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Peptides. 2002:23(10):1803-8.DOI: 10.1016/s0196-9781(02)00137-7

Vasoactive intestinal peptide regulation of nerve growth factor in the embryonic mouse

Hill, Joanna M; Mehnert, Janice; McCune, Susan K; Brenneman, Douglas E
Vasoactive intestinal peptide (VIP), a regulator of embryonic growth, increased the concentration of nerve growth factor (NGF)-like immunoreactivity in the conditioned medium of cultured explanted embryonic day (E) 9.5 neural tube preparations compared to control preparations. VIP treatment also induced an increase of NGF-like immunoreactivity (NGF-IR) within the neural tube preparation tissue. A 60 kDa isoform was the primary form of NGF detected. VIP is shown to be a regulator of NGF in the E9.5 embryonic mouse and stimulates the release of a high molecular weight isoform of NGF.
PMID: 12383868
ISSN: 0196-9781
CID: 4448772