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Increased survival rate may be due to public education
Rigel DS; Kopf AW; Friedman RJ
ORIGINAL:0005507
ISSN: 0898-6665
CID: 62417
PHOTOGRAPHS ARE USEFUL FOR DETECTION OF MALIGNANT MELANOMAS IN PATIENTS WHO HAVE DYSPLASTIC NEVI [Editorial]
Kopf, AW; Rivers, JK; Slue, W; Rigel, DS; Friedman, RJ
ISI:A1988R205700030
ISSN: 0190-9622
CID: 31430
Skin types in dysplastic nevus syndrome
Kopf AW; Goldman RJ; Rivers JK; Levenstein M; Rigel DS; Friedman RJ; Bart RS
In order to determine if individuals with dysplastic nevi (DN) are relatively more sun-sensitive than controls who do not have DN, the sun-reactivity skin types (based on the Harvard classification) were determined in these two groups. Compared with controls, sun-sensitive types were significantly overrepresented in the DN group. This is consistent with the hypothesis that the fundamental defect in the dysplastic nevus syndrome is the genetically unstable melanocyte, which is susceptible to neoplastic transformation induced by sunlight
PMID: 3397442
ISSN: 0148-0812
CID: 10998
DERM/INFONET: a concept becomes a reality
Kopf AW; Rigel DS; White R; Rosenthal L; Jordan WP; Carter DM; Everett MA; Moore J
The DERMatology INFOrmation NETwork (DERM/INFONET) of the American Academy of Dermatology has become a reality. DERM/INFONET consists of a number of data bases providing information and educational programs for the dermatologist. Currently the components are: DERM/MLS (Medical Literature Search), DERM/RX (dermatologic therapy), DERM/USP (United States Pharmacopeia data base), DERM/ALLERGENS (Food and Drug Administration and Environmental Protection Agency Listings of allergens); Melanoma Prognosis Model; Electronic Mail; Bulletin Board; Meetings Calendar; ICD/CPT (International Classification of Diseases/Current Procedural Terminology) codes; AAD Membership/Committee Directories; and Dermatology Quiz. Additional data bases are planned. As audiovisual and alphanumeric communication systems evolve, newer opportunities for enhancing the DERM/INFONET Biomedical Communication Network will undoubtedly provide even greater opportunities for aiding the dermatologist in delivering state-of-the art management for their patients
PMID: 3385038
ISSN: 0190-9622
CID: 11099
The relationship between melanocytic nevi and malignant melanoma
Friedman RJ; Rigel DS; Heilman ER
In conclusion, although there are data, some quite convincingly implicating dysplastic nevi and congenital nevi (particularly 'giant') as 'precursors' of malignant melanomas, our ability to predict the magnitude of these associations is lacking. Thus, until additional basic and clinical research data are forthcoming, any recommendation to prophylactically remove all congenital nevi or all dysplastic nevi in order to decrease the incidence of malignant melanoma is premature. In regard to congenital nevi, evidence exists that giant (larger than 20 cm in diameter) congenital nevi may have a significant risk factor so as to warrant, when feasible, prophylactic excision of such lesions. In our opinion, no uniform recommendation can be made at this time for the management of small and medium-sized congenital nevi. Patients with familial dysplastic nevus syndrome should be followed carefully and educated concerning the early detection of malignant melanoma. Patients with sporadic dysplastic nevus syndrome deserve further study to enable us to accurately determine their risk of developing malignant melanoma
PMID: 3378371
ISSN: 0733-8635
CID: 11123
Risk factors for the development of malignant melanoma--I: Review of case-control studies
Evans RD; Kopf AW; Lew RA; Rigel DS; Bart RS; Friedman RJ; Rivers JK
Data concerning risk factors for the development of cutaneous malignant melanoma (MM) were abstracted from published case-control studies. Relative risks (more appropriately 'odds ratios') and 95% confidence intervals were quoted or calculated for each risk factor in each study. Those risk factors that were reported to be significant in over half of the studies include: phenotypic factors (blue eyes, blond or red hair, light complexion, freckles, sun sensitivity, and inability to tan); personal history of non-melanoma cutaneous cancer or precancer; higher socioeconomic status; increased numbers of nevocytic nevi; and bursts of sun exposure. Further study is needed on family history and personal history of MM; these were not found to be significant risk factors in over half the reviewed case-control studies. This review leaves out other undoubtedly important risk factors such as dysplastic nervus syndrome and race, which need investigation by the case-control method. Determination of risk factors allows the identification of that subset of the population most at risk for the development of MM. Given the continued increase in the incidence of MM, these data can help to focus preventive measures on the more susceptible subgroups of the population
PMID: 3280634
ISSN: 0148-0812
CID: 16833
Risk gradient for malignant melanoma in individuals with dysplastic naevi [Letter]
Rigel DS; Rivers JK; Friedman RJ; Kopf AW
PMID: 2893154
ISSN: 0140-6736
CID: 8384
The rate of malignant melanoma in the United States: are we making an impact?
Rigel DS; Kopf AW; Friedman RJ
PMCID:4486123
PMID: 3501436
ISSN: 0190-9622
CID: 11302
Prognostic significance of hypopigmentation in malignant melanoma
Bystryn JC; Rigel D; Friedman RJ; Kopf A
It has been suggested that the presence of cutaneous hypopigmentation favorably influences the prognosis of patients with malignant melanoma (MM). To examine this possibility, we have compared the actual with the predicted survival of 46 patients with MM and hypopigmentation who were among 1130 patients with MM entered in a long-term prospective study of MM at the New York University Medical Center. The actual average five-year survival rate of the patients with MM and hypopigmentation (86.3%) was significantly better than predicted (74.8%) on the basis of the risk factors present in each patient at the time of entry into the study. The findings suggest that hypopigmentation is a factor that beneficially influences the prognosis of MM, and that the mechanisms that inhibit or destroy normal melanocytes in patients with MM may also slow the growth of this cancer
PMID: 3631983
ISSN: 0003-987x
CID: 16246
Thickness of malignant melanoma: global analysis of related factors
Kopf AW; Welkovich B; Frankel RE; Stoppelmann EJ; Bart RS; Rogers GS; Rigel DS; Friedman RJ; Levenstein MJ; Gumport SL; et al.
PMID: 3558930
ISSN: 0148-0812
CID: 16834