Searched for: in-biosketch:true
person:florer02
The In-House Manufacture of Sterilizable, Scaled, Patient-Specific 3D-Printed Models for Rhinoplasty
Bekisz, Jonathan M; Liss, Hannah A; Maliha, Samantha G; Witek, Lukasz; Coelho, Paulo G; Flores, Roberto L
Background/UNASSIGNED:Rhinoplasty relies on clear patient communication and precise execution of a three-dimensional (3D) plan to achieve optimal results. As 3D imaging and printing continue to grow in popularity within the medical field, rhinoplasty surgeons have begun to leverage these resources as an aid to preoperative planning, patient communication, and the technical performance of this challenging operation. Objective/UNASSIGNED:Utilizing departmentally-available resources and open access 3D imaging platforms, we have developed an affordable, reproducible protocol for rapid in-house virtual surgical planning (VSP) and subsequent manufacture of 3D-printed rhinoplasty models. Methods/UNASSIGNED:Preoperative 3D photographic images underwent virtual rhinoplasty using a freely-available 3D imaging and sculpting program (BlenderTM [Version 2.78, Amsterdam, The Netherlands]). Once the ideal postoperative result was digitally achieved, scaled, sterilizable and patient-specific 3D models of the preoperative and ideal postoperative result were manufactured in-house using a departmentally-owned 3D printer. Results/UNASSIGNED:3D-printed models have successfully been manufactured and employed for 12 patients undergoing rhinoplasty. The average time to prepare a set of pre- and postoperative models was 3 hours, while the printing process required 18-24 hours per model. Each set of surgical models can be manufactured at a total materials cost of approximately $5.00. Conclusions/UNASSIGNED:We describe an affordable means to construct sterilizable, scaled, patient-specific 3D-printed models for rhinoplasty. This technique may become of increasing interest to academic and cosmetic centers as hardware costs of 3D printers continues to fall.
PMID: 29982464
ISSN: 1527-330x
CID: 3192322
Long-term outcomes of 3D-printed bioactive ceramic scaffolds for regeneration of the pediatric skeleton
Chapter by: Wang, M. M.; Rodriguez Colon, R.; Kurgansky, G. D.; Witek, L.; Torroni, A.; Cronstein, B. N.; Flores, R. L.; Coelho, P. G.
in: Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium by
[S.l. : s.n.], 2019
pp. 138-?
ISBN: 9781510883901
CID: 3913082
Tissue-engineered alloplastic scaffolds for reconstruction of alveolar defects
Chapter by: Witek, Lukasz; Colon, Ricardo Rodriguez; Wang, Maxime M.; Torroni, Andrea; Young, Simon; Melville, James; Lopez, Christopher D.; Flores, Roberto L.; Cronstein, Bruce N.; Coelho, Paulo G.
in: Handbook of Tissue Engineering Scaffolds: Volume One by
[S.l.] : Elsevier, 2019
pp. 505-520
ISBN: 9780081025642
CID: 4394182
A Prospective Randomized Blinded Trial Comparing Digital Simulation to Textbook for Cleft Surgery Education
Plana, Natalie M; Rifkin, William J; Kantar, Rami S; David, Joshua A; Maliha, Samantha G; Farber, Scott J; Staffenberg, David A; Grayson, Barry H; Diaz-Siso, J Rodrigo; Flores, Roberto L
BACKGROUND:Simulation is progressively being integrated into surgical training, yet its utility in plastic surgery has not been well described. We present a prospective, randomized, blinded trial comparing digital simulation to a surgical textbook for conceptualization of cleft-lip repair. METHODS:Thirty-five medical students were randomized to learning cleft repair using a simulator or textbook. Participants outlined markings for a standard cleft-lip repair before (pre-intervention) and after (post-intervention) 20 minutes of studying their respective resource. Two expert reviewers blindly graded markings according to a 10-point scale, on two separate occasions. Intra-rater and inter-rater reliability were calculated using intra-class correlation coefficients. Paired and independent t-tests were performed to compare scoring between study groups. A validated student satisfaction survey was administered to assess the two resources separately. RESULTS:Intra-rater grading reliability was excellent among both raters for pre-intervention and post-intervention grading (rater 1 ICC=0.94 and 0.95, respectively; rater 2 ICC=0.60 and 0.92, respectively; p<0.001). Mean pre-intervention performances for both groups were comparable (0.82±1.17 vs. 0.64±0.95; p=0.31). Significant improvement from pre-intervention to post-intervention performance was observed in the textbook (0.82±1.17 v. 3.50±1.62; p<0.001) and simulator (0.64±0.95 vs. 6.44±2.03; p<0.001) groups. However, the simulator group demonstrated a significantly greater improvement (5.81±2.01 vs. 2.68±1.49; p<0.001). Participants reported the simulator to be more effective (p<0.001) and a clearer tool (p<0.001), that allowed better learning (p<0.001) than textbooks. All participants would recommend the simulator to others. CONCLUSIONS:We present level I evidence supporting online digital simulation as a superior educational resource for novice learners, compared to traditional textbooks.
PMID: 30325894
ISSN: 1529-4242
CID: 3368362
3D Printing and Adenosine Receptor Activation for Craniomaxillofacial Regeneration
Chapter by: Lopez, Christopher D; Witek, Lukasz; Flores, Roberto L; Torroni, Andrea; Rodriguez, Eduardo D; Cronstein, Bruce N; Coelho, Paulo G
in: Regenerative strategies for maxillary and mandibular reconstruction : a practical guide by Melville, James C; et al [Eds]
Cham, Switzerland : Springer, [2019]
pp. 255-267
ISBN: 9783319936673
CID: 5457522
Sustainable Cleft Care Through Education: The First Simulation-Based Comprehensive Workshop in the Middle East and North Africa Region
Kantar, Rami S; Ramly, Elie P; Almas, Fernando; Patel, Krishna G; Rogers-Vizena, Carolyn R; Roche, Nathalie A; Zgheib, Elias; Munoz-Pareja, Jennifer C; Nader, Marie K; Kummer, Ann W; Flores, Roberto L; Van Aalst, John A; Hamdan, Usama S
OBJECTIVE:/UNASSIGNED:To describe the conduct of the first multidisciplinary simulation-based workshop in the Middle East/North Africa region and evaluate participant satisfaction. DESIGN:/UNASSIGNED:Cross-sectional survey-based evaluation. SETTING:/UNASSIGNED:Educational comprehensive multidisciplinary simulation-based cleft care workshop. PARTICIPANTS:/UNASSIGNED:Total of 93 workshop participants from over 20 countries. INTERVENTIONS:/UNASSIGNED:Three-day educational comprehensive multidisciplinary simulation-based cleft care workshop. MAIN OUTCOME MEASURES:/UNASSIGNED:Number of workshop participants, number of participants stratified by specialty, satisfaction with workshop, number of workshop staff, and number of workshop staff stratified by specialty. RESULTS:/UNASSIGNED:The workshop included 93 participants from over 20 countries. The response rate was 47.3%, and participants reported high satisfaction with all aspects of the workshop. All participants reported they would recommend it to colleagues (100.0%) and participate again (100.0%). No significant difference was detected based on participant specialty or years of experience. The majority were unaware of other cleft practitioners in their countries (68.2%). CONCLUSION:/UNASSIGNED:Multidisciplinary simulation-based cleft care workshops are well received by cleft practitioners in developing countries, serve as a platform for intellectual exchange, and are only possible through strong collaborations. Advocates of international cleft surgery education should translate these successes from the regional to the global arena in order to contribute to sustainable cleft care through education.
PMID: 30426759
ISSN: 1545-1569
CID: 3458652
Single-Stage Primary Cleft Lip and Palate Repair: A Review of the Literature
Kantar, Rami S; Rifkin, William J; Cammarata, Michael J; Maliha, Samantha G; Diaz-Siso, J Rodrigo; Farber, Scott J; Flores, Roberto L
BACKGROUND:Single-stage cleft lip and palate repair is a debated surgical approach. While some studies have described favorable outcomes, concerns include the effect on craniomaxillofacial growth and increased risk of complications. To this date, there has not been a comprehensive appraisal of available data following combined cleft lip and palate repair. METHODS:An extensive literature review was performed to identify all relevant articles. The level of evidence of these articles was graded according to the Oxford Centre for Evidence-Based Medicine Levels of Evidence Scale. RESULTS:A total of 22 relevant articles were identified, all of which were retrospective in nature. Patient age at the time of surgery ranged from 1 month to 10 years, the longest duration of follow-up was 18 years, and the largest study included 106 patients. Review of the literature shows that overall surgical outcomes following combined cleft lip and palate repair are encouraging. An increased rate of postoperative fistulas with associated speech abnormalities in some studies is noteworthy. Importantly, there is no evidence to suggest an impact on craniomaxillofacial growth, and psychosocial outcomes and parental satisfaction seem to be improved with single-stage surgery as compared with the staged approach. CONCLUSIONS:Our review shows overall favorable outcomes associated with combined cleft lip and palate repair. The limited follow-up time or nature of evaluated outcomes in some studies may underrepresent the true rate of adverse events, and highlights the need for additional long-term studies with standardized follow-up. To our knowledge, our review is the first to evaluate existing data regarding outcomes following combined cleft lip and palate repair.
PMID: 29944528
ISSN: 1536-3708
CID: 3162792
Haptic, Physical, and Web-Based Simulators: Are They Underused in Maxillofacial Surgery Training?
Maliha, Samantha G; Diaz-Siso, J Rodrigo; Plana, Natalie M; Torroni, Andrea; Flores, Roberto L
PURPOSE/OBJECTIVE:Surgical residencies have increasingly incorporated both digital and mannequin simulation into their training programs. The aim of our review was to identify all digital and mannequin maxillofacial simulators available for education and training, highlight their benefit, and critically assess the evidence in support of these educational resources. MATERIALS AND METHODS/METHODS:We performed a comprehensive literature review of all peer-reviewed publications of digital and mannequin simulators that met the inclusion criteria, defined as any simulator used in education or training. All simulators used in surgical planning were excluded. Before the query, it was hypothesized that most studies would be descriptive in nature and supported by low levels of evidence. Literature search strategies included the use of multiple combinations of key search terms, review of titles and abstracts, and precise identification of the use of the simulator described. All statistics were descriptive. RESULTS:The primary search yielded 259 results, from which 22 total simulators published on from 2001 to 2016 were identified using the inclusion and exclusion criteria: 10 virtual reality haptic-based simulators, 6 physical model simulators, and 6 Web-based simulators used for a variety of procedures such as dental skills, instrument handling, orthognathic surgery (Le Fort I osteotomy, vertical ramus osteotomy, bilateral sagittal split ramus osteotomy), genioplasty, bone grafting, sinus surgery, cleft lip repair, orbital floor repair, and oral biopsy. Only 9 formalized studies were completed; these were classified as low-level evidence-based cohort studies (Levels IV and V). All other simulator reports were descriptive in nature. There were no studies with high levels of evidence completed (Level I to III). CONCLUSIONS:The results of this review suggest that, although seemingly beneficial to the trainee in maxillofacial surgery, simulation in education in this field is an underused commodity because of the significant lack of scientific and validated study designs reported on in the literature thus far. The maxillofacial and simulation communities would benefit from studies on utility and efficacy with higher levels of evidence.
PMID: 30081008
ISSN: 1531-5053
CID: 3226292
Digital-Facial Translocation in Amniotic Band Sequence: Evidence of the Intrinsic Theory
Weinstein, Brielle; Hassouba, Mahmoud; Flores, Roberto L; Staffenberg, David A; Gordon, Christopher B; Runyan, Christopher M
Amniotic band sequence is a complex congenital anomaly in which infants with typically no known genetic mutation have bands of maternal amniotic tissue wrapped around body parts, most commonly the limbs and digits. The authors report a novel variation on this presentation in 3 patients from 2 centers with complex craniofacial clefting and amniotic band sequence. They presented with hypertelorism, different forms of complex craniofacial clefting, and bands connecting ipsilateral hands to facial clefts, with digital-facial translocation in 2 cases. These findings support a model in which complex craniofacial clefts result in areas of exposed, sticky, and temporally and spatially coincident mesenchyme within the embryo that are susceptible to adherence of ipsilateral fetal hands. This strongly supports the intrinsic and adhesion theories of the etiology of amniotic band syndrome.
PMID: 30106805
ISSN: 1536-3732
CID: 3254592
Treacher Collins Syndrome and Tracheostomy: Decannulation Using Mandibular Distraction Osteogenesis
Ali-Khan, Safi; Runyan, Christopher; Nardini, Gil; Shetye, Pradip; Staffenberg, David; McCarthy, Joseph G; Flores, Roberto L
INTRODUCTION/BACKGROUND:Treacher Collins syndrome (TC) and Pierre Robin sequence (RS) are associated with hypoplastic mandible, glossoptosis, and consequent airway obstruction. Although TC and RS are often grouped together, airway outcomes of bilateral mandibular distraction osteogenesis (MDO) have not been specifically studied in TC. The purpose of this study is to report on the clinical outcomes of MDO in the TC patient population. MATERIALS AND METHODS/METHODS:A twenty-year single-institution retrospective review of all patients with TC who underwent bilateral MDO was performed. Twenty-four patients were identified after exclusion due to different diagnoses or insufficient medical records. Data on comorbidities, airway status, MDO operations, and complications were collected. Data were compared with published clinical outcomes in RS and data for 13 RS patients from our institution. RESULTS:Surgical success, defined as prevention of imminent tracheostomy or successful decannulation within 1 year after primary distraction, was observed in 21% of TC patients and 65% of RS patients (P = 0.01). Repeat distraction was necessary for 11 TC patients (46%) and 1 RS patient. Complications were divided into minor, moderate, and major based on need for invasive management. Overall, 67% of TC patients had complications, 20% of which were major. CONCLUSIONS:Clinical outcomes to airway function after MDO are significantly inferior in patients with TC compared with patients with RS. Repeat MDO and longer course to decannulation are more prevalent in patients affected by TC.
PMID: 29905603
ISSN: 1536-3708
CID: 3155322