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Medical student research exposure via a series of modular research programs

Langhammer, Christopher G; Garg, Karan; Neubauer, Judith A; Rosenthal, Susan; Kinzy, Terri Goss
BACKGROUND: The falling percentage of doctors of medicine applying for National Institute of Health-funded research grants is 1 indicator that physician-scientists are a disappearing breed. This is occurring at a time when increased translational, disease-oriented, patient-oriented, and clinical research are national goals. One of the keys to providing sufficient numbers of physician-scientists to support this goal is the active targeting of medical students. We hypothesize that an improved research program infrastructure and responsiveness to changing student needs will increase student participation in research-oriented electives. METHODS: We have developed a student research program consisting of 2 Students Interested in Research noncredit electives (lecture and laboratory based), summer fellowships, support for year-out fellowships, and a Distinction in Research program that spans undergraduate medical education. Student participation and short-term research outcomes from fall 2004 through spring 2008 are analyzed to examine program efficacy. RESULTS: Students involved in the early parts of the program initially experienced higher application and success rates for summer funding opportunities, but as the program has matured, these rates have fallen in line with the class average. Independently, students participating in later portions of the program increasingly submit or publish a first author paper and have taken a year off for research during medical school. Overlap of participation in the programs is generally smaller than expected. CONCLUSION: Although structured programs can provide step-wise research experiences of increasing intensity, students may not experience a training pipeline in which each stage relies on those before and after, and instead may sample an a la carte selection of research-based enrichment opportunities.
PMID: 19092679
ISSN: 1081-5589
CID: 162332

Copolymerizations of omega-pentadecalactone and trimethylene carbonate by chemical and lipase catalysis

Kumar, A; Garg, K; Gross, RA
Copolymerizations of omega -pentadecalactone (PDL) with trimethylene carbonate (TMC) were studied using chemical and enzyme catalysts. By using stannous octanoate, methylaluminoxane (MAO), or aluminum isopropoxide, copolymerizations of PDL with TMC with 1:1 feed ratio resulted in either homo-polyTMC or PDL/TMC block copolymers. These catalysts polymerize TMC more rapidly than PDL. A copolymerization catalyzed by MAO gave poly(TMC-co-16 mol % PDL) with M-n 26.4 x 10(3)g/mol and randomness numder (B) about 1.1. The sodium ethoxide-catalyzed copolymerization led to products with low M-n (<6.8 x 10(3)) but nearly random sequence distribution. The copolymerization of PDL with TMC was also studied by using lipase catalysts. Of the six lipases evaluated for PDL/TMC copolymerizations in toluene at 70 degreesC, an immobilized form of lipase B from Candida antarctica (Novozyme-435) was preferred. Changing the PDL/TMC comonomer feed ratio from 1:10 to 10:1 (mol/mol) provided copolymers that ranged in M, and PDL mol % from 7.3 x 10(3) to 25.2 x 10(3) and 28 to 88, respectively. In contrast to the chemical catalyst systems, Novozyme-435 catalysis showed that PDL was consumed more rapidly than TMC. Also, in contrast to most of the chemical catalysts, H-1 and C-13 NMR analyses showed that the copolymers from Novozyme-435 catalysis were able to give a random distribution of the repeat units at extended reaction times. Furthermore, in contrast to TMC polymerization in the presence of preformed polyPDL with MAO, Novozyme-435 catalyzed polymerization led to random copolymers.
ISI:000168833000007
ISSN: 0024-9297
CID: 3647132

Lipase-catalysis facilitates coopolymerixations that were othewise difficult or impossible tby alternate chemical approaches

Kumar, A; Garg, Karan; Gao, W; Gross, RA
ORIGINAL:0013270
ISSN: 0032-3934
CID: 3649452

Lipase-catalysis facilitates copolymerizations that were otherwise difficult or impossible by alternative chemical approaches. [Meeting Abstract]

Kumar, A; Garg, K; Gao, W; Gross, RA
ISI:000166091301740
ISSN: 0065-7727
CID: 3647122