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Is regional only anesthesia a safe choice in anticoagulated hip fracture patients?

Herbosa, Carolyn; Petit, Christopher; Konda, Sanjit; Ganta, Abhishek; Furgiuele, David; Rivero, Steven; Egol, Kenneth
METHODS:This study assessed the safety of the lateral femoral cutaneous and over the hip (LOH) block, a regional anesthetic, in anticoagulated hip fracture patients while maintaining efficacy. A retrospective review of patients diagnosed with hip fractures (AO/OTA 31A/B) who presented to a single academic medical center and level 1 trauma center actively using oral anticoagulants. Patients were grouped based on anesthesia type: LOH block (LOH) versus general anesthesia (GA) and LOH versus spinal anesthesia (SA). LOH patients were matched based on anticoagulant type, OTA/AO classification, and risk (STTGMA) score with a 3:1 ratio to GA and a 1:1 ratio to SA. Outcome comparisons included: time to surgery, operative and anesthesia time, and bleeding complications, demographics (age, sex, race, BMI, CCI, and STTGMA), postoperative complications, 90-day readmission rates, mortality within 1 year, and discharge location. RESULTS:A total of 135 patients: 27 LOH, 27 SA, and 81 GA, were analyzed. Compared to GA, LOH block patients had a shorter time to surgery (1.31 ± 0.082 vs. 0.89 ± 0.69, p = 0.014), lower rates of 90-day readmission (3.7% vs. 19.8%, p = 0.047), and a greater discharge to home with health services rate (33.3% vs. 8.6%, p = 0.024). The GA population trended-toward more major complications (p = 0.077) and mortality within 1 year (p = 0.077). Compared to SA, LOH patients were slightly underweight (25.1 ± 4.19 vs. 22.7 ± 4.16, p = 0.035) and got to surgery faster (0.89 ± 0.69 vs 1.54 ± 1.48, p = 0.039). Across all groups, there were no differences in the need for blood transfusion or other quality markers. CONCLUSION/CONCLUSIONS:The LOH block was safe and effective for use in anticoagulated hip fracture patients. This technique provided an intraoperative safety profile similar to other anesthetic choices, allowed for less delay to surgery compared to spinal anesthesia and improved discharge parameters compared to GA. LEVEL OF EVIDENCE III/METHODS:Prognostic Level III.
PMID: 41087586
ISSN: 1432-1068
CID: 5954682

Isolated Fifth Metatarsal Fractures: A Spectrum of Patterns With Similar Clinical and Radiographic Outcomes Regardless of Management

Kadiyala, Manasa L; Kingery, Matthew T; Walls, Raymond; Leucht, Philipp; Ganta, Abhishek; Konda, Sanjit R; Egol, Kenneth A
INTRODUCTION/BACKGROUND:Several types of fifth metatarsal (MT) fractures exist and are treated with various methods of immobilization, weight bearing restrictions, and occasionally operative procedures. This study evaluated the differences in clinical and radiographic outcomes among pseudo-Jones fractures (Zones 1 and 2), true Jones fractures (Zone 3), and fifth metatarsal shaft and neck fractures. METHODS:A retrospective review of a consecutive series of patients presenting to a single academic medical center with a fifth metatarsal fracture between 2012 and 2022 was conducted. Radiographs obtained at the initial presentation were reviewed, and fracture patterns were categorized as either Zone 1, Zone 2, Zone 3, shaft, neck, or head fractures. RESULTS:In total, 1314 patients with isolated fifth metatarsal fractures were treated (mean age = 49.6 ± 18.0 years). In total, 1217 fractures (92.5%) were initially treated nonoperatively, and 97 fractures (7.5%) were treated operatively. The overall time to clinical and radiographic healing for all fifth metatarsal fractures treated nonoperatively was 9.9 ± 8.7 weeks and 17.9 ± 15.6 weeks, respectively (P = .245, P = .088). Immediate weightbearing led to a faster time to clinical healing by (P = .035). There was no statistically significant difference in time to clinical or radiographic union among the different fracture types (P = .496, P = .400). Likewise, there was no evidence of any difference in time to clinical or radiographic union for patients treated operatively versus nonoperatively (P > .05). CONCLUSION/CONCLUSIONS:.
PMID: 40968738
ISSN: 1938-7636
CID: 5935532

Slimming the risks: GLP-1 receptor agonist therapy may reduce in-hospital complications and hospital readmissions rates for hip fractures compared to obese patients not on these medications

Goldstein, Amelia R; Olson, Danielle; Leucht, Phillip; Tejwani, Nirmal; Ganta, Abhishek; Konda, Sanjit; Egol, Kenneth A
INTRODUCTION/BACKGROUND:To evaluate the impact of prolonged GLP-1 usage on mortality, readmission, incidence of in-hospital complications, and incidence of implant failure following hip fracture surgery across various BMI strata. METHODS:A prospective hip fracture registry (2014-2024) at a single institution was used to identify 58 obese patients on prolonged GLP-1 therapy at the time of injury. These patients (Group A) were matched by age, fracture pattern, and comorbidity burden to BMI-based control cohorts: normal (Group B), overweight (Group C), and obese (Group D). Postoperative complication rates, readmissions, and implant failures were compared. Major complications were defined as events needing further procedures, extended hospitalization, or causing significant functional impairment. Minor complications were those managed with minimal treatment. Statistical analysis included ANOVA, chi-square, and post hoc residual testing. Data were analyzed using IBM SPSS Statistics (Version 21.0, Chicago, IL). RESULTS: ≈ 17.33, p < 0.001): 22.41% in Group A, 55.17% in Group B, 51.72% in Group C, and 60.34% in Group D. Group D exhibited significantly higher 30-day (17.24%, p < 0.001) and 90-day (24.14%, p < 0.05) readmission rates. No significant differences were observed in major complications, hardware failure incidence, or 30-day or 1-year. CONCLUSIONS: ≥ 6 months of continuous GLP-1 receptor agonist therapy was associated with a reduction in 30-day and 90-day readmission rates and overall and minor in-hospital complications in obese patients undergoing hip fracture surgery. LEVEL OF EVIDENCE/METHODS:III.
PMID: 40892123
ISSN: 1432-1068
CID: 5986942

Functional Outcomes in Older Patients following Patella Fracture Repair

Contractor, Amaya Milan; Konda, Sanjit R; Leucht, Philipp; Ganta, Abhishek; Egol, Kenneth A
PURPOSE/OBJECTIVE:The purpose of this study is to examine the effect of age on outcomes following repair of acute displaced patella fractures Methods: 248 patients who sustained a displaced patella fracture and underwent open reduction and internal fixation were identified. Patients included underwent a similar operative protocol, were prescribed a standard post-operative protocol of therapy, and were seen at standard follow-up intervals. Patients were divided into groups of < 65 years old (young) and ≥ 65 years old (older). Statistical analysis was run to determine if there was a significant difference in range of knee motion and rate of major complications. RESULTS:Of the 248 patients, 149 were young and 99 were older. The mean age of the older group was 74.5 ± 6.7 and the mean age of the young group was 50 ± 12. Fracture pattern and BMI were similar the groups, however the older group had a higher average CCI (p<0.001). Additionally, the groups had similar length of follow up (p=0.693) and similar mean time to radiographic healing (p=0.533). Older patients had limited knee extension at 6 months (compared young patients (p=0.031). Finally, older patients had a higher rate of all complications compared to young patients. Two percent of older patients developed a fracture related infection (FRI), 4% developed a symptomatic nonunion and 11% were underwent re-operation including removal of hardware, total knee replacement, irrigation and debridement and manipulation under anesthesia. CONCLUSION/CONCLUSIONS:Complication rates following patella fracture fixation in older patients were higher than young patients, despite having similar injury patterns, surgical treatment and follow up. These findings can better inform treating physicians during surgical intervention of older patients with patella fractures.
PMID: 40228553
ISSN: 1938-2480
CID: 5827542

Factors associated with decline in ambulatory ability following intramedullary nailing of 42A-C diaphyseal tibia fractures

Lashgari, Alexander M; Esper, Garret; Ganta, Abhishek; Egol, Kenneth A; Konda, Sanjit
BACKGROUND/UNASSIGNED:The purpose of this study was to examine factors that were associated with a decline in functional ambulatory status following fractures of the tibial diaphysis. METHODS/UNASSIGNED:A retrospective review of an IRB-approved tibial diaphysis fracture database from 2012 to 2024 was conducted. Inclusion criteria were age ≥18, isolated OTA 42A-C tibia fracture treated with an intramedullary nail, and minimum 12 months follow-up. Demographics, injury, and surgical information were collected. Functional ambulatory status was measured at routine follow up intervals by the Functional Ambulatory Category (FAC) score, a six-point scale where zero represents non-ambulation and five represents normal ambulatory ability. Univariate analysis was performed using Student's T-tests and Chi-squared tests. A backwards stepwise multivariate logistic regression analysis was performed to determine factors that were independently associated with a decline in FAC score (SPSS version 29, Armonk, NY). RESULTS/UNASSIGNED:289 patients, with a mean follow up time of 15.04 ± 6.18 months, were included in the analysis with a mean age of 43.24 ± 16.22 years, body mass index of 27.19 ± 6.30, and age-unadjusted Charlson Comorbidity Index of 0.18 ± 0.54. 39.1 % of patients were female, 28.0 % patients sustained open fractures, and 52.6 % sustained high energy injuries. The logistic regression demonstrated that older age (OR = 1.04 p < .001), higher BMI (OR = 1.06 p = .024), high-energy mechanism (OR = 3.18 p = .003), nonunion (OR = 3.66, p = .005), and concomitant lower extremity fractures (OR = 4.47 p = 002), were risk factors for a decrease in final FAC score. The AUROC of the logistic regression equation was 0.787 indicating a moderate ability to discriminate between patients that will experience a loss in functional ambulatory ability and those who will not. CONCLUSION/UNASSIGNED:This study suggests that concomitant lower extremity injuries, increased age, increased BMI, high-energy mechanisms, and nonunion are risk factors that are associated with a decline in ambulatory capacity following diaphyseal tibia fractures.
PMCID:12274951
PMID: 40687745
ISSN: 0976-5662
CID: 5901142

Does the addition of demineralized bone matrix to fixation of acute comminuted clavicle fractures affect healing outcomes?

Linker, Jacob A; Ganta, Abhishek; Konda, Sanjit R; Egol, Kenneth A
PURPOSE/OBJECTIVE:To assess the healing outcomes of patients who sustained a comminuted clavicle fracture and underwent operative fixation with or without the addition of demineralized bone matrix (DBM). METHODS:A total of 271 comminuted midshaft clavicle fractures that presented to our hospital system and underwent operative fixation with a plate and screw construct were retrospectively reviewed. Data collected include patient demographics, initial injury information, and use of demineralized bone matrix during surgery to enhance bone healing. Patients were grouped based on whether or not their fixation was augmented with DBM. Fracture-related infection (FRI), lack of fracture healing, and the need for revision fracture surgery were reviewed. Adhesive capsulitis of the shoulder and screw back out were categorized as "minor complications." Clinical healing was defined as non-tenderness about the fracture site, and radiographic healing was defined as presence of bridging callus and lack of fracture line on X-ray. Chi-square, T-test, and linear regression analysis were used to determine any significant differences between cohorts. RESULTS:Sixty-nine patients had DBM used in their repair, and 202 patients did not. Cohorts had a similar follow-up (range: 6-18 months). There were no differences in patient demographics or fracture pattern between the two groups (P > 0.05 for all). There were no differences in major and minor complications; however, the cohort treated with DBM had shorter time to radiographic healing, confirmed with regression analysis (P < 0.05). CONCLUSION/CONCLUSIONS:Augmentation of midshaft clavicle fracture constructs with DBM was associated with quicker radiographic healing.
PMID: 40879830
ISSN: 1432-1068
CID: 5910732

Posterior Sternoclavicular Joint Dislocation and Reconstruction [Case Report]

Lin, Charles C; Morgan, Allison; Doran, Michael; Jejurikar, Neha; Resad-Ferati, Sehar; Markus, Danielle H; Ganta, Abhishek; Konda, Sanjit R
This case presentation describes a technique for reconstruction of an acute posterior sternoclavicular joint dislocation. The patient was a 37 year-old female who sustained a left posterior sternoclavicular dislocation after a fall. A curvilinear incision was made directly over the sternoclavicular joint. After reduction, a semitendinosus allograft was used to reconstruct the sternoclavicular joint in a figure-of-8 fashion through drill holes in the manubrium and the proximal clavicle and secured with suture tape. Sternoclavicular reconstruction with semitendinosis allograft provides a reliable option with good clinical outcomes and low rates of recurrent instability.
PMID: 40932255
ISSN: 1531-2291
CID: 5936492

Technical Trick: Coronoid Fracture "Lasso" Repair Using Arthroscopic Instrumentation in Terrible Triad Injuries With Fixable Radial Head Fractures [Case Report]

Bi, Andrew S; Herbosa, Carolyn; Abola, Matthew V; Konda, Sanjit R; De Tolla, Jadie; Ganta, Abhishek
A single-stage operative repair of terrible triad injuries through a laterally-based approach using arthroscopic instrument-assisted reduction of the coronoid fracture in cases in which the radial head is deemed appropriate for repair rather than arthroplasty is described in this technical trick. Using an arthroscopic suture lasso, adjustable drill guides, cannulated guide-pins with nitinol shuttling wires, and a suspensory cortical button allow for a more precise and facile technique of "lasso" fixation of coronoid fractures and anterior capsular injuries with intact radial heads in terrible triad injuries.
PMID: 40932269
ISSN: 1531-2291
CID: 5936502

Triceps-sparing versus triceps-splitting approaches for OTA 12A-C and 13A2-3 distal-third humeral shaft fractures have similar 1 year functional outcomes

Ganta, Abhishek; Goldstein, Amelia; Lezak, Bradley; Campbell, Hillary; Egol, Kenneth; Konda, Sanjit
PURPOSE/OBJECTIVE:To compare functional outcomes of distal third humeral shaft fractures (OTA 12A-C and 13A2-3) treated with either triceps-splitting or triceps-sparing surgical approach. Secondarily, the purpose was to compare healing and complication rates between the two surgical approaches. METHOD/METHODS:A retrospective review of a prospectively collected humeral shaft registry was performed from 01/2018-12/2024. Inclusion criteria was: age > 18yo, OTA 12A-C or 13A2-3 distal third humeral shaft fracture, either triceps-splitting or triceps-sparing surgical approach, and minimum 1-year follow-up. The primary outcome was 1-year postoperative functional status measured using the Disabilities of the Arm, Shoulder, and Hand (DASH) score. Secondary outcomes measures included surgical time, radiographic union times, union rates, iatrogenic nerve injury, fracture related infection, hardware failure, reoperation, and documented range of motion (ROM) at last follow-up. Univariate analysis with two-tailed Student's t-tests and chi-square tests was used to compare demographics, injury and surgical characteristics. RESULT/RESULTS:A total of 39 patients met inclusion criteria: 27 (69.2%) underwent a triceps-splitting approach and 12 (30.8%) a triceps-sparing approach. There were no significant differences in baseline demographics. At final follow-up, functional outcomes were comparable. DASH scores were similar between groups (7.7 ± 13.8 vs 7.0 ± 9.0, p = 0.89), as were fracture healing times (5.5 ± 2.2 vs 6.1 ± 3.6 months, p = 0.63), with all fractures achieving union. Surgical duration was shorter in the splitting group (83 ± 42 vs 103 ± 52 min, p = 0.26), though not statistically significant. No hardware-related complications were reported. Two radial nerve palsies (7.6%) occurred in the splitting group, while one postoperative infection (8.3%) occurred in the sparing group (all p > 0.05). Elbow range of motion was similar. Mean flexion was 137.9 ± 10.0° in the splitting group vs 131.3 ± 30.0° in the sparing group (p = 0.47); mean extension was 2.3 ± 4.7° vs 4.6 ± 5.5°, respectively (p = 0.21). CONCLUSION/CONCLUSIONS:There is no difference in 1-year functional outcomes as measured by the DASH score between the triceps-splitting versus triceps-sparing approach for surgical fixation of the OTA 12A-C and 13A2-3 distal third humeral shaft fractures. Either surgical approach is viable for distal third humeral shaft fractures. LEVEL OF EVIDENCE/METHODS:Level III.
PMID: 40721679
ISSN: 1432-1068
CID: 5903132

Impact of Surgeon Subspecialty on Outcome Following Hip Arthroplasty for Femoral Neck Fracture

Hammond, Benjamin; Olson, Danielle; Ganta, Abhishek; Konda, Sanjit R; Aggarwal, Vinay; Egol, Kenneth A
BACKGROUND:The purpose of this study was to compare hospital quality and patient outcomes of hip arthroplasty for femoral neck fractures (FNFs) based on the subspecialty training of the treating surgeon: orthopaedic trauma (OT) versus adult reconstruction (AR) fellowship training. METHODS:A retrospective review was conducted on 1,008 elderly patients treated for an FNF with hemiarthroplasty or total hip arthroplasty between 2014 and 2024. Patients were grouped by their surgeon's subspecialty training (OT versus AR). Outcomes analyzed included length of stay, complications, 30-day and 90-day readmissions, dislocations, infections, and 30-day mortality. Statistical significance was set at P < 0.05. RESULTS:Baseline patient demographics were similar between groups, except for a higher proportion of women in the AR cohort (P = 0.008) and Black patients in the OT cohort (P = 0.016). Although age-unadjusted Charlson Comorbidity Index (CCI) was significantly higher in the AR group (P = 0.046), Score for Trauma Triage in the Geriatric and Middle Aged (STTGMA) scores, which take CCI and other health factors into account, were not significantly different (P = 0.59). In-hospital outcomes, including length of stay (P = 0.89) and minor and major complication rates (P = 0.38, P = 0.38), demonstrated no significant differences between groups. Post-discharge outcomes, including readmissions (30-day: P = 0.52, 90-day: P = 0.16), infections (P = 0.25), dislocations (P = 0.89), and 30-day mortality (P = 0.14), were also similar. CONCLUSION/CONCLUSIONS:No differences were identified in any of the outcomes analyzed between OT-trained and AR-trained surgeons in our study. This suggests that when FNFs are treated at high-volume academic institutions, subspecialty training may not substantially influence the short-term results of FNFs treated with hip arthroplasty. These findings highlight the importance of timely surgical intervention rather than waiting for a particularly trained surgeon to be available.
PMID: 40685026
ISSN: 1532-8406
CID: 5901092