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194


Immunosuppression affects CD4+mRNA and induces Th2 dominance in the inflammatory microenvironment of cutaneous squamous cell carcinoma in organ transplant recipients [Meeting Abstract]

Dziunycz, P; Kosmidis, M; Suarez-Farinas, M; Muhleisen, B; Scharer, L; Lauchli, S; French, LE; Schmidt-Weber, C; Carucci, JA; Hofbauer, GF
ISI:000269264100438
ISSN: 0022-202x
CID: 114993

"The human cutaneous SCC microenvironment is associated with CD163+macrophages, IL-10 and MMPs 1, 3, 9, 10, 11, 13 and 14" [Meeting Abstract]

Pitts-Kiefer, A; Bluth, MJ; Fan, L; Lowes, MA; Carucci, JA
ISI:000264994000337
ISSN: 0022-202x
CID: 114990

Human cutaneous squamous cell carcinoma is associated with increased density of lymphatics in the tumor microenvironment and upregulated lymphangiogenic genes [Meeting Abstract]

Moussai, D; Mayte, S; Irma, C; Carucci, JA
ISI:000264994000338
ISSN: 0022-202x
CID: 114991

Myeloid dendritic cells from human squamous cell carcinoma are poor stimulators of T cell proliferation [Meeting Abstract]

Bluth, MJ; Zaba, LC; Moussai, D; Suarez-Farinas, M; Pitts-Kiefer, A; Fan, L; Pierson, KC; Guttman-Yassky, E; Krueger, JG; Lowes, MA; Carucci, JA
ISI:000264994000341
ISSN: 0022-202x
CID: 114992

Repair of a defect of the helical rim [Case Report]

Imahiyerobo, Joyce; Carucci, John A
PMID: 19243400
ISSN: 1524-4725
CID: 114946

Low expression of the IL-23/Th17 pathway in atopic dermatitis compared to psoriasis

Guttman-Yassky, Emma; Lowes, Michelle A; Fuentes-Duculan, Judilyn; Zaba, Lisa C; Cardinale, Irma; Nograles, Kristine E; Khatcherian, Artemis; Novitskaya, Inna; Carucci, John A; Bergman, Reuven; Krueger, James G
The classical Th1/Th2 paradigm previously defining atopic dermatitis (AD) and psoriasis has recently been challenged with the discovery of Th17 T cells that synthesize IL-17 and IL-22. Although it is becoming evident that many Th1 diseases including psoriasis have a strong IL-17 signal, the importance of Th17 T cells in AD is still unclear. We examined and compared skin biopsies from AD and psoriasis patients by gene microarray, RT-PCR, immunohistochemistry, and immunofluorescence. We found a reduced genomic expression of IL-23, IL-17, and IFN-gamma in AD compared with psoriasis. To define the effects of IL-17 and IL-22 on keratinocytes, we performed gene array studies with cytokine-treated keratinocytes. We found lipocalin 2 and numerous other innate defense genes to be selectively induced in keratinocytes by IL-17. IFN-gamma had no effect on antimicrobial gene-expression in keratinocytes. In AD skin lesions, protein and mRNA expression of lipocalin 2 and other innate defense genes (hBD2, elafin, LL37) were reduced compared with psoriasis. Although AD has been framed by the Th1/Th2 paradigm as a Th2 polar disease, we present evidence that the IL-23/Th17 axis is largely absent, perhaps accounting for recurrent skin infections in this disease
PMCID:3470474
PMID: 18981165
ISSN: 1550-6606
CID: 114945

Repair of a defect on the ala [Case Report]

Kaporis, Helen G; Carucci, John A
PMID: 18384616
ISSN: 1524-4725
CID: 114944

Reduced expression of the IL-23/IL-17 axis in atopic dermatitis skin may impair innate immunity [Meeting Abstract]

Guttman-Yassky, E; Lowes, M; Judy, F; Irma, C; Zaba, LC; Zaba, LC; Khatcherian, A; Novitskaya, I; Carucci, JA; Bergman, R; Krueger, JG
ISI:000254353800399
ISSN: 0022-202x
CID: 114994

Human cutaneous squamous cell carcinoma is associated with poorly functioning myeloid dendritic cells and regulatory T cells [Meeting Abstract]

Bluth, M; Zaba, L; Kaporis, H; Fuentes-Doculun, J; Moussai, D; Krueger, J; Michelle, L; Carucci, J
ISI:000254353801105
ISSN: 0022-202x
CID: 114995

Commentary: A responsible approach to maintaining adequate serum vitamin D levels [Editorial]

Lim, Henry W; Carucci, John A; Spencer, James M; Rigel, Darrell S
PMID: 17637482
ISSN: 1097-6787
CID: 94446