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Delayed reconstruction with cryopreserved vein of an iatrogenically ligated inferior vena cava
Garg, Karan; Riegel, Daniel A; Williams, Brittny H; Jacobowitz, Glenn R
We report the case of delayed reconstruction of an iatrogenically transected inferior vena cava (IVC). A 47-year-old male underwent a laparoscopic right nephrectomy complicated by an unrecognized IVC transection. Postoperatively, he developed severe lower extremity edema, abdominal distension, and discomfort, prompting further investigation. A computed tomography scan showed a staple line extending across the IVC with thrombus extending distally to the level of the left renal vein. Repair of the suprarenal portion of the IVC was undertaken using a cryopreserved femoral vein allograft. The patient demonstrated clinical improvement with follow-up imaging demonstrating graft patency at 15 months.
PMID: 26992973
ISSN: 2213-333x
CID: 2051412
The Utility of the ABI Value as a Screening Test for Disseminated Atherosclerosis [Meeting Abstract]
Garg, Karan; Berger, Jeffrey S.; Jacobowitz, Glenn R.; Maldonado, Thomas S.; Adelman, Mark A.; Riles, Thomas S.; Veith, Frank J.; Rockman, Caron B.
ISI:000327663100050
ISSN: 0741-5214
CID: 700882
Preoperative relative abdominal aortic aneurysm thrombus burden predicts endoleak and sac enlargement after endovascular anerysm repair
Sadek, Mikel; Dexter, David J; Rockman, Caron B; Hoang, Han; Mussa, Firas F; Cayne, Neal S; Jacobowitz, Glen R; Veith, Frank J; Adelman, Mark A; Maldonado, Thomas S
BACKGROUND: Endoleak and sac growth remain unpredictable occurrences after EVAR, necessitating regular surveillance imaging, including CT angiography. This study was designed to identify preoperative CT variables that predict AAA remodeling and sac behavior post-EVAR. METHODS: Pre- and postoperative CT scans from 136 abdominal aortic aneurysms treated with EVAR were analyzed using M2S (West Lebanon, NH) software for size measurements. Preoperative total sac volume and proportion of thrombus and calcium in the sac were assessed. Sac change was defined as a 3-mm difference in diameter and a 10-mm(3) difference in volume when compared with preoperative measurements. Univariate analysis was performed for age, gender, AAA size, relative thrombus/calcium volume, device type, presence of endoleak, and the effects on sac size. RESULTS: Gender, device type, age, AAA size, and percent calcium were not predictive of sac change post-EVAR. Increased proportion of thrombus on pre-EVAR resulted in a greater likelihood of sac shrinkage (P = 0.002). Patients with aneurysms that grew on postoperative CT scan had less sac thrombus on pre-EVAR (mean 27.5%) than patients without evidence of endoleak (mean 41.9%, P < 0.0001). Only 2 of 30 patients with >50% pre-EVAR thrombus developed endoleak. A >50% thrombus burden resulted in endoleak in significantly fewer patients (6.7%) compared with those who had <50% thrombus (43.1%). CONCLUSIONS: The proportion of thrombus on preoperative CT may predict sac behavior after EVAR and development of an endoleak. Greater than 50% thrombus appears to predict absence of endoleak after EVAR. Aneurysms with large thrombus burden are less likely to grow and may require less vigilant postoperative surveillance than comparable AAA with relatively little thrombus.
PMID: 23992607
ISSN: 0890-5096
CID: 586262
Increasing ablation distance peripheral to the saphenofemoral junction may result in a diminished rate of endothermal heat-induced thrombosis
Sadek, Mikel; Kabnick, Lowell S; Rockman, Caron B; Berland, Todd L; Zhou, Di; Chasin, Cara; Jacobowitz, Glenn R; Adelman, Mark A
OBJECTIVE: The treatment of venous insufficiency using endovenous laser ablation or radiofrequency ablation may result in endothermal heat-induced thrombosis (EHIT), a form of deep venous thrombosis. This study sought to assess whether increasing the ablation distance peripheral to the deep venous junction would result in a reduction in the incidence of EHIT II. METHODS: This study was a retrospective review of a prospectively maintained database from April 2007 to December 2011. Consecutive patients undergoing great saphenous vein (GSV) or small saphenous vein (SSV) ablation were evaluated. Previous to February 2011, all venous ablations were performed 2 cm peripheral to the saphenofemoral or saphenopopliteal junction (group I). Subsequent to February 2011, ablations were performed greater than or equal to 2.5 cm peripheral to the respective deep system junction (group II). The primary outcome was the development of EHIT II or greater (ie, thrombus protruding into the deep venous system but comprising less than 50% of the deep vein lumen). Secondary outcomes included procedure-site complications such as thrombophlebitis and hematomas. chi2 tests were performed for all discrete variables, and unpaired Student's t-tests were performed for all continuous variables. P < .05 was considered statistically significant. RESULTS: A total of 4223 procedures were performed among group I (n = 3239) and group II (n = 984). Patient demographics were similar between the two groups; however, the CEAP classification was higher by a small margin in group II, and the result was significant (group I: 2.6% +/- 0.9% vs group II: 2.8% +/- 1.0%; P = .006). The incidence of EHIT II was 76 in group I and 13 in group II. This represented a trend toward diminished frequency in group II as compared with group I (group I: 2.3% vs group II: 1.3%; P = .066). There were no reported cases of EHIT III or IV in this patient cohort. Patients who developed an EHIT II in group I were treated using anticoagulation 54% of the time, and patients who developed an EHIT II in group II were treated using anticoagulation 100% of the time. CONCLUSIONS: This study suggests that changing the treatment distance from 2 cm to greater than or equal to 2.5 cm peripheral to the deep venous junction may result in a diminished incidence of EHIT II. Ongoing evaluation is required to validate these results and to affirm the long-term durability of this technique.
PMID: 26992584
ISSN: 2213-3348
CID: 2047492
The prevalence of carotid artery stenosis varies significantly by race
Rockman, Caron B; Hoang, Han; Guo, Yu; Maldonado, Thomas S; Jacobowitz, Glenn R; Talishinskiy, Toghrul; Riles, Thomas S; Berger, Jeffrey S
OBJECTIVE: Certain races are known to be at increased risk for stroke, and the prevalence of carotid artery stenosis (CAS) is thought to vary by race. The goal of this report was to study the prevalence of CAS in different races by analyzing a population of subjects who underwent vascular screening examinations. METHODS: The study data were provided by Life Line Screening. The cohort consists of self-referred individuals who paid for vascular screening tests. Subjects <40 and >100 years of age and those who reported a prior stroke or carotid artery intervention were excluded. Of the remaining 3,291,382 subjects, 3.7% did not self-identify a race. CAS was defined as stenosis in either internal carotid artery >/=50% by duplex ultrasound velocity criteria. RESULTS: The 3,291,382 subjects available for analysis consisted of Caucasian (2,845,936 [90%]), African American (97,502 [3.1%]), Hispanic (75,240 [2.4%]), Asian (60,982 [1.9%]), and Native American (87,757 [2.8%]) individuals. The prevalence of CAS was 3.4% in females and 4.2% in males (P = .001). Controlling for gender and age, there was marked variation in the prevalence of CAS (P < .001) by race. Native American subjects had the highest prevalence of CAS across all age categories and in both sexes. Caucasian subjects had the second highest prevalence of CAS across most age decades and in both sexes. Among males, African American individuals had the lowest prevalence of CAS in nearly all age categories. In contrast to males, Asian females had the lowest prevalence of CAS compared with females of other races in most age groups. Multivariate analysis adjusting for atherosclerotic risk factors in addition to age confirmed race as a significant independent predictor of CAS. Compared with Caucasian subjects, African American (odds ratio [OR], 0.65), Asian (OR, 0.69), and Hispanic (OR, 0.74) subjects had a significantly lower risk of CAS, whereas Native American (OR, 1.3) subjects had a significantly higher risk of CAS. CONCLUSIONS: The prevalence of clinically significant CAS varies significantly by race. Native American and Caucasian individuals have the highest prevalence of CAS, whereas African American males and Asian females appear to have the lowest prevalence. This information adds evidence to the hypothesis that the increased stroke rate in African American subjects is likely not related to extracranial cerebrovascular disease. Furthermore, this is a novel report of an extremely high prevalence of CAS in the Native American population.
PMID: 23177534
ISSN: 0741-5214
CID: 213612
Coil embolization of a gastroduodenal artery pseudoaneurysm secondary to cholangitis: technical aspects and review of the literature
Sadek, Mikel; Rockman, Caron B; Berland, Todd L; Maldonado, Thomas S; Jacobowitz, Glenn R; Adelman, Mark A; Mussa, Firas F
A 72-year-old woman with end-stage renal disease was admitted with right upper quadrant pain, hypotension, an elevated bilirubin, and leukocytosis. A computed tomography scan showed a dilated common bile duct and an associated 4.5 cm gastroduodenal artery pseudoaneurysm. The pseudoaneurysm was coil embolized successfully while maintaining dual access from the brachial and femoral arteries using the "body floss" technique. Subsequently, the patient underwent endoscopic treatment for her obstructive jaundice. We report on the technical aspects of this case and review the literature.
PMID: 22903332
ISSN: 1538-5744
CID: 180472
Contemporary presentation and management of carotid artery aneurysms and pseudoaneurysms
Garg, K; Rockman, CB; Lee, V; Maldonado, TS; Jacobowitz, GR; Adelman, MA; Mussa, FF
OBJECTIVE: The objective of this study was to review a single-institution contemporary experience with extracranial aneurysms of the carotid artery. METHODS: A retrospective review was conducted of patients evaluated for an aneurysm of the extracranial carotid artery from 2005 to 2010. Demographics, presentation, and operative management were reviewed. The mean follow-up was 22 months (range, 1-58 months). RESULTS: Over the study period, 16 aneurysms and pseudoaneurysms were identified in 15 patients. Of these, 14 aneurysms (in six men and eight women with mean age of 63 years) underwent surgical repair. The mean aneurysm size was 2.45 cm (range, 0.8-5 cm). One aneurysm (7.1%) was associated with neurologic symptoms, and 13 were asymptomatic. The underlying etiology was trauma in five (35.7%), prior carotid endarterectomy in five (35.7%), and degenerative atherosclerosis in four (28.6%). Aneurysms were isolated to the common carotid artery in six (42.9%), internal carotid artery in five (35.7%), and carotid bifurcation in three (21.4%). Five patients underwent aneurysmectomy with primary repair; seven underwent repair with an interposition graft, one required an innominate to common carotid artery bypass, and one patient had a plication and patch angioplasty. No mortalities or neurologic events were documented within 30 days. One patient had transient cranial nerve palsy. One patient required reintervention at 4 months for stenosis of the bypass graft, and one patient died at 10 months from an unrelated condition. There were no neurologic events on follow-up. CONCLUSIONS: Carotid artery aneurysms and pseudoaneurysms are uncommon and usually asymptomatic. Prior trauma and carotid surgery were common etiologies. The location of the aneurysms was equally distributed between the internal and common carotid arteries. Surgical repair was safe and effective with no significant morbidity or mortality and good midterm stroke prevention.
PMID: 22341576
ISSN: 0741-5214
CID: 162331
Outcome of endovascular repair of popliteal artery aneurysm using the Viabahn endoprosthesis
Garg, Karan; Rockman, Caron B; Kim, Billy J; Jacobowitz, Glenn R; Maldonado, Thomas S; Adelman, Mark A; Veith, Frank J; Cayne, Neal S
OBJECTIVE: This study reviews a single-center experience of endovascular popliteal aneurysm (PAA) repair. METHODS: A retrospective review was performed to identify all endovascular PAA repairs performed between September 2004 and January 2011. RESULTS: We identified 21 patients (mean age, 74 +/- 9 years, 91% men) with PAAs (mean size, 2.89 +/- 1.0 cm) in 26 limbs, of which 38% were symptomatic. All patients underwent endovascular repair with a Viabahn covered stent graft (W. L. Gore & Assoc, Inc, Flagstaff, Ariz). Postoperatively, all patients were maintained on antiplatelet therapy with clopidogrel or aspirin, or both. Mean follow-up was 22 +/- 17 months (range, 1-57 months). One patient with one aneurysm was lost to follow-up. Primary and secondary patencies were both 91.2% at 1 year and were 85.5% and 91.2%, respectively, at 2 years. The limb salvage rate was 100%. Four stent graft failures occurred at a mean of 12.3 +/- 11 months. One technical failure due to stent graft infolding required conversion to an open femoral-popliteal bypass. Three additional graft failures occurred in patients with poor (single-vessel) runoff. Compared with patients with two- or three-vessel runoff, the graft failure rate in patients with single-vessel runoff was statistically significant (P = .02). Two of the graft failures were successfully treated with open thrombectomy, and one required a tibial artery bypass for limb salvage. CONCLUSIONS: Endovascular repair of PAAs is feasible and has acceptable midterm patency rates. Poor distal runoff predicted graft failure.
PMID: 22608040
ISSN: 0741-5214
CID: 167506
Hormone Replacement Therapy is Associated With a Decreased Prevalence of Peripheral Arterial Disease in Postmenopausal Women
Rockman, Caron B; Maldonado, Thomas S; Jacobowitz, Glenn R; Adelman, Mark A; Riles, Thomas S
BACKGROUND: The effect of hormone replacement therapy (HRT) in postmenopausal women on the development of peripheral atherosclerosis remains in question. The goal of this study was to analyze the use of HRT in a large population of postmenopausal women and to determine its association with the prevalence of peripheral arterial disease (PAD). METHODS: A prospective database of patients who underwent voluntary vascular screening was used. Identification of patients as postmenopausal, and their use of HRT, was based on patient questionnaires. PAD was defined to be present if either lower extremity ankle-brachial index was =0.9. RESULTS: Analysis was performed on data from 847,982 postmenopausal women; 433,178 (51.1%) reported having used HRT. HRT subjects were slightly older than patients who had not used HRT (64.5 years vs. 63.6 years). Caucasian women were significantly more likely to have used HRT than non-Caucasian women (52.4% vs. 47.6%). HRT subjects were significantly more likely to have smoked cigarettes (42.8% vs. 40.6%), to have hypertension (47.9% vs. 45.1%), and to have hypercholesterolemia (55% vs. 51.5%) than women who had not used HRT (all P < 0.001). However, HRT subjects were significantly less likely to have diabetes mellitus (8.6% vs. 10.2%, P < 0.001). Despite the increased prevalence of several atherosclerotic risk factors among women who used HRT, they were significantly less likely to have PAD (3.3% vs. 4.1%, P < 0.001). Multivariate analysis adjusting for age, race, and medical comorbidities that predispose toward the development of atherosclerosis confirmed that HRT was independently associated with a decreased risk of PAD (odds ratio: 0.8, 95% confidence interval: 0.78-0.82). In subsets of postmenopausal women with known atherosclerotic risk factors, the significant effect of HRT on the prevalence of PAD was maintained; in women with either a smoking history, hypertension, hypercholesterolemia, diabetes, or age of >/=70 years, the odds ratio of HRT use with regard to PAD remained approximately 0.8. CONCLUSIONS: The use of HRT in postmenopausal women appears to be associated with a significant reduction in the prevalence of PAD in this population-based study. This association appeared to be significant even in postmenopausal women with known atherosclerotic risk factors. These observational data may suggest a relationship between HRT and the prevalence of PAD that has not been the specific subject of previous randomized prospective studies.
PMID: 22285341
ISSN: 0890-5096
CID: 162029
Complications of endovenous lasers
Dexter, D; Kabnick, L; Berland, T; Jacobowitz, G; Lamparello, P; Maldonado, T; Mussa, F; Rockman, C; Sadek, M; Giammaria, L E; Adelman, M
Endovenous laser ablation (EVLA) and radiofrequencey ablation have become the procedures of choice for the treatment of superficial venous insufficiency. Their minimally invasive technique and safety profile when compared with operative saphenectomy have led to this change. As EVLA has replaced saphenectomy as the procedure of choice, the distribution of complications has changed. We evaluated the most common and most devastating complications in the literature including burns, nerve injury, arterio-venous fistula (AVF), endothermal heat-induced thrombosis and deep venous thrombosis. The following review will discuss the most frequently encountered complications of treatment of superficial venous insufficiency using EVLA. The majority of the complications described can be avoided with the use of good surgical technique and appropriate duplex ultrasound guidance. Overall, EVLA has an excellent safety profile and should be considered among the first line for treatment of superficial venous reflux.
PMID: 22312066
ISSN: 0268-3555
CID: 157762