Faculty Bibliography

Try a new search

Format these results:

Searched for:

in-biosketch:true

person:raetze01

Total Results:

293

Blood. 2015:126(23).DOI:

Capizzi-Style Methotrexate with Pegasparagase (C-MTX) Is Superior to High-Dose Methotrexate (HDMTX) in T-Lineage Acute Lymphoblastic Leukemia (T-ALL): Results from Children's Oncology Group (COG) AALL0434 [Meeting Abstract]

Winter, Stuart S; Devidas, Meenakshi; Chen, Si; Asselin, Barbara; Carroll, William L; Wood, Brent L; Esiashvili, Natia; Nikki, Briegel J; Hayashi, Robert J; Loh, Mignon L; Carroll, Andrew J; Heerema, Nyla A; Raetz, Elizabeth; Winick, Naomi J; Hunger, Stephen P; Dunsmore, Kimberly P
ISI:000368019002231
ISSN: 1528-0020
CID: 2019432
Blood. 2015:126(23).DOI:

Genetic and Response-Based Risk Classification Identifies a Subgroup of NCI High Risk Childhood B-Lymphoblastic Leukemia (HR B-ALL) with Outstanding Outcomes: A Report from the Children's Oncology Group (COG) [Meeting Abstract]

Raetz, Elizabeth; Loh, Mignon L; Devidas, Meenakshi; Maloney, Kelly; Larsen, Eric C; Mattano, Leonard A., Jr; Borowitz, Michael J; Wood, Brent L; Carroll, Andrew J; Heerema, Nyla A; Chen, I-Ming; Friedmann, Alison M; Schultz, Kirk R; Relling, Mary V; Harvey, Richard C; Gastier-Foster, Julie; Willman, Cheryl L; Winick, Naomi J; Hunger, Stephen P; Carroll, William L
ISI:000368019002244
ISSN: 1528-0020
CID: 2019442
Blood. 2015:126(23).DOI:

Incidence of Allergic Reactions to Pegaspargase (PEG) Administered Intramuscularly Versus Intravenously (IM vs. IV) in Children and Young Adults with High Risk B-Lymphoblastic Leukemia (HR B-ALL): Results of Children's Oncology Group (COG) Studies AALL0232/AALL1131 [Meeting Abstract]

Salzer, Wanda; Burke, Michael J; Larsen, Eric C; Chen, Si; Gore, Lia; Hilden, Joanne M; Loh, Mignon L; Raetz, Elizabeth; Winick, Naomi J; Carroll, William L; Devidas, Meenakshi; Hunger, Stephen P
ISI:000368019004103
ISSN: 1528-0020
CID: 2019462
Blood. 2014:124(21).DOI:

Deciphering the Epigenetic Landscape of Relapsed Pediatric Acute Lymphoblastic Leukemia [Meeting Abstract]

Bhatla, Teena; Blum, Roy; Wang, Jinhua; Jones, Courtney L; Morrison, Debra J; Raetz, Elizabeth A; Burke, Michael J; Brown, Patrick; Harvey, Richard C; Willman, Cheryl L; Loh, Mignon; Hunger, Stephen P; Carroll, William L
ISI:000349233800048
ISSN: 1528-0020
CID: 1497472
Blood. 2014:124(21).DOI:

Glutamate Receptor Polymorphisms Contribute to Glucocorticoid-Associated Osteonecrosis [Meeting Abstract]

Chang, Tamara; Yang, Wenjian; Sara, Van Driest L; Kaste, Sue C; Bowten, Erica A; Basford, Melissa; Bastarache, Lisa; Roden, Dan M; Denny, Joshua C; Mattano, Leonard A; Larsen, Eric C; Winick, Naomi J; Carroll, William L; Cheng, Cheng; Pei, Deqing; Fernandez, Christian A; Liu, Chengcheng; Smith, Colton; Loh, Mignon; Raetz, Elizabeth A; Hunger, Stephen; Scheet, Paul; Jeha, Sima; Pui, Ching-Hon; Evans, William E; Devidas, Meenakshi; Relling, Mary V
ISI:000349233803192
ISSN: 1528-0020
CID: 1497552
Blood. 2014:124(21).DOI:

Genetic Variation in NFATC2 Is Associated with a Higher Risk of Asparaginase Allergy [Meeting Abstract]

Fernandez, Christian A; Smith, Colton; Yang, Wenjian; Mullighan, Charles G; Qu, Chunxu; Larsen, Eric C; Bowman, William Paul; Liu, Chengcheng; Ramsey, Laura B; Chang, Tamara; Karol, Seth E; Loh, Mignon L; Raetz, Elizabeth A; Winick, Naomi J; Hunger, Stephen; Carroll, William L; Jeha, Sima; Pui, Ching-Hon; Evans, William E; Devidas, Meenakshi; Relling, Mary V
ISI:000349233805109
ISSN: 1528-0020
CID: 1497582
Blood. 2014:124(21).DOI:

MAPK Signaling Cascades Mediate Distinct Glucocorticoid Resistance Mechanisms in Pediatric B-Precursor ALL [Meeting Abstract]

Jones, Courtney L; Gearheart, Christy M; Fosmire, Susan; Delgado-Martin, Cristina; Pais, Faye; Wang, Jinhua; Bhatla, Teena; Bitterman, Danielle S; de Rijk, Simone R; Bourgeois, Wallace; Dandekar, Smita C; Raetz, Elizabeth A; Hermiston, Michelle L; Garabedian, Michael J; Porter, Christopher C; Carroll, William L
ISI:000349233808103
ISSN: 1528-0020
CID: 1497612
Blood. 2014:124(21).DOI:

Effect of High-Dose Methotrexate (HD-MTX) Vs Capizzi Methotrexate/Pegaspargase (C-MTX/ASNase) on Osteonecrosis (ON) Incidence in Children and Young Adults with T-Acute Lymphoblastic Leukemia (T-ALL): Results of Children's Oncology Group (COG) Study AALL0434 [Meeting Abstract]

Mattano, Leonard A; Devidas, Meenakshi; Chen, Si; Esiashvili, Natia; Asselin, Barbara; Winick, Naomi J; Loh, Mignon; Raetz, Elizabeth A; Hunger, Stephen; Carroll, William L; Winter, Stuart S; Dunsmore, Kimberly P
ISI:000349243503062
ISSN: 1528-0020
CID: 1497672
Blood. 2014:124(21).DOI:

Outstanding Outcome for Children with Standard Risk-Low (SR-Low) Acute Lymphoblastic Leukemia (ALL) and No Benefit to Intensified Peg-Asparaginase (PEG-ASNase) Therapy: Results of Children's Oncology Group (COG) Study AALL0331 [Meeting Abstract]

Mattano, Leonard A; Devidas, Meenakshi; Friedmann, Alison M; Raetz, Elizabeth A; Loh, Mignon; Buckley, Patrick; Borowitz, Michael J; Carroll, Andrew J; Gastier-Foster, Julie; Heerema, Nyla A; Kadan-Lottick, Nina; Matloub, Yousif; Marshall, David T; Stork, Linda C; Wood, Brent L; Winick, Naomi J; Hunger, Stephen; Carroll, William L; Maloney, Kelly
ISI:000349243505162
ISSN: 1528-0020
CID: 1497722
Journal of clinical oncology. 2014:32(34):3874-82.DOI: 10.1200/JCO.2014.55.5763

Pharmacokinetic and Pharmacodynamic Properties of Calaspargase Pegol Escherichia coli L-Asparaginase in the Treatment of Patients With Acute Lymphoblastic Leukemia: Results From Children's Oncology Group Study AALL07P4

Angiolillo, Anne L; Schore, Reuven J; Devidas, Meenakshi; Borowitz, Michael J; Carroll, Andrew J; Gastier-Foster, Julie M; Heerema, Nyla A; Keilani, Taha; Lane, Ashley R; Loh, Mignon L; Reaman, Gregory H; Adamson, Peter C; Wood, Brent; Wood, Charlotte; Zheng, Hao W; Raetz, Elizabeth A; Winick, Naomi J; Carroll, William L; Hunger, Stephen P
PURPOSE: Asparaginase is a critical agent used to treat acute lymphoblastic leukemia (ALL). Pegaspargase (SS-PEG), a pegylated form of Escherichia coli L-asparaginase with a succinimidyl succinate (SS) linker, is the first-line asparaginase product used in Children's Oncology Group (COG) ALL trials. Calaspargase pegol (SC-PEG) replaces the SS linker in SS-PEG with a succinimidyl carbamate linker, creating a more stable molecule. COG AALL07P4 was designed to determine the pharmacokinetic and pharmacodynamic comparability of SC-PEG to SS-PEG in patients with newly diagnosed high-risk (HR) B-cell ALL. PATIENTS AND METHODS: A total of 165 evaluable patients were randomly assigned at a 2:1 ratio to receive SC-PEG at 2,100 (SC-PEG2100; n =69) or 2,500 IU/m2 (SC-PEG2500; n=42) versus SS-PEG 2,500 IU/m2 (SS-PEG2500; n =54) as part of an otherwise identical chemotherapy regimen. The groups were similar demographically, except more female patients received SC-PEG2500. RESULTS: The mean half-life of plasma asparaginase activity for both SC-PEG doses was approximately 2.5x longer than that of SS-PEG2500. The total systemic exposure, as defined by induction area under the curve from time 0 to 25 days, was greater with SC-PEG2500 than with SS-PEG2500 or SC-PEG2100. The proportion of patients with plasma asparaginase activity >/= 100 mIU/mL and >/= 400 mIU/mL was higher in patients who received SC-PEG as compared with SS-PEG2500. After one dose of pegylated asparaginase on induction day 4, plasma asparagine was undetectable for 11 days for SS-PEG2500 and 18 days for both SC-PEG groups. CONCLUSION: SC-PEG2500 achieves a significantly longer period of asparaginase activity above defined thresholds and asparagine depletion compared with SS-PEG2500 and has a comparable toxicity profile in children with HR B-cell ALL.
PMCID:4239306
PMID: 25348002
ISSN: 0732-183x
CID: 1322652