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Pseudogastroparesis as a presentation of adenocarcinoma of the proximal jejunum [Case Report]
Osias GL; Tepper RE; Zanzi I; Katz S
Establishing the presence of adenocarcinoma of the small bowel is exceedingly difficult. Survival is contingent on prompt diagnosis. We describe a patient with an atypical presentation of jejunal adenocarcinoma visualized via small bowel enteroclysis. She was referred with 'gastroparesis,' based on both a radionucleotide scan that revealed markedly delayed gastric emptying and a 'normal' small bowel series. A markedly abnormal scintigraphic study and a negative small bowel series does not exclude disease of the small intestine and should provide the impetus to further pursue the possibility of an obstructing lesion. The enteroclysis is a relatively safe and effective study in the preoperative diagnosis of small bowel tumors
PMID: 9647036
ISSN: 0002-9270
CID: 12102
Ulcerative colitis, hyperamylasemia, and asymptomatic pancreatic calcifications: making the case for pancreatitis as an extra luminal manifestation [Case Report]
Ahmad M; Bauer W; Katz S
PMID: 9399780
ISSN: 0002-9270
CID: 12206
Differences in risk of Crohn's disease in offspring of mothers and fathers with inflammatory bowel disease
Akolkar, P N; Gulwani-Akolkar, B; Heresbach, D; Lin, X Y; Fisher, S; Katz, S; Silver, J
OBJECTIVE: To determine whether there are any unusual patterns of transmission of susceptibility to inflammatory bowel disease (IBD) within multiplex families. METHODS: Individuals with IBD were recruited for genome-wide screening of susceptibility genes. The extent of familial aggregation and blood relationships in multiplex families were determined by questionnaires given to participants followed up by confirmation of disease diagnosis by participants' physicians. RESULTS: Of 135 families identified in which both a parent and a child had IBD, 93 involved transmission of susceptibility to disease from mother to child versus 42 examples of transmission from father to child (p = 0.00001, exact two-tailed binomial test). This distortion in transmission on the basis of the sex of the parent was observed only among non-Jewish pairs with Crohn's disease (CD), in which, of 33 parent-child pairs with CD, disease susceptibility was transmitted from the mother 28 times (p = 0.00007). CONCLUSION: Susceptibility to CD in a subset of patients may involve a gene that is imprinted
PMID: 9399762
ISSN: 0002-9270
CID: 140502
Inflammatory bowel disease: A managed care perspective [Meeting Abstract]
Katz, S; Miner, PB; Hanauer, SB; Singleton, JW; Sugerman, HJ; Jacobs, R; Platt; Moore; Edwards; Greenberg; Burns
ISI:000074774100001
ISSN: 1088-0224
CID: 53410
Preferential transmission of Crohn's disease from the mother to child. [Meeting Abstract]
Akolkar, P; GulwaniAkolkar, B; Lin, XY; Katz, S; Silver, J
ISI:A1997WV41903666
ISSN: 0016-5085
CID: 1446342
Inflammatory bowel disease : keys to diagnosis & treatment : a physician reference guide
Katz, Seymour; Sachar, David B; Achkar, Edgar; Kornbluth, Asher; Hanauer, Stephen B
Arlington, VA : American College of Gastroenterology, 1997
Extent: 1 volume (unpaged) ; 28 cm
ISBN: n/a
CID: 1446432
Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease
Lih-Brody L; Powell SR; Collier KP; Reddy GM; Cerchia R; Kahn E; Weissman GS; Katz S; Floyd RA; McKinley MJ; Fisher SE; Mullin GE
Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation whose cellular components are capable of oxidative respiratory bursts that may result in tissue injury. Mucosal biopsies were analyzed for protein carbonyl content (POPs), DNA oxidation products [8-hydroxy-2'-deoxyguanosine (8-OHdG)], reactive oxygen intermediates (ROIs), trace metals (copper, zinc, and iron) and superoxide dismutase (Cu-Zn SOD). In Crohn's disease biopsies, there was an increase in ROIs, POPs, 8-OHdG, and iron, while decreased copper and Cu-Zn SOD activity were found in inflamed tissues compared to controls. For ulcerative colitis, there was an increase in ROIs, POPs, and iron in inflamed tissue compared to controls, while decreased zinc and copper were observed. An imbalance in the formation of reactive oxygen species and antioxidant micronutrients may be important in the pathogenesis and/or perpetuation of the tissue injury in IBD and may provide a rationale for therapeutic modulation with antioxidants
PMID: 8888724
ISSN: 0163-2116
CID: 12530
Adenocarcinoma in situ in Barrett's esophagus with stricture of 10-yr duration: a cytological diagnosis [Case Report]
Bauer W; Ali SZ; Urmacher C; Katz S
PMID: 8759681
ISSN: 0002-9270
CID: 36475
Inflammatory bowel disease mucosal biopsies have specialized lymphokine mRNA profiles
Mullin, G E; Maycon, Z R; Braun-Elwert, L; Cerchia, R; James, S P; Katz, S; Weissman, G S; McKinley, M J; Fisher, S E
: Crohn's disease (CD) and ulcerative colitis (UC) are idiopathic inflammatory bowel diseases (IBD) that are characterized by chronic intestinal inflammation and are associated with abnormalities of peripheral and mucosal immune function. The aim of our study was to determine whether CD or UC is characterized by discrete profiles of intestinal lymphokine production. Total cellular RNA was isolated from biopsies of healthy controls and from patients with IBD. Messenger RNA transcript levels in biopsies were determined for interleukin-2 (IL-2), IL-4, IL-5, and interferon-gamma (IFN-gamma), using a quantitative reverse transcriptase polymerase chain reaction method. Compared with inflamed UC mucosa and controls, CD mucosal lesions contained higher IL-2 and IFN-gamma mRNA (p < 0.05), which is consistent with a T-helper cell 1 (Th1)-like pattern. In UC, IL-5 mRNA content was higher in involved areas compared with controls (p < 0.05) and inflamed CD lesions (p < 0.05), suggestive of a Th2 pattern. We conclude that the intestinal mucosa of CD and UC have inflammatory responses characterized by discrete T-helper profiles of lymphokines. This strongly suggests that the immunopathogenesis of these two forms of IBD are different.
PMID: 23282452
ISSN: 1078-0998
CID: 442142
Megacolon as a presenting finding of acute pancreatitis associated with chronic ulcerative colitis: unusual presentation of an unusual association [Case Report]
Bauer, W; Tepper, R; Katz, S
PMID: 7771399
ISSN: 0002-9270
CID: 1446422