Searched for: in-biosketch:true
person:pomarn01
Aging and cortisol resistance to suppression by dexamethasone: a positive correlation
Oxenkrug GF; Pomara N; McIntyre IM; Branconnier RJ; Stanley M; Gershon S
Cortisol resistance to suppression by 0.5 mg of dexamethasone given at 11 p.m. was studied in 30 normal subjects, 17 to 78 years of age. Serum cortisol concentrations were determined by radioimmunoassay. A strong positive correlation was found between age and cortisol concentrations 9 hours after dexamethasone administration. The data suggest that aging, per se, might contribute to the increased cortisol resistance to suppression by dexamethasone reported in depression and dementia
PMID: 6581489
ISSN: 0165-1781
CID: 23727
Failure of single-dose lecithin to alter aspects of central cholinergic activity in Alzheimer's disease
Pomara N; Domino EF; Yoon H; Brinkman S; Tamminga CA; Gershon S
The effect of a single dose (15 g/70 kg) of lecithin (95% phosphatidylcholine) on several measures of central cholinergic activity (memory, cortisol, prolactin, pulse, blood pressure) was assessed in individuals with Alzheimer's disease. In contrast to the reported effects of physostigmine, a cholinesterase inhibitor, lecithin had no effect on these parameters, despite significant increases in plasma and erythrocyte choline
PMID: 6874650
ISSN: 0160-6689
CID: 23728
Elevation of RBC glycine and choline levels in geriatric patients treated with lithium
Pomara N; Banay-Schwartz M; Block R; Stanley M; Gershon S
During 6 weeks of lithium treatment, the RBC glycine and choline levels of five cognitively impaired geriatric subjects without affective disorders increased significantly and correlated with RBC and plasma lithium levels. The subjects' cognitive processes did not improve
PMID: 6407342
ISSN: 0002-953x
CID: 23729
Attenuation of pilocarpine-induced hypothermia in response to chronic administration of choline
Pomara N; Block R; Demetriou S; Fucek F; Stanley M; Gershon S
Chronic treatment of rats with choline caused a decrease in the hypothermic response to pilocarpine. The action of choline on the muscarinic receptors is consistent with electrophysiological and binding studies, supporting a direct muscarinic action for choline. Administration of direct muscarinic agonists has been shown to cause a decrease in the number of muscarinic receptors. Thus, the long-term use of cholinergic precursors could have some adverse effects on central cholinergic functioning
PMID: 6410440
ISSN: 0033-3158
CID: 23730
Combined cholinergic precurson treatment and dihydroergotoxine mesylate in Alzheimer's disease
Pomara N; Block R; Abraham J; Domino EF; Gershon S
ORIGINAL:0004207
ISSN: 0305-6481
CID: 23736
Caution in the use of diazepam in the elderly
Pomara N; Block R; Guido J; Stanley M
ORIGINAL:0004210
ISSN: 0028-4793
CID: 23739
Pharmacologic treatment of Alzheimer's disease : future directions
Chapter by: Pomara, Nunzio; Brinkman, Samuel; Gershon, Samuel
in: Alzheimer's disease by Reisberg, Barry [Eds]
New York : Free Press ; London : Collier Macmillan, c1983
pp. ?-?
ISBN: 9780029262306
CID: 591682
Cholinergic precursors in Alzheimer's disease [Letter]
Pomara N; Stanley M
PMID: 6127534
ISSN: 0140-6736
CID: 23731
A dose-ranging study of lecithin in the treatment of primary degenerative dementia (Alzheimer disease)
Brinkman SD; Pomara N; Goodnick PJ; Barnett N; Domino EF
PMID: 7119136
ISSN: 0271-0749
CID: 23732
Lithium, memory RBC plasma choline in Alzheimer-type dementia
Brinkman SD; Pomara N; Domino EF; Barnett N; Gershon S
ORIGINAL:0004206
ISSN: 0305-6481
CID: 23735