Searched for: in-biosketch:true
person:kondzd01
Initial Experience in MRI-Based Brain Metastases Detection Using Deep Learning [Meeting Abstract]
Teruel, J.; Bernstein, K.; Galavis, P.; Spuhler, K.; Silverman, J.; Kondziolka, D.; Osterman, K.
ISI:000699863600701
ISSN: 0094-2405
CID: 5320872
Endometrial adenocarcinoma presenting as a suprasellar mass: lessons to be learned [Case Report]
Granina, Evgenia; Fehniger, Julia; Kondziolka, Douglas; Silverman, Joshua; Downey, Andrea; Placantonakis, Dimitris; Muggia, Franco
A 66-year-old woman with a history of stage IA mixed endometrioid and serous endometrial cancer presented to our centre with 2 weeks of worsening headaches nearly 4 years after her initial surgery. At admission, she manifested bitemporal hemianopsia, difficulty walking and clinical and laboratory findings of panhypopituitarism, including diabetes insipidus. Magnetic resonance imaging of the brain revealed a 2.7 cm sellar/suprasellar mass compressing the optic chiasm and infiltrating the pituitary stalk. Computerised tomography documented mediastinal, lung, adrenal and liver involvement, including a 2.5 cm palpable left supraclavicular node that on excisional biopsy demonstrated metastatic endometrial adenocarcinoma. Due to the advanced stage of her cancer as well as the presence of multiple metastases, including lung and hepatic metastases causing post-obstructive pneumonia and coagulopathy, the sellar/suprasellar mass was treated with fractionated radiosurgery rather than surgical excision.
PMCID:7434505
PMID: 32863877
ISSN: 1754-6605
CID: 4615322
Radiation-induced meningiomas
Benjamin, Carolina; Shah, Jugal K; Kondziolka, Douglas
Radiation-induced meningiomas (RIMs) became more common as the use of ionizing radiation was adopted in the treatment of medical conditions, both benign and malignant. Currently, RIMs represent the most common radiation-induced tumors. They are heterogeneous in terms of patient characteristics, radiographic appearance, genetics, pathology, symptoms, and management strategies. They tend to occur in a younger population and are generally more aggressive in nature than their spontaneous counterparts. Their characteristics also vary based on the dose of radiation received, which is most commonly separated into low dose (<10Gy) and high dose (>10Gy). The importance of the dosing classification is that it can provide insight into the nature and biologic behavior of the tumor. Given their heterogeneity, RIMs pose significant challenges in management. While surgical resection remains the preferred treatment when feasible, recent data supports stereotactic radiosurgery (SRS) as a comparable alternative. Although there is more knowledge about the molecular pathways leading to RIMs, targeted drug therapy is still limited and is the focus of current research.
PMID: 32553295
ISSN: 0072-9752
CID: 4498822
SINGLE ARM, OPEN-LABEL, MULTICENTER PHASE II STUDY OF THE RADIONUCLIDE (LU)-L-177-DOTATATE (LUTATHERA) IN ADULTS WITH ADVANCED INTRACRANIAL MENINGIOMA [Meeting Abstract]
Kurz, Sylvia; Zan, Elcin; Gurewitz, Jasone; Cordova, Christine; Troxel, Andrea B.; Sawaged, Zacharia; Sevillano-Torres, Hector; Silverman, Joshua S.; Snuderl, Matija; Zagzag, David; Golfinos, John; Kondziolka, Douglas; Sulman, Erik
ISI:000590061300220
ISSN: 1522-8517
CID: 4688132
SURVIVAL IN PATIENTS FULFILLING CCTG CE.7 ELIGIBILITY CRITERIA: EVALUATING INITIAL STEREOTACTIC RADIOSURGERY FOR 5-15 BRAIN METASTASES [Meeting Abstract]
Gurewitz, Jason; Donahue, Bernadine; Silverman, Joshua S.; Benjamin, Carolina; Bernstein, Kenneth; Kondziolka, Douglas
ISI:000590061300765
ISSN: 1522-8517
CID: 4688212
How Many Lesions can be Treated With Radiosurgery? Whole Brain Dose from Radiosurgery of Multiple Targets [Meeting Abstract]
Becker, S. J.; Jozsef, G.; Molitoris, J. K.; Silverman, J. S.; Presser, J.; Kondziolka, D.
ISI:000582521501140
ISSN: 0360-3016
CID: 4686222
Hippocampal Dosimetry In Patients Receiving Radiosurgery For >= 25 Brain Metastases: Implications For HA-WBRT [Meeting Abstract]
Kavi, A.; Gurewitz, J.; Benjamin, C.; Bernstein, K.; Silverman, J. S.; Donahue, B. R.; Kondziolka, D.
ISI:000582521502444
ISSN: 0360-3016
CID: 4686332
PROSPECTIVE OBSERVATIONAL STUDY TO DETERMINE THE IMMUNE SYSTEM RESPONSE TO GAMMA KNIFE RADIOSURGERY FOR VESTIBULAR SCHWANNOMAS [Meeting Abstract]
Silverman, Joshua S.; Gurewitz, Jason; Gunter, Courtney; Cooper, Benjamin; Palermo, Amy; Boulio, Lynda; Schafrick, Jessica; Lim, Whei Ying; Karhan, Ece; Renzullo, Stephanie; Kozhaya, Lina; Golfinos, John; Sulman, Erik; Unutmaz, Derya; Kondziolka, Douglas
ISI:000590061300802
ISSN: 1522-8517
CID: 4688222
An International Radiosurgery Research Foundation Multicenter Retrospective Study of Gamma Ventral Capsulotomy for Obsessive Compulsive Disorder
Gupta, Amitabh; Shepard, Matthew J; Xu, Zhiyuan; Maiti, Tanmoy; Martinez-Moreno, Nuria; Silverman, Joshua; Iorio-Morin, Christian; Martinez-Alvarez, Roberto; Barnett, Gene; Mathieu, David; Borghei-Razavi, Hamid; Kondziolka, Douglas; Sheehan, Jason P
BACKGROUND:Obsessive compulsive disorder (OCD) across its full spectrum of severity is a psychiatric illness affecting ∼2% to 3% of the general population and results in significant functional impairment. There are few large patient series regarding Gamma ventral capsulotomy (GVC). OBJECTIVE:To evaluate clinical outcomes of severe medically refractory OCD treated with GVC. METHODS:This is an international, multicenter, retrospective cohort study. Forty patients with pre-GVC Yale-Brown Obsessive Compulsive Scale (Y-BOCS) scores ≥ 24 (indicating severe OCD) were included. GVC was performed with 1 or 2 isocenters with a median maximum dose of 135 Gy (range, 120-180 Gy). Patients were deemed "responders" to GVC if there was ≥35% reduction of follow-up Y-BOCS scores, and considered in remission if their Y-BOCS scores were ≤16. The median follow-up was 36 mo (range, 6-96 mo). RESULTS:The median pre-SRS Y-BOCS score was 35 (range, 24-40). Eighteen patients (45%) were considered "responders," and 16 (40%) of them were in remission at their last follow-up. Nineteen patients (47.5%) remained stable with Y-BOCS of 33 (range, 26-36) following GVC, whereas 3 patients (7.5%) experienced worsening in Y-BOCS scores. Patients treated with 2 isocenters were more likely to have improvement in Y-BOCS score at 3 and 5 yr (P < .0005). Ten patients (25%) experienced post-GVC mood disturbance and neurological complications in 3 patients (7.5%). One patient developed radiation necrosis with edema that improved with steroids. CONCLUSION/CONCLUSIONS:GVC serves as a reasonable treatment strategy for severe medical refractory OCD. Patients treated with 2 isocenters were more likely to have substantial improvement in OCD.
PMID: 30476294
ISSN: 1524-4040
CID: 4246062
Outcomes of stereotactic radiosurgery for pilocytic astrocytoma: an international multiinstitutional study
Murphy, Erin S; Parsai, Shireen; Kano, Hideyuki; Sheehan, Jason P; Martinez-Alvarez, Roberto; Martinez-Moreno, Nuria; Kondziolka, Douglas; Simonova, Gabriela; Liscak, Roman; Mathieu, David; Lee, Cheng-Chia; Yang, Huai-Che; Lee, John Y; McShane, Brendan J; Fang, Fang; Trifiletti, Daniel M; Sharma, Mayur; Barnett, Gene H
OBJECTIVE:The current standard initial therapy for pilocytic astrocytoma is maximal safe resection. Radiation therapy is considered for residual, recurrent, or unresectable pilocytic astrocytomas. However, the optimal radiation strategy has not yet been established. Here, the authors describe the outcomes of stereotactic radiosurgery (SRS) for pilocytic astrocytoma in a large multiinstitutional cohort. METHODS:An institutional review board-approved multiinstitutional database of patients treated with Gamma Knife radiosurgery (GKRS) between 1990 and 2016 was queried. Data were gathered from 9 participating International Radiosurgery Research Foundation (IRRF) centers. Patients with a histological diagnosis of pilocytic astrocytoma treated using a single session of GKRS and with at least 6 months of follow-up were included in the analysis. RESULTS:A total of 141 patients were analyzed in the study. The median patient age was 14 years (range 2-84 years) at the time of GKRS. The median follow-up was 67.3 months. Thirty-nine percent of patients underwent SRS as the initial therapy, whereas 61% underwent SRS as salvage treatment. The median tumor volume was 3.45 cm3. The tumor location was the brainstem in 30% of cases, with a nonbrainstem location in the remainder. Five- and 10-year overall survival rates at the last follow-up were 95.7% and 92.5%, respectively. Five- and 10-year progression-free survival (PFS) rates were 74.0% and 69.7%, respectively. On univariate analysis, an age < 18 years, tumor volumes < 4.5 cm3, and no prior radiotherapy or chemotherapy were identified as positive prognostic factors for improved PFS. On multivariate analysis, only prior radiotherapy was significant for worse PFS. CONCLUSIONS:This represents the largest study of single-session GKRS for pilocytic astrocytoma to date. Favorable long-term PFS and overall survival were observed with GKRS. Further prospective studies should be performed to evaluate appropriate radiosurgery dosing, timing, and sequencing of treatment along with their impact on toxicity and the quality of life of patients with pilocytic astrocytoma.
PMID: 31783364
ISSN: 1933-0693
CID: 4216282