Faculty Bibliography
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251
Resolution of large aortic valve vegetations in antiphospholipid syndrome treated with therapeutic anticoagulation: a report of two cases and literature review
Non-bacterial thrombotic endocarditis in antiphospholipid syndrome presents a management dilemma. Large mobile valvular lesions pose an increased risk of stroke and arterial embolization. However, surgical excision or valve replacement in such patients carries high morbidity and mortality, while anticoagulation alone has limited data. We describe two patients with antiphospholipid syndrome presenting with neurologic events and large non-bacterial aortic valve vegetations. Both patients were successfully managed with anticoagulation and demonstrated rapid dissolution of lesions without evidence of recurrent embolic events. We provide a literature review describing additional cases managed with anticoagulation with dissolution of valvular lesions over time. Our cases further support the efficacy and safety of anticoagulation in patients with antiphospholipid syndrome and non-bacterial thrombotic endocarditis in the context of arterial embolization.
PMID: 30290716
ISSN: 1477-0962
CID: 3329342
10X Genomics-Based Single-Cell RNA-Seq Analysis Identifies a Transcriptional Landscape of Inflammation and Fibrosis in Lupus Nephritis [Meeting Abstract]
ISI:000447268905272
ISSN: 2326-5191
CID: 3726302
Dysfunction of the DNASE1L3 Pathway and Antigen Accumulation in Lupus Nephritis [Meeting Abstract]
ISI:000447268902185
ISSN: 2326-5191
CID: 3387062
Association of the Variant Form of rs17408553 at Human Leukocyte Antigen-C Supports Evidence That Hypo-Responsive Natural Killer Cells Adversely Influence the Course of Nephritis [Meeting Abstract]
ISI:000447268903322
ISSN: 2326-5191
CID: 3726272
Pregnancy Outcomes in Mixed Connective Tissue Disease: Results from a Multicentre Cohort Study [Meeting Abstract]
ISI:000447268904146
ISSN: 2326-5191
CID: 3726292
Commensal Gut Bacteria of Anti-Ro Positive Mothers of Children with Neonatal Lupus in Aggregate Resemble Healthy Subjects without Overt Dysbiosis of Abundance of Microorganisms [Meeting Abstract]
ISI:000447268902190
ISSN: 2326-5191
CID: 3726282
Erythrocyte Bound C4d in the Presence of Adverse Pregnancy Outcome Events in Pregnant Women with Systemic Lupus Erythematosus [Meeting Abstract]
ISI:000447268903058
ISSN: 2326-5191
CID: 3726262
Validation of New Systemic Lupus Erythematosus Classification Criteria [Meeting Abstract]
ISI:000447268905250
ISSN: 2326-5191
CID: 3726152
Salivary Dysbiosis Correlates with Clinical Status of Anti-Ro Positive Mothers of Children with Neonatal Lupus [Meeting Abstract]
ISI:000447268902672
ISSN: 2326-5191
CID: 3726172
A protective Langerhans cell-keratinocyte axis exists that is dysfunctional in photosensitivity [Meeting Abstract]
Photosensitivity, or skin sensitivity to ultraviolet radiation (UVR), is a feature of lupus erythematosus (LE) and other autoimmune and dermatologic conditions. Photosensitivity is associated with increased keratinocyte apoptosis, but mechanisms that modulate keratinocyte apoptosis that are dysfunctional in photosensitivity are poorly understood. Here, we identify a Langerhans cell (LC)-keratinocyte axis that limits UVR-induced keratinocyte apoptosis and skin injury via keratinocyte epidermal growth factor receptor (EGFR) stimulation. LCs express EGFR ligands and ADAM17, the metalloprotease that activates EGFR ligands. LC ADAM17 is required for skin protection and is activated by UVR, suggesting that LCs protect by providing activated EGFR ligands to keratinocytes. Photosensitive systemic LE (SLE) models have reduced LC ADAM17, and topical EGFR ligand reduces photosensitivity. Human SLE skin shows reduced EGFR activation. Together, our data identify a new tissue protective function for LCs, delineate a novel mechanism that limits skin injury, and suggest EGFR stimulation as a treatment for photosensitivity and possibly other dermatologic conditions.
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Copyright
EMBASE:2000994884
ISSN: 0190-9622
CID: 4385132
