Searched for: in-biosketch:true
person:caplaa02
To evaluate hypertrichosis with low dose oral minoxidil and spironolactone combination therapy for alopecia [Letter]
Nohria, Ambika; Desai, Deesha; Sikora, Michelle; Mandal, Soutrik; Caplan, Avrom; Shapiro, Jerry; Sicco, Kristen I Lo
Low dose oral minoxidil (LDOM) is an efficacious and safe treatment for alopecia, however, a notable side effect is hypertrichosis. Spironolactone, known for treating hirsutism, is also used off-label for the treatment of certain forms of alopecia and may reduce LDOM-induced hypertrichosis. We performed a retrospective review of 54 patients seen at NYU Langone Health and compared hypertrichosis rates in female alopecia patients on LDOM monotherapy versus those on combination therapy with spironolactone. Among 54 patients, 37 received LDOM alone and 17 received the combination. Hypertrichosis developed in 33.3% of patients, with lower rates in the combination group (17.6% vs. 40.5% for monotherapy). Although not statistically significant, the trend suggests spironolactone may mitigate hypertrichosis. The study highlights the potential of combination therapy to address hypertrichosis and calls for larger studies to confirm these findings.
PMID: 39133327
ISSN: 1432-069x
CID: 5697112
Eosinophilic Pustular Folliculitis in an HIV-Positive 63-Year-Old Male
Sikora, Michelle; Buontempo, Michael G; Ramachandran, Vignesh; Knutsen, Dorothy A; Meehan, Shane A; Hejazi, Emily Z; Caplan, Avrom S; Lo Sicco, Kristen I; Tattersall, Ian W
PMID: 38588935
ISSN: 1555-7162
CID: 5657272
Chronic cutaneous sarcoidosis: Disparate impact on patients with skin of colour
Obijiofor, Chinemelum; Sikora, Michelle; Caplan, Avrom S.
SCOPUS:85184169747
ISSN: 2768-6566
CID: 5700842
Potential Sexual Transmission of Tinea Pubogenitalis From TMVII
Caplan, Avrom S; Sikora, Michelle; Strome, Arianna; Akoh, Christine C; Otto, Caitlin; Chaturvedi, Sudha; Zampella, John G
PMID: 38837127
ISSN: 2168-6084
CID: 5665372
Clinical Course, Antifungal Susceptibility, and Genomic Sequencing of Trichophyton indotineae
Caplan, Avrom S; Todd, Gabrielle C; Zhu, YanChun; Sikora, Michelle; Akoh, Christine C; Jakus, Jeannette; Lipner, Shari R; Babbush, Kayla; Acker, Karen P; Morales, Ayana E; Rolón, Rebecca M Marrero; Westblade, Lars F; Fonseca, Maira; Cline, Abigail; Gold, Jeremy A W; Lockhart, Shawn R; Smith, Dallas J; Chiller, Tom; Greendyke, William G; Manjari, Swati R; Banavali, Nilesh K; Chaturvedi, Sudha
IMPORTANCE/UNASSIGNED:Trichophyton indotineae is an emerging dermatophyte causing outbreaks of extensive tinea infections often unresponsive to terbinafine. This species has been detected worldwide and in multiple US states, yet detailed US data on infections with T indotineae are sparse and could improve treatment practices and medical understanding of transmission. OBJECTIVE/UNASSIGNED:To correlate clinical features of T indotineae infections with in vitro antifungal susceptibility testing results, squalene epoxidase gene sequence variations, and isolate relatedness using whole-genome sequencing. DESIGN, SETTING, AND PARTICIPANTS/UNASSIGNED:This retrospective cohort study of patients with T indotineae infections in New York City spanned May 2022 to May 2023. Patients with confirmed T indotineae infections were recruited from 6 New York City medical centers. MAIN OUTCOME AND MEASURE/UNASSIGNED:Improvement or resolution at the last follow-up assessment. RESULTS/UNASSIGNED:Among 11 patients with T indotineae (6 male and 5 female patients; median [range] age, 39 [10-65] years), 2 were pregnant; 1 had lymphoma; and the remainder were immunocompetent. Nine patients reported previous travel to Bangladesh. All had widespread lesions with variable scale and inflammation, topical antifungal monotherapy failure, and diagnostic delays (range, 3-42 months). Terbinafine treatment failed in 7 patients at standard doses (250 mg daily) for prolonged duration; these patients also had isolates with amino acid substitutions at positions 393 (L393S) or 397 (F397L) in squalene epoxidase that correlated with elevated terbinafine minimum inhibitory concentrations of 0.5 μg/mL or higher. Patients who were treated with fluconazole and griseofulvin improved in 2 of 4 and 2 of 5 instances, respectively, without correlation between outcomes and antifungal minimum inhibitory concentrations. Furthermore, 5 of 7 patients treated with itraconazole cleared or had improvement at the last follow-up, and 2 of 7 were lost to follow-up or stopped treatment. Based on whole-genome sequencing analysis, US isolates formed a cluster distinct from Indian isolates. CONCLUSION AND RELEVANCE/UNASSIGNED:The results of this case series suggest that disease severity, diagnostic delays, and lack of response to typically used doses and durations of antifungals for tinea were common in this primarily immunocompetent patient cohort with T indotineae, consistent with published data. Itraconazole was generally effective, and the acquisition of infection was likely in Bangladesh.
PMID: 38748419
ISSN: 2168-6084
CID: 5658682
Response to "Low-dose oral minoxidil for androgenetic alopecia is not associated with clinically significant blood-pressure changes: a retrospective study" [Letter]
Desai, Deesha; Nohria, Ambika; Sikora, Michelle; Mandal, Soutrik; Shapiro, Jerry; Caplan, Avrom S; Garshick, Michael; Lo Sicco, Kristen
PMID: 38499178
ISSN: 1097-6787
CID: 5640192
Household Transmission of Tinea Infections: Analysis of a Large Commercial Health Insurance Claims Database, United States, 2021
Benedict, Kaitlin; Lipner, Shari R; Caplan, Avrom S; Gold, Jeremy A W
Among 207 914 multimember households with a tinea case, a secondary case was diagnosed in another household member in 8.5%. Excluding same-day diagnoses (20%), the median time from index case to first secondary case was 138 days. To prevent household tinea transmission, appropriate treatment and strategies to reduce environmental contamination are needed.
PMCID:11218768
PMID: 38957688
ISSN: 2328-8957
CID: 5732752
Hospitalization and Continuity of Care in Anti-MDA5 Dermatomyositis
Richardson, William Mark; Shah, Jill T; Mazori, Daniel R; Caplan, Avrom S; Lo Sicco, Kristen I; Femia, Alisa N
PMCID:11024728
PMID: 38630455
ISSN: 2168-6084
CID: 5671502
Methotrexate Use and Risk of Interstitial Lung Disease in Dermatomyositis
Shah, Jill T; Richardson, William Mark; Mittal, Lavanya; Castillo, Rochelle; Mazori, Daniel R; Caplan, Avrom S; Femia, Alisa N
PMCID:11063920
PMID: 38691354
ISSN: 2168-6084
CID: 5658102
A hypopigmented and enlarging granulomatous eruption
Sikora, Michelle; Lo Sicco, Kristen; Meehan, Shane; Martiniuk, Frank; Levis, William; Caplan, Avrom S
PMCID:11070320
PMID: 38716298
ISSN: 2352-5126
CID: 5733932