery, as well as age at time of operation, on adolescents who underwent LSG at our institution. METHODS:We performed a retrospective review of patients, aged 10 to 19 years, who underwent LSG from January 2010 to December 2019. The adolescent bariatric surgical dataset maintained by our group was used to obtain patient demographics, weight, body mass index (BMI), and parental history of bariatric surgery. RESULTS:Among 328 patients, 76 (23.2%) had parents who had previously undergone bariatric surgery. These patients were significantly heavier by weight (p = 0.012) at the time of operation but had no difference in postoperative weight loss. When all patients were compared by age at operation (< 16 years, n = 102, ≥ 16 years, n = 226), there were few differences in outcomes. CONCLUSIONS:LSG is an effective approach to surgical weight loss in adolescents. Patient age should not be a barrier to weight loss surgery, especially among patients with a parental history of obesity. By intervening at a younger age, the metabolic sequelae of obesity may be reduced.
PMID: 35403902
ISSN: 1432-2218
CID: 5201792

It's time to deconstruct treatment-failure: A randomized controlled trial of nonoperative management of uncomplicated pediatric appendicitis with antibiotics alone [Meeting Abstract]

Otero, Sofia Perez; Metzger, Julia W.; Choi, Beatrix H.; Ramaraj, Akila; Tashiro, Jun; Kuenzler, Keith A.; Ginsburg, Howard B.; Tomita, Sandra S.; Fisher, Jason C.
ISI:000748293000011
ISSN: 0022-3468
CID: 5242732

Metrics of shock in pediatric trauma patients: A systematic search and review

Alberto, Emily C; McKenna, Elise; Amberson, Michael J; Tashiro, Jun; Donnelly, Katie; Thenappan, Arunachalam A; Tempel, Peyton E; Ranganna, Adesh S; Keller, Susan; Marsic, Ivan; Sarcevic, Aleksandra; O'Connell, Karen J; Burd, Randall S
INTRODUCTION/BACKGROUND:. Shock-index (SI) and systolic blood pressure (SBP) are metrics for identifying children and adults with hemodynamic instability following injury. The purpose of this systematic review was to assess the quality of these metrics as predictors of outcomes following pediatric injury. MATERIALS AND METHODS/METHODS:We conducted a literature search in Pubmed, SCOPUS, and CINAHL to identify studies describing the association between shock metrics on the morbidity and mortality of injured children and adolescents. We used the data presented in the studies to calculate the sensitivity and specificity for each metric. This study was registered with Prospero, protocol CRD42020162971. RESULTS:Fifteen articles met the inclusion criteria. seven studies evaluated SI or SIPA score, an age-corrected version of SI, as predictors of outcomes following pediatric trauma, with one study comparing SIPA score and SBP and one study comparing SI and SBP. The remaining eight studies evaluated SBP as the primary indicator of shock. The median sensitivity for predicting mortality and need for blood transfusion was highest for SI, followed by SIPA, and then SBP. The median specificity for predicting these outcomes was highest for SBP, followed by SIPA, and then SI. CONCLUSIONS:Common conclusions were that high SIPA scores were more specific than SI and more sensitive than SBP. SIPA score had better discrimination for severely injured children compared to SI and SBP. An elevated SIPA was associated with a greater need for blood transfusion and higher in-hospital mortality. SIPA is specific enough to exclude most patients who do not require a blood transfusion.
PMID: 34238538
ISSN: 1879-0267
CID: 4996482

Variations in the management of adolescent adnexal torsion at a single institution and the creation of a unified care pathway

Alberto, Emily C; Tashiro, Jun; Zheng, Yinan; Sandler, Anthony; Kane, Timothy; Gomez-Lobo, Veronica; Petrosyan, Mikael
PURPOSE/OBJECTIVE:Adnexal torsion is a gynecologic emergency, requiring intervention for tissue preservation. At our institution, torsion is managed by pediatric surgeons or gynecologists. We evaluated differences between specialties to streamline evaluation for children with gynecological emergencies, develop a clinical pathway, and prevent care delays. METHODS:A retrospective review of adolescents undergoing intervention for adnexal torsion from 2004-2018 was performed. Differences in time to intervention, operation duration, the procedure performed, and length of stay (LOS) between the specialties were analyzed. RESULTS:Eighty-six patients underwent 94 operations for presumed adnexal torsion with 87 positive cases. Pediatric surgeons performed 60 operations and 34 cases were performed by gynecologists. Preservation of fertility was the goal in both cohorts and the rate of oophoropexy, cystectomy, and oophorectomy were similar between the cohorts (p = 0.14, p = 1.0, p = 0.39, respectively). There was no difference in intra-operative time (p = 0.69). LOS was shorter in the gynecology cohort (median 1 day [1-2] vs. 2 days [2-3], p > 0.001). CONCLUSIONS:Adnexal torsion is a time-sensitive diagnosis requiring prompt intervention for ovarian or fallopian tube preservation. A multidisciplinary institutional care pathway should be developed and implemented.
PMID: 33242170
ISSN: 1437-9813
CID: 4996452

Current management of pediatric achalasia

Tashiro, Jun; Petrosyan, Mikael; Kane, Timothy D
Achalasia is a rare condition affecting esophageal motility in children. In a manner similar to the disease found in the adult population, children experience symptoms of dysphagia, regurgitation, and chest pain due to a failure of relaxation of the lower esophageal sphincter. Standard diagnostic approaches include upper endoscopy and esophageal manometry. New developments in diagnosis include high-resolution esophageal manometry and the endoscopic functional lumen imaging probe. Therapies available include endoscopic balloon dilations and botulinum toxin injections into the lower esophageal sphincter, as well as surgical interventions. The Heller myotomy was first described in 1913; since then, there have been many modifications to the procedure to improve outcomes and lower morbidity. Currently, the most commonly performed surgical procedure is the laparoscopic Heller myotomy, in which the sphincter muscle is divided using longitudinal incisions with or without a partial fundoplication procedure. In recent years, per oral endoscopic myotomy (POEM) is gaining support as a viable natural orifice therapy for achalasia. Complications of POEM occur at a relatively low rate, and outcomes following the procedure have been promising. The treatment of end-stage achalasia however, may include partial or total esophagectomy with reconstruction if possible. Future research is focused primarily on increasing the efficacy, and lowering complications, of existing therapeutic modalities.
PMCID:8343414
PMID: 34423154
ISSN: 2415-1289
CID: 4996492

Preclinical evaluation of ultrasound-augmented needle navigation for laparoscopic liver ablation

Liu, Xinyang; Plishker, William; Kane, Timothy D; Geller, David A; Lau, Lung W; Tashiro, Jun; Sharma, Karun; Shekhar, Raj
PURPOSE/OBJECTIVE:For laparoscopic ablation to be successful, accurate placement of the needle to the tumor is essential. Laparoscopic ultrasound is an essential tool to guide needle placement, but the ultrasound image is generally presented separately from the laparoscopic image. We aim to evaluate an augmented reality (AR) system which combines laparoscopic ultrasound image, laparoscope video, and the needle trajectory in a unified view. METHODS:We created a tissue phantom made of gelatin. Artificial tumors represented by plastic spheres were secured in the gelatin at various depths. The top point of the sphere surface was our target, and its 3D coordinates were known. The participants were invited to perform needle placement with and without AR guidance. Once the participant reported that the needle tip had reached the target, the needle tip location was recorded and compared to the ground truth location of the target, and the difference was the target localization error (TLE). The time of the needle placement was also recorded. We further tested the technical feasibility of the AR system in vivo on a 40-kg swine. RESULTS:The AR guidance system was evaluated by two experienced surgeons and two surgical fellows. The users performed needle placement on a total of 26 targets, 13 with AR and 13 without (i.e., the conventional approach). The average TLE for the conventional and the AR approaches was 14.9 mm and 11.1 mm, respectively. The average needle placement time needed for the conventional and AR approaches was 59.4 s and 22.9 s, respectively. For the animal study, ultrasound image and needle trajectory were successfully fused with the laparoscopic video in real time and presented on a single screen for the surgeons. CONCLUSION/CONCLUSIONS:By providing projected needle trajectory, we believe our AR system can assist the surgeon with more efficient and precise needle placement.
PMCID:7295074
PMID: 32323211
ISSN: 1861-6429
CID: 4603662

Laparoscopic Versus Open Cholecystectomy in Pediatric Patients: A Propensity Score-Matched Analysis

Babb, Jaqueline; Davis, James; Tashiro, Jun; Perez, Eduardo A; Sola, Juan E; Pandya, Samir
PMID: 32045322
ISSN: 1557-9034
CID: 4603652