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The effect of sunscreen on melanoma risk
Mulliken, Jennifer S; Russak, Julie E; Rigel, Darrell S
Total cumulative sun exposure is associated with the development of squamous cell and basal cell cancers, whereas intense intermittent sun exposure is associated with the development of melanoma. Exposure to UV radiation is the only known modifiable cause of melanoma, but the role of sunscreen in melanoma prevention remains somewhat controversial. This article discusses how UV radiation contributes to the pathogenesis of melanoma, how sunscreen modulates the action of UV radiation on the skin, and the effect of sunscreen on the risk of developing melanoma. A review of available sunscreen agents and their sun-protective properties is also included.
PMID: 22800545
ISSN: 0733-8635
CID: 173032
Impact of guidance from a computer-aided multispectral digital skin lesion analysis device on decision to biopsy lesions clinically suggestive of melanoma
Rigel, Darrell S; Roy, Mrinalini; Yoo, Jane; Cockerell, Clay J; Robinson, June K; White, Richard
PMID: 22351788
ISSN: 0003-987x
CID: 166549
Adverse effects of ultraviolet radiation from the use of indoor tanning equipment: time to ban the tan
Lim, Henry W; James, William D; Rigel, Darrell S; Maloney, Mary E; Spencer, James M; Bhushan, Reva
The incidence of melanoma skin cancer is increasing rapidly, particularly among young women in the United States. Numerous studies have documented an association between the use of indoor tanning devices and an increased risk of skin cancer, especially in young women. Studies have shown that ultraviolet exposure, even in the absence of erythema or burn, results in DNA damage. Countries and regulatory bodies worldwide have recognized the health risks associated with indoor tanning. In the United States, 32 states have passed legislation to regulate the indoor tanning industry, but there is an urgent need to restrict the use of indoor tanning devices at the federal level. The Food and Drug Administration is currently reviewing the classification of these devices. For all of these reasons, the Food and Drug Administration should prohibit the use of tanning devices by minors and reclassify tanning devices to at least class II to protect the public from the preventable cancers and other adverse effects caused by ultraviolet radiation from indoor tanning.
PMID: 21496701
ISSN: 0190-9622
CID: 923212
Adverse effects of ultraviolet radiation from the use of indoor tanning equipment: time to ban the tan
Lim, Henry W; James, William D; Rigel, Darrell S; Maloney, Mary E; Spencer, James M; Bhushan, Reva
The incidence of melanoma skin cancer is increasing rapidly, particularly among young women in the United States. Numerous studies have documented an association between the use of indoor tanning devices and an increased risk of skin cancer, especially in young women. Studies have shown that ultraviolet exposure, even in the absence of erythema or burn, results in DNA damage. Countries and regulatory bodies worldwide have recognized the health risks associated with indoor tanning. In the United States, 32 states have passed legislation to regulate the indoor tanning industry, but there is an urgent need to restrict the use of indoor tanning devices at the federal level. The Food and Drug Administration is currently reviewing the classification of these devices. For all of these reasons, the Food and Drug Administration should prohibit the use of tanning devices by minors and reclassify tanning devices to at least class II to protect the public from the preventable cancers and other adverse effects caused by ultraviolet radiation from indoor tanning.
PMID: 21295374
ISSN: 0190-9622
CID: 923202
Comparing diagnostic sensitivity and specificity for pigmented lesions in clinical dermatologists versus a multispectral digital dermascopy system [Meeting Abstract]
Yoo, Jane; Rigel, Darrell
ISI:000286780500481
ISSN: 0190-9622
CID: 126449
The frequency of self-skin examination and full body skin examination in dermatologists
Saitta, Peter; Cohen, David E; Rigel, Darrell; Grekin, Steven K; Brancaccio, Ronald
Purpose: Mortalities due to skin cancer are escalating, but early detection via skin examinations can be beneficial. To date, dermatologists have not been isolated as a high-risk population for developing skin cancer, although some evidence suggests that they are a high-risk group. Therefore, the specific aims of this study were to measure the frequency at which dermatologists perform self-skin examination and receive full-body skin examination. Patients and methods: A sample of 476 respondents provided data for this cross-sectional, nine-item survey, which was e-mailed to all registered members in the American Society for Dermatologic Surgery. The initial invitation was sent in the summer of 2007, with reminders sent at four and eight weeks. E-mails contained a unique identifier, and each member could only respond once to the survey sent to that particular e-mail address. Results: 71.7 percent of the respondents reported that they routinely gave themselves a self-skin examination, 25.4 percent reported a monthly exam, 24.5 percent every six months, 17.2 percent once per year, and 4.6 percent every five years. Performing a self-skin examination was not related to age, gender, or history of skin malignancy. Seventy-six percent of all respondents never had a full-body skin examination conducted by another dermatologist, which persisted when analyzed by age (p = 0.0490) and gender (p = 0.0184). Conclusion: Dermatologists are more likely to perform self-skin examination rather than visit another dermatologist for a full-body skin examination
PMCID:3140903
PMID: 21779412
ISSN: 1941-2789
CID: 137963
Trends in dermatology: melanoma incidence
Rigel, Darrell S
PMID: 20231504
ISSN: 0003-987x
CID: 923182
Trends in dermatology: geographic density of US dermatologists
Yoo, Jane Y; Rigel, Darrell S
PMID: 20644040
ISSN: 0003-987x
CID: 923192
A comparison of sunburn protection of high-sun protection factor (SPF) sunscreens: SPF 85 sunscreen is significantly more protective than SPF 50 [Letter]
Russak, Julie E; Chen, Theresa; Appa, Yohini; Rigel, Darrell S
PMID: 20115958
ISSN: 0190-9622
CID: 107746
Tanning bed hygiene: microbes found on tanning beds present a potential health risk [Letter]
Russak, Julie E; Rigel, Darrell S
PMID: 20082899
ISSN: 0190-9622
CID: 107747