Faculty Bibliography

OBJECTIVE:To compare the utility of generic health quality of life (QOL) and condition specific indicators as patient reported outcomes measures for urethral stricture surgery. MATERIALS AND METHODS/METHODS:Patient data were obtained from the Trauma and Urologic Reconstructive Network of Surgeons collaborative database. Patients who underwent any successful urethroplasty and completed both pre- and postoperative generic and condition-specific questionnaires were included. RESULTS:A total of 201 patients met inclusion criteria. Urethral-stricture specific measures improved after surgery: mean LUTS score (13.1-4.0, p<0.05), Peeling curve (3.1-1.7, p < 0.05), and overall interference of urinary symptoms on life (3.0-1.6, p < 0.05). Mean overall health status visual analog scale (74.2-80.0, p < 0.05) and generic health QOL EQ-5D index scores (0.90-0.95, p < 0.05) also improved; however, individual EQ-5D measures assessing mobility, self-care, and activity level did not change. EQ-5D measures for pain/discomfort (1.48-1.23, p < 0.05) and anxiety/depression (1.33-1.21, p < 0.05) improved, but not to the same extent as stricture-specific measures. More patients reported improvement in condition-specific urethra/penis pain and bladder pain compared to improvement in generic EQ-5D pain/discomfort (p < 0.001). CONCLUSION/CONCLUSIONS:Generic health QOL indicators are less meaningful in the assessment of urethral stricture surgery and should be replaced with condition-specific outcomes measures. It is important to ensure that appropriate condition-specific outcomes measures are utilized as patient reported outcomes measures become more prevalent in medicine and potentially become utilized to evaluate surgeon outcomes and determine surgeon reimbursement.

INTRODUCTION AND OBJECTIVE/OBJECTIVE:To identify predictors of thirty-day perioperative complications after urethroplasty and create a model to predict patients at increased risk. METHODS:We selected all patients recorded in the National Surgery Quality Improvement Program (NSQIP) from 2005 to 2015 who underwent urethroplasty, determined by Current Procedural Terminology (CPT) codes. The primary outcome of interest was a composite 30-day complication rate. To develop predictive models of urethroplasty complications we used random forest and logistic regression with tenfold cross-validation employing demographic, comorbidity, laboratory, and wound characteristics as candidate predictors. Models were selected based on the receiver operating characteristic (ROC) curve, with the primary measure of performance being the area under curve (AUC). RESULTS:We identified 1135 patients who underwent urethroplasty and met inclusion criteria. The mean age was 53 years with 84% being male. The overall incidence of complications was 8.6% (n = 98). Patients who experienced a complication more commonly had diabetes, a preoperative blood transfusion, preoperative sepsis, lower hematocrit and albumin, as well as a longer operative time (p < 0.05). LASSO logistic and random forest logistic models for predicting urethroplasty complications had an AUC (95% CI) 0.73 (0.58-0.87), and 0.48 (0.33-0.68), respectively. The variables that were determined to be most important and included in the predictive models were operative time, age, American Society of Anesthesiologists (ASA) classification and preoperative laboratory values (white blood cell count, hematocrit, creatinine, platelets). CONCLUSION/CONCLUSIONS:Our predictive models of complications perform well and may allow for improved preoperative counseling and risk stratification in the surgical management of urethral stricture.

PURPOSE/OBJECTIVE:We report multi-institutional outcomes in patients who underwent urethroplasty with a rectal mucosa graft. MATERIALS AND METHODS/METHODS:We used the TURNS (Trauma and Urologic Reconstructive Network of Surgeons) database to identify patients who underwent urethral reconstruction with transanal harvest of a rectal mucosa graft. We reviewed preoperative demographics, stricture etiology, previous management and patient outcomes. RESULTS:We identified 13 patients from April 2013 to June 2017. Median age at surgery was 54 years. The stricture etiology was lichen sclerosus in 6 of 13 patients (46%), idiopathic in 2 (15%), hypospadias in 1 (7%), prior gender confirming surgery in 3 (23%) and rectourethral fistula after radiation for prostate cancer in 1 (7%). Prior procedures included failed urethroplasty with a buccal mucosa graft in 9 of 13 patients (69%), direct vision internal urethrotomy in 2 (15 %) and none in 2 (15%). Median stricture length was 13 cm. Stricture location in the 9 cisgender patients was panurethral in 5 (56%), bulbopendulous in 2 (22%) and bulbar in 2 (22%). It was located at the junction of the fixed urethra extending into the neophallus in all 3 patients (100%) who underwent prior gender confirming surgery. Mean rectal mucosa graft length for urethroplasty was 10.6 cm (range 3 to 16). Repair types included dorsal or ventral onlay, or 2-stage repair. Stricture recurred at a median followup of 13.5 months in 2 of 13 patients ( 15%). Postoperative complications included glans dehiscence, urethrocutaneous fistula and compartment syndrome in 1 patient each (7%). No rectal or bowel related complications were reported. CONCLUSIONS:Urethral reconstruction with a transanal harvested rectal mucosa graft is a safe technique when a buccal mucosa graft is unavailable or not indicated.

Introduction& Objective: Penile inversion vaginoplasty (PIV) is the standard operation for genital reconstruction in transwomen. Despite usually providing an excellent aesthetic result, the technique can be complicated by vaginal stenosis and inadequate depth, particularly in transwomen with limited penile and scrotal tissue. Vascularized peritoneal flaps have been used to augment vaginal depth in neovaginal creation in patients with congenital vaginal agenesis.Here, we review our experience with the novel application of peritoneal flaps in penile inversion vaginoplasty in transwomen, to augment the neovaginal apex with well-vascularized tissue.
Method(s): Between 2017 and 2018, 20 female-to-male patients were identified who underwent a robotically assisted PIV using peritoneal flaps. In brief, approximately 5cm by 5cm peritoneal flaps are raised from the anterior rectum and posterior bladder to create the apex of the neovagina and serve as an attachment for inverted penile skin and scrotal skin graft. Patient demographics, medical comorbidities, intra-operative details, peri-operative complications, and neovagina measurements served as primary outcome measures.
Result(s): In our cohort of 20 patients, average age at time of surgery was 33.5+/-11.2 years. Average length of procedure was 319.3+/-41.6 minutes and the average inpatient stay was 5 days. Average length of follow up was 54.6+/-42.1 days and at most recent follow up, vaginal depth and width were measured to be 12.83+/-1.1 cm and 2.85+/-.3 cm respectively. The peritoneal flap added an additional 5 cm of depth. There were no complications related to peritoneal flap harvest.
Conclusion(s): Penile inversion vaginoplasty remains the gold standard for primary genital reconstruction in transwomen. Neovaginal depth can be limited by available donor tissue. With increased use of puberty blockade, we believe that there will be an increase in women presenting with limited natal tissue. While intestinal flaps or extragenital skin grafts have been used when there is inadequate penile and scrotal skin, there can be considerable donor site morbidity. Peritoneal flaps provide an alternative technique for increased neovaginal depth, creating a wellvascularized apex without additional donor morbidity

Introduction & Objective: To present our technique of robotic reconstruction of bilateral long segment proximal ureteral obstruction with appendix onlay and buccal mucosa.
Method(s): We report a case of a 32 year-old female with idiopathic bilateral ureteral obstruction of the proximal ureters (Figure). She was previously managed with intermittent stent placement and ureteroscopic treatment at an outside institution. The patient was placed in supine position with trendelenberg, ports were placed horizontally below the umbilicus, and the DaVinci XI robot was docked to allow access to both ureters. Simultaneously, bilateral ureteroscopy was performed to identify the location of the obstruction. The right ureter was opened anteriorly at the level of the obstruction. After excision of the obstructing tissue, an 8cm segment of right ureter required reconstruction. Frozen section analysis of the obstructing tissue confirming no malignancy. An appendix flap onlay was performed by opening the appendix on its anti-mesenteric border. Intravenous Indocyanine Green (ICG) confirmed good perfusion to the appendix. The appendix was then sutured onto the ureteral defect with running 5-0 PDS. Next, a 5 cm area of left ureteral obstruction was identified and the anterior surface of the ureter was opened sharply. After excision of the obstructing tissue, a 5 x 1cm segment of buccal mucosa was harvested. Buccal mucosa graft ureteroplasty was performed with a running anastomosis with 5-0 PDS after ureteral stent placement. An omental flap was used to provide perfusion to the grafted segment. Intravenous ICG confirmed good perfusion to the ureter and the omentum.
Result(s): The patient had a prolonged hospital course due to infection but otherwise uneventful. The patient developed pyelonephritis which delayed discharge on day 9. On post-operative day 3, the Foley catheter was removed and she had return of bowel function. Final ureteral pathology demonstrated nephrogenic adenoma. Ureteral stents were removed after 1 month followed by nephrostomy removal at 2months. Antegrade nephrostograms and diuretic renal scan demonstrate no obstruction.
Conclusion(s): Long segment bilateral ureteral strictures can be managed in a single setting with robotic ureteral reconstruction. Appendix onlay and buccal mucosa graft ureteroplasty are safe and technically feasible options for a complex ureteral reconstruction

Introduction & Objective: Buccal mucosal grafts (BMG) are traditionally used in urethral reconstruction; however, rectal mucosa is an alternative with less post-operative pain, no impairment in eating and speaking, and larger attainable graft dimension. Laparoscopic transanal minimally invasive surgery (TAMIS) has been described by our group. Due to the technical challenges of harvesting a sizable graft within a confined space, we adopted a new approach using the Intuitive da Vinci Xi system. We present a video which fully demonstrates our technique in the novel procedure of Robotic TAMIS (R-TAMIS) rectal mucosal harvest, for the purpose of onlay graft urethroplasty.
Method(s): A 53-year-old transgender male presented with postphalloplasty urethral stricture and underwent robotic rectal mucosal harvest. His past surgical history included vaginectomy and metoidioplasty usingBMGin 2008, followed by right forearmfree flap phalloplasty five months prior to presentation. The procedure was first demonstrated in an animal model using bovine colon. IRB approval was obtained. The surgery was performed under general anesthesia with the patient in lithotomy position. The GelPOINTTM Path Transanal Access Platform was used. As demonstrated, the rectal mucosa was dissected using robotic instruments after submucosal hydrodissection. Following specimen retrieval, flexible sigmoidoscopy was used to ensure hemostasis. The rectal mucosa graft was placed as an onlay for urethroplasty.
Result(s): Harvested graft size was 3.5 x 10cm, correlating well with surface area needed for urethral reconstruction as determined by the urologist. There were no intraoperative or postoperative complications, and the patient recovered well, without morbidity or mortality. He regained bowel function on the first postoperative day, and reported significantly less postoperative pain in comparison to his prior BMG harvest.
Conclusion(s): To our knowledge, this is the first use of R-TAMIS for harvest of rectal mucosal graft. The robotic approach is safe and feasible. This is a promising minimally-invasive technique to harvest rectal mucosa, which can be used for urethral or vaginal reconstruction. Demonstrated feasibility and potential avoidance of the challenging recovery associated withBMGharvest warrants further application and long-term evaluation of this procedure

Introduction & Objective: To demonstrate the technique and the outcomes of robot assisted Y-V plasty bladder neck reconstruction (RYVBNR).
Method(s): We present our technique for treatment of recalcitrant bladder neck contracture (BNC) in seven patients who underwent RYVBNR at our institution between March 2016 and September 2017. Indication for the procedure was incomplete emptying, recurrent urinary tract infections and dysuria. On follow-up, patients were assessed for clinical success by absence of infections, symptoms and cystoscopic evaluation. Robotic assisted dissection is performed to open the space of Retzius and mobilize the bladder. The cystoscope is passed to the level of the BNC, and FireflyTM technology is used to localize the BNC. The BNC is incised anteriorly, and a V-shaped bladder flap is advanced into the BNC in a Y-V plasty fashion (figure 1). We place a perioperative closed suction drain, which is removed before discharge, and a catheter which will be removed in the office at approximately two weeks.
Result(s): Six men with recalcitrant BNCs and one with recalcitrant vesicourethral anastomotic stenosis underwent treatment (figure 2). All patients had previously undergone an endoscopic procedure. Median time for last attempt at endoscopic management to RABNR was 4.7 months. The average number of prior attempts at endoscopic management was 2. All patients underwent RYVBNR without conversion to open surgery. The median operative time was 240min, estimated blood loss was 67 ml, and length of stay was 1 day. There were no intraoperative complications. Catheters were removed in the office at a median time of 15 days. At a median follow-up of 8 months, all cases were successful with no evidence of recurrence. Only two patients had persistent urinary incontinence at 1 pad per day.
Conclusion(s): RYVBNR with a Y-V plasty is a feasible and effective technique for managing a difficult reconstructive problem. (Table Presented)