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In reply [Letter]
Blecker, Saul; Katz, Stuart D; Ladapo, Joseph A; Gavin, Nicholas P
PMID: 27217134
ISSN: 1097-6760
CID: 2114532
Association of HbA1c with hospitalization and mortality among patients with heart failure and diabetes
Blecker, Saul; Park, Hannah; Katz, Stuart D
BACKGROUND: Comorbid diabetes is common in heart failure and associated with increased hospitalization and mortality. Nonetheless, the association between glycemic control and outcomes among patients with heart failure and diabetes remains poorly characterized, particularly among low income and minority patients. METHODS: We performed a retrospective cohort study of outpatients with heart failure and diabetes in the New York City Health and Hospitals Corporation, the largest municipal health care system in the United States. Cox proportional hazard models were used to measure the association between HbA1c levels and outcomes of all-cause hospitalization, heart failure hospitalization, and mortality. RESULTS: Of 4723 patients with heart failure and diabetes, 42.6 % were black, 30.5 % were Hispanic/Latino, 31.4 % were Medicaid beneficiaries and 22.9 % were uninsured. As compared to patients with an HbA1c of 8.0-8.9 %, patients with an HbA1c of <6.5, 6.5-6.9, 7.0-7.9, and >/=9.0 % had an adjusted hazard ratio (aHR) (95 % CI) for all-cause hospitalization of 1.03 (0.90-1.17), 1.05 (0.91-1.22), 1.03 (0.90-1.17), and 1.13 (1.00-1.28), respectively. An HbA1c >/= 9.0 % was also associated with an increased risk of heart failure hospitalization (aHR 1.33; 95 % CI 1.11-1.59) and a non-significant increased risk in mortality (aHR 1.20; 95 % CI 0.99-1.45) when compared to HbA1c of 8.0-8.9 %. CONCLUSIONS: Among a cohort of primarily minority and low income patients with heart failure and diabetes, an increased risk of hospitalization was observed only for an HbA1c greater than 9 %.
PMCID:4875651
PMID: 27206478
ISSN: 1471-2261
CID: 2112492
Revascularization in Patients with Multivessel Coronary Artery Disease and Severe Left Ventricular Systolic Dysfunction: Everolimus Eluting Stents vs. Coronary Artery Bypass Graft Surgery
Bangalore, Sripal; Guo, Yu; Samadashvili, Zaza; Blecker, Saul; Hannan, Edward L
BACKGROUND: -Guidelines recommend coronary artery bypass graft surgery (CABG) over percutaneous coronary intervention (PCI) for multivessel disease and severe left ventricular (LV) systolic dysfunction. However, CABG has not been compared with PCI in such patients in randomized trials. METHODS AND RESULTS: -Patients with multivessel disease and severe LV systolic dysfunction (ejection fraction =35%) who underwent either PCI with everolimus-eluting stent (EES) or CABG were selected from the New York State registries. The primary outcome was long-term all-cause death. Secondary outcomes were individual outcomes of MI, stroke and repeat revascularization. Among the 4,616 patients who fulfilled our inclusion criteria (1,351 EES and 3,265 CABG), propensity score matching identified 2,126 patients with similar propensity scores. At short-term, PCI was associated with a lower risk of stroke [HR=0.05; 95% CI 0.01-0.39; P=0.004] when compared with CABG. At long-term follow-up (median-2.9 years), PCI was associated with a similar risk of death (HR=1.01; 95% CI 0.81-1.28; P=0.91), a higher risk of MI (HR=2.16; 95% CI 1.42-3.28; P=0.0003), a lower risk of stroke (HR=0.57; 95% CI 0.33-0.97; P=0.04) and a higher risk of repeat revascularization (HR=2.54; 95% CI 1.88-3.44; P<0.0001). The test for interaction was significant (P=0.002) for completeness of revascularization, such that in patients where complete revascularization was achieved with PCI, there was no difference in MI between PCI and CABG. CONCLUSIONS: -Among patients with multivessel disease and severe LV systolic dysfunction, PCI with EES had comparable long-term survival when compared with CABG. PCI was associated with higher risk of MI (in those with incomplete revascularization) and repeat revascularization, and CABG was associated with higher risk of stroke.
PMID: 27151532
ISSN: 1524-4539
CID: 2101292
Association of Occupation as a Physician With Likelihood of Dying in a Hospital
Blecker, Saul; Johnson, Norman J; Altekruse, Sean; Horwitz, Leora I
PMCID:5235900
PMID: 26784781
ISSN: 1538-3598
CID: 1921432
Observation Units as Substitutes for Hospitalization or Home Discharge
Blecker, Saul; Gavin, Nicholas P; Park, Hannah; Ladapo, Joseph A; Katz, Stuart D
STUDY OBJECTIVE: Observation unit admissions have been increasing, a trend that will likely continue because of recent changes in reimbursement policies. The purpose of this study is to determine the effect of the availability of observation units on hospitalizations and discharges to home for emergency department (ED) patients. METHODS: We studied ED visits with a final diagnosis of chest pain in the National Hospital Ambulatory Medical Care Survey from 2007 to 2010. ED visits that resulted in an observation unit admission were propensity-score matched to visits at hospitals without an observation unit. We used logistic regression to develop a prediction model for hospitalization versus discharge home for matched patients treated at nonobservation hospitals. The model was applied to matched observation unit patients to determine the likely alternative disposition had the observation unit not been available. RESULTS: There were 1,325 eligible visits that represented 5,079,154 visits in the United States. Two hundred twenty-seven visits resulted in an observation unit admission. The predictive model for hospitalization had a c statistic of 0.91; variables significantly associated with subsequent hospitalization included age, history of coronary atherosclerosis, systolic blood pressure less than 115 beats/min, and administration of antianginal medications. When the model was applied to matched observation unit patients, 49.9% of them were categorized as discharge home likely. CONCLUSION: In this study, we estimated that half of ED visits for chest pain that resulted in an observation unit admission were made by patients who may have been discharged home had the observation unit not been available. Increased availability of observation units may result in both decreased hospitalizations and decreased discharges to home.
PMCID:4976781
PMID: 26619756
ISSN: 1097-6760
CID: 1863232
Changes in Discharge Location and Readmission Rates Under Medicare Bundled Payment
Jubelt, Lindsay E; Goldfeld, Keith S; Chung, Wei-Yi; Blecker, Saul B; Horwitz, Leora I
PMCID:5289893
PMID: 26595453
ISSN: 2168-6114
CID: 1856802
Appropriateness of cardiac stress test use among primary care physicians and cardiologists in the United States
Ladapo, Joseph A; Blecker, Saul; Douglas, Pamela S
PMCID:4688169
PMID: 26569369
ISSN: 1874-1754
CID: 1848382
PREDICTING CHRONIC COMORBID CONDITIONS OF TYPE 2 DIABETES IN NEWLY-DIAGNOSED DIABETIC PATIENTS [Meeting Abstract]
Razavian, N; Smith-McLallen, A; Nigam, S; Blecker, S; Schmidt, AM; Sontag, D
ISI:000354498500282
ISSN: 1524-4733
CID: 2333322
PREVALENCE AND TIMING OF COMORBID COMPLICATIONS OF TYPE 2 DIABETES IN LARGE COHORT OF INSURANCE SUBSCRIBERS [Meeting Abstract]
Razavian, N; Smith-McLallen, A; Nigam, S; Blecker, S; Schmidt, AM; Sontag, D
ISI:000354498500284
ISSN: 1524-4733
CID: 2333332
Population-level Prediction of Type 2 Diabetes from Insurance Claims and Analysis of Risk Factors [Meeting Abstract]
Razavian, Narges; Smith-Mclallen, Aaron; Nigam, Somesh; Blecker, Saul; Schmidt, Ann Marie; Sontag, David
ISI:000359482700153
ISSN: 1939-327x
CID: 2333342