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Platelet-Rich Plasma Outcomes Do Not Correlate with Patient Satisfaction or Perceived Cost-Effectiveness
Mojica, Edward Stephan; Lin, Charles; Kirschner, Noah; Ortega, Paola; Hurley, Eoghan T; Campbell, Kirk; Alaia, Michael; Jazrawi, Laith
BACKGROUND/UNASSIGNED:As platelet-rich plasma injection for knee osteoarthritis (OA) has increased in popularity, it has become more important to assess its effectiveness and satisfaction with its use in the context of its high cost. The purpose of this study was to determine satisfaction, commercial appeal, and effectiveness of platelet-rich plasma (PRP) for the treatment of knee OA. METHODS/UNASSIGNED:A retrospective review of patients who underwent PRP injection in the knee from 2016 to 2019 was performed. Satisfaction with the PRP injection (out of 100), whether the patient would want to undergo PRP injection again, whether they would recommend the injection and whether they felt that the injection was worth the cost was collected. VAS pain scores were collected and measured out of 100. RESULTS/UNASSIGNED:Overall, 114 patients were included. The mean pre-injection pain score was 70.4, and the mean pain level decreased after injection to 36.8. Patients rated their satisfaction on average at 49.2, 50.9% stated that they would get the PRP injection again, 60.5% would recommend to a friend, and 50.9% felt the injection was worth the cost. Younger age and improved post-injection pain correlated with increasing likelihood of desiring further PRP injection. CONCLUSIONS/UNASSIGNED:Patients on average rated satisfaction slightly below average, indicating net indifference skewing towards dissatisfaction with their injection, and only half indicated that it was worth the cost and that they would receive it again. Younger age and pain relief increased desire for further injection, but efficacy did not correlate with patients saying that the injection was worth the cost.
PMID: 34985383
ISSN: 2326-3660
CID: 5107132
High Tibial Osteotomies for the Treatment of Osteoarthritis of the Knee
Kanakamedala, Ajay C; Hurley, Eoghan T; Manjunath, Amit K; Jazrawi, Laith M; Alaia, Michael J; Strauss, Eric J
»:A high tibial osteotomy (HTO) is a joint-preserving procedure that can be used to treat symptomatic unicompartmental cartilage disorders in the presence of limb malalignment. »:Appropriate patient selection and careful preoperative planning are vital for optimizing outcomes. »:Based on past literature, correction of varus malalignment to 3° to 8° of valgus appears to lead to favorable results. Recently, there has been growing awareness that it is important to consider soft-tissue laxity during preoperative planning. »:Although there has been a recent trend toward performing opening-wedge rather than closing-wedge or dome HTOs for unicompartmental osteoarthritis, current data suggest that all 3 are acceptable techniques with varying complication profiles. »:Based on current evidence, an HTO provides pain relief, functional improvement, and a high rate of return to sport, with reported survivorship ranging from 74.7% to 97.6% and 66.0% to 90.4% at 10 and 15 years, respectively.
PMID: 35020711
ISSN: 2329-9185
CID: 5118822
Reducing Post-Operative Opioid Prescribing Following Posterior Lumbar Fusion Does Not Significantly Change Patient Satisfaction
Bloom, David A; Manjunath, Amit K; Dinizo, Michael; Fried, Jordan W; Jazrawi, Laith M; Protopsaltis, Themistocles S; Fischer, Charla R
STUDYDESIGN/UNASSIGNED:Retrospective-comparative; LOE-3. OBJECTIVE:The purpose of this study was to investigate what effect, if any, an institutional opioid reduction prescribing policy following 1-or-2-level lumbar fusion has on Hospital-Consumer-Assessment-of-Healthcare-Providers-and-Systems-(HCAHPS)-survey results. SUMMARY OF BACKGROUND DATA/BACKGROUND:Prior research has demonstrated that high levels of opioid-prescribing may be related, in part, to a desire to produce superior patient satisfaction. METHODS:A retrospective review of prospectively-collected data was conducted on patients who underwent 1-or-2-level lumbar fusions L3-S1 between October 2014-October 2019 at a single institution. Patients with complete survey information were included in the analysis. Patients with a history of trauma, fracture, spinal deformity, fusions > 2 levels, or prior lumbar fusion surgery L3-S1 were excluded. Cohorts were based on date of surgery relative to implementation of an institutional opioid reduction policy, which commenced in October 1, 2018. To better compare groups, opioid prescriptions were converted into milligram-morphine-equivalents (MME). RESULTS:330 patients met inclusion criteria, 259 pre-protocol, 71 post-protocol. There were 256 1-level fusions and 74 2-level fusions included. There were few statistically significant differences between groups with respect to patient demographics (p > 0.05) with the exception of number of patients who saw the pain management service, which increased from 36.7%(95) pre-protocol, to 59.2%(42) post-protocol; p < 0.001. Estimated blood loss (EBL) decreased from 533 ± 571 mL to 346 ± 328 mL; p = 0.003. Percentage of patients who underwent concomitant laminectomy decreased from 71.8% to 49.3%; p < 0.001. Average opioids prescribed on discharge in the pre-protocol period was was 534 ± 425 MME, compared to after initiation of the protocol it was 320 ± 174 MME; P < 0.001. There was no statistically significant difference with respect to satisfaction with pain control, 4.49 ± 0.85 pre-protocol vs 4.51 ± 0.82 post-protocol; p = 0.986. CONCLUSION/CONCLUSIONS:A reduction in opioids prescribed at discharge after 1-or-2-level lumbar fusion is not associated with any statistically significant change in patient satisfaction with pain management, as measured by the HCAHPS survey.Level of Evidence: 3.
PMID: 34091561
ISSN: 1528-1159
CID: 4899482
Distal posterolateral corner injury in the setting of multiligament knee injury increases risk of common peroneal palsy
Essilfie, Anthony A; Alaia, Erin F; Bloom, David A; Hurley, Eoghan T; Doran, Michael; Campbell, Kirk A; Jazrawi, Laith M; Alaia, Michael J
PURPOSE/OBJECTIVE:The purpose of this study was to identify if the location of posterolateral corner (PLC) injury was predictive of clinical common peroneal nerve (CPN) palsy. METHODS:A retrospective chart review was conducted of patients presenting to our institution with operative PLC injuries. Assessment of concomitant injuries and presence of neurologic injury was completed via chart review and magnetic resonance imaging (MRI) review. A fellowship-trained musculoskeletal radiologist reviewed the PLC injury and categorized it into distal, middle and proximal injuries with or without a biceps femoral avulsion. The CPN was evaluated for signs of displacement or neuritis. RESULTS:Forty-seven operatively managed patients between 2014 and 2019 (mean age-at-injury 29.5 ± 10.7 years) were included in this study. Eleven (23.4%) total patients presented with a clinical CPN palsy. Distal PLC injuries were significantly associated with CPN palsy [9 (81.8%) patients, (P = 0.041)]. Nine of 11 (81.8%) patients with CPN palsy had biceps femoral avulsion (P = 0.041). Of the patients presenting with CPN palsy, only four (36.4%) patients experienced complete neurologic recovery. Three of 7 patients (43%) with an intact CPN had full resolution of their clinically complete CPN palsy at the time of follow-up (482 ± 357 days). All patients presenting with a CPN palsy also had a complete anterior cruciate ligament (ACL) rupture in addition to a PLC injury (P = 0.009), with or without a posterior cruciate ligament (PCL) injury. No patient presenting with an isolated pattern of PCL-PLC injury (those without ACL tears) had a clinical CPN palsy. CONCLUSION/CONCLUSIONS:Distal PLC injuries have a strong association with clinical CPN palsy, with suboptimal resolution in the initial post-operative period. Specifically, the presence of a biceps femoris avulsion injury was highly associated with a clinical CPN palsy. Additionally, CPN palsy in the context of PLC injury has a strong association with concomitant ACL injury. Furthermore, the relative rates of involvement of the ACL vs. PCL suggest that specific injury mechanism may have an important role in CPN palsy. LEVEL OF EVIDENCE/METHODS:IV.
PMID: 33558949
ISSN: 1433-7347
CID: 4779512
Transosseous-Equivalent/Suture-Bridge Arthroscopic Rotator Cuff Repair in Combination with Late Post-Operative Mobilization Yield Optimal Outcomes and Retear Rate-A Network Meta-Analysis of Randomized Controlled Trials
Colasanti, Christopher A; Fried, Jordan W; Hurley, Eoghan T; Anil, Utkarsh; Matache, Bogdan A; Gonzalez-Lomas, Guillem; Strauss, Eric J; Jazrawi, Laith M
PURPOSE/OBJECTIVE:The purpose of this study was to perform a network meta-analysis of the randomized controlled trials (RCTs) in the literature in order to assess the evidence defining the optimal combination of surgical technique single row repair (SRR), double-row repair (DRR), or transosseous-equivalent/suture-bridge (TOE/SB) arthroscopic rotator cuff repair (ARCR) and postoperative rehabilitation (early or late) protocol for ARCR. METHODS:The literature search was performed based on the PRISMA guidelines. Randomized SSR-Early trials (RCT) comparing SRR vs DRR vs TOE/SB ARCR techniques were included, as well as early versus late postoperative ROM. Clinical outcomes were compared using a frequentist approach to network meta-analysis, with statistical analysis performed using R. The treatment options were ranked using the P-Score. RESULTS:28 studies comprising 2,181 total shoulders met the inclusion criteria. TOE/SB-late (OR 0.19 [0.08;0.46) and DRR-late (OR 0.25 [0.12;0.52) were found to significantly reduce the rate of re-tear, with TOE/SB-late resulting in the highest P-score for the American Shoulder & Elbow Surgeons (ASES) (P Score: 0.7911) score and re-tear rate (P Score: 0.8725). DRR-early did not result in any significant improvements over the SRR-early group, except in internal rotation. There was no significant difference in forward flexion between groups, with almost equivalent P-Scores. Furthermore, TOE/SB-early and TOE/SB-late trended toward worsening external rotation compared to the control. CONCLUSION/CONCLUSIONS:The current study suggests that rotator cuff repair using the transosseous-equivalent/suture-bridge technique and late postoperative mobilization yields the highest functional outcomes and lowest re-tear rate in the arthroscopic management of symptomatic rotator cuff tears.
PMID: 34082023
ISSN: 1526-3231
CID: 4891932
Clinical outcomes of revision arthroscopic Bankart repair for anterior shoulder instability: a systematic review of studies
Haskel, Jonathan D; Wang, Karina H; Hurley, Eoghan T; Markus, Danielle H; Campbell, Kirk A; Alaia, Michael J; Millett, Peter J; Jazrawi, Laith M
BACKGROUND:The purpose of this study was to review the literature to ascertain the functional outcomes, recurrence rates, and subsequent revision rates following revision arthroscopic Bankart repair. METHODS:Two independent reviewers performed a literature search based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines using the Embase, MEDLINE, and Cochrane Library databases. Studies in which arthroscopic Bankart repair was performed as a revision procedure were included. The clinical outcomes extracted and analyzed were functional outcomes, return to play, and recurrent instability. RESULTS:Fourteen studies with 433 patients met the inclusion criteria. The majority of patients were male patients (63.7%); the average age was 26.1 years (range, 14-58 years), and the mean follow-up period was 37.6 months (range, 10-144 months). The mean Rowe score was 84.2, and 79.7% of patients had good to excellent outcomes. The rate of return to play was 78.5%, with 47.5% of patients returning to their preinjury level of play across 10 studies. The rate of recurrent instability was reported in 12 studies, with 328 shoulders demonstrating 86 instability events (26.2%). The rate of recurrent instability due to dislocation was reported in 7 studies (n = 176), with 19 events (10.8%), whereas the rate of subluxation was reported in 4 studies (n = 76), with 6 events (7.9%). CONCLUSIONS:Revision arthroscopic Bankart repair for anterior shoulder instability was shown to result in a high rate of recurrent shoulder instability. There was a relatively poor rate of return to sport among athletes, and only about half of the patients were able to return at or above their preoperative level of ability.
PMID: 34358668
ISSN: 1532-6500
CID: 5060952
The Role of Anterolateral Procedures: Anterolateral Ligament Reconstruction
Chapter by: Kaplan, Daniel J; Mannino, Brian J; Gonzalez-Lomas, Guillem; Jazrawi, Laith M
in: Revision Anterior Cruciate Ligament Reconstruction : A Case-Based Approach by Alaia, Michael J; Jones, Kristofer J [Eds]
Cham : Springer International Publishing AG, 2022
pp. 235-257
ISBN: 9783030969967
CID: 5363772
Current Controversies and Decision-Making in the Management of Biceps Pathologies
Blaeser, Anna M; Markus, Danielle H; Hurley, Eoghan T; Gonzalez-Lomas, Guillem; Strauss, Eric J; Jazrawi, Laith M
»:Biceps tendon pathologies include a spectrum of injuries that range from mild tendinosis to complete tendon rupture. »:Tendinosis, the most common pathology, occurs more frequently with age and is likely related to chronic degeneration. On the other side of the spectrum of severity lies a rupture of the long head of the biceps tendon (LHBT), which may be accompanied by injury to the glenoid labrum. »:Superior labral anterior-posterior (SLAP) tears are frequently associated with biceps pathology. Surgical management for injuries of the bicipital-labral complex includes biceps tenodesis or tenotomy and SLAP repair. A consensus as to which of these procedures is the optimal choice has not been reached, and management may ultimately depend on patient-specific characteristics. »:Due to the relatively low incidence of distal biceps tendon rupture, agreement on the optimal management strategy has not been reached. Surgical repair, or reconstruction in the case of a chronic rupture, is often chosen. However, nonoperative management has also been utilized in older, less-active patients.
PMID: 34962898
ISSN: 2329-9185
CID: 5108132
The Minimal Clinically Important Difference: A Review of Clinical Significance
Bloom, David A; Kaplan, Daniel J; Mojica, Edward; Strauss, Eric J; Gonzalez-Lomas, Guillem; Campbell, Kirk A; Alaia, Michael J; Jazrawi, Laith M
BACKGROUND/UNASSIGNED:The minimal clinically important difference (MCID) is a term synonymous with orthopaedic clinical research over the past decade. The term represents the smallest change in a patient-reported outcome measure that is of genuine clinical value to patients. It has been derived in a myriad of ways in existing orthopaedic literature. PURPOSE/UNASSIGNED:To describe the various modalities for deriving the MCID. STUDY DESIGN/UNASSIGNED:Narrative review; Level of evidence, 4. METHODS/UNASSIGNED:The definitions of common MCID determinations were first identified. These were then evaluated by their clinical and statistical merits and limitations. RESULTS/UNASSIGNED:There are 3 primary ways for determining the MCID: anchor-based analysis, distribution-based analysis, and sensitivity- and specificity-based analysis. Each has unique strengths and weaknesses with respect to its ability to evaluate the patient's clinical status change from baseline to posttreatment. Anchor-based analyses are inherently tied to clinical status yet lack standardization. Distribution-based analyses are the opposite, with strong foundations in statistics, yet they fail to adequately address the clinical status change. Sensitivity and specificity analyses offer a compromise of the other methodologies but still rely on a somewhat arbitrarily defined global transition question. CONCLUSION/UNASSIGNED:This current concepts review demonstrates the need for (1) better standardization in the establishment of MCIDs for orthopaedic patient-reported outcome measures and (2) better study design-namely, until a universally accepted MCID derivation exists, studies attempting to derive the MCID should utilize the anchor-based within-cohort design based on Food and Drug Administration recommendations. Ideally, large studies reporting the MCID as an outcome will also derive the value for their populations. It is important to consider that there may be reasonable replacements for current derivations of the MCID. As such, future research should consider an alternative threshold score with a more universal method of derivation.
PMID: 34854345
ISSN: 1552-3365
CID: 5065762
Posterior Glenoid Bone-Block Transfer for Posterior Shoulder Instability - A Systematic Review
Mojica, Edward S; Schwartz, Luke B; Hurley, Eoghan T; Gonzalez-Lomas, Guillem; Campbell, Kirk A; Jazrawi, Laith M
PUPROSE/UNASSIGNED:The purpose of this study is to systematically review the literature and evaluate patient-reported outcomes and complication/revision rates of bone-block augmentation in the treatment of posterior shoulder instability (PSI). METHODS:PUBMED was searched according to PRIMSA guidelines to find clinical studies evaluating patient-report outcomes, revision and complication rates in posterior bone block for posterior shoulder instability. A literature search of MEDLINE, EMBASE and The Cochrane Library, was performed based on the PRISMA guidelines. Clinical studies reporting on the complications following posterior bone block were included. RESULTS:Overall, 11 (LOE III: 2, LOE IV: 9) studies met inclusion criteria, with 225 shoulders. Recurrent instability after the posterior bone block was found to be 9.8%. The overall complication rate was 13.8%, with 0.89% having graft complications, 11.1% having hardware complications, 0.4% having wound complications, 0.4% having nerve complications, and 0.89% having other complications. Residual pain was found in 11.6% of shoulders operated on. Patient-reported outcomes were evaluated most commonly by Rowe (81.4), Constant (84.6), and Walch - Duplay (81.6). CONCLUSION/CONCLUSIONS:There is a moderate rate of recurrence following posterior bone block for PSI. However, the patient-reported outcomes are high despite there being commonly reported persistent shoulder pain postoperatively. LEVEL OF EVIDENCE/METHODS:Level IV; Systematic Review.
PMID: 34298145
ISSN: 1532-6500
CID: 4948762