Faculty Bibliography

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257

Multiple sclerosis. 2016:22:781-782.DOI:

Effect of delayed-release dimethyl fumarate on lymphocyte subsets in patients with relapsing multiple sclerosis: a retrospective, multicentre, observational study (REALIZE) [Meeting Abstract]

Buckle, G.; Bandari, D.; Greenstein, J.; Gudesblatt, M.; Khatri, B.; Kita, M.; Repovic, P.; Riser, E.; Weinstock-Guttman, B.; Potts, J.; Everage, N.; von Hehn, C.; Mann, M.
ISI:000383267203160
ISSN: 1352-4585
CID: 5343452
Neurology. 2016:86.DOI:

Transcranial Doppler Bubble Detection of Paradoxical Emboli and the Presence of Brain Atrophy in People with Migraine: A Cause for Alarm? [Meeting Abstract]

Dunham, Patricia; Wissemann, Karl; Salomone, Danielle; Buhse, Marijean; Fafard, Lori; Zarif, Myassar; Gudesblatt, Mark
ISI:000411279001396
ISSN: 0028-3878
CID: 5343472
Neurology. 2016:86.DOI:

Multiple Sclerosis, EDSS and Gait: Pulling Legs That Work on a Walking Scale [Meeting Abstract]

Muratori, Lisa; Martin, Erin; Fafard, Lori; Bumstead, Barbara; Zarif, Myassar; Gudesblatt, Mark
ISI:000411279004418
ISSN: 0028-3878
CID: 5343482
Neurology. 2016:86.DOI:

Multiple Sclerosis and EDSS: A Walking Scale Standing on No Apparent Legs [Meeting Abstract]

Zarif, Myassar; Wissemann, Karl; Marcote, Peter; Bumstead, Barbara; Burke, Christina; Fafard, Lori; Thotam, Smitha; Buhse, Marijean; Sosnoff, Jacob; Muratori, Lisa; Gudesblatt, Mark
ISI:000411279005019
ISSN: 0028-3878
CID: 5343492
Neurology. 2016:86.DOI:

Multiple Sclerosis, EDSS and Gait: Putting Legs That Work on a Walking Scale [Meeting Abstract]

Muratori, Lisa; Martin, Erin; Fafard, Lori; Bumstead, Barbara; Zarif, Myassar; Gudesblatt, Mark
ISI:000411279005180
ISSN: 0028-3878
CID: 5343502
Neurology. 2016:86.DOI:

Multiple Sclerosis: Population Analysis of Predicted Medication Adherence Behavior by Morisky Medication Adherence Scale [Meeting Abstract]

Wissemann, Karl; Gudesblatt, Mark; Bumstead, Barbara; Zarif, Myassar; Fafard, Lori; Thotam, Smitha; Buhse, Marijean; Golan, Daniel; Becker, Shenira; Sullivan, Cynthia; Wilken, Jeffrey; Morisky, Donald
ISI:000411279005186
ISSN: 0028-3878
CID: 5343512
Neurology. 2016:86.DOI:

Multiple Sclerosis, EDSS and Walking: Computerized Objective Gait Analysis of the Impact of a 6-Minute Timed Walk on Selected Gait Characteristics in People with Multiple Sclerosis - Putting Long Legs on a Walking Scale [Meeting Abstract]

Burke, Christina; Gudesblatt, Mark; Wissemann, Karl; Zarif, Myassar; Bumstead, Barbara; Fafard, Lori; Thotam, Smitha; Magel, John; Buhse, Marijean; Muratori, Lisa
ISI:000411279005215
ISSN: 0028-3878
CID: 5343522
Neurology. 2016:86.DOI:

Multiple Sclerosis, Fatigue and Discordant Patient Reported Outcomes: Sleep Quality (Sleep-NeuroQoL), Neurological Disability and Depression [Meeting Abstract]

Gudesblatt, Mark; Wissemann, Karl; Zarif, Myassar; Bumstead, Barbara; Fafard, Lori; Sullivan, Cynthia; Wilken, Jeffrey; Buhse, Marijean; Golan, Daniel
ISI:000411279005231
ISSN: 0028-3878
CID: 5343532
Neurology. 2016:86.DOI:

Autoimmunity & Autonomic Impairment: Preliminary Characterization of a Clinical Syndrome with Sjogren's Features Associated with Novel Organ Specific Antibodies [Meeting Abstract]

Gudesblatt, Mark; Wissemann, Karl; Stiles, Lauren; Xian, Steven; Zarif, Myassar; Fafard, Lori; Bumstead, Barbara; Loftus, Hos; Jadoo, Cindy; Buhse, Marijean; Jamison-Forgnone, Jennifer; Suresh, Lakshmanan
ISI:000411328605202
ISSN: 0028-3878
CID: 5343542
Neurology. 2015:84(11):1145-52.DOI: 10.1212/WNL.0000000000001360

Effects of delayed-release dimethyl fumarate on MRI measures in the phase 3 CONFIRM study

Miller, David H; Fox, Robert J; Phillips, J Theodore; Hutchinson, Michael; Havrdova, Eva; Kita, Mariko; Wheeler-Kingshott, Claudia A M; Tozer, Daniel J; MacManus, David G; Yousry, Tarek A; Goodsell, Mary; Yang, Minhua; Zhang, Ray; Viglietta, Vissia; Dawson, Katherine T; Wilson, Kate; Antel, Jack; Ware, James; Polman, Chris; Kowey, Peter R; Chung, Raymond; Bakris, George; Richert, John; Seibert, Burt; Brandes, David; Brassat, David; Cohen, Bruce; Diem, Ricarda; Goldman, Myla; Herndon, Robert; Miller, Aaron; Tumani, Hayrettin; Alfaro-Vidal, Teresa; Crespo, Carolina; Foster, Jo; Hunter, Kelvin; Garcia-Gomez, Almudena; Santana, Virginia; Kneebone, Christopher; Fedulau, Aliaksandr; Likhachev, Sergey; Mikhailova, Elena; Naumova, Halina; Decoo, Danny; Gaer, Luc Vande; Sindic, Christian; Grgic, Sanja; Sinanovic, Osman; Suljic, Enra Mehmedika; Deleva, Nadezhda; Georgiev, Dimitar; Haralanov, Lyubomir; Ivanova, Sonyia; Manchev, Ivan; Minchev, Dimitar; Stamenova, Paraskeva; Tournev, Ivailo; Vacheva, Elena; Zahariev, Zahari; Bar-Or, Amit; Blevins, Gregg; Kremenchutzky, Marcelo; Veloso, Felix; Witt, Norbert; Vargas Howell, Roberto; Vindas, Alexander Parajeles; Habek, Mario; Rudež, Josip; Soldo-Butković, Silva; Vurdelja, Ranka Baraba; Doležil, David; Havrdova, Eva; Nova'k, Jiří; Vaclavik, Daniel; Antsov, Katrin; Gross-Paju, Katrin; Haldre, Sulev; Palu, Alla; Toomsoo, Toomas; Al Khedr, Abdullatif; Camu, William; Debouverie, Marc; Defer, Gilles; De Seze, Jérôme; Labauge, Pierre; Moreau, Thibault; Pelletier, Jean; Rumbach, Lucien; Daskalovska, Vera; Angnstwurm, Klemens; Benes, Heike; Berthele, Achim; Boldt, Hans-Jürgen; Christopher, Angelika; Derfuß, Tobias; Eisensehr, Ilonka; Emrich, Peter; Feneberg, Wolfgang; Hoffmann, Frank; Hohlfeld, Reinhard; Hüntemann, Reinhard; Kallmann, Boris-Alexander; Kieseier, Bernd; Landefeld, Harald; Lüer, Wilfried; Masri, Sabine; Nelles, Gereon; Oschmann, Patrick; Paschen, Christine; Reifschneider, Gerd; Sailer, Michael; Schimrigk, Sebastian; Spiegel-Meixensberger, Mechthild; Storch-Hagenlocher, Brigitte; Tackenberg, Björn; Tiel-Wilck, Klaus; Karageorgiou, Clementine; Papathanasopoulos, Panagiotis; Thomaides, Thomas; Vlaikidis, Nicholas; Arjundas, Deepak; Behari, Madhuri; Ghosh, Amitabha; Ghosh, Pahari; Ichaporia, Nasli Rustom; Khurana, Dheeraj; Kulkarni, Rahul Vitthal; Kumar, Suresh; Mehndiratta, Man Mohan; Mehta, Neeta Abhay; Misra, Usha Kant; Mukherji, Joy Dev; Nellikunja, Shankara; Salem, Abdul; Sethi, Prahlad Kumar; Shah, Shalin Dipinkumar; Singh, Gagandeep; Singh, Maneesh Kumar; Singh, Yash Pal; Srinivasa, Rangasetty; Vijayan, Krishnan; Sweeney, Bernard; Gilad, Ronit; Shahien, Radi; Paegle, Anita; Delgado, Cesar; Escamilla, Juan; Estañol, Bruno; Lopez, Minerva; Macias, Miguel Angel; Punzo, Guillermo; Quiñones, Sandra; Renteria, Mariela; Santos, Jose; Gavriliuc, Mihail; Groppa, Stanislav; Odainic, Olesea; Timmings, Paul; Czlonkowska, Anna; Dorobek, Malgorzata; Drozdowski, Wieslaw; Fryze, Waldemar; Hertmanowska, Hanka; Kaminska, Anna; Kapelusiak-Pielok, Magdalena; Kleczkowska, Magdalena; Kochanowicz, Jan; Losy, Jacek; Nowacki, Przemyslaw; Nyka, Walenty; Pierzchala, Krystyna; Podemski, Ryszard; Potemkowski, Andrzej; Selmaj, Krzysztof; Stelmasiak, Zbigniew; Szczudlik, Andrzej; Tutaj, Andrzej; Wajgt, Andrzej; Zielinski, Tomasz; Balasa, Rodica; Ionescu-Dimancea, Valentin; Mihancea, Petru; Popescu, Cristian; Protosevici, Liviu Codrut; Miletić Drakulić, Svetlana; Nadj, Congor; Raicevic, Ranko; Vojinovic, Slobodan; Kahancová, Edita; Kurca, Egon; Lisý, L'ubomir; Turčáni, Peter; Arroyo, Rafael; Fernández, Oscar; Guijarro, Cristina; Izquierdo, Guillermo; Lopez, Fernando Sanchez; Montalbán, Xavier; Oreja-Guevara, Celia; Prieto, Jose Maria; Buchakchyys'ka, Nataliya; Chmyr, Galyna; Goloborodko, Alla; Kobys, Tetyana; Kushnir, Grygory; Lebedynets, Volodymyr; Lytvynenko, Nataliya; Moskovko, Sergii; Nehrych, Tetyana; Palamar, Borys; Pasyura, Igor; Ryabichenko, Tatyana; Voloshina, Nataliya; Apperson, Michelle; Applebee, Angela; Asher, Stephen; Ayala, Ricardo; Ayres, Donald; Azizi, S Ausim; Baker, Matthew; Bauer, Brendan; Bomprezzi, Roberto; Buckler, Richard; Carlini, Walter; Chinea, Angel; Cohan, Stanley; Crowell, Giles; Edwards, Keith; Eubank, Geoffery; Felton, Warren 3rd; Fodor, Patricia; Foley, John; Ford, Corey; Fox, Edward; Fox, Robert; Forester, Mary; Freedman, Steven; Garmany, George Jr; Gazda, Suzanne; Giang, Daniel; Glaun, Braeme; Gold, Scott; Gottesman, Malcolm; Gudesblatt, Mark; Herbert, Joseph; Herskowitz, Allan; Honeycutt, William; Huddlestone, John; Hull, Richard; Hunter, Samuel; Hutton, George; Jacobs, Dina; Janicki, Mark; Khatri, Bhupendra; Kinkel, Revere Philip; Kita, Mariko; Krolczyk, Stanley; Krupp, Lauren; LaGanke, Christopher; Levin, Michael; Licht, Jonathan; Luzzio, Christopher; Lynch, Sharon; Mattson, David; Mikol, Daniel; Miller, Tamara; Minagar, Alireza; Mitchell, Galen; Moses, Harold Jr; Negroski, Donald; Newman, Stephen; Pardo, Gabriel; Patel, Malti; Perel, Allan; Phillips, Joseph Jr; Picone, Mary Ann; Rammohan, Kottil; Rao, T Hemanth; Rinker, John 2nd; Sadiq, Saud; Schaeffer, John; Sheremata, William; Shin, Robert; Shubin, Richard; Silverman, Stuart; Smith, Robert; Stein, Lee; Stein, Michael; Steiner, David; Steingo, Brian; Sullivan, Herman; Sunter, William Jr; Vaishnav, Anand; Vasquez, Alberto; Voci, James; Warach, Jonathan; Weinstock-Guttman, Bianca; Williams, Mitzi; Wray, Sibyl
OBJECTIVE:To evaluate the effects of oral delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF) on MRI lesion activity and load, atrophy, and magnetization transfer ratio (MTR) measures from the Comparator and an Oral Fumarate in Relapsing-Remitting Multiple Sclerosis (CONFIRM) study. METHODS:CONFIRM was a 2-year, placebo-controlled study of the efficacy and safety of DMF 240 mg twice (BID) or 3 times daily (TID) in 1,417 patients with relapsing-remitting multiple sclerosis (RRMS); subcutaneous glatiramer acetate 20 mg once daily was included as an active reference comparator. The number and volume of T2-hyperintense, T1-hypointense, and gadolinium-enhancing (Gd+) lesions, as well as whole brain volume and MTR, were assessed in 681 patients (MRI cohort). RESULTS:DMF BID and TID produced significant and consistent reductions vs placebo in the number of new or enlarging T2-hyperintense lesions and new nonenhancing T1-hypointense lesions after 1 and 2 years of treatment and in the number of Gd+ lesions at week 24, year 1, and year 2. Lesion volumes were also significantly reduced. Reductions in brain atrophy and MTR changes with DMF relative to placebo did not reach statistical significance. CONCLUSIONS:The robust effects on MRI active lesion counts and total lesion volume in patients with RRMS demonstrate the ability of DMF to exert beneficial effects on inflammatory lesion activity in multiple sclerosis, and support DMF therapy as a valuable new treatment option in RRMS. CLASSIFICATION OF EVIDENCE/METHODS:This study provides Class I evidence of reduction in brain lesion number and volume, as assessed by MRI, over 2 years of delayed-release DMF treatment.
PMCID:4371413
PMID: 25681448
ISSN: 1526-632x
CID: 5348212