Try a new search

Format these results:

Searched for:

in-biosketch:true

person:tyriel01

Total Results:

15


Resection-plication-release for hypertrophic cardiomyopathy: clinical and echocardiographic follow-up

Balaram, Sandhya K; Tyrie, Leslie; Sherrid, Mark V; Afthinos, John; Hillel, Zak; Winson, Glenda; Swistel, Daniel G
BACKGROUND: Abnormal positioning and size of the mitral valve contribute to the systolic anterior motion and mitral-septal contact that are important components of obstructive hypertrophic cardiomyopathy (HCM). The RPR repair (resection of the septum, plication of the anterior leaflet, and release of papillary muscle attachments) addresses all aspects of this complex pathology. This study reports outcomes regarding effectiveness of the RPR repair. METHODS: Fifty consecutive unselected patients (average age, 55.8 years) undergoing RPR repair for obstructive HCM from 1997 to 2007 were studied. Each patient underwent preoperative and postoperative transthoracic echocardiograms to document gradient, ejection fraction, degree of mitral regurgitation, and systolic anterior motion. Intraoperative transesophageal echocardiogram was used to guide all surgical repairs. Clinical follow-up included patient interviews to determine New York Heart Association (NYHA) status. RESULTS: Concomitant operations were performed in 25 patients (50%). Postoperative mortality was 0%. Average mean left ventricular outflow tract gradients decreased from 134 +/- 40 to 2.8 +/- 8.0. Mitral regurgitation improved from a mean of 2.5 to 0.1 (p < 0.001). Average length of stay was 6.9 +/- 2.7 days. NYHA class improved from 3.0 +/- 0.6 to 1.2 +/- 0.5. Follow-up was 100%, with a mean of 2.5 +/- 1.8 years. Average mitral regurgitation at follow-up was 0.9, with no residual systolic anterior motion. CONCLUSIONS: The RPR repair is safe and effective for symptomatic obstructive HCM. Our data support repair of the mitral valve that results in good intermediate outcomes with respect to gradient, mitral regurgitation, and clinical status.
PMID: 19049745
ISSN: 1552-6259
CID: 1562832

AneuMastat reduces aneurysm incidence in the angiotensin II (AngII)-induced model of abdominal aortic aneurysm (AAA) in the wildtype C57BL6 mouse [Meeting Abstract]

Tyrie, Leslie S; Fujikura, Kana; Luo, Jianwen; Selegean, Sorin; Attiyeh, Marc; Collin, Peter; Konofagou, Elisa; Gaetz, Harold; Tilson, MD
ISI:000249397300243
ISSN: 1072-7515
CID: 1815872

Sudden death at the San Diego Zoo: aortic dissection/rupture in a 34 year old Western Lowland Gorilla [Meeting Abstract]

Tilson, Martin David; Hardy, Karen; Tyrie, Leslie
ISI:000247470400021
ISSN: 1358-863x
CID: 4765392

Non-invasive imaging of the aortic pulse-wave propagation for the detection of abdominal aortic aneurysms in vivo [Meeting Abstract]

Fujikura, Kana; Luo, Jianwen; Tyrie, Leslie; Tilson, M. D., III; Konofagou, Elisa E.
ISI:000250394302698
ISSN: 0009-7322
CID: 4765402

Pulse wave imaging of abdominal aortic aneurysms [Meeting Abstract]

Luo, Jianwen; Fujikura, Kana; Tyrie, Leslie S.; Tilson, M. David, III; Konofagoul, Elisa E.
ISI:000254281800236
ISSN: 1051-0117
CID: 4765412