Faculty Bibliography

INTRODUCTION/BACKGROUND:The purpose of this multicenter, double-blinded, prospective, randomized controlled trial was to determine the safest and most effective dose of intravenous (IV) dexamethasone administered during primary total knee arthroplasty (TKA). METHODS:There were 404 patients undergoing inpatient primary TKA randomized across 11 centers to receive four mg (n = 138), eight mg (n = 137), or 16 mg (n = 129) of IV dexamethasone intraoperatively. All sites utilized the same perioperative multimodal protocol. Opioid consumption measured in morphine milligram equivalents (MME), pain scores, nausea scores, vomiting episodes, and sleep duration was collected for seven days postoperatively. Glucose levels were measured on postoperative day (POD) one. The mean age was 68 years, the mean body mass index was 33, and 62% were women. Independent sample t-tests were used for continuous data, and Chi-square and Fisher's exact tests were used for discrete data. Demographic characteristics were comparable between groups, suggesting successful randomization. RESULTS:Patients who received 16 mg IV dexamethasone consumed less MME on POD one (38 versus 37 versus 27 MME; P = 0.047) and had fewer vomiting episodes (P = 0.02). Patients who received 16 mg also had lower pain scores at rest at 24 hours, 48 hours, and one week. There were no differences in cumulative opioid consumption within the first 48 hours (P = 0.24), one week (P = 0.43), or pain with activity at any time point. The POD one glucose was highest in patients who received 16 mg (P < 0.001). There were no differences in length of stay, hours slept, or 90-day complication rates between groups. CONCLUSION/CONCLUSIONS:High-dose (16 mg) IV dexamethasone in TKA reduces opioid consumption, pain, and vomiting on the first day after surgery. Outcomes, including opioid consumption, sleep, and nausea, are comparable beyond 24 hours for all doses.

INTRODUCTION/BACKGROUND:Total knee arthroplasty can substantially affect global lower limb alignment. However, its specific impacts on ankle and subtalar joint alignment remain poorly understood. This study investigates changes in ankle and subtalar alignment following varying degrees of varus/valgus knee correction in order to further our understanding of this association. MATERIALS AND METHODS/METHODS:This retrospective study included 100 patients who underwent surgery for primary osteoarthritis. Patients diagnosed with conditions other than primary knee OA and those with incomplete or poor-quality imaging were excluded. Patients were categorized into four groups by the degree of intraoperative coronal knee alignment correction: Group 1 (< 10° varus, n = 37), Group 2 (≥ 10° varus, n = 30), Group 3 (< 10° valgus, n = 18), and Group 4 (≥ 10° valgus, n = 15). Hip-knee-ankle angle, tibial plafond inclination, talar inclination, tibiotalar tilt, and subtalar varus-valgus angle, were measured preoperatively and postoperatively on full-length, standing, anteroposterior X-ray images. RESULTS:TKA resulted in postoperative changes in all measured angles regardless of the degree of varus/valgus correction. Notably, ≥ 10° valgus correction led to statistically significant postoperative alterations in ankle and subtalar alignment: tibial plafond inclination from 84.9 to 89.5° (Δ 4.6, range,1.5-7.8, P <.01), tibiotalar tilt from 83.1 to 89.3° (Δ 6.2, range,1.1-9.6, P =.02), and subtalar varus-valgus angle from 66.4 to 72.6° (Δ 6.2, range,1.9-12.1, P <.01). CONCLUSION/CONCLUSIONS:While knee deformity correction during TKA generally realigns the ankle and subtalar joint, our study has shown that large valgus knee correction (≥ 10°) during TKA significantly alters ankle and subtalar joint alignment. Thus, potentially leading to unfavorable postoperative outcomes in patients with abnormal or stiff joints. We recommend that future studies investigate the long-term effects of large valgus knee corrections during TKA on ankle and subtalar joint alignment and their impact on postoperative outcomes.

Total hip arthroplasty (THA) is one of the most common and successful procedures for the treatment of end-stage hip arthritis. However, in certain complex scenarios, THA can present important and unique challenges, specifically following acetabular fractures in adolescent patients, following failed fixation of proximal femoral fractures, and in developmental dysplasia of the hip (DDH). As these cases involve distorted anatomy, poor bone quality, retained hardware, and previous surgeries, detailed planning, specialized instrumentation and implants, and novel surgical techniques are required. This narrative review examines the challenges, surgical considerations, outcomes, and complications in complex THA management.

BACKGROUND:Robotic assistance (RA) is increasingly used in total knee arthroplasty (TKA) for more accurate bony resection and balancing. However, the impact of robotic TKA (RATKA) on clinical outcomes and patient-reported measures (PROMs) remains unclear. This study aims to compare RATKA and conventional TKA (CTKA) using a novel robotic system. METHODS:A retrospective review was conducted on 10,031 patients who underwent TKA from February 2021 to October 2024. 289 RATKAs were performed with a hand-held robotic system. These RATKA cases were 1:1 propensity-score matched to CTKA for patient demographics, surgeon, implant system, and articulation design. Postoperative and clinical outcomes including surgical time, length of stay (LOS), discharge disposition, 90-day emergency department (ED) visits, manipulation under anesthesia (MUA), debridement, reoperations and revisions were collected and analyzed. Patient-reported outcomes measures (PROMs) included Knee Injury and Osteoarthritis Outcome Scores (KOOS, JR) and Patient Reported Outcome Measurement Information System (PROMIS) scores. RESULTS:RATKA demonstrated significantly shorter LOS (30.04 vs. 51.91 hours, p < 0.001, respectively) compared to CTKA. There was no difference in surgical time (107.18 vs. 106.22 minutes, p = 0.349). Although there was no statistical difference in 90-day ED visits, the majority of the CTKA revisits were due to surgery-related causes when compared to the RATKAs (1.38% vs. 0.34%, p = 0.239). While RATKAs had higher incidence of MUAs (2.07% vs. 0.34%, p = 0.201), CTKAs had more reoperations (1 vs. 0, p = 0.369) and more revisions than the RATKAs (6 vs. 0, p = 0.117). In terms of PROMs, both RATKAs and CTKAs showed similar improvements in KOOS, JR and PROMIS pain scores following TKA, with no significant differences in the magnitude of improvement at early postoperative timepoints. However, at the one-year follow-up, RATKA demonstrated significantly greater reduction in PROMIS pain intensity (Δ-9.12, p = 0.032) compared to CTKAs. CONCLUSIONS:This retrospective analysis showed that the novel RATKA resulted in reduced length of stay, fewer reoperations, and greater reduction in one-year PROMIS pain intensity compared to CTKAs, despite having a higher incidence of MUA rates. Further research is needed to clarify these differences clinically and enhance patient outcomes.

BACKGROUND:Arthrofibrosis is a debilitating complication of total knee arthroplasty (TKA) and may benefit from arthroscopic lysis of adhesions (LOA) to improve range of motion and decrease pain. However, the rates of periprosthetic joint infection (PJI) and of the need for future revision TKA (rTKA) have only been studied in a limited capacity in the literature. In this study, we aimed to compare PJI and revision outcomes in patients who had undergone TKA between those who subsequently underwent arthroscopic LOA and those who did not undergo arthroscopic LOA. METHODS:The PearlDiver database was utilized to identify patients who had undergone primary TKA between 2016 and 2021. ICD-10 (International Classification of Diseases, Tenth Revision) and CPT (Current Procedural Terminology) codes were then used to identify patients who underwent LOA for arthrofibrosis. The rates of PJI and rTKA were compared between patients who did and did not undergo LOA. Multivariable logistic and Cox regressions, controlling for age, sex, Charlson Comorbidity Index, tobacco use, and a body mass index of >30 kg/m2, were performed to compare the rates of PJI and revision between the LOA and no-LOA groups. RESULTS:A total of 383,143 patients were identified, of whom 703 had undergone arthroscopic LOA. Patients who underwent LOA had higher overall rates of PJI (2.7% versus 1.3%; p = 0.001) and all-cause revision (9.8% versus 1.8%; p < 0.001) than those who did not. Patients who underwent LOA had significantly higher odds of PJI (odds ratio [OR], 2.00; p < 0.014), aseptic loosening-related revision (OR, 3.31; p = 0.002), and all-cause revision (OR, 5.32; p < 0.001) within 1 year after the initial TKA. There was no significant difference in 1-year PJI-related revisions between the groups (OR, 1.71; p = 0.193). In a time-to-event analysis, patients undergoing LOA had significantly higher risks of PJI (p = 0.003) and all-cause revision (p = 0.001) but not PJI-related revision (p = 0.322) or aseptic loosening-related revision (p = 0.111). CONCLUSIONS:Arthroscopic LOA after primary TKA was associated with higher rates of PJI and subsequent revision surgery. Surgeons should consider the results of these studies when counseling patients on the importance of early rehabilitation and improving modifiable risk factors after TKA. LEVEL OF EVIDENCE/METHODS:Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.

BACKGROUND:Sleep impairment following total hip arthroplasty (THA) is common and may decrease patient satisfaction and early recovery. Standardized postoperative recommendations for sleep disturbance have not been established. We aimed to assess whether melatonin use improves sleep quality and quantity in the acute period following THA. METHODS:Patients undergoing primary, elective THA between July 2021 and March 2024 were prospectively enrolled and randomized to receive either five mg of melatonin or a placebo nightly for 14 days postoperatively. Participants recorded nightly pain scores on the visual analog scale (VAS), the number of hours slept, and the number of nighttime awakenings in a sleep diary. Sleep disturbance was assessed preoperatively and on postoperative day (POD) 14 using the patient-reported outcome measurement information system sleep disturbance (PROMIS-SD) form. Epworth Sleepiness Scores (ESS) were collected to assess sleep quality and were the primary outcome of this study. Of the 139 patients who completed the study protocol, there were 64 patients in the placebo group and 75 patients in the melatonin group. RESULTS:Both groups demonstrated comparable postoperative ESS (melatonin: 6.0 ± 4.0; placebo: 6.8 ± 4.5, P = 0.35). Melatonin patients experienced significantly more hours slept on POD2 (6.5 ± 1.7; 5.7 ± 2.4, P = 0.017) and averaged over POD one to three (6.1 ± 1.6; 5.7 ± 2.0, P = 0.14), although this was not statistically significant. Fewer nighttime awakenings in the melatonin group were observed on POD two (2.7 ± 1.5; 3.1 ± 2.0, P = 0.28), although this was not statistically significant. The melatonin group demonstrated significantly lower postoperative PROMIS-SD scores (52.5 ± 9.3; 56.3 ± 9.2, P = 0.040). CONCLUSION/CONCLUSIONS:Melatonin may not improve overall postoperative sleep quality following THA as measured by the ESS. Melatonin may promote sleep duration in the POD one to three period, although potential benefits wane after POD three. Melatonin is safe and can be considered for THA patients experiencing early postoperative sleep disturbance.

BACKGROUND:Periprosthetic joint infection (PJI) is a high-cost and extremely morbid complication following total joint arthroplasty (TJA); thus, developing a better understanding of perioperative infection prevention strategies is prudent. Literature is mixed regarding the efficacy of vancomycin powder and dilute povidone-iodine lavage, and limited on the combination thereof. To our knowledge, no prospective orthopaedic clinical trials to date have evaluated the efficacy of local vancomycin powder, dilute povidone-iodine lavage, or a combination vancomycin-povidone-iodine-protocol (VPIP) against normal saline irrigation. METHODS:In a large, prospective, multi-center, randomized-controlled study, four distinct infection prevention strategies were implemented in high-risk TJA patients. Local vancomycin powder, dilute povidone-iodine solution, combined VPIP, and saline control were used. Primary outcomes included PJI, wound complications, revisions, emergency department (ED) visits, readmissions, and serious adverse events within three months of index surgery. Chi-square tests were used to compare incidence rates. The criteria used for the diagnosis of PJI were the International Consensus Meeting (ICM) guidelines. RESULTS:There were 821 total hip arthroplasty (THA) and 1,080 total knee arthroplasty (TKA) patients randomized into well-balanced study groups. In the THA and TKA cohorts, respectively, there were no statistically significant differences in rates of persistent wound drainage or dehiscence (P = 0.98, P = 0.95), cellulitis or abscess (P = 0.81, P = 0.51), 3-month infection rates (P = 0.14, P = 0.13), type of septic revisions performed (P = 0.51, P = 0.80), aseptic revision rates (P = 0.07, P = 0.90), ED visits (P = 0.61, P = 0.46), or readmissions (P = 0.78, P = 0.87) between the four treatment groups. CONCLUSIONS:There were no statistically significant differences in PJI or other surgical outcomes following THA or TKA among the study groups. Therefore, the use of such prophylactic measures, including povidone-iodine and vancomycin powder in high-risk patients, can be left up to the surgeon or hospital discretion.

INTRODUCTION/BACKGROUND:A two-stage revision has long been the gold standard for chronic periprosthetic joint infections (PJI), with real-component articulating spacers becoming overwhelmingly popular. While several studies have evaluated the success of these spacers in revision total knee arthroplasty (rTKA), to our knowledge, this is the first to specifically compare outcomes of spacers stratified by the level of liner constraint. METHODS:This retrospective analysis reviewed 135 patients who were indicated for two-stage rTKA due to PJI between 2011 and 2023 at a single specialty urban academic institution. Patients were categorized into three groups based on the polyethylene liner constraint used during the first stage: cruciate retaining (CR), posterior stabilized (PS), and varus-valgus constrained (VVC). Of these 135 patients, 60 (44%) were categorized in the CR group, 47 (35%) were in the PS group, and 28 (21%) were in the VVC group. These groups were compared after each stage for peri- and postoperative outcomes such as operative time, length of stay (LOS), discharge disposition, knee range of motion (ROM), as well as incidence of re-revision and reinfection. RESULTS:The mean postoperative LOS was not different among cohorts for both stages. Operative time was significantly longer in the VVC group after the second stage (P = 0.007), while there was no difference after the first stage (P = 0.085). There were no differences in ROM after both stages. The mean ROM after the first stage was 92° in the CR group, 90° in the PS group, and 85° in the VVC group (P = 0.46). After the second stage, ROM was 101° in both the CR and VVC groups and 107° in the PS group (P = 0.28). There were no differences in the risk of re-revision due to re-infection across the groups after the first or second stage procedures. The re-infection incidence after the first stage was 14% in the VVC group, compared to 5% in the CR group and 4% in the PS group (P = 0.14). After the second stage, the reinfection risk was 21% in the VVC group, 8% in the CR group, and 13% in the PS group (P = 0.21). CONCLUSION/CONCLUSIONS:No significant differences were observed in the risk of complications such as re-infection, re-revisions, and postoperative ROM, suggesting that the choice of liner constraint in two-stage revision can be left up to surgeon's discretion.

INTRODUCTION/BACKGROUND:Modular dual mobility (DM) liners are commonly used in total hip arthroplasty (THA) to decrease the risk of instability. However, there are concerns about accelerated wear, corrosion, and metal ion release in modular DM constructs. This study aimed to investigate serum metal ion levels over time after THA and evaluate any differences between implant manufacturers. METHODS:This retrospective study enrolled 165 patients who underwent THA with a modular DM liner. Serum cobalt (Co), chromium (Cr), and zirconium (Zr) levels were assessed via a one-time blood draw. Patients were grouped into time cohorts of one to two, two to five, five to eight, and eight plus years based on years since DM placement. The primary outcome was serum Co, Cr, and Zr levels. Reference values of < 1.5 mcg/L for Co and < 1.2 mcg/L for Cr were considered within normal limits. RESULTS:Median Co and Cr levels were 0.3 (range, 0.2 to seven) and 0.3 (range, zero to 3.1) mcg/L, respectively. There were 13 patients (7.9%) who had abnormally elevated metal ion levels; 10 received Implant A (13%), two received Implant B (4%), and one received Implant C (3%). The Zr levels were undetectable in all patients. Median Co levels (0.4 mcg/L) were higher within two years of DM implantation and had a greater range of values than other time periods (P < 0.001). Successive time periods displayed a decreased range of Co values over time. CONCLUSION/CONCLUSIONS:There was a greater range of Co levels within two years of implantation, which reduced in variability over successive time periods. Although this could suggest an initial "settling-in" period of DM constructs, sequential blood draws from individual patients over time are needed to confirm such trends. Longitudinal tracking of metal ion levels over time in modular DM implants is recommended.

INTRODUCTION/BACKGROUND:Maintaining follow-up after total joint arthroplasty (TJA) is critical to monitor patient outcomes and complications. However, patient factors associated with follow-up compliance have not been described previously. This study aimed to characterize demographic and perioperative characteristics associated with TJA follow-up compliance. METHODS:This was a retrospective review of all primary, elective total hip and knee arthroplasty (THA and TKA) procedures at an urban, tertiary care center from 2011 to 2022. Patient follow-ups were categorized as early (0 to 90 days), mid-term (91 days to two years), and late-term (greater than two years). Patient characteristics, including age, sex, race, smoking status, spoken language, body mass index, income class, insurance type, distance from hospital, 90-day readmission, American Society of Anesthesia Status, and Charlson Comorbidity Index (CCI), were compared at each period, and logistic regression identified predictors of follow-up. RESULTS:In total, 2,836 TKA and 3,056 THA procedures were analyzed, with overall follow-up rates of 78.9 and 76.8%, respectively. Among all TJA patients, those who did not have follow-up were more likely to be younger, men, White, active smokers, live further from the hospital, and have lower CCIs. Uniquely, for TKA patients, higher income status predicted lower overall and early follow-up rates, while English-speaking predicted lower early and higher late follow-up rates in this subgroup. Differences between groups based on follow-up status decreased as follow-up time increased. Regression analyses showed loss to follow-up increased with increased distance from the hospital and current smoking. Uniquely, for THA, men predicted loss-to-follow-up. CONCLUSION/CONCLUSIONS:Younger age, men, White race, higher income, current smoking, and increased distance from the hospital are associated with increased early, but not late, loss to follow-up after TJA. Future studies should assess the influence of other factors, including home support and telemedicine use, on follow-up rates.