Faculty Bibliography
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616
Higher weight in adolescence and young adulthood is associated with an earlier age at multiple sclerosis onset
BACKGROUND: Growing evidence suggests an association between adolescent obesity and increased risk of multiple sclerosis (MS). OBJECTIVE: The objective of this paper is to investigate whether weight or body mass index (BMI) in adolescence and young adulthood was associated with age at MS symptom onset. METHODS: Our cohort is comprised of a sub-group of 184 women enrolled in the New York State MS Consortium registry. Individuals were asked to recall their weight at the time of first menstruation and at age 25. BMI was calculated accordingly for age 25. Regression analyses were carried out to investigate the association between weight or BMI and age at onset. RESULTS: Weight at menarche was significantly related to younger age at symptom onset (beta = -0.073, p = 0.001). These results were also found at age 25 for weight (beta = -0.080, p < 0.001) and BMI (beta = -0.448, p = 0.001). Significantly earlier disease onset (26.9 years +/-9.9) was observed in individuals who were overweight at 25 compared to those who were not overweight (32.1 years +/-9.2, p = 0.006). CONCLUSIONS: Women who reported higher weight in adolescence and BMI in early adulthood were younger at MS onset. Future research should investigate whether there is a causal link between body weight and MS, as prevention lifestyle and dietary interventions could be implemented.
PMID: 25392327
ISSN: 1477-0970
CID: 2237042
Effects of delayed-release dimethyl fumarate on MRI measures in the phase 3 CONFIRM study
OBJECTIVE:To evaluate the effects of oral delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF) on MRI lesion activity and load, atrophy, and magnetization transfer ratio (MTR) measures from the Comparator and an Oral Fumarate in Relapsing-Remitting Multiple Sclerosis (CONFIRM) study. METHODS:CONFIRM was a 2-year, placebo-controlled study of the efficacy and safety of DMF 240 mg twice (BID) or 3 times daily (TID) in 1,417 patients with relapsing-remitting multiple sclerosis (RRMS); subcutaneous glatiramer acetate 20 mg once daily was included as an active reference comparator. The number and volume of T2-hyperintense, T1-hypointense, and gadolinium-enhancing (Gd+) lesions, as well as whole brain volume and MTR, were assessed in 681 patients (MRI cohort). RESULTS:DMF BID and TID produced significant and consistent reductions vs placebo in the number of new or enlarging T2-hyperintense lesions and new nonenhancing T1-hypointense lesions after 1 and 2 years of treatment and in the number of Gd+ lesions at week 24, year 1, and year 2. Lesion volumes were also significantly reduced. Reductions in brain atrophy and MTR changes with DMF relative to placebo did not reach statistical significance. CONCLUSIONS:The robust effects on MRI active lesion counts and total lesion volume in patients with RRMS demonstrate the ability of DMF to exert beneficial effects on inflammatory lesion activity in multiple sclerosis, and support DMF therapy as a valuable new treatment option in RRMS. CLASSIFICATION OF EVIDENCE/METHODS:This study provides Class I evidence of reduction in brain lesion number and volume, as assessed by MRI, over 2 years of delayed-release DMF treatment.
PMCID:4371413
PMID: 25681448
ISSN: 1526-632x
CID: 5348212
Assessing cognition in MS clinical trials : the cognitive assessment interview (CAI) [Meeting Abstract]
ORIGINAL:0011418
ISSN: 1526-632x
CID: 2236612
Gut microbiome in early pediatric MS : a case-control study [Meeting Abstract]
ORIGINAL:0011420
ISSN: 1526-632x
CID: 2236632
Pregnancy exposures and risk for paediatric onset MS [Meeting Abstract]
ISI:000365729402283
ISSN: 1477-0970
CID: 2234182
Acquisition of early developmental milestones and need for special education services in paediatric-onset multiple sclerosis [Meeting Abstract]
ISI:000365729400145
ISSN: 1477-0970
CID: 2234332
Association of dietary salt intake and relapse rate in pediatric multiple sclerosis [Meeting Abstract]
ISI:000365729400155
ISSN: 1477-0970
CID: 2234342
The geographic distribution of pediatric MS in the US [Meeting Abstract]
ISI:000365729402284
ISSN: 1477-0970
CID: 2234352
Remotely-supervised cognitive remediation is feasible and effective: results of a pilot study [Meeting Abstract]
ISI:000365729401057
ISSN: 1477-0970
CID: 2225142
The Test of Everyday Cognitive Ability (TECA) Links Cognitive Measures to Real-Life Functioning in Adults with Multiple Sclerosis (MS) [Meeting Abstract]
ISI:000362668600010
ISSN: 1531-8249
CID: 2225182
