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Comparison of pain, early functional recovery, and inpatient opioid consumption between direct anterior and posterior approach total hip arthroplasty

Antonioli, Sophia S; Prinos, Alana; Kennedy, Mitchell F; Habibi, Akram; Furgiuele, David; Rozell, Joshua C; Schwarzkopf, Ran
INTRODUCTION/BACKGROUND:Use of the direct anterior approach (DAA) in total hip arthroplasty (THA) has increased, with suggested benefits of faster recovery and less pain. However, consensus regarding the optimal approach is lacking. This study compared post-operative pain, functional recovery, and opioid use between DAA and posterior approach (PA) THA. METHODS:-tests. RESULTS: 0.001), but these small differences do not reflect clinical significance. MME comparison showed a trend towards decreased opioid consumption within the DAA cohort, but the clinical relevance of these differences is unknown. CONCLUSIONS:Pain, function, and opioid use were largely comparable between DAA and PA, with minor statistical differences unlikely to be clinically meaningful.
PMID: 42157562
ISSN: 1724-6067
CID: 6038142

Outcomes of conversion of hip resurfacing arthroplasty to total hip arthroplasty with acetabular component revision

Kennedy, Mitchell F; Bussey-Sutton, Cameron; Antonioli, Sophia S; Marwin, Scott; Schwarzkopf, Ran; Macaulay, William
BACKGROUND:Hip resurfacing arthroplasty (HRA) is a femoral bone-preserving alternative to total hip arthroplasty (THA) for younger, active patients. However, complications such as fractures, loosening, and metal wear can require conversion to THA. In some cases, revision of both the acetabular and femoral components is required. METHODS:We conducted a retrospective review of 15 patients who underwent conversion of HRA to THA at a single, academic tertiary care centre between January 2011 and April 2024. Demographic data, surgical details, implant characteristics, and indications for conversion were collected. Postoperative outcomes including complications, reoperations, and revisions were investigated. Revision-free survival was estimated using Kaplan-Meier analysis. RESULTS: = 3). Dual-mobility (DM) constructs were used in 11 cases (73.3%). There were no dislocations. There was 1 90-day readmission due to persistent wound drainage which underwent debridement, antibiotics, and implant retention (DAIR) 14 days post-conversion. The average follow-up duration after the conversion procedure was 6.1 years. Kaplan-Meier analysis demonstrated 93% revision-free survival at one-year, which remained stable through 13 years. CONCLUSIONS:In this study of 15 both-component HRA conversions, we observed 93% revision-free survivorship at mid-term follow-up. While the small cohort size limits definitive conclusions, our findings suggest that revision of the acetabulum during conversion, particularly with dual-mobility constructs, may be an effective strategy to mitigate instability and manage metal-on-metal failure in appropriate patients. Further research with larger cohorts is warranted to confirm our findings.
PMID: 42157566
ISSN: 1724-6067
CID: 6038152

Technology-Assisted Total Knee Arthroplasty Is Associated with Faster Initial Recovery, But Similar One-Year Outcomes: A Retrospective Cohort Study of Patient-Reported Outcomes in 2,002 Patients

Omran, Kareem; Wixted, Colleen; Waren, Daniel; Rozell, Joshua C; Schwarzkopf, Ran
BACKGROUND:Robotic and navigation-assisted total knee arthroplasty (TKA) systems aim to optimize surgical performance; however, their influence on the speed of functional recovery remains unclear. This study compared the time to achieve a minimal clinically important difference (MCID) among patients undergoing robotic-assisted (RA), navigation-assisted (NA), and conventional TKA using Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS-JR) questionnaires. METHODS:This retrospective cohort study included patients undergoing primary TKA for osteoarthritis at a tertiary academic center from July 2017 to July 2024. Inclusion required preoperative and postoperative KOOS-JR scores within 12 months of surgery. Exclusion criteria were non-osteoarthritis indications, bilateral procedures, or revision within one year. The MCID was defined using both anchor-based and distribution-based methods. The time to MCID was analyzed using multivariable interval-censored accelerated failure time models, accounting for clinical and demographic variables and the operating surgeon. A total of 2,002 patients met the inclusion criteria: 433 (21.6%) underwent RA-TKA, 713 (35.6%) NA-TKA, and 856 (42.8%) conventional TKA. RESULTS:Both technology-assisted approaches were associated with faster MCID achievement compared to conventional TKA. Using distribution-based thresholds, NA-TKA achieved MCID 29% faster (time ratio [TR] = 0.71, 95% confidence interval (CI): 0.58 to 0.88, P = 0.002) and RA-TKA 26% faster (TR = 0.74, 95% CI: 0.57 to 0.95, P = 0.018), with covariate-standardized estimated median times of 19.9, 20.7, and 28.0 days, respectively. Using anchor-based thresholds, NA-TKA achieved MCID 27% faster (TR = 0.73, 95% CI: 0.57 to 0.95, P = 0.017) and RA-TKA 26% faster (TR = 0.74, 95% CI: 0.55 to 1.00, P = 0.050), with corresponding median times of 52.8, 53.5, and 71.9 days. The one-year MCID attainment rates were similar across all techniques (P > 0.6 for both definitions). CONCLUSIONS:Both RA-TKA and NA-TKA were associated with 26 to 29% faster achievement of clinically meaningful improvement compared with conventional TKA, corresponding to approximately seven to 19 fewer days to reach MCID, despite similar one-year attainment rates. Prospective multicenter studies are needed to validate these results and determine whether accelerated recovery translates to advantages in quality of life, healthcare utilization, and patient satisfaction.
PMID: 42134641
ISSN: 1532-8406
CID: 6036992

Immediate Weight Bearing Is Safe Following Combined Extended Trochanteric Osteotomy and Revision Total Hip Arthroplasty

Abwini, Laith Z; Tang, Alex; Zeiman, Mallery; Andriani, Nicholas T; Gillinov, Lauren; Shichman, Ittai; Schwarzkopf, Ran; Liporace, Frank A; Yoon, Richard S
INTRODUCTION/BACKGROUND:An extended trochanteric osteotomy (ETO) is used in complex cases to enhance access to the femoral canal and aid implant and cement removal during revision total hip arthroplasty (RTHA). However, there is no consensus regarding postoperative rehabilitation protocols. The aim of this study was to assess the efficacy and safety of immediate weight-bearing (WB) protocols in patients undergoing ETO during RTHA. METHODS:A multicenter retrospective review was conducted at two academic medical centers between 2014 and 2021 to identify patients undergoing an ETO during RTHA with a minimum 1-year follow-up. Thirty-nine patients underwent an immediate WB protocol postoperatively. Union rates, ambulatory status, 90-day orthopaedic-related complications, revision surgeries, revisions, and Hip Disability and Osteoarthritis Outcome Score Joint Replacement (HOOS JR) scores were collected. RESULTS:Fifty-three patients were included in the final analysis. The average follow-up time was 15.8 ± 20.4 months, with a mean age of 63.7 ± 11.5 years. Bony union was achieved in 46 patients (86.8%). The mean earliest time to union was 4.2 ± 5.4 months. Average HOOS JR scores significantly improved from preoperative to 1-year follow-up (mean 16.4 ± 4.1 vs 3.5 ± 4.2), P ≤ 0.000001). At the final follow-up, ambulatory status improved, with fewer patients kept as non-weight bearing (11 (21.6%) versus 7 (15.2%)). Two complications (3.8%) due to deep infection, 5 revision surgeries (9.4%), and 6 revisions (11.0%) were observed within 90 days. CONCLUSION/CONCLUSIONS:Most patients who underwent ETO during RTHA and were placed on an immediate WB protocol achieved union at 4.2 months on average. HOOS JR scores improved as early as 2 weeks. More importantly, a greater proportion of patients experienced an improved ambulatory status at the final follow-up. These findings suggest that an immediate WB protocol-particularly WBAT-may be effective and safely implemented in patients undergoing an ETO during RTHA. LEVEL OF EVIDENCE/METHODS:Level III retrospective cohort comparison study.
PMID: 42114103
ISSN: 1940-5480
CID: 6036452

Outcomes of Conversion of Hip Resurfacing Arthroplasty to Total Hip Arthroplasty with Retention of the Acetabular Component

Antonioli, Sophia S; Kennedy, Mitchell F; Bussey-Sutton, Cameron; Marwin, Scott; Schwarzkopf, Ran; Macaulay, William
BACKGROUND:Complications of hip resurfacing arthroplasty (HRA) may require conversion to total hip arthroplasty (THA). While well-fixed acetabular components are often retained during conversion, data on implant survival and associated risks are limited. This study evaluated implant-related outcomes, survivorships, and complications in patients who undergo HRA to THA conversion with acetabular component retention. METHODS:A retrospective review of 40 patients having undergone conversion from HRA to THA was conducted. Patients were included if the original HRA acetabular component was retained, provided they had at least one year of clinical follow-up. Demographics, perioperative variables, implant characteristics, and clinical outcomes were collected via chart review. The mean time to conversion was 8.2 years (range, 0.1 to 14.2) with an average of 4.1-years of follow-up (range, 1.0 to 10.9). Common indications for conversion included metallosis (40.0%), mechanical loosening (32.5%), and periprosthetic fracture (22.5%). Most cases (97.5%) were converted to dual-mobility constructs. RESULTS:There were six patients (15.0%) who underwent subsequent reoperation following conversion, including three for infection, one for dislocation, and two for aseptic stem loosening. Kaplan-Meier analysis demonstrated an all-cause revision-free survivorship of 90.0% at one year and 81.2% at 10 years, with aseptic survivorship of 88.5% and acetabular component survivorship of 100% through final follow-up. CONCLUSION/CONCLUSIONS:Conversion of HRA to THA with retention of a well-fixed acetabular component and conversion to a dual-mobility construct provides durable survivorship up to 10 years (mean follow-up: 4.1 years). However, the rates of periprosthetic joint infection (PJI) and reoperation are more aligned with those seen in revision THA than primary THA, emphasizing the need for careful patient selection and transparent preoperative counseling. These findings highlight that while this approach can be an effective option for failed hip resurfacing, appropriate caution is warranted to mitigate the elevated risks of infection and reoperation in this cohort.
PMID: 42019778
ISSN: 1532-8406
CID: 6032832

Failure to Achieve an Early Distribution-Based Minimum Clinically Important Difference Almost Triples the Odds of Poor Patient-Reported Outcomes Within the First Year Following total Hip Arthroplasty: A Retrospective Cohort Study

Omran, Kareem; Wixted, Colleen; Waren, Daniel; Rozell, Joshua C; Schwarzkopf, Ran
BACKGROUND:Postoperative improvement in patient-reported outcomes is a key measure of total hip arthroplasty success. The Minimum Clinically Important Difference (MCID) represents the smallest improvement perceived as beneficial. Distribution-based MCIDs have been criticized for producing thresholds smaller than anchor-based values, questioning their clinical relevance. We hypothesized they may capture early biological recovery signals associated with subsequent patient-reported outcomes and aimed to determine whether failure to achieve an early distribution-based MCID (seven to 31 days) was associated with failure to achieve a late anchor-based MCID (90 to 365 days). METHODS:This retrospective cohort study included patients undergoing primary unilateral total hip arthroplasty for osteoarthritis from January 1, 2021, to January 1, 2025, comprising 844 patients. Patients were included if they completed 'Hip disability and Osteoarthritis Outcome Score, Joint Replacement' questionnaires preoperatively, at seven to 31 days, and at 90 to 365 days. Distribution-based MCID was defined as a ≥ 7.8-point improvement, and anchor-based MCID as ≥ 23 points. Multivariable regression assessed associations between early distribution-based and late anchor-based MCID failure, adjusting for demographics and clinical factors. RESULTS:In the early period (seven to 31 days), 565 patients (67.0%) achieved the distribution-based MCID, whereas 573 (67.9%) achieved the late anchor-based MCID (90 to 365 days). Among patients who failed to attain an early distribution-based MCID, 54.1% (151 of 279) also failed the late anchor-based MCID, compared with 21.2% (120 of 565) among early achievers (P < 0.001). Early distribution-based MCID failure was a strong independent predictor of late anchor-based MCID failure (odds ratio: 2.61; 95% confidence interval: 1.85 to 3.68; P < 0.001). Higher baseline Hip disability and Osteoarthritis Outcome Score, Joint Replacement scores and facility-based discharge were also independently associated with late failure (P < 0.05). CONCLUSIONS:Failure to achieve an early distribution-based MCID is strongly associated with poor patient-reported outcomes up to one year. Early distribution-based MCID attainment may represent an important prognostic marker, enabling timely clinical intervention.
PMID: 42001912
ISSN: 1532-8406
CID: 6032042

Outcomes of a Cementless Nonmodular Dual Mobility Acetabular Cup Inserted via Posterior Approach Without Technology: Mean Two-Year Follow-Up

Sundaram, Vishal; Saba, Braden V; White, Andrew J; Hepinstall, Matthew S; Schwarzkopf, Ran; Macaulay, William B
BACKGROUND:Nonmodular dual mobility (DM) articulations in total hip arthroplasty (THA) aim to reduce dislocations through a large outer bearing diameter while minimizing wear via a smaller inner bearing where most motion occurs. Although routine use remains uncommon in the United States, this construct may protect against dislocation. This study aimed to evaluate clinical outcomes of a cementless, nonmodular DM acetabular cup at a mean follow-up of two years. METHODS:We conducted a single-arm retrospective review of 604 primary, elective THAs using a cementless nonmodular DM acetabular cup between April 2017 and August 2024 at a single health system with at least 90 days of follow-up. All surgeries were performed by a single hip surgeon via posterior approach. Cases were planned using digital templating and performed with manual instruments without enabling technology. Clinical outcomes were collected, including 90-days readmission and revision rates, reasons for readmission and revision, and dislocation rates. RESULTS:At a mean follow-up of 2.0 years (range, 0.25 to 8.0), all-cause and aseptic acetabular cup implant survivorship was 99.8%. There were six revisions during the study period. There was one acetabular component (0.2%) that was revised due to cup dissociation from the pelvis. The remaining revisions included two for periprosthetic femoral fracture (0.3%), one for femoral loosening (0.2%), and two for acute periprosthetic joint infection (0.3%), none of which involved revision of the acetabular cup. There were no dislocations observed, and no patients required revision for instability. CONCLUSIONS:Cementless nonmodular DM acetabular cups offered excellent clinical outcomes in primary THA at a mean follow-up of 2.0 years, with no observed dislocations in 604 cases and high implant survivorship. These findings support the use of nonmodular DM implants as a viable option to achieve THA implant stability and durable fixation even when using a posterior approach without enabling technology.
PMID: 42001914
ISSN: 1532-8406
CID: 6032052

Timing and Trends of Periprosthetic Joint Infections Following Over 1,500,000 Primary and Revision Total Knee and Hip Arthroplasty Cases

Trudeau, Maxwell T; Wang, Eric; Schaffer, Olivia; Aggarwal, Vinay; Rozell, Joshua C; Schwarzkopf, Ran
BACKGROUND/UNASSIGNED:Periprosthetic joint infections (PJIs) following primary and revision total knee arthroplasty (rTKA) and revision total hip arthroplasty (rTHA) have been studied, but a contemporary large-scale analysis of incidence has not been performed. This study assessed PJI incidence and trends for TKA, THA, rTKA, and rTHA using a contemporary database. METHODS/UNASSIGNED:Epic Cosmos database was retrospectively queried (2015-2023). Current procedureal terminology codes identified patients: 27447 (TKA), 27130 (THA), 27486 (rTKA one component), 27487 (rTKA both components), 27134 (rTHA both components), 27137 (rTHA acetabular component), and 27138 (rTHA femoral component). PJI rates were identified using International Classification of Diseases 9/10 codes and analyzed using linear regression. RESULTS/UNASSIGNED:= .08). CONCLUSIONS/UNASSIGNED:Significant PJI reduction after primary TKA and THA was observed over the last decade, but infection rates remained stable in revision cohorts. Further investigations are required to assess underlying reasons for observed PJI rate reductions following primary arthroplasty.
PMCID:13137004
PMID: 42088069
ISSN: 2352-3441
CID: 6031182

How do new arthroplasty surgeons incorporate technology into their practice?

Bahlouli, Laith; Schaffer, Olivia; Bieganowski, Thomas; Sarfraz, Anzar; Khury, Farouk; Schwarzkopf, Ran; Aggarwal, Vinay K; Rozell, Joshua C
The use of technology in adult reconstruction (AR) reflects a balance of perceived utility, workflow considerations, and training exposure. This study evaluated whether exposure to technology during residency and fellowship training influences early-career AR surgeons’ utilization of and attitudes towards technology in total joint arthroplasty (TJA). An online survey was distributed to a nationwide cohort of 51 AR surgeons who completed fellowship between 2011 and 2022 at 13 U.S. programs. Survey items assessed exposure to technology during training, utilization, and perceived impact of technology on clinical practice. 36 surgeons (71%) reported using technology in fewer than half their training cases (< 50% group), while 15 (29%) reported use in the majority of cases (> 50% group). Most surgeons (88%) reported access to technology in their current practice, with no statistically significant difference between training exposure groups (p = 0.999). Similarly, among those with access, most surgeons (78%) reported using technology in their current practice, with no statistically significant difference between training groups (p = 0.238). However, surgeons with greater exposure rated the importance of technology in TJA and its impact on patient outcomes significantly higher (p = 0.003 for both). Greater exposure to technology during training was thus associated with higher perceived value, though no significant differences in access or utilization in early practice were observed.
PMCID:13136190
PMID: 42071070
ISSN: 1863-2491
CID: 6030702

Does weight gain from time of indication to date of surgery affect outcomes in total knee arthroplasty?

Sarfraz, Anzar; Di Pauli von Treuheim, Theodor; Ruff, Garrett; Saba, Braden V; Khury, Farouk; Schwarzkopf, Ran; Rozell, Joshua C; Aggarwal, Vinay K
BACKGROUND:The impact of body mass index (BMI) on outcomes after total knee arthroplasty (TKA) is a highly debated topic. Our study aims to investigate the implications of BMI changes from the day of surgical booking to the surgery date on perioperative and postoperative outcomes. METHODS:We retrospectively reviewed patients who underwent elective, primary, unilateral TKA at an urban academic institution from 2015-2024 with a minimum 90-day follow-up. The cohort was classified into three groups by percent BMI change from surgical booking date to TKA date: Group 1, decrease in BMI; Group 2, 0-5% increase in BMI; and Group 3, > 5% increase in BMI. Propensity-score matching (1:1:1) based on age, gender, BMI at surgical booking, and smoking status was performed; perioperative and postoperative outcomes were compared. Multivariate regression analysis evaluated risk factors for interval change in BMI. RESULTS:Before matching, 12,990 patients were included, with 39.6% in Group 1, 41.2% in Group 2, and the remaining 19.2% in Group 3. Notably, Group 3 had the longest length of stay (50.3 h vs. 48.6 [1] & 47.1 [2]; P = 0.002) and the lowest discharge-to-home rates (88.7% vs. 89.8% [1] & 91.7% [2]; P = 0.014). No significant difference was seen in 90-day ED visits, 90-day readmissions, or revision rates. Logistic regression of the pre-match cohort found that prolonged surgical booking delays were associated with decreased all-cause revisions (OR = 0.98; P = 0.038), while percent BMI change in this period did not impact revision incidence. Duration of surgical booking delay had no impact on BMI changes in obese patients. CONCLUSION/CONCLUSIONS:Our study evaluated preoperative BMI change between surgical booking and TKA, finding that most patients (60.4%) gain weight during this time. While patients with significant BMI increases (> 5%) had longer hospital stays and lower discharge-to-home rates, Percent BMI change during this period did not impact all-cause or septic revision incidence.
PMCID:13154894
PMID: 42104432
ISSN: 2524-7948
CID: 6031702