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51


CHILDREN WITH ACUTE SEVERE HEPATITIS OF UNDETERMINED ETIOLOGY HAVE A SYSTEMIC T CELL ACTIVATION AND INTERFERON GAMMA (IFN-G) ACTIVITY REMINISCENT OF HEMOPHAGOCYTIC HISTIOCYTOSIS: A POTENTIAL ROLE FOR T CELL AND IFN-G DIRECTED THERAPIES [Meeting Abstract]

Nguyen, Thinh H.; Satwani, Prakash; Kumar, Deepak; Prince, Chengyu; Remotti, Helen; Goldner, Dana; Vittorio, Jennifer M.; Romero, Rene; Chandrakasan, Shanmuganathan
ISI:000870796604460
ISSN: 0270-9139
CID: 5397512

BARRIERS TO IDENTIFYING AND INTERVENING ON SOCIAL NEEDS IN PEDIATRIC LIVER TRANSPLANTATION: QUALITATIVE RESULTS FROM THE MULTI-CENTER SOCIAL & CONTEXTUAL IMPACT ON CHILDREN UNDERGOING LIVER TRANSPLANTATION (SOCIAL-TX) STUDY [Meeting Abstract]

Wadhwani, Sharad; Alvarado, Alejandra; Shifman, Holly; Squires, James E.; Campbell, Kathleen M.; Ebel, Noelle; Hsu, Evelyn K.; Vittorio, Jennifer M.; Zielsdorf, Shannon; Desai, Dev M.; Bucuvalas, John C.; Gottlieb, Laura; Kotagal, Uma; Lyles, Courtney; Lai, Jennifer Cindy
ISI:000870796604420
ISSN: 0270-9139
CID: 5397502

RELATIONSHIPS BETWEEN DECREASES IN SERUM BILE ACIDS, PRURITUS, AND SLEEP DISTURBANCE SCORES WITH UP TO 72 WEEKS OF ODEVIXIBAT TREATMENT IN PATIENTS WITH PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS [Meeting Abstract]

Dalgic, Buket; Verkade, Henkjan J.; Lachaux, Alain; Baumann, Ulrich; D\Antiga, Lorenzo; Czubkowski, Piotr; Artan, Reha; Vittorio, Jennifer; Ozen, Hasan; Gupte, Girish; Grammatikopoulos, Tassos; Ni, Quanhong; Kjems, Lise; Horn, Patrick
ISI:000826446205139
ISSN: 0016-5085
CID: 5397492

Analysis of quality of life, hepatic biochemical markers, and sleep in patients with progressive familial intrahepatic cholestasis who had a pruritus response with odevixibat treatment [Meeting Abstract]

Gupte, Girish; Thompson, Richard J.; D\Antiga, Lorenzo; Grammatikopoulos, Tassos; Gonzales, Emmanuel; Lacaille, Florence; Lachaux, Alain; Roquelaure, Bertrand; Baumann, Ulrich; Lainka, Elke; Sturm, Ekkehard; Shteyer, Eyal; Czubkowski, Piotr; Artan, Reha; Dalgic, Buket; Ozen, Hasan; Loomes, Kathleen M.; Vittorio, Jennifer M.; Karpen, Saul J.; McKiernan, Patrick; Mack, Cara L.; Di Giorgio, Angelo; Yu, Qifeng; Kjems, Lise; Horn, Patrick
ISI:000826275102360
ISSN: 0168-8278
CID: 5397482

Changes in hepatic parameters, growth, sleep, and biochemical markers with odevixibat treatment across patients with various types of progressive familial intrahepatic cholestasis [Meeting Abstract]

D\Antiga, Lorenzo; Gupte, Girish; Thompson, Richard J.; Sturm, Ekkehard; Calvo, Pier Luigi; Shagrani, Mohammad Ali; Stoll, Janis M.; Artan, Reha; Dalgic, Buket; Ozen, Hasan; Loomes, Kathleen M.; Vittorio, Jennifer M.; Karpen, Saul J.; Di Giorgio, Angelo; Ni, Quanhong; Kjems, Lise; Horn, Patrick
ISI:000826275102359
ISSN: 0168-8278
CID: 5397472

CURRENT APPROACH TO HEALTH CARE TRANSITION FOR PEDIATRIC LIVER TRANSPLANT RECIPIENTS: A CALL FOR PARTNERSHIP [Meeting Abstract]

King, Lindsay Y.; Jackson, Whitney E.; Parish, Alice; Niedzwiecki, Donna; Vittorio, Jennifer M.
ISI:000707188005306
ISSN: 0270-9139
CID: 5397452

EFFECTS ON SERUM BILE ACIDS, PRURITUS, AND SAFETY WITH UP TO 72 WEEKS OF ODEVIXIBAT TREATMENT: POOLED DATA FROM THE PEDFIC 1 AND PEDFIC 2 STUDIES IN CHILDREN WITH PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS [Meeting Abstract]

Loomes, Kathleen M.; Verkade, Henkjan J.; Thompson, Richard J.; Kamath, Binita; Hardikar, Winita; Lacaille, Florence; Mozer-Glassberg, Yael; Shteyer, Eyal; Calvo, Pier Luigi; Dalgic, Buket; Grammatikopoulos, Tassos; Rajwal, Sanjay; Vittorio, Jennifer M.; Soufi, Nisreen; McKiernan, Patrick James; Tessier, Mary Elizabeth; Yu, Qifeng; Kjems, Lise; Horn, Patrick
ISI:000707188005309
ISSN: 0270-9139
CID: 5397462

A HIGH DIAGNOSTIC RATE FOR MENDELIAN LIVER DISORDERS: LESSONS FROM EXOME SEQUENCING IN 10,804 INDIVIDUALS WITH OR WITHOUT LIVER DISEASES [Meeting Abstract]

Kong, Xiao-Fei; Bogyo, Kelsie; Rasouly, Hila Milo; Cocchi, Enrico; Martinez, Mercedes; Vittorio, Jennifer M.; Dove, Lorna M.; Shea, Patrick; Bier, Louise; Worman, Howard J.; Marasa, Maddalena; Wang, Timothy C.; Emond, Jean C.; Verna, Elizabeth C.; Wattacheril, Julia J.; Goldstein, David; Gharavi, Ali G.
ISI:000707188001322
ISSN: 0270-9139
CID: 5397442

Substantial clinical benefits with odevixibat treatment across progressive familial intrahepatic cholestasis genetic deficiencies: subgroup analysis of serum bile acids, pruritus, and safety using pooled data from the PEDFIC 1 and 2 studies [Meeting Abstract]

Thompson, Richard; Horn, Patrick; Houwen, Roderick H. J.; Lacaille, Florence; Ni, Quanhong; Stein, Philip; Tessier, Mary Elizabeth; Thompson, Carrie; Vittorio, Jennifer; Kjems, Lise
ISI:000667753801336
ISSN: 0168-8278
CID: 5397432

Bone Fractures in Children With Cholestatic Liver Disease May Mimic Those Seen in Child Abuse

Goldner, Dana; Vittorio, Jennifer; Barrios, Dulce M; McGuire, Jillian; Brodlie, Susan; Brown, Jocelyn; Lobritto, Steven; Martinez, Mercedes
Certain fractures in children are highly specific for child abuse. Metabolic bone disease frequently develops in patients with cholestatic liver disease (CLD); this can result in weakened bones and a predisposition to pathologic fractures. Fractures that occur in patients with rickets and osteopenia may mimic a bone response to inflicted injury, which in children raise the concern of child abuse. Here we report a series of 15 patients with CLD who developed pathologic fractures in the setting of metabolic bone disease. During initial evaluation, the caretakers of 5 of these 15 patients were reported to child protective services and investigated for child abuse. Pediatricians should be aware that children with CLD have an increased incidence of pathologic fractures, even after the cholestasis has resolved.
PMID: 30672906
ISSN: 1535-1815
CID: 5397302