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Dynamic perfusion computed tomography in the diagnosis of cerebral vasospasm - Comments [Editorial]
Loch Macdonald, R.; Komotar, Ricardo J.; D\Ambrosio, Anthony L.; Connolly, E. Sander, Jr.; Ogilvy, Christopher S.; Krex, Dietmar; Schackert, Gabriele; Kim, Paul E.
ISI:000239763800034
ISSN: 0148-396x
CID: 4621112
The subtemporal interdural approach to dumbbell-shaped trigeminal Schwannomas: Cadaveric prosection - Comments [Editorial]
Bederson, Joshua; Post, Kalmon D.; Nanda, Anil; D\Ambrosio, Anthony; Bruce, Jeffrey N.
ISI:000241419500018
ISSN: 0148-396x
CID: 4621122
Structure-function relationships in the human visual system using DTI, fMRI and visual field testing: pre- and post-operative assessments in patients with anterior visual pathway compression
Rosiene, Joel; Liu, X; Imielinska, C; Ferrera, J; Bruce, J; Hirsch, J; D'Ambrosio, A
The focus of this project is to improve our understanding of the relationships between brain structure and function in patients presenting with anterior visual pathway compression using functional MRI (fMRI), visual field(VF) maps and diffusion tensor imaging (DTI). Significant visual loss can occur when large pituitary lesions compress the optic chiasm. Surgical resection of these lesions decompresses the chiasm and can lead to visual recovery. In this preliminary study, we selected patients presenting with slowly progressive visual loss secondary to a compressive pituitary region mass. Using preoperative DTI data, we reconstructed white matter projections of the optic radiations and demonstrated a structural correlation with functional vision as quantified by formal visual field mapping and fMRI. The structural data generated through a fiber tracking algorithm may represent a potentially powerful tool to better understand functional visual deficits in patients with anterior visual pathway compression. Furthermore, we believe that specific patterns in preoperative DTI data may predict the likelihood of postoperative visual recovery in a select group of patients.
PMID: 16404100
ISSN: 0926-9630
CID: 5459272
Quantification of diffusion-weighted images (DWI) and apparent diffusion coefficient maps (ADC) in the detection of acute stroke [Meeting Abstract]
Tulipano, P. Karina; Millar, William S.; Imielinska, Celina; Liu, Xin; Rosiene, Joel; D\Ambrosio, Anthony L.
ISI:000237637000029
ISSN: 0277-786x
CID: 5459332
Enhanced techniques for asymmetry quantification in brain imagery [Meeting Abstract]
Liu, Xin; Imielinska, Celina; Rosiene, Joel; Connolly, E. Sander; D\Ambrosio, Anthony L.
ISI:000238033302081
ISSN: 0277-786x
CID: 5459342
Statistical bilateral asymmetry measurement in brain images
Liu, Xin; Ogden, R Todd; Imielinska, Celina; Laine, Andrew; Connolly, E Sander; D'Ambrosio, Anthony L
We present an improvement of an automated generic methodology for symmetry identification, asymmetry quantification, and segmentation of brain pathologies, utilizing the inherent bi-fold mirror symmetry in brain imagery. In the pipeline of operations starting with detection of the symmetry axis, hemisphere-wise cross registration, statistical correlation and quantification of asymmetries, we segment a target brain pathology. The detection of pathological difference left to right in brain imagery is complicated by normal variations as well as geometric misalignment in anatomical structures between two hemispheres. Introducing hemisphere-wise registration and spatial correlation makes our approach perform robustly in the presence of normal asymmetries and systematic artifacts such as bias field and acquisition noise.
PMID: 17946891
ISSN: 1557-170x
CID: 4620982
Symmetry identification using partial surface matching and tilt correction in 3D brain images
Liu, Xin; Imielinska, Celina; Laine, Andrew; Connolly, E Sander; D'Ambrosio, Anthony L
We propose a novel method to automatically compute the symmetry plane and correct the 3D orientation of patient brain images. Many images of the brain are clinically unreadable because of the misalignment of the patient's head in the scanner. We proposed an algorithm that represents the brain volume as a re-parameterized surface point cloud where each location has been parameterized by its elevation (latitude), azimuth (longitude) and radius. The removal of the interior contents of the brain makes this approach perform robustly in the presence of the brain pathologies, e.g. tumor, stroke and bleed. Thus, we decompose the symmetry plane computation problem into a surface matching routine. The search for the best matching surface is implemented in a multi-resolution paradigm so as to decrease computational time considerably. Spatial affine transform then is performed to rotate the 3D brain images and align them within the coordinate system of the scanner. The corrected brain volume is re-sliced such that each planar image represents the brain at the same axial level.
PMID: 17946874
ISSN: 1557-170x
CID: 4620972
Clinicopathological review: giant cell reparative granuloma of the orbit
D'Ambrosio, Anthony L; Williams, Susan C; Lignelli, Angela; Salchow, Daniel J; Spicer, Galin; Libien, Jenny; Chin, Steven S; Liebsch, Norbert J; Kazim, Michael; Bruce, Jeffrey N; Connolly, E Sander Jr
PMID: 16239891
ISSN: 1524-4040
CID: 142888
Toward objective quantification of perfusion-weighted computed tomography in subarachnoid hemorrhage: quantification of symmetry and automated delineation of vascular territories
Imielinska, Celina; Liu, Xin; Rosiene, Joel; Sughrue, Michael E; Komotar, Ricardo J; Mocco, J; Ransom, Evan R; Lignelli, Angela; Zacharia, Brad E; Connolly, E Sander; D'Ambrosio, Anthony L
RATIONALE AND OBJECTIVES/OBJECTIVE:Perfusion-weighted computed tomography (CTP) is a relatively recent innovation that estimates a value for cerebral blood flow (CBF) using a series of axial head CT images tracking the time course of a signal from an intravenous contrast bolus. MATERIALS AND METHODS/METHODS:CTP images were obtained using a standard imaging protocol and were analyzed using commercially available software. A novel computer-based method was used for objective quantification of side-to-side asymmetries of CBF values calculated from CTP images. RESULTS:Our method corrects for the inherent variability of the CTP methodology seen in the subarachnoid hemorrhage (SAH) patient population to potentially aid in the diagnosis of cerebral vasospasm (CVS). This method analyzes and quantifies side-to-side asymmetry of CBF and presents relative differences in a construct termed a Relative Difference Map (RDM). To further automate this process, we have developed a unique methodology that enables a computer to delineate vascular territories within a brain image, regardless of the size and shape of the brain. CONCLUSIONS:While both the quantification of image symmetry using RDMs and the automated assignment of vascular territories were initially designed for the analysis of CTP images, it is likely that they will be useful in a variety of applications.
PMID: 16039541
ISSN: 1076-6332
CID: 4620942
Decompressive hemicraniectomy for poor-grade aneurysmal subarachnoid hemorrhage patients with associated intracerebral hemorrhage: clinical outcome and quality of life assessment
D'Ambrosio, Anthony L; Sughrue, Michael E; Yorgason, Joshua G; Mocco, J D; Kreiter, Kurt T; Mayer, Stephan A; McKhann, Guy M; Connolly, E Sander
OBJECTIVE:Decompressive hemicraniectomy has been proposed as a potential treatment strategy in patients with poor-grade aneurysmal subarachnoid hemorrhage presenting with focal intracerebral hemorrhage causing significant mass effect. Although hemicraniectomy improves overall survival rates, the long-term quality of life (QoL) for survivors in this patient population has not been reported. METHODS:Using adjudicated outcome assessments, we compare long-term clinical outcomes and QoL between a group of patients with poor-grade aneurysmal subarachnoid hemorrhage receiving decompressive hemicraniectomy (n=12) and a control group of similar patients managed more conservatively (n=10). RESULTS:Patients receiving decompressive hemicraniectomy experienced a statistically insignificant decrease in short-term mortality compared with controls (25 versus 42%); however, long-term QoL in hemicraniectomy survivors was generally poor. Furthermore, hemicraniectomy patients did not experience an increase in mean quality-adjusted life years over control patients (2.31 versus 2.22 yr). CONCLUSION/CONCLUSIONS:Decompressive hemicraniectomy prolongs short-term survival in patients with poor-grade aneurysmal subarachnoid hemorrhage with associated intracerebral hemorrhage; however, this trend is not statistically significant, and the overall QoL experienced by survivors is poor. Decompressive hemicraniectomy may be indicated if performed early in a select subset of patients. On the basis of our preliminary data, large prospective studies to investigate this issue further may not be warranted.
PMID: 15617581
ISSN: 1524-4040
CID: 4620932