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ASSOCIATION OF RADIOGRAPHIC OUTCOMES WITH LOW DISEASE ACTIVITY AND REMISSION AND SUSTAINABILITY OF RESPONSE WITH SUBCUTANEOUS ABATACEPT OR ADALIMUMAB: 2-YEAR RESULTS FROM THE AMPLE TRIAL [Meeting Abstract]

Fleischmann, R; Schiff, M; Weinblatt, M; Maldonado, M; Massarotti, E; Fay, J; Yazici, Y
ISI:000346919802137
ISSN: 1468-2060
CID: 1598932

RANDOMIZATION TO PATIENT-REPORTED RAPID3 VERSUS PHYSICIAN-BASED CDAI TOOLS FOR PREDICTION OF TREATMENT RESPONSE AND ASSESSMENT OF PATIENT-REPORTED OUTCOMES IN RHEUMATOID ARTHRITIS PATIENTS RECEIVING CERTOLIZUMAB PEGOL: RESULTS FROM THE PREDICT STUDY [Meeting Abstract]

Curtis, JR; Churchill, M; Kivitz, A; Samad, A; Gauer, L; Coteur, G; Gervitz, L; Koetse, W; Melin, J; Yazici, Y
ISI:000346919802108
ISSN: 1468-2060
CID: 1598922

HALF OF HIGH SCHOOL STUDENTS PLAYING SPORTS EXPERIENCE INJURIES, EVEN MORE WITH CONTACT SPORTS: TIME FOR NEW REGULATIONS? [Meeting Abstract]

Ince, DC; Swearingen, CJ; Yazici, Y
ISI:000346919801375
ISSN: 1468-2060
CID: 1598902

A PATIENT REPORTED OUTCOME MEASURES-BASED COMPOSITE INDEX (RAPID3) FOR THE ASSESSMENT OF DISEASE ACTIVITY IN ANKYLOSING SPONDYLITIS [Meeting Abstract]

Cinar, M; Yilmaz, S; Cinar, FI; Koca, SS; Erdem, H; Pay, S; Dinc, A; Yazici, Y; Simsek, I
ISI:000346919801106
ISSN: 1468-2060
CID: 1598862

When is it not ethical to withhold treatment for rheumatoid arthritis?

Yazici, Yusuf
PMID: 24368513
ISSN: 0003-4967
CID: 789932

Criteria for Behcet's disease with reflections on all disease criteria

Yazici, Hasan; Yazici, Yusuf
With no specific histologic, laboratory or imaging features the diagnosis/classification of Behcet's Disease (BD) remains clinical. As such, disease criteria are needed. The International Study Group Criteria set is the most widely used. It has some limitations, especially in telling BD from Crohn's disease. On the other hand the main issue, as it also applies to many of the other criteria sets in rheumatology, is our lack of appreciation of a list of misconceptions - some examples of which are unluckily also found in the 2010 ACR/EULAR RA Criteria set- about diagnostic/classification criteria making and their implementation. 1. The view that classification and diagnostic criteria should be different is ill advised in that the cerebral/arithmetic basis of both are the same. 2. The default promise of diagnostic criteria to come once we formulate a classification criteria set is an extension of the previous misconception. 3.Taking pains to avoid circularity in criteria making is unwarranted since the essence of criteria making is circular. In addition we fail to exploit the utility of the disease criteria in ruling out, rather than ruling in, the diseases we seek. Finally we also fail to appreciate the paramount importance of the Bayesian prior (the pretest) probability in formulating and implementing these disease criteria. To formulate criteria tailored to subspecialties, as well as giving the often forgotten family history more importance in our criteria sets are some ways to improve the prior probability on which our diagnostic/classification decisions will be based. We first have to reconcile with ourselves that probabilities are very important in our practice and research. Moreover that reconciliation must also be shared with the public, which includes our patients.
PMID: 24461382
ISSN: 0896-8411
CID: 783692

Massive Ex Vivo Expansion of Functionally Stable Behcet's Patient-Derived Regulatory T Cell Clones. [Meeting Abstract]

Nowatzky, Johannes; Manches, Olivier; Yazici, Yusuf; Lafaille, Juan
ISI:000344384905409
ISSN: 2326-5191
CID: 5340392

Racial and ethnic disparities in disease activity in patients with rheumatoid arthritis

Greenberg, Jeffrey D; Spruill, Tanya M; Shan, Ying; Reed, George; Kremer, Joel M; Potter, Jeffrey; Yazici, Yusuf; Ogedegbe, Gbenga; Harrold, Leslie R
BACKGROUND: Observational studies of patients with rheumatoid arthritis have suggested that racial and ethnic disparities exist for minority populations. We compared disease activity and clinical outcomes across racial and ethnic groups using data from a large, contemporary US registry. METHODS: We analyzed data from 2 time periods (2005-2007 and 2010-2012). The Clinical Disease Activity Index was examined as both a continuous measure and a dichotomous measure of disease activity states. Outcomes were compared in a series of cross-sectional and longitudinal multivariable regression models. RESULTS: For 2005-2007, significant differences of mean disease activity level (P < .001) were observed across racial and ethnic groups. Over the 5-year period, modest improvements in disease activity were observed across all groups, including whites (3.7; 95% confidence interval [CI], 3.2-4.1) compared with African Americans (4.3; 95% CI, 2.7-5.8) and Hispanics (2.7; 95% CI, 1.2-4.3). For 2010-2012, significant differences of mean disease activity level persisted (P < .046) across racial and ethnic groups, ranging from 11.6 (95% CI, 10.4-12.8) in Hispanics to 10.7 (95% CI, 9.6-11.7) in whites. Remission rates remained significantly different across racial/ethnic groups across all models for 2010-2012, ranging from 22.7 (95% CI, 19.5-25.8) in African Americans to 27.4 (95% CI, 24.9-29.8) in whites. CONCLUSIONS: Despite improvements in disease activity across racial and ethnic groups over a 5-year period, disparities persist in disease activity and clinical outcomes for minority groups versus white patients.
PMCID:4006346
PMID: 24262723
ISSN: 0002-9343
CID: 652382

Systems Approach To The Study Of the Microbiome and Inflammatory Pathways In Oral Ulcer Tissue From Patients With Active Behcet's Syndrome (BS) [Meeting Abstract]

Sibley, Cailin ; Hatemi, Gulen ; Yazici, Yusuf ; Liu, Yin ; Brooks, Steve ; Yazici, Hasan ; Goldbach-Mansky, Raphaela
ISI:000325359203149
ISSN: 0004-3591
CID: 656472

Disparity In Biologic Therapy In Ethnic Minorities With Rheumatoid Arthritis: Can It All Be Due To Lack Of Access To Drug? [Meeting Abstract]

Kerr, Gail S. ; Mikuls, Ted R. ; Swearingen, Christopher J. ; Luo, Chunqiao ; Yazici, Yusuf
ISI:000325359204173
ISSN: 0004-3591
CID: 657272