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254


Influence of anatomic location on prognosis of malignant melanoma: attempt to verify the BANS model

Rogers GS; Kopf AW; Rigel DS; Levenstein ML; Friedman RJ; Harris MN; Golomb FM; Hennessey P; Gumport SL; Roses DF; et al.
Stage I cutaneous malignant melanomas between 0.76 and 1.69 mm thick (Breslow measurement) in BANS (upper part of the back, posterior aspects of the arms, posterior and lateral aspects of the neck, posterior aspect of the scalp) areas have been reported to portend a relatively poor prognosis compared to non-BANS sites. We were unable to confirm the 15% poorer survival for BANS area lesions (84% BANS, 99% non-BANS) originally reported. In this report of 211 patients, malignant melanomas in BANS sites had a 4.6% poorer 5-year cumulative survival rate (88.9% BANS, 93.5% non-BANS; p = 0.35). Although many more patients need to be studied, we believe this small difference in survival is insufficient to influence therapeutic management strategies
PMID: 3745528
ISSN: 0190-9622
CID: 16841

Importance of complete cutaneous examination for the detection of malignant melanoma

Rigel DS; Friedman RJ; Kopf AW; Weltman R; Prioleau PG; Safai B; Lebwohl MG; Eliezri Y; Torre DP; Binford RT; et al.
With the rate of melanoma increasing 1,000% in the past 50 years, the early detection of the disease is becoming more important. Data from 2,239 persons seen at the Manhattan Melanoma/Skin Cancer Detection Screening Program were analyzed to determine if a complete cutaneous examination would significantly increase the chance of detecting melanoma. Thirteen of the fourteen melanomas detected were on anatomic sites normally covered by clothing. Patients having complete skin examinations were 6.4 times more likely to have a melanoma detected than those having partial examinations (p = 0.025). These findings reinforce the importance of complete skin examination for the early detection of malignant melanoma
PMID: 3711396
ISSN: 0190-9622
CID: 16842

Computers in dermatology

Rosenthal, Lawrence E.; Rigel, Darrell S
Philadelphia : Saunders, 1986
Extent: xi p., p. 533-677 : ill. ; 27 cm
ISBN: n/a
CID: 420

Self-examination of the skin: the patient's role in early detection

Kopf AW; Friedman RJ; Rigel DS
ORIGINAL:0005502
ISSN: 0898-6665
CID: 62412

The incredible increasing incidence of malignant melanoma in the United States

Kopf AW; Rigel DS; Friedman RJ
ORIGINAL:0005503
ISSN: 0898-6665
CID: 62413

Mohs surgery for periocular basal cell carcinomas

Robins P; Rodriguez-Sains R; Rabinovitz H; Rigel D
Cure rates for 631 periocular basal cell carcinomas treated by Mohs surgery proved to be 98.1% for primary lesions and 93.6% for previously treated lesions. All recurrences of primary lesions post-Mohs surgery were located in the medial canthus. Among lesions previously treated, recurrence rates after Mohs surgery were twice as high for medial canthal lesions as for other periocular basal cell carcinomas, 9.5 and 4.5%, respectively. A threefold increased risk of recurrence was observed for medial canthal lesions (post-Mohs surgery) previously treated by radiation as compared to all other treatment modalities. This high recurrence rate may reflect past practices of treating large medial canthal basal cell carcinomas with radiation rather than by other means. Results of our study indicate that primary basal cell carcinomas in the medial canthus can be treated by microscopically controlled excision with excellent results
PMID: 4067056
ISSN: 0148-0812
CID: 16881

Prevalence of congenital-nevus-like nevi, nevi spili, and cafe au lait spots

Kopf AW; Levine LJ; Rigel DS; Friedman RJ; Levenstein M
To determine the clinical prevalence of medium-sized (1.5- to 19.9-cm-diameter) congenital-nevus-like nevi (CNLN), a consecutive series of 601 patients (mostly adults) had total cutaneous examinations. In this series, 15 (2.5%) were found to have such lesions. In addition, 14 (2.3%) had nevi spili and 83 (13.8%) had cafe au lait spots. All three types of lesions were equally represented in both sexes and tended to spare the head, neck, and upper extremities. Compared with CNLN, nevi spili were found to have significantly larger diameters and lower mean age, suggesting that these are different types of lesions. Some recommend the surgical removal of all congenital nevocytic nevi because of their malignant potential. Since it is not possible to clinically distinguish congenital nevocytic nevi and CNLN and since the observed prevalence of these lesions in adults is over four times that previously reported in newborns, such a recommendation becomes less feasible
PMID: 4004301
ISSN: 0003-987x
CID: 16843

Early detection of malignant melanoma: the role of physician examination and self-examination of the skin

Friedman RJ; Rigel DS; Kopf AW
The combination of routine physician examination of the skin coupled with self-examination provides a realistic opportunity for the identification of early malignant melanomas. Removal of such thin lesions can significantly reduce the mortality rate from this potentially serious form of cutaneous cancer
PMID: 3921200
ISSN: 0007-9235
CID: 16844

Relationship of nevocytic nevi to sun exposure in dysplastic nevus syndrome

Kopf AW; Lindsay AC; Rogers GS; Friedman RJ; Rigel DS; Levenstein M
In eighty consecutive patients who have the dysplastic nevus syndrome, the concentration of nevocytic nevi on the relatively sun-protected lateral thoracic area was compared to the concentration on the relatively sun-exposed areas of the anterior and posterior thorax. Nevocytic nevi in an area 7 X 20 cm were counted in each location. There was a total of 177 nevi on the lateral thorax (average, 2.2 nevi/person), 361 on the anterior thorax (average, 4.5 nevi/person), and 506 on the posterior thorax (average, 6.3 nevi/person). Men showed no significant difference in the number of nevi on the anterior and posterior thoracic areas, but women had fewer nevi on the anterior than on the posterior thoracic sites. These findings are consonant with the hypothesis that sunlight induces nevocytic nevi in patients who have the dysplastic nevus syndrome
PMID: 3989027
ISSN: 0190-9622
CID: 16845

Precursors of malignant melanoma. Problems in computing the risk of malignant melanoma arising in dysplastic and congenital nevocytic nevi

Rigel DS; Friedman RJ; Kopf AW; Rogers GS; Heilman ER
It has recently been shown that both dysplastic and congenital nevi are precursors to malignant melanoma. These findings are based upon mathematical models that show an increased risk of the nevi evolving into melanoma over random choice. However, problems exist with these models that may invalidate their results. The recommendation to remove dysplastic and congenital nevi prophylactically based upon models such as these is premature
PMID: 3830497
ISSN: 0733-8635
CID: 16846