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Electrical impedance scanning as a new breast cancer risk stratification tool for young women

Stojadinovic, Alexander; Nissan, Aviram; Shriver, Craig D; Mittendorf, Elizabeth A; Akin, Mark D; Dickerson, Vivian; Lenington, Sarah; Platt, Lawrence D; Stavros, Thomas; Goldstein, Steven R; Moskovitz, Orah; Gallimidi, Zahava; Fields, Scott I; Yeshaya, Arieh; Allweis, Tanir M; Manassa, Raymond; Pappo, Itzhak; Ginor, Ron X; D'Agostino, Ralph B; Gur, David
BACKGROUND:Electrical impedance scanning (EIS) measures changes in breast tissue associated with breast cancer (Br-Ca) development. The T-Scan(tm2000 (ED is designed to use EIS to identify women ages 30-39 with elevated risk of breast cancer (i.e., T-Scan+ women). AIM/OBJECTIVE:To estimate the relative probability of breast cancer in a T-Scan+ woman compared to a randomly selected young woman. METHODS:A prospective, two-cohort trial was conducted in pre-menopausal women. The Specificity (S(p))-Cohort evaluated T-Scan specificity in 1,751 asymptomatic women ages 30-39. The Sensitivity)S(n))-Cohort evaluated T-Scan sensitivity in 390 women ages 45-30 scheduled for biopsy. Specificity, sensitivity, and conservative estimate of disease prevalence were used to calculate relative probability. RESULTS:In the S(p)-Cohort, 93 of 1,751 women were T-Scan+ (S(p) = 94.7%; 95% CI: 93.7-95.7%). In the S(n)-Cohort, 23 of 87 biopsy-proven cancers were T-Scan+ (S(n) = 26.4%; 95% CI: 17.4-35.4%). Given S(p) = 94.7%, S(n) = 26.4% and prevalence of 1.5 cancers/1,000 women (ages 30-39), the relative probability of a T-Scan+ woman having Br-Ca is 4.95: (95% CI: 3.16-7.14). CONCLUSION/CONCLUSIONS:EIS can identify a subset of young women with a relative probability of breast cancer almost five times greater than in the population of young women at-large. T-Scan+ women have a sufficiently high risk of Br-Ca to warrant further surveillance or imaging.
PMID: 18050282
ISSN: 0022-4790
CID: 3889752

Accreditation, certification: why all the confusion? [Editorial]

Goldstein, Steven R
Tremendous confusion exists concerning the issues of physician certification and practice accreditation in obstetric and gynecologic ultrasonography. Certification speaks to physician competence. All obstetrician-gynecologists who have finished residency training since 1982 are deemed 'competent' to perform obstetric and gynecologic ultrasonography by virtue of their training. Those trained before 1982 need to be able to describe their level of experience in performing obstetric and gynecologic ultrasonography. Accreditation deals with issues of patient safety and quality control, including equipment calibration, transducer cleaning and disinfection, universal precautions and Occupational Safety and Health Administration regulations, ultrasound examination protocols, and qualifications of nonphysician personnel performing ultrasound examinations. A new field of radiology benefit managers has arisen in response to attempts by health insurers to manage care, and reduce their costs and utilization. They have adopted ultrasound accreditation, originally intended to enhance patient safety, to help restrict utilization. Currently two organizations are recognized as accrediting bodies: The American Institute of Ultrasound in Medicine (AIUM), which recognizes obstetric and gynecologic residency training as evidence of competency, and The American College of Radiologists, which does not. Obstetrician-gynecologists should realize that AIUM's accreditation is their 'lifeboat' in this time of increasing interference by health care insurers into decision making in clinical practice
PMID: 18055738
ISSN: 0029-7844
CID: 75487

If it ain't broke, why are we fixing it?

Goldstein SR
CINAHL:2009694457
ISSN: 0090-3159
CID: 74918

Predicting uterine weight before hysterectomy: ultrasound measurements vs clinical assessment [Letter]

Goldstein, Steven R
PMID: 17346506
ISSN: 0002-9378
CID: 642022

Raloxifene vs tamoxifen [Letter]

Goldstein, Steven R
PMID: 17227974
ISSN: 1538-3598
CID: 73835

Ultrasound in gynecology

Timor-Tritsch, Ilan E; Goldstein, Steven R
Philadelphia : Elsevier Churchill Livingstone, 2007
Extent: xx, 329 p. ; 29 cm
ISBN: 0443066302
CID: 1387

An expert approach to common menopause-related problems

Goldstein, SR
SCOPUS:36749090699
ISSN: 0090-3159
CID: 643102

Abnormal uterine bleeding: the role of ultrasound

Goldstein, Steven R
Abnormal uterine bleeding is an important clinical concern and accounts for much medical intervention. This article presents an ultrasound-based approach to help exclude endometrial carcinoma and identify the source of bleeding for better clinical management. Saline infusion sonohysterography can help to triage patients to (1) no anatomic pathology, (2) globally thickened anatomic pathology that may be evaluated with blind endometrial sampling, or (3) focal abnormalities that must be evaluated under direct vision
PMID: 17147992
ISSN: 0033-8389
CID: 70316

Effects of raloxifene on the incidence of invasive breast cancer in postmenopausal women at low and high risk of breast cancer by the gail model [Meeting Abstract]

Goldstein, SR; Mershon, J; Wong, M; Natanegara, F; Mitchell, BD
ISI:000242255000095
ISSN: 1072-3714
CID: 70748

Pregnancies of unknown location: consensus statement [Editorial]

Condous, G; Timmerman, D; Goldstein, S; Valentin, L; Jurkovic, D; Bourne, T
ISI:000239807100001
ISSN: 0960-7692
CID: 67865