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MRI Evaluation of Bipolar Bone Loss Using the On-Track Off-Track Method: A Feasibility Study

Gyftopoulos, Soterios; Beltran, Luis S; Bookman, Jared; Rokito, Andrew
OBJECTIVE: The purpose of this study was to determine whether the simultaneous MRI evaluation of Hill-Sachs lesions and glenoid bone loss by use of the on-track off-track method can be used to predict engagement during arthroscopy. MATERIALS AND METHODS: The records of 75 consecutively registered patients (60 male patients, 15 female patients) with a history of previous anterior shoulder instability who underwent preoperative MRI of the shoulder and arthroscopy at our institution were reviewed. A total of 76 MRI examinations were included. Two readers reviewed the MR images of each patient blindly and independently and used the on-track off-track method to predict engagement. These results were compared with the findings related to engagement seen during arthroscopy, which was performed by one of seven orthopedic surgeons. Statistical analyses included Fisher exact test, logistic regression, ROC analysis, and calculation of intraclass correlation coefficients. RESULTS: Using the on-track off-track technique of reading MR images, the reviewers correctly predicted 13 of the 18 engaging (off-track) lesions (sensitivity, 72.2%). Among the 58 shoulders that did not engage (on-track), they correctly predicted 51 (specificity, 87.9%). Overall, the accuracy of the on-track off-track method was 84.2% with a positive predictive value of 65.0% and negative predictive value of 91.1%. CONCLUSION: Our study showed that the on-track off-track method can be used in MRI to accurately assess the bipolar bone loss seen in patients with anterior shoulder instability for predicting the presence of engaging, or off-track, lesions. This information can be used preoperatively to help guide the type of stabilization procedure performed on patients with anterior shoulder instability.
PMID: 26397335
ISSN: 1546-3141
CID: 1786532

MRI-Arthroscopy Correlation for Shoulder Anatomy and Pathology: A Teaching Guide

Gyftopoulos, Soterios; Strauss, Eric J
OBJECTIVE: The objectives of the article are to improve the radiologist's understanding of shoulder arthroscopy and see how it correlates with MRI. We review the basic principles of arthroscopy followed by a comparison of its strengths and weaknesses relative to MRI. This discussion is supplemented by a series of cases that show the relationship between arthroscopy and MRI in terms of the visualization of normal and abnormal anatomy in the diagnosis of common shoulder abnormalities. CONCLUSION: By understanding what our orthopedic colleagues are seeing (and not seeing) during arthroscopic shoulder surgery, we can better understand the strengths and weaknesses of MRI, which provides us the opportunity to improve our imaging interpretations and produce valuable management-guiding diagnostic reports.
PMID: 26001257
ISSN: 1546-3141
CID: 1591262

Hill-Sachs lesion location: does it play a role in engagement?

Gyftopoulos, Soterios; Wang, Annie; Babb, James
OBJECTIVE: To see if there is an association between engagement on physical examination (PE) and the location of the Hill-Sachs lesion (HSL) as assessed by the modified biceps angle. MATERIALS AND METHODS: Sixty-two patients with a history of anterior shoulder dislocation, who underwent preoperative MRI and arthroscopy at our institution and were tested for engagement on PE, were collected. Two musculoskeletal radiologists reviewed the MR studies, noting the presence of an HSL and documenting the location of the HSL with the modified biceps angle. Statistical analysis included the Mann-Whitney (MW) test and ROC (receiver-operating characteristic) curve. RESULTS: Of 62 patients, there were 58 males and 4 females with a mean age of 30 (range 18-59 years). Twenty patients demonstrated engagement on PE, while 42 did not. All patients had evidence of an HSL on MRI and arthroscopy. The mean biceps angle for the engaging group was 151.5 +/- 13.9 degrees , and 142.4 +/- 17.3 degrees for the non-engaging group. The biceps angle was statistically significantly higher among patients who had engagement compared to those who did not (p = 0.027). Overall, diagnostic accuracy was highest for a biceps angle >149 degrees , which resulted in a sensitivity of 70 % and specificity of 67 %. CONCLUSION: The modified biceps angle, as measured on MRI, was significantly higher in patients who demonstrated engagement on physical examination than in those who did not. This supports the theory that the location of the Hill-Sachs lesion may play a role in engagement and may be its most important characteristic when determining its significance.
PMID: 25846480
ISSN: 1432-2161
CID: 1528292

Presence of gout is associated with increased prevalence and severity of knee osteoarthritis among older men: results of a pilot study

Howard, Rennie G; Samuels, Jonathan; Gyftopoulos, Soterios; Krasnokutsky, Svetlana; Leung, Joseph; Swearingen, Christopher J; Pillinger, Michael H
BACKGROUND: Gout and osteoarthritis (OA) are the most prevalent arthritides, but their relationship is neither well established nor well understood. OBJECTIVES: We assessed whether a diagnosis of gout or asymptomatic hyperuricemia (AH) is associated with increased prevalence/severity of knee OA. METHODS: One hundred nineteen male patients aged 55 to 85 years were sequentially enrolled from the primary care clinics of an urban Veterans Affairs hospital, assessed and categorized into 3 groups: gout (American College of Rheumatology Classification Criteria), AH (serum urate >/=6.8 mg/dL, no gout), and control (serum urate <6.8 mg/dL, no gout). Twenty-five patients from each group subsequently underwent formal assessment of knee OA presence and severity (American College of Rheumatology Clinical/Radiographic Criteria, Kellgren-Lawrence grade). Musculoskeletal ultrasound was used to detect monosodium urate deposition at the knees and first metatarsophalangeal joints. RESULTS: The study showed 68.0% of gout, 52.0% of AH, and 28.0% of age-matched control subjects had knee OA (gout vs control, P = 0.017). Odds ratio for knee OA in gout versus control subjects was 5.46 prior to and 3.80 after adjusting for body mass index. Gout subjects also had higher Kellgren-Lawrence grades than did the control subjects (P = 0.001). Subjects with sonographically detected monosodium urate crystal deposition on cartilage were more likely to have OA than those without (60.0 vs 27.5%, P = 0.037), with crystal deposition at the first metatarsophalangeal joints correlating most closely with OA knee involvement. CONCLUSIONS: Knee OA was more prevalent in gout patients versus control subjects and intermediate in AH. Knee OA was more severe in gout patients versus control subjects.
PMCID:4714979
PMID: 25710856
ISSN: 1076-1608
CID: 1473722

Reply to "upper extremity trauma radiographs" [Letter]

Gyftopoulos, Soterios; Chitkara, Munish; Bencardino, Jenny
PMID: 25714327
ISSN: 0361-803x
CID: 1473872

The Throwing Shoulder: The Common Injuries and their Underlying Mechanisms

Gyftopoulos, Soterios; Recht, Michael
The mechanics of the throwing shoulder are complex, resulting in a variety of adaptations that can lead to increased performance for the athlete. These adaptations can eventually fail and result in pathology to the stabilizing structures of the shoulder, most notably the rotator cuff and glenoid labrum. The understanding of the relationship between the mechanisms and injuries is evolving, resulting in improved diagnostic, therapeutic, and preventative measures. Our goal is to clarify the relationship between the mechanisms, common types of injury, and their appearance on imaging, specifically MRI, in a comprehensive, easy-to-understand manner that will leave you more confident when evaluating this subset of patients.
PMID: 25184395
ISSN: 1089-7860
CID: 1173802

Misses and errors in upper extremity trauma radiographs

Gyftopoulos, Soterios; Chitkara, Munish; Bencardino, Jenny T
OBJECTIVE. The article reviews a select group of traumatic upper extremity injuries that can be easily misinterpreted on radiographs. CONCLUSION. The awareness of these specific injuries and an understanding of their underlying pathophysiology and the role that radiographs can play in their evaluation will give the reader the best opportunity to make the important imaging findings and guide appropriate treatment.
PMID: 25148150
ISSN: 0361-803x
CID: 1142662

Osseous injuries associated with anterior shoulder instability: what the radiologist should know

Gyftopoulos, Soterios; Albert, Marissa; Recht, Michael P
OBJECTIVE. The purpose of this article is to review the current understanding of the underlying pathophysiology of the Hill-Sachs lesion and anterior glenoid bone loss and to discuss the role of imaging in identifying and accurately describing these injuries. CONCLUSION. Understanding the underlying mechanics of anterior shoulder instability that result in Hill-Sachs lesions and glenoid bone loss, the strengths and weaknesses of the different imaging modalities ordered for their evaluation, and the methods used to characterize these osseous injuries on imaging are essential for the radiologist in this clinical setting.
PMID: 24848847
ISSN: 0361-803x
CID: 1005052

Use of 3D MR reconstructions in the evaluation of glenoid bone loss: a clinical study

Gyftopoulos, Soterios; Beltran, Luis S; Yemin, Avner; Strauss, Eric; Meislin, Robert; Jazrawi, Laith; Recht, Michael P
OBJECTIVE: To assess the ability of 3D MR shoulder reconstructions to accurately quantify glenoid bone loss in the clinical setting using findings at the time of arthroscopy as the gold standard. MATERIALS AND METHODS: Retrospective review of patients with MR shoulder studies that included 3D MR reconstructions (3D MR) produced using an axial Dixon 3D-T1W-FLASH sequence at our institution was conducted with the following inclusion criteria: history of anterior shoulder dislocation, arthroscopy (OR) performed within 6 months of the MRI, and an estimate of glenoid bone loss made in the OR using the bare-spot method. Two musculoskeletal radiologists produced estimates of bone loss along the glenoid width, measured in mm and %, on 3D MR using the best-fit circle method, which were then compared to the OR measurements. RESULTS: There were a total of 15 patients (13 men, two women; mean age, 28, range, 19-51 years). There was no significant difference, on average, between the MRI (mean 3.4 mm/12.6 %; range, 0-30 %) and OR (mean, 12.7 %; range, 0-30 %) measurements of glenoid bone loss (p = 0.767). A 95 % confidence interval for the mean absolute error extended from 0.45-2.21 %, implying that, when averaged over all patients, the true mean absolute error of the MRI measurements relative to the OR measurements is expected to be less than 2.21 %. Inter-reader agreement between the two readers had an IC of 0.92 and CC of 0.90 in terms of percentage of bone loss. CONCLUSIONS: 3D MR reconstructions of the shoulder can be used to accurately measure glenoid bone loss.
PMID: 24318071
ISSN: 0364-2348
CID: 745902

Imaging in anterior glenohumeral instability

Bencardino, Jenny T; Gyftopoulos, Soterios; Palmer, William E
In the shoulder, the advantages of range of motion are traded for the disadvantages of vulnerability to injury and the development of instability. Glenohumeral instability encompasses a broad spectrum of clinical complaints and presentations. The diagnosis can be obvious or entirely unsuspected. Imaging findings depend on numerous factors and range from gross osseous defects to equivocal labral abnormalities and undetectable capsular lesions. This review focuses on the imaging findings in three distinct clinical scenarios: acute first-time shoulder dislocation, chronic instability with repeated dislocation, and chronic instability without repeated dislocation. The biomechanics of dislocation and the pathophysiology of labral-ligamentous injury are discussed. The authors distinguish the findings that occur in the acutely traumatized shoulder from those that typify the chronic unstable joint. The roles of different imaging modalities are also distinguished, including magnetic resonance arthrography and the value of specialized imaging positions. The goal of imaging depends on the clinical scenario. Image interpretation and reporting may need to emphasize diagnosis and the identification of lesions that are associated with instability or the characterization of lesions for treatment planning.
PMID: 24155283
ISSN: 1527-1315
CID: 3119702