Faculty Bibliography
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122
Cranial computed tomography 1: technical aspects for clinicians
The importance of cranial computed tomography in the diagnosis and follow up of intracranial pathology cannot be underestimated. Clinicians at every level should have a basic understanding of this technique. This first of two articles looks at the technical strengths and weaknesses of cranial computed tomography, and cranial anatomy.
PMID: 20852488
ISSN: 1750-8460
CID: 1071882
Imaging of stroke and transient ischaemic attack
Non-fatal stroke has significant social and financial implications, and the use of appropriate imaging is essential for early diagnosis and treatment to prevent permanent disability. This article discusses the pivotal role radiological imaging plays in the management of stroke and transient ischaemic attack.
PMID: 20631654
ISSN: 1750-8460
CID: 1071902
Parotid incidentaloma detected during thoracic PET imaging: how should these lesions be managed? [Case Report]
Preoperative positron emission tomography (PET) scanning of three patients with lung cancer revealed increased unilateral focal activity in a parotid gland. Further investigation with ultrasound and core biopsy confirmed benign parotid neoplasm in all three cases. The phenomenon of imaging-related incidentaloma is increasingly recognized and further investigation of these lesions remains controversial. This article discusses PET incidentaloma in the parotid, why tracer uptake may occur and how these lesions may be managed with changes in patient management that ensue.
PMID: 20448501
ISSN: 1750-8460
CID: 1414642
Striatal BOLD Response Reflects the Impact of Herd Information on Financial Decisions
Like other species, humans are sensitive to the decisions and actions of conspecifics, which can lead to herd behavior and undesirable outcomes such as stock market bubbles and bank runs. However, how the brain processes this socially derived influence is only poorly understood. Using functional magnetic resonance imaging (fMRI), we scanned participants as they made decisions on whether to buy stocks after observing others' buying decisions. We demonstrate that activity in the ventral striatum, an area heavily implicated in reward processing, tracked the degree of influence on participants' decisions arising from the observation of other peoples' decisions. The signal did not track non-human, non-social control decisions. These findings lend weight to the notion that the ventral striatum is involved in the processing of complex social aspects of decision making and identify a possible neural basis for herd behavior.
PMCID:2892997
PMID: 20589242
ISSN: 1662-5161
CID: 4372282
A super-Earth transiting a nearby low-mass star
A decade ago, the detection of the first transiting extrasolar planet provided a direct constraint on its composition and opened the door to spectroscopic investigations of extrasolar planetary atmospheres. Because such characterization studies are feasible only for transiting systems that are both nearby and for which the planet-to-star radius ratio is relatively large, nearby small stars have been surveyed intensively. Doppler studies and microlensing have uncovered a population of planets with minimum masses of 1.9-10 times the Earth's mass (M[symbol:see text]), called super-Earths. The first constraint on the bulk composition of this novel class of planets was afforded by CoRoT-7b (refs 8, 9), but the distance and size of its star preclude atmospheric studies in the foreseeable future. Here we report observations of the transiting planet GJ 1214b, which has a mass of 6.55M[symbol:see text]), and a radius 2.68 times Earth's radius (R[symbol:see text]), indicating that it is intermediate in stature between Earth and the ice giants of the Solar System. We find that the planetary mass and radius are consistent with a composition of primarily water enshrouded by a hydrogen-helium envelope that is only 0.05% of the mass of the planet. The atmosphere is probably escaping hydrodynamically, indicating that it has undergone significant evolution during its history. The star is small and only 13 parsecs away, so the planetary atmosphere is amenable to study with current observatories.
PMID: 20016595
ISSN: 1476-4687
CID: 4372272
An occult breast mass
PMID: 19889732
ISSN: 0959-8146
CID: 1414652
Re: CT "invisible" lesion of the major salivary glands-a diagnostic pitfall of contrast-enhanced CT [Letter]
PMID: 19822250
ISSN: 0009-9260
CID: 1414662
A breathless woman with asthma [Case Report]
PMID: 19812143
ISSN: 0959-8146
CID: 1414672
Clinical and molecular phenotype of Aicardi-Goutieres syndrome
Aicardi-Goutieres syndrome (AGS) is a genetic encephalopathy whose clinical features mimic those of acquired in utero viral infection. AGS exhibits locus heterogeneity, with mutations identified in genes encoding the 3'-->5' exonuclease TREX1 and the three subunits of the RNASEH2 endonuclease complex. To define the molecular spectrum of AGS, we performed mutation screening in patients, from 127 pedigrees, with a clinical diagnosis of the disease. Biallelic mutations in TREX1, RNASEH2A, RNASEH2B, and RNASEH2C were observed in 31, 3, 47, and 18 families, respectively. In five families, we identified an RNASEH2A or RNASEH2B mutation on one allele only. In one child, the disease occurred because of a de novo heterozygous TREX1 mutation. In 22 families, no mutations were found. Null mutations were common in TREX1, although a specific missense mutation was observed frequently in patients from northern Europe. Almost all mutations in RNASEH2A, RNASEH2B, and RNASEH2C were missense. We identified an RNASEH2C founder mutation in 13 Pakistani families. We also collected clinical data from 123 mutation-positive patients. Two clinical presentations could be delineated: an early-onset neonatal form, highly reminiscent of congenital infection seen particularly with TREX1 mutations, and a later-onset presentation, sometimes occurring after several months of normal development and occasionally associated with remarkably preserved neurological function, most frequently due to RNASEH2B mutations. Mortality was correlated with genotype; 34.3% of patients with TREX1, RNASEH2A, and RNASEH2C mutations versus 8.0% RNASEH2B mutation-positive patients were known to have died (P=.001). Our analysis defines the phenotypic spectrum of AGS and suggests a coherent mutation-screening strategy in this heterogeneous disorder. Additionally, our data indicate that at least one further AGS-causing gene remains to be identified.
PMCID:2227922
PMID: 17846997
ISSN: 0002-9297
CID: 4372262
Intrapartum stillbirths in hospital unrelated to uteroplacental vascular insufficiency
The aim of this study was to investigate the causes of intrapartum asphyxia and its relationship to placental abnormalities. Twenty intrapartum fetal death autopsies carried out over a 10-year period in one hospital pathology department associated with a large obstetric unit were reviewed. All the intrapartum fetal deaths occurred in the hospital, while the mothers were being monitored during and after labor. On morphologic grounds, all the fetal deaths were thought to be caused by intrapartum asphyxia. Seven of the intrapartum fetal deaths were associated with intrauterine infection causing funisitis, and in 6 of these cases, chorioamnionitis was present as well. Two cases were caused by placental abruption, and 1 case was caused by cord compression. In 8 of the 10 remaining cases in which the placenta was examined, a minor placental abnormality was detected in only 1 case. Five of the 10 cases had a mild astrocytosis in the intracerebral periventricular white matter, suggestive of intrauterine ischemia at least 12 hours before death. Five of the 10 cases were thought by the delivering obstetrician to have umbilical cord abnormalities. The main conclusions from this study are that, except in cases of intrauterine infection, placental vascular abnormalities are unlikely to be associated with intrapartum asphyxia leading to fetal death during labor. The number of cases with umbilical cord abnormalities raises the possibility that cord accidents may be a significant cause of intrapartum stillbirth.
PMID: 17378621
ISSN: 1093-5266
CID: 4372252
