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197


Can axillary dissection be avoided in patients with sentinel node micrometastasis? The role of pathologic assessment of breast tumors in predicting non-sentinel node metastasis [Meeting Abstract]

Gupta, R; Cangiarella, J; Singh, B; Guth, A; Axelrod, D; Roses, D; Darvishian, F
ISI:000252181100146
ISSN: 0023-6837
CID: 75927

Invasive lobular carcinoma of the breast: role of endothelial lymphatic marker D2-40

Laser, Jordan; Cangiarella, Joan; Singh, Baljit; Melamed, Jonathan; Chiriboga, Luis; Yee, Herman; Darvishian, Farbod
Lymphovascular invasion (LVI) of breast cancer is an independent adverse prognosticator that is associated with increased regional and distant tumor recurrence. LVI is infrequently encountered in invasive lobular carcinoma when compared to invasive ductal carcinoma. We employed D2-40 antibody, a novel marker for lymphatic endothelial cells, in an attempt to enhance the detection of LVI in invasive lobular carcinomas. We identified 78 patients with invasive lobular carcinoma with known axillary status, who were studied between 2003 and 2006. D2-40 antibody was applied to one representative paraffin block from each case and the results were compared to LVI on routine histology. LVI was identified in 12 (15%) and 19 (24%) cases by routine histology and D2-40 antibody, respectively. Eleven of 12 patients (92%) with LVI identified by routine histology had axillary nodal metastasis compared to 14 of 19 patients (74%) with LVI identified by D2-40 antibody. LVI was missed by routine histology in 8 cases (10%). D2-40 antibody enhanced the identification of LVI by 9% in node negative patients. D2-40 antibody increased the identification of LVI by 12% in classic invasive lobular carcinoma. In conclusion, D2-40 antibody staining may be useful as an adjunct in detecting LVI in invasive lobular carcinoma, especially in node-negative patients with the classic variant of invasive lobular carcinoma
PMID: 18469353
ISSN: 1550-8080
CID: 78828

Inflammatory breast cancer pathogenesis is mediated in significant part by translation initiation factor eIF4G amplification and unorthodox protein synthesis [Meeting Abstract]

Silvera, D; Arju, R; Darvishian, F; Levine, PH; Formenli, SC; Schneider, RJ
ISI:000251398500048
ISSN: 0167-6806
CID: 75798

Prophylactic mastectomy - trends in pathology findings [Meeting Abstract]

Wen, YH; Roses, DF; Axelrod, DM; Guth, AA; Shapiro, RL; Cangiarella, J; Ziguridis, N; Darvishian, F; Singh, B
ISI:000251398500377
ISSN: 0167-6806
CID: 75803

Accuracy of intraoperative sentinel lymph node evaluation for breast [Meeting Abstract]

Richards, V; Roses, DF; Axelrod, DM; Guth, AA; Shapiro, RL; Cangiarella, J; Ziguridis, N; Darvishian, F
ISI:000244922400196
ISSN: 0893-3952
CID: 93501

Accuracy of intraoperative sentinel lymph node evaluation for breast cancer [Meeting Abstract]

Richards, V; Roses, DF; Axelrod, DM; Guth, AA; Shapiro, RL; Cangiarella, J; Ziguridis, N; Darvishian, F; Singh, B
ISI:000244935300196
ISSN: 0023-6837
CID: 93502

Impact of complete removal of breast carcinoma by aggressive biopsy techniques [Meeting Abstract]

Wen, YH; Roses, DF; Axelrod, DM; Guth, AA; Shapiro, RL; Cangiarella, J; Ziguridis, N; Darvishian, F; Mercado, C; Singh, B
ISI:000244922400227
ISSN: 0893-3952
CID: 93504

Impact of complete removal of breast carcinoma by aggressive biopsy techniques [Meeting Abstract]

Wen, YH; Roses, DF; Axelrod, DM; Guth, AA; Shapiro, RL; Cangiarella, J; Ziguridis, N; Darvishian, F; Mercado, C; Singh, B
ISI:000244935300227
ISSN: 0023-6837
CID: 93505

Breast carcinoma in women 30 years and younger [Meeting Abstract]

Wen, YH; Roses, DF; Axelrod, DM; Guth, AA; Shapiro, RL; Cangiarella, JF; Ziguridis, N; Darvishian, F; Singh, B
ISI:000244096200156
ISSN: 1068-9265
CID: 93503

Microinvasive breast cancer: The role of sentinel node biopsy [Meeting Abstract]

Guth, AA; Mercado, C; Roses, DF; Darvishian, F; Singh, B; Cangiarella, JF
ISI:000244096200132
ISSN: 1068-9265
CID: 71054