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Multiple Sclerosis and EDSS: A Walking Scale Standing on No Apparent Legs [Meeting Abstract]
Zarif, Myassar; Wissemann, Karl; Marcote, Peter; Bumstead, Barbara; Burke, Christina; Fafard, Lori; Thotam, Smitha; Buhse, Marijean; Sosnoff, Jacob; Muratori, Lisa; Gudesblatt, Mark
ISI:000411279005019
ISSN: 0028-3878
CID: 5343492
Multiple Sclerosis, EDSS and Gait: Putting Legs That Work on a Walking Scale [Meeting Abstract]
Muratori, Lisa; Martin, Erin; Fafard, Lori; Bumstead, Barbara; Zarif, Myassar; Gudesblatt, Mark
ISI:000411279005180
ISSN: 0028-3878
CID: 5343502
Multiple Sclerosis: Population Analysis of Predicted Medication Adherence Behavior by Morisky Medication Adherence Scale [Meeting Abstract]
Wissemann, Karl; Gudesblatt, Mark; Bumstead, Barbara; Zarif, Myassar; Fafard, Lori; Thotam, Smitha; Buhse, Marijean; Golan, Daniel; Becker, Shenira; Sullivan, Cynthia; Wilken, Jeffrey; Morisky, Donald
ISI:000411279005186
ISSN: 0028-3878
CID: 5343512
Multiple Sclerosis, EDSS and Walking: Computerized Objective Gait Analysis of the Impact of a 6-Minute Timed Walk on Selected Gait Characteristics in People with Multiple Sclerosis - Putting Long Legs on a Walking Scale [Meeting Abstract]
Burke, Christina; Gudesblatt, Mark; Wissemann, Karl; Zarif, Myassar; Bumstead, Barbara; Fafard, Lori; Thotam, Smitha; Magel, John; Buhse, Marijean; Muratori, Lisa
ISI:000411279005215
ISSN: 0028-3878
CID: 5343522
Multiple Sclerosis, Fatigue and Discordant Patient Reported Outcomes: Sleep Quality (Sleep-NeuroQoL), Neurological Disability and Depression [Meeting Abstract]
Gudesblatt, Mark; Wissemann, Karl; Zarif, Myassar; Bumstead, Barbara; Fafard, Lori; Sullivan, Cynthia; Wilken, Jeffrey; Buhse, Marijean; Golan, Daniel
ISI:000411279005231
ISSN: 0028-3878
CID: 5343532
Autoimmunity & Autonomic Impairment: Preliminary Characterization of a Clinical Syndrome with Sjogren's Features Associated with Novel Organ Specific Antibodies [Meeting Abstract]
Gudesblatt, Mark; Wissemann, Karl; Stiles, Lauren; Xian, Steven; Zarif, Myassar; Fafard, Lori; Bumstead, Barbara; Loftus, Hos; Jadoo, Cindy; Buhse, Marijean; Jamison-Forgnone, Jennifer; Suresh, Lakshmanan
ISI:000411328605202
ISSN: 0028-3878
CID: 5343542
Effects of delayed-release dimethyl fumarate on MRI measures in the phase 3 CONFIRM study
Miller, David H; Fox, Robert J; Phillips, J Theodore; Hutchinson, Michael; Havrdova, Eva; Kita, Mariko; Wheeler-Kingshott, Claudia A M; Tozer, Daniel J; MacManus, David G; Yousry, Tarek A; Goodsell, Mary; Yang, Minhua; Zhang, Ray; Viglietta, Vissia; Dawson, Katherine T; Wilson, Kate; Antel, Jack; Ware, James; Polman, Chris; Kowey, Peter R; Chung, Raymond; Bakris, George; Richert, John; Seibert, Burt; Brandes, David; Brassat, David; Cohen, Bruce; Diem, Ricarda; Goldman, Myla; Herndon, Robert; Miller, Aaron; Tumani, Hayrettin; Alfaro-Vidal, Teresa; Crespo, Carolina; Foster, Jo; Hunter, Kelvin; Garcia-Gomez, Almudena; Santana, Virginia; Kneebone, Christopher; Fedulau, Aliaksandr; Likhachev, Sergey; Mikhailova, Elena; Naumova, Halina; Decoo, Danny; Gaer, Luc Vande; Sindic, Christian; Grgic, Sanja; Sinanovic, Osman; Suljic, Enra Mehmedika; Deleva, Nadezhda; Georgiev, Dimitar; Haralanov, Lyubomir; Ivanova, Sonyia; Manchev, Ivan; Minchev, Dimitar; Stamenova, Paraskeva; Tournev, Ivailo; Vacheva, Elena; Zahariev, Zahari; Bar-Or, Amit; Blevins, Gregg; Kremenchutzky, Marcelo; Veloso, Felix; Witt, Norbert; Vargas Howell, Roberto; Vindas, Alexander Parajeles; Habek, Mario; Rudež, Josip; Soldo-Butković, Silva; Vurdelja, Ranka Baraba; Doležil, David; Havrdova, Eva; Nova'k, JiÅ™Ã; Vaclavik, Daniel; Antsov, Katrin; Gross-Paju, Katrin; Haldre, Sulev; Palu, Alla; Toomsoo, Toomas; Al Khedr, Abdullatif; Camu, William; Debouverie, Marc; Defer, Gilles; De Seze, Jérôme; Labauge, Pierre; Moreau, Thibault; Pelletier, Jean; Rumbach, Lucien; Daskalovska, Vera; Angnstwurm, Klemens; Benes, Heike; Berthele, Achim; Boldt, Hans-Jürgen; Christopher, Angelika; Derfuß, Tobias; Eisensehr, Ilonka; Emrich, Peter; Feneberg, Wolfgang; Hoffmann, Frank; Hohlfeld, Reinhard; Hüntemann, Reinhard; Kallmann, Boris-Alexander; Kieseier, Bernd; Landefeld, Harald; Lüer, Wilfried; Masri, Sabine; Nelles, Gereon; Oschmann, Patrick; Paschen, Christine; Reifschneider, Gerd; Sailer, Michael; Schimrigk, Sebastian; Spiegel-Meixensberger, Mechthild; Storch-Hagenlocher, Brigitte; Tackenberg, Björn; Tiel-Wilck, Klaus; Karageorgiou, Clementine; Papathanasopoulos, Panagiotis; Thomaides, Thomas; Vlaikidis, Nicholas; Arjundas, Deepak; Behari, Madhuri; Ghosh, Amitabha; Ghosh, Pahari; Ichaporia, Nasli Rustom; Khurana, Dheeraj; Kulkarni, Rahul Vitthal; Kumar, Suresh; Mehndiratta, Man Mohan; Mehta, Neeta Abhay; Misra, Usha Kant; Mukherji, Joy Dev; Nellikunja, Shankara; Salem, Abdul; Sethi, Prahlad Kumar; Shah, Shalin Dipinkumar; Singh, Gagandeep; Singh, Maneesh Kumar; Singh, Yash Pal; Srinivasa, Rangasetty; Vijayan, Krishnan; Sweeney, Bernard; Gilad, Ronit; Shahien, Radi; Paegle, Anita; Delgado, Cesar; Escamilla, Juan; Estañol, Bruno; Lopez, Minerva; Macias, Miguel Angel; Punzo, Guillermo; Quiñones, Sandra; Renteria, Mariela; Santos, Jose; Gavriliuc, Mihail; Groppa, Stanislav; Odainic, Olesea; Timmings, Paul; Czlonkowska, Anna; Dorobek, Malgorzata; Drozdowski, Wieslaw; Fryze, Waldemar; Hertmanowska, Hanka; Kaminska, Anna; Kapelusiak-Pielok, Magdalena; Kleczkowska, Magdalena; Kochanowicz, Jan; Losy, Jacek; Nowacki, Przemyslaw; Nyka, Walenty; Pierzchala, Krystyna; Podemski, Ryszard; Potemkowski, Andrzej; Selmaj, Krzysztof; Stelmasiak, Zbigniew; Szczudlik, Andrzej; Tutaj, Andrzej; Wajgt, Andrzej; Zielinski, Tomasz; Balasa, Rodica; Ionescu-Dimancea, Valentin; Mihancea, Petru; Popescu, Cristian; Protosevici, Liviu Codrut; Miletić Drakulić, Svetlana; Nadj, Congor; Raicevic, Ranko; Vojinovic, Slobodan; Kahancová, Edita; Kurca, Egon; Lisý, L'ubomir; TurÄáni, Peter; Arroyo, Rafael; Fernández, Oscar; Guijarro, Cristina; Izquierdo, Guillermo; Lopez, Fernando Sanchez; Montalbán, Xavier; Oreja-Guevara, Celia; Prieto, Jose Maria; Buchakchyys'ka, Nataliya; Chmyr, Galyna; Goloborodko, Alla; Kobys, Tetyana; Kushnir, Grygory; Lebedynets, Volodymyr; Lytvynenko, Nataliya; Moskovko, Sergii; Nehrych, Tetyana; Palamar, Borys; Pasyura, Igor; Ryabichenko, Tatyana; Voloshina, Nataliya; Apperson, Michelle; Applebee, Angela; Asher, Stephen; Ayala, Ricardo; Ayres, Donald; Azizi, S Ausim; Baker, Matthew; Bauer, Brendan; Bomprezzi, Roberto; Buckler, Richard; Carlini, Walter; Chinea, Angel; Cohan, Stanley; Crowell, Giles; Edwards, Keith; Eubank, Geoffery; Felton, Warren 3rd; Fodor, Patricia; Foley, John; Ford, Corey; Fox, Edward; Fox, Robert; Forester, Mary; Freedman, Steven; Garmany, George Jr; Gazda, Suzanne; Giang, Daniel; Glaun, Braeme; Gold, Scott; Gottesman, Malcolm; Gudesblatt, Mark; Herbert, Joseph; Herskowitz, Allan; Honeycutt, William; Huddlestone, John; Hull, Richard; Hunter, Samuel; Hutton, George; Jacobs, Dina; Janicki, Mark; Khatri, Bhupendra; Kinkel, Revere Philip; Kita, Mariko; Krolczyk, Stanley; Krupp, Lauren; LaGanke, Christopher; Levin, Michael; Licht, Jonathan; Luzzio, Christopher; Lynch, Sharon; Mattson, David; Mikol, Daniel; Miller, Tamara; Minagar, Alireza; Mitchell, Galen; Moses, Harold Jr; Negroski, Donald; Newman, Stephen; Pardo, Gabriel; Patel, Malti; Perel, Allan; Phillips, Joseph Jr; Picone, Mary Ann; Rammohan, Kottil; Rao, T Hemanth; Rinker, John 2nd; Sadiq, Saud; Schaeffer, John; Sheremata, William; Shin, Robert; Shubin, Richard; Silverman, Stuart; Smith, Robert; Stein, Lee; Stein, Michael; Steiner, David; Steingo, Brian; Sullivan, Herman; Sunter, William Jr; Vaishnav, Anand; Vasquez, Alberto; Voci, James; Warach, Jonathan; Weinstock-Guttman, Bianca; Williams, Mitzi; Wray, Sibyl
OBJECTIVE:To evaluate the effects of oral delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF) on MRI lesion activity and load, atrophy, and magnetization transfer ratio (MTR) measures from the Comparator and an Oral Fumarate in Relapsing-Remitting Multiple Sclerosis (CONFIRM) study. METHODS:CONFIRM was a 2-year, placebo-controlled study of the efficacy and safety of DMF 240 mg twice (BID) or 3 times daily (TID) in 1,417 patients with relapsing-remitting multiple sclerosis (RRMS); subcutaneous glatiramer acetate 20 mg once daily was included as an active reference comparator. The number and volume of T2-hyperintense, T1-hypointense, and gadolinium-enhancing (Gd+) lesions, as well as whole brain volume and MTR, were assessed in 681 patients (MRI cohort). RESULTS:DMF BID and TID produced significant and consistent reductions vs placebo in the number of new or enlarging T2-hyperintense lesions and new nonenhancing T1-hypointense lesions after 1 and 2 years of treatment and in the number of Gd+ lesions at week 24, year 1, and year 2. Lesion volumes were also significantly reduced. Reductions in brain atrophy and MTR changes with DMF relative to placebo did not reach statistical significance. CONCLUSIONS:The robust effects on MRI active lesion counts and total lesion volume in patients with RRMS demonstrate the ability of DMF to exert beneficial effects on inflammatory lesion activity in multiple sclerosis, and support DMF therapy as a valuable new treatment option in RRMS. CLASSIFICATION OF EVIDENCE/METHODS:This study provides Class I evidence of reduction in brain lesion number and volume, as assessed by MRI, over 2 years of delayed-release DMF treatment.
PMCID:4371413
PMID: 25681448
ISSN: 1526-632x
CID: 5348212
Regional gray matter atrophy in relapsing remitting multiple sclerosis: baseline analysis of multi-center data
Datta, Sushmita; Staewen, Terrell D; Cofield, Stacy S; Cutter, Gary R; Lublin, Fred D; Wolinsky, Jerry S; Narayana, Ponnada A; Nelson, F; Vainrub, I; Gates, B; Ton, K; Agius, M; Bashir, K; Baumhefner, R; Birnbaum, G; Blevins, G; Bomprezzi, R; Boster, A; Brown, T; Burkholder, J; Camac, A; Campagnolo, D; Carter, J; Cohen, B; Cooper, J; Corboy, J; Cross, A; Dewitt, L; Dunn, J; Edwards, K; Eggenberger, E; English, J; Felton, W; Fodor, P; Freedman, M; Galetta, S; Garmany, G; Goodman, A; Gottesman, M; Gottschalk, C; Gruental, M; Gudesblatt, M; Hamill, R; Herbert, J; Holub, R; Honeycutt, W; Hughes, B; Hutton, G; Jacobs, D; Johnson, K; Kasper, L; Kattah, J; Kaufman, M; Keegan, M; Khan, O; Khatri, B; Kita, M; Koffman, B; Lallana, E; Lindsey, J; Loge, P; Lynch, S; McGee, F; Mejico, L; Metz, L; O'Connor, P; Pandey, K; Panitch, H; Preiningerova, J; Rammohan, K; Riley, C; Riskind, P; Rolak, L; Royal, W; Scarberry, S; Schulman, A; Scott, T; Sheppard, C; Sheremata, W; Stone, L; Stuart, W; Subramaniam, S; Thadani, V; Thomas, F; Thrower, B; Tullman, M; Turel, A; Vollmer, T; Waldman, S; Wendt, J; Williams, R; Yeung, M
Regional gray matter (GM) atrophy in multiple sclerosis (MS) at disease onset and its temporal variation can provide objective information regarding disease evolution. An automated pipeline for estimating atrophy of various GM structures was developed using tensor based morphometry (TBM) and implemented on a multi-center sub-cohort of 1008 relapsing remitting MS (RRMS) patients enrolled in a Phase 3 clinical trial. Four hundred age and gender matched healthy controls were used for comparison. Using the analysis of covariance, atrophy differences between MS patients and healthy controls were assessed on a voxel-by-voxel analysis. Regional GM atrophy was observed in a number of deep GM structures that included thalamus, caudate nucleus, putamen, and cortical GM regions. General linear regression analysis was performed to analyze the effects of age, gender, and scanner field strength, and imaging sequence on the regional atrophy. Correlations between regional GM volumes and expanded disability status scale (EDSS) scores, disease duration (DD), T2 lesion load (T2 LL), T1 lesion load (T1 LL), and normalized cerebrospinal fluid (nCSF) were analyzed using Pearson׳s correlation coefficient. Thalamic atrophy observed in MS patients compared to healthy controls remained consistent within subgroups based on gender and scanner field strength. Weak correlations between thalamic volume and EDSS (r=-0.133; p<0.001) and DD (r=-0.098; p=0.003) were observed. Of all the structures, thalamic volume moderately correlated with T2 LL (r=-0.492; P-value<0.001), T1 LL (r=-0.473; P-value<0.001) and nCSF (r=-0.367; P-value<0.001).
PMCID:4366621
PMID: 25787188
ISSN: 2211-0356
CID: 5348172
Effect of in-painting on cortical thickness measurements in multiple sclerosis: A large cohort study
Govindarajan, Koushik A; Datta, Sushmita; Hasan, Khader M; Choi, Sangbum; Rahbar, Mohammad H; Cofield, Stacey S; Cutter, Gary R; Lublin, Fred D; Wolinsky, Jerry S; Narayana, Ponnada A; Agius, M; Bashir, K; Baumhefner, R; Birnbaum, G; Blevins, G; Bomprezzi, R; Boster, A; Brown, T; Burkholder, J; Camac, A; Campagnolo, D; Carter, J; Cohen, B; Cooper, J; Corboy, J; Cross, A; Dewitt, L; Dunn, J; Edwards, K; Eggenberger, E; English, J; Felton, W; Fodor, P; Ford, C; Freedman, M; Galetta, S; Garmany, G; Goodman, A; Gottesman, M; Gottschalk, C; Gruental, M; Gudesblatt, M; Hamill, R; Herbert, J; Holub, R; Honeycutt, W; Hughes, B; Hutton, G; Jacobs, D; Johnson, K; Kasper, L; Kattah, J; Kaufman, M; Keegan, M; Khan, O; Khatri, B; Kita, M; Koffman, B; Lallana, E; Lava, N; Lindsey, J; Loge, P; Lynch, S; McGee, F; Mejico, L; Metz, L; O'Connor, P; Pandey, K; Panitch, H; Preiningerova, J; Rammohan, K; Riley, C; Riskind, P; Rolak, L; Royal, W; Scarberry, S; Schulman, A; Scott, T; Sheppard, C; Sheremata, W; Stone, L; Stuart, W; Subramaniam, S; Thadani, V; Thomas, F; Louis, Saint; Thrower, B; Tullman, M; Turel, A; Vollmer, T; Waldman, S; Weinstock-Guttman, B; Wendt, J; Williams, R; Wynn, D; Yeung, M
A comprehensive analysis of the effect of lesion in-painting on the estimation of cortical thickness using magnetic resonance imaging was performed on a large cohort of 918 relapsing-remitting multiple sclerosis patients who participated in a phase III multicenter clinical trial. An automatic lesion in-painting algorithm was developed and implemented. Cortical thickness was measured using the FreeSurfer pipeline with and without in-painting. The effect of in-painting was evaluated using FreeSurfer's paired analysis pipeline. Multivariate regression analysis was also performed with field strength and lesion load as additional factors. Overall, the estimated cortical thickness was different with in-painting than without. The effect of in-painting was observed to be region dependent, more significant in the left hemisphere compared to the right, was more prominent at 1.5 T relative to 3 T, and was greater at higher lesion volumes. Our results show that even for data acquired at 1.5 T in patients with high lesion load, the mean cortical thickness difference with and without in-painting is ∼2%. Based on these results, it appears that in-painting has only a small effect on the estimated regional and global cortical thickness. Hum Brain Mapp 36:3749-3760, 2015. © 2015 Wiley Periodicals, Inc.
PMCID:4839289
PMID: 26096844
ISSN: 1097-0193
CID: 5348142
The relationship between objective parameters of sleep and measures of fatigue, depression, and cognition in multiple sclerosis
Sater, R A; Gudesblatt, M; Kresa-Reahl, K; Brandes, D W; Sater, P A
BACKGROUND:People with multiple sclerosis (MS) often report poor sleep, fatigue, sleepiness, depression and cognitive dysfunction. Interrelationships between symptoms and sleep are poorly understood. OBJECTIVES/OBJECTIVE:To document objective parameters of sleep measured by polysomnography (PSG) and multi-sleep latency tests (MSLTs) in patients experiencing fatigue or sleepiness and to determine whether they correlate with symptoms. METHODS:Thirty-two MS patients, not on therapy, with fatigue or sleepiness completed the Modified Fatigue Impact Scale, Fatigue Severity Scale, Epworth Sleepiness Scale, Beck Depression Index and NeuroTrax cognitive tests and underwent PSG and MSLTs. RESULTS:Sleep efficiency (SE) averaged 75.1%. wake after sleep onset (WASO), sleep onset latency and multi-sleep latency were 66.2, 43.4 and 10.43 min, respectively. Stage N3 and rapid eye movement sleep were absent in 10 and four patients, respectively. Increased limb movements were observed in eight patients. Obstructive sleep apnea was observed in 12 patients. Neither SE nor WASO correlated with fatigue or sleepiness. SE correlated with the global cognitive score and with executive function and information processing subscales. CONCLUSIONS:Overall, 30/32 MS patients reporting fatigue or sleepiness had evidence of one or more sleep disturbances. PSG should be considered in MS patients reporting fatigue or sleepiness in order to rule out treatable disturbances.
PMCID:5433423
PMID: 28607689
ISSN: 2055-2173
CID: 5342492
