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252


Malignant melanoma in the 1990s: the continued importance of early detection and the role of physician examination and self-examination of the skin

Friedman RJ; Rigel DS; Silverman MK; Kopf AW; Vossaert KA
Despite the exciting new techniques being developed to help diagnose early malignant melanoma, the current standard of care remains periodic examination of the skin. The combination of routine physician examination coupled with self-examination of the skin provides an opportunity for the identification of early malignant melanoma. Removal of such thin lesions can significantly reduce the ever-increasing mortality rate from this potentially serious form of cutaneous cancer
PMID: 2049635
ISSN: 0007-9235
CID: 13970

Prospective follow-up for malignant melanoma in patients with atypical-mole (dysplastic-nevus) syndrome

Tiersten AD; Grin CM; Kopf AW; Gottlieb GJ; Bart RS; Rigel DS; Friedman RJ; Levenstein MJ
A total of 357 white patients who had melanocytic nevi that fulfilled the clinical criteria for the 'classic' atypical-mole (dysplastic-nevus) syndrome (100 or more melanocytic nevi; one or more melanocytic nevi 8 mm or larger in diameter; and, one or more melanocytic nevi with atypical features) were followed for the development of cutaneous malignant melanomas. Seventeen patients (4.8%) developed malignant melanomas during an average follow-up period of 49 months. One patient developed two malignant melanomas. Eight of the malignant melanomas detected were in situ and ten were invasive melanomas (less than 0.86 mm in Breslow thickness), implying an excellent prognosis. The number of malignant melanomas detected in these patients exceeded significantly the number expected to occur in age- and sex-matched white controls. All groups were shown to have an increased risk for the development of malignant melanomas. Total-body photographs were helpful in detecting changes in size, shape, and color that led to the diagnosis of malignant melanoma. These data support the concept that patients with this readily regionalized clinical presentation of classic atypical-mole syndrome are at an increased risk for malignant melanomas and, therefore, should be examined regularly
PMID: 1991880
ISSN: 0148-0812
CID: 8192

Cancer of the skin

Friedman, Robert J.; Rigel, Darrell S.; Kopf, Alfred W.; Harris, Matthew N.; Baker, Daniel C
Philadelphia : Saunders, 1991
Extent: xvii, 620 p. : ill. (some col.) ; 29 cm
ISBN: n/a
CID: 244

Melanoma

Rigel, Darrell S.; Thiers, Bruce H
Philadelphia, PA : Saunders, 1991
Extent: xv p., p. 617-830 : ill. ; 27 cm
ISBN: n/a
CID: 363

Clinical characteristics of malignant melanomas developing in persons with dysplastic nevi

Rivers JK; Kopf AW; Vinokur AF; Rigel DS; Friedman RJ; Heilman ER; Levenstein M
A total of 452 patients with dysplastic nevi (DN) were followed prospectively by repetitive, complete cutaneous examinations in order to determine the clinical features of early malignant melanomas (MM) arising in them. Sixteen patients (3.5%) developed 18 newly diagnosed MM during an average follow-up period of 27 months. Twelve of the 18 MM were in situ and all of the primary invasive MM diagnosed prospectively in this follow-up were less than 0.89 mm in Breslow thickness, implying an excellent prognosis. The principal clinical clue to the diagnosis of MM was change in a preexisting pigmented lesion. Total-body photographs were very useful in helping to identify the early MM in these patients
PMID: 2302671
ISSN: 0008-543x
CID: 16831

Atypical mole syndrome

Kopf AW; Friedman RJ; Rigel DS
PMID: 2298947
ISSN: 0190-9622
CID: 16832

Skin aging

Rigel, Darrell S
Secaucus, NJ : Network for Continuing Medical Education, 1990, c1989
Extent: 1 videocassette (15 min.) : sd., col. ; 1/2 in
ISBN: n/a
CID: 263

Another view of melanoma and dysplastic nevi

Rigel DS; Kopf AW; Friedman RJ
ORIGINAL:0005528
ISSN: 0743-8176
CID: 62439

The article reviewed on diagnosis and management of dysplastic nevus syndrome and early melanoma

Rigel DS; Kopf AW; Friedman RJ
ORIGINAL:0005569
ISSN: 0890-9091
CID: 62481

Dysplastic nevi. Markers for increased risk for melanoma

Rigel DS; Rivers JK; Kopf AW; Friedman RJ; Vinokur AF; Heilman ER; Levenstein M
A total of 452 white patients, classified into four dysplastic nevi groups, were followed prospectively by repetitive, complete cutaneous examinations using total-body photographs taken on entry into the study. Sixteen patients (3.5%) developed 18 newly diagnosed malignant melanomas (MM) during an average follow-up period of 27 months. Twelve of the 18 MM were in situ, and all of the six primary invasive MM diagnosed prospectively in this follow-up were less than 0.89 mm in Breslow thickness, implying an excellent prognosis. Compared with reference populations, the number of MM detected significantly exceeded the number estimated to occur in the comparable age-matched control groups. These data support the concept of repetitive follow-ups of all groups of patients with dysplastic nevi
PMID: 2910446
ISSN: 0008-543x
CID: 8193