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314


Invited commentary [Comment]

Rockman, Caron B
PMID: 23806254
ISSN: 0741-5214
CID: 737922

Increasing ablation distance peripheral to the saphenofemoral junction may result in a diminished rate of endothermal heat-induced thrombosis

Sadek, Mikel; Kabnick, Lowell S; Rockman, Caron B; Berland, Todd L; Zhou, Di; Chasin, Cara; Jacobowitz, Glenn R; Adelman, Mark A
OBJECTIVE: The treatment of venous insufficiency using endovenous laser ablation or radiofrequency ablation may result in endothermal heat-induced thrombosis (EHIT), a form of deep venous thrombosis. This study sought to assess whether increasing the ablation distance peripheral to the deep venous junction would result in a reduction in the incidence of EHIT II. METHODS: This study was a retrospective review of a prospectively maintained database from April 2007 to December 2011. Consecutive patients undergoing great saphenous vein (GSV) or small saphenous vein (SSV) ablation were evaluated. Previous to February 2011, all venous ablations were performed 2 cm peripheral to the saphenofemoral or saphenopopliteal junction (group I). Subsequent to February 2011, ablations were performed greater than or equal to 2.5 cm peripheral to the respective deep system junction (group II). The primary outcome was the development of EHIT II or greater (ie, thrombus protruding into the deep venous system but comprising less than 50% of the deep vein lumen). Secondary outcomes included procedure-site complications such as thrombophlebitis and hematomas. chi2 tests were performed for all discrete variables, and unpaired Student's t-tests were performed for all continuous variables. P < .05 was considered statistically significant. RESULTS: A total of 4223 procedures were performed among group I (n = 3239) and group II (n = 984). Patient demographics were similar between the two groups; however, the CEAP classification was higher by a small margin in group II, and the result was significant (group I: 2.6% +/- 0.9% vs group II: 2.8% +/- 1.0%; P = .006). The incidence of EHIT II was 76 in group I and 13 in group II. This represented a trend toward diminished frequency in group II as compared with group I (group I: 2.3% vs group II: 1.3%; P = .066). There were no reported cases of EHIT III or IV in this patient cohort. Patients who developed an EHIT II in group I were treated using anticoagulation 54% of the time, and patients who developed an EHIT II in group II were treated using anticoagulation 100% of the time. CONCLUSIONS: This study suggests that changing the treatment distance from 2 cm to greater than or equal to 2.5 cm peripheral to the deep venous junction may result in a diminished incidence of EHIT II. Ongoing evaluation is required to validate these results and to affirm the long-term durability of this technique.
PMID: 26992584
ISSN: 2213-3348
CID: 2047492

Management of carotid stenosis in women: Consensus document

De Rango, Paola; Brown, Martin M; Didier, Leys; Howard, Virginia J; Moore, Wesley S; Paciaroni, Maurizio; Ringleb, Peter; Rockman, Caron; Caso, Valeria
OBJECTIVE: Specific guidelines for management of cerebrovascular risk in women are currently lacking. This study aims to provide a consensus expert opinion to help make clinical decisions in women with carotid stenosis. METHODS: Proposals for the use of carotid endarterectomy (CEA), carotid stenting (CAS), and medical therapy for stroke prevention in women with carotid stenosis were provided by a group of 9 international experts with consensus method. RESULTS: Symptomatic women with severe carotid stenosis can be managed by CEA provided that the perioperative risk of the operators is low (<4%). Periprocedural stroke risks may be increased in symptomatic women if revascularization is performed by CAS; however, the choice of CAS vs CEA can be tailored in subgroups best fit for each procedure (e.g., women with restenosis or severe coronary disease, best suited for CAS; women with tortuous vessels or old age, best suited for CEA). There is currently limited evidence to consider medical therapy alone as the best choice for women with neurologically severe asymptomatic carotid stenosis, who should be best managed within randomized trials including a medical arm. Medical management and cardiovascular risk factor control must be implemented in all women with carotid stenosis in periprocedural period and lifelong regardless of whether or not intervention is planned. CONCLUSIONS: The suggestions provided in this article may constitute a decision-making basis for planning treatment of carotid stenosis in women. Most recommendations are of limited strength; however, it is unlikely that new robust data will emerge soon to induce relevant changes.
PMCID:3721103
PMID: 23751919
ISSN: 0028-3878
CID: 399212

Association between Advanced Age and Vascular Disease in Different Arterial Territories: A Population Database of Over 3.6 Million Subjects

Savji, Nazir; Rockman, Caron B; Skolnick, Adam; Guo, Yu; Adelman, Mark A; Riles, Thomas; Berger, Jeffrey S
OBJECTIVE: This study sought to determine the relationship between vascular disease in different arterial territories and advanced age. BACKGROUND: Vascular disease in the peripheral circulation is associated with significant morbidity and mortality. There is little data to assess the prevalence of different phenotypes of vascular disease in the very elderly. METHODS: Over 3.6 million self-referred participants from 2003-2008 who completed a medical and lifestyle questionnaire in the United States were evaluated by screening ankle brachial indices <0.9 for peripheral artery disease (PAD), and ultrasound imaging for carotid artery stenosis (CAS) >50% and abdominal aortic aneurysm (AAA) >3cm. Participants were stratified by decade of life. Multivariate logistic regression analysis was used to estimate odds of disease in different age categories. RESULTS: Overall, the prevalence of PAD, CAS, and AAA, was 3.7%, 3.9%, and 0.9%, respectively. Prevalence of any vascular disease increased with age (40-50y: 2%; 51-60y: 3.5%; 61-70y: 7.1%; 71-80y: 13.0%; 81-90y: 22.3%; 91-100y: 32.5%; P<0.0001). Prevalence of disease in each vascular territory increased with age. After adjustment for sex, race/ethnicity, body mass index, family history of cardiovascular disease, smoking, diabetes, hypertension, hypercholesterolemia, and exercise, the odds of PAD (OR 2.14, 95% CI 2.12-2.15), CAS (OR 1.80, 95% CI 1.79-1.81), and AAA (OR 2.33, 95% CI 2.30-2.36]) increased with every decade of life. CONCLUSION: There is a dramatic increase in the prevalence of PAD, CAS, and AAA with advanced age. More than 20% and 30% of octo- and nonagenarians, respectively, have vascular disease in at least 1 arterial territory.
PMID: 23500290
ISSN: 0735-1097
CID: 248012

The prevalence of carotid artery stenosis varies significantly by race

Rockman, Caron B; Hoang, Han; Guo, Yu; Maldonado, Thomas S; Jacobowitz, Glenn R; Talishinskiy, Toghrul; Riles, Thomas S; Berger, Jeffrey S
OBJECTIVE: Certain races are known to be at increased risk for stroke, and the prevalence of carotid artery stenosis (CAS) is thought to vary by race. The goal of this report was to study the prevalence of CAS in different races by analyzing a population of subjects who underwent vascular screening examinations. METHODS: The study data were provided by Life Line Screening. The cohort consists of self-referred individuals who paid for vascular screening tests. Subjects <40 and >100 years of age and those who reported a prior stroke or carotid artery intervention were excluded. Of the remaining 3,291,382 subjects, 3.7% did not self-identify a race. CAS was defined as stenosis in either internal carotid artery >/=50% by duplex ultrasound velocity criteria. RESULTS: The 3,291,382 subjects available for analysis consisted of Caucasian (2,845,936 [90%]), African American (97,502 [3.1%]), Hispanic (75,240 [2.4%]), Asian (60,982 [1.9%]), and Native American (87,757 [2.8%]) individuals. The prevalence of CAS was 3.4% in females and 4.2% in males (P
PMID: 23177534
ISSN: 0741-5214
CID: 213612

Mid- and long-term results of the treatment of infrainguinal arterial occlusive disease with precuffed expanded polytetrafluoroethylene grafts compared with vein grafts

Loh, Shang A; Howell, Brittny S; Rockman, Caron B; Cayne, Neal S; Adelman, Mark A; Gulkarov, Iosif; Veith, Frank J; Maldonado, Thomas S
BACKGROUND: Prosthetic grafts for lower-extremity bypass have limited patency compared with autologous vein grafts. Precuffed expanded polytetrafluoroethylene (ePTFE) grafts alter the geometry of the distal hood to improve patency. This study reports the authors' long-term results on the use of precuffed ePTFE grafts for infrainguinal bypasses in patients with arterial occlusive disease and compares these with results of reversed great saphenous vein grafts (rSVG). METHODS: A retrospective review of billing codes identified 101 polytetrafluoroethylene (PTFE) and 47 rSVG bypasses performed over a 6-year period. Femoral to below-knee popliteal and femoral to tibial bypasses were analyzed. Data collected consisted of risk factors, Rutherford classification, bypass inflow and outflow, runoff vessels, patency, amputation, and death. Primary end points consisted of primary, assisted-primary, and secondary patency along with limb salvage. RESULTS: Mean age of the patients was 76 years in the PTFE group and 69.8 years in the rSVG group. For femoral to below-knee popliteal bypasses, primary patency at 1, 3, and 5 years in the PTFE group was 76.9%, 48.7%, and 43.3%, respectively, compared with 77.1%, 77.1%, and 77.1%, respectively, in the rSVG group (P = 0.225). Secondary patency was 89.2%, 70.9%, and 50.6% in the PTFE group compared with 84.4%, 84.4%, and 84.4% in the rSVG group (P = 0.269). Limb salvage was similar in the PTFE compared with the rSVG group (97.7%, 90.5%, and 79.4% vs. 83.3%, 83.3%, and 83.3%; P = 0.653). For femoral to tibial bypasses, primary patency in the PTFE group at 1, 3, and 5 years was 57.1%, 40.4%, and 22.1%, respectively, compared with 67.4%, 67.4%, and 50.6%, respectively, for the rSVG group (P = 0.246). Secondary patency was 75.5%, 44.9%, and 22.7% in the PTFE group compared with 91.8%, 91.8%, and 52.5% in the rSVG group (P = 0.022). Limb salvage at 1, 3, and 5 years was 79.2%, 55.7%, and 55.7%, respectively, in the PTFE group compared with 96.4%, 96.4%, and 64.3%, respectively, in the rSVG group (P = 0.046). CONCLUSIONS: Precuffed ePTFE grafts demonstrate similar 1-year patency to that of rSVG. However, mid- and long-term patency is reduced compared with saphenous vein grafts (SVG), especially to tibial targets. PTFE grafts to the popliteal demonstrate limb salvage rates similar to those of SVG. In the tibial vessels, limb salvage rates for PTFE grafts are significantly worse compared with SVG.
PMID: 22998787
ISSN: 0890-5096
CID: 217782

Left subclavian artery coverage during thoracic endovascular aortic aneurysm repair does not mandate revascularization

Maldonado, Thomas S; Dexter, David; Rockman, Caron B; Veith, Frank J; Garg, Karan; Arko, Frank; Bertoni, Hernan; Ellozy, Sharif; Jordan, William; Woo, Edward
OBJECTIVE: This study assessed the risk of left subclavian artery (LSA) coverage and the role of revascularization in a large population of patients undergoing thoracic endovascular aortic aneurysm repair. METHODS: A retrospective multicenter review of 1189 patient records from 2000 to 2010 was performed. Major adverse events evaluated included cerebrovascular accident (CVA) and spinal cord ischemia (SCI). Subgroup analysis was performed for noncovered LSA (group A), covered LSA (group B), and covered/revascularized LSA (group C). RESULTS: Of 1189 patients, 394 had LSA coverage (33.1%), and 180 of these patients (46%) underwent LSA revascularization. In all patients, emergency operations (9.5% vs 4.3%; P = .001), renal failure (12.7% vs 5.3%; P = .001), hypertension (7% vs 2.3%; P = .01), and number of stents placed (1 = 3.7%, 2 = 7.4%, >/=3 = 10%; P = .005) were predictors of SCI. History of cerebrovascular disease (9.6% vs 3.5%; P = .002), chronic obstructive pulmonary disease (9.5% vs 5.4%; P = .01), coronary artery disease (8.5% vs 5.3%; P = .03), smoking (8.9% vs 4.2%) and female gender (5.3% men vs 8.2% women; P = .05) were predictors of CVA. Subgroup analysis showed no significant difference between groups B and C (SCI, 6.3% vs 6.1%; CVA, 6.7% vs 6.1%). LSA revascularization was not protective for SCI (7.5% vs 4.1%; P = .3) or CVA (6.1% vs 6.4%; P = .9). Women who underwent revascularization had an increased incidence of CVA event compared with all other subgroups (group A: 5.6% men, 8.4% women, P = .16; group B: 6.6% men, 5.3% women, P = .9; group C: 2.8% men, 11.9% women, P = .03). CONCLUSIONS: LSA coverage does not appear to result in an increased incidence of SCI or CVA event when a strategy of selective revascularization is adopted. Selective LSA revascularization results in similar outcomes among the three cohorts studied. Revascularization in women carries an increased risk of a CVA event and should be reserved for select cases.
PMID: 23021570
ISSN: 0741-5214
CID: 207302

ASSOCIATION BETWEEN DIABETES MELLITUS AND PREVALENCE OF VASCULAR DISEASE IN DIFFERENT ARTERIAL TERRITORIES [Meeting Abstract]

Shah, Binita; Rockman, Caron; Chesner, Jaclyn; Guo, Yu; Schwartzbard, Arthur; Weintraub, Howard; Adelman, Mark; Riles, Thomas; Berger, Jeffrey
ISI:000316555202254
ISSN: 0735-1097
CID: 1795282

Coil embolization of a gastroduodenal artery pseudoaneurysm secondary to cholangitis: technical aspects and review of the literature

Sadek, Mikel; Rockman, Caron B; Berland, Todd L; Maldonado, Thomas S; Jacobowitz, Glenn R; Adelman, Mark A; Mussa, Firas F
A 72-year-old woman with end-stage renal disease was admitted with right upper quadrant pain, hypotension, an elevated bilirubin, and leukocytosis. A computed tomography scan showed a dilated common bile duct and an associated 4.5 cm gastroduodenal artery pseudoaneurysm. The pseudoaneurysm was coil embolized successfully while maintaining dual access from the brachial and femoral arteries using the "body floss" technique. Subsequently, the patient underwent endoscopic treatment for her obstructive jaundice. We report on the technical aspects of this case and review the literature.
PMID: 22903332
ISSN: 1538-5744
CID: 180472

Subsequent Open Surgical Revascularization Following an Initial Endovascular Approach for Critical Limb Ischemia [Meeting Abstract]

Moridzadeh, Rameen; Kaszubski, Patrick A; Rockman, Caron B; Veith, Frank J; Mussa, Firas F
ISI:000308085500050
ISSN: 0741-5214
CID: 2781702