Faculty Bibliography

Juvenile granulosa cell tumor (GCT) of the ovary is a rare neoplasm occurring in premenarchal girls and young women. Juvenile GCT that occurs in premenarchal girls usually produces sexual precocity as a consequence of estrogen secretion. Juvenile GCTs are more likely to grow to a relatively large size with a much smaller likelihood of peritoneal spread, unlike their counterpart, epithelial ovarian neoplasms. We report the radiology and pathology of a patient with juvenile GCT and review the literature of this rare tumor.

OBJECTIVE:The purpose of our study was to prospectively determine the incidence and nature of unblinding by authors as to their identities or institutions in their submission of original major manuscripts to two radiology journals with double-blinded peer review policies. MATERIALS AND METHODS/METHODS:The editors of two radiology journals reviewed 880 major original manuscripts submitted to their journals during a 6-month period without knowledge of the identities and institutions of the authors. Each manuscript was inventoried for possible author or institutional unblinding and for the specific types of unblinding violations. RESULTS:Of 880 manuscripts, 300 (34%) contained information that potentially unblinded the identities of the authors, their institutions, or both. The editors correctly identified the authors or institutions in 221 (74%) of the 300 manuscripts, which represented 25% of the total manuscripts. The most frequent unblinding violations were statement of the authors' initials within the manuscript, referencing work "in press," identifying references as the authors' previous work, and revealing the identity of the institution in the figures. CONCLUSION/CONCLUSIONS:Despite explicit instructions to authors, 34% of 880 prospectively evaluated manuscripts submitted to two radiology journals contained information that potentially or definitely unblinded the identities of the authors or their institutions.

Forty outpatients were randomized into two groups of 20. Twenty patients received 1 mg of intravenous glucagon and the other 20 did not. Three radiologists evaluated the bowel using a qualitative score and mean scores for each bowel level were compared. A different radiologist measured the maximal diameter of bowel at seven levels. There were no significant differences in qualitative or quantitative data for the two groups. Intravenous glucagon is therefore not routinely recommended for helical CT of the abdomen.

The combination of computed tomographic (CT) venography and pulmonary angiography (CTVPA) was initially described in 1998 as a single comprehensive noninvasive imaging examination for suspected thromboembolic disease. It allowed the identification of pulmonary embolism as well as deep venous thrombosis (DVT) in the abdomen, pelvis, thighs, and calves. The venographic portion of CTVPA has now been studied by multiple researchers and has been shown to be an accurate imaging study for the thigh veins in comparison with lower extremity sonography. In contrast to sonography, however, CTVPA readily and rapidly permits evaluation of the inferior vena cava, the pelvic veins, the calf veins, and all of the superficial venous system. Complex venous anatomy can be surveyed, an additional sonographic study is not required, and only a few extra minutes and images are required over and above CT pulmonary angiography. A review of 957 recent cases of suspected pulmonary embolism examined with CTVPA revealed an overall 10.5% frequency of DVT, with a nearly equal distribution of thrombosis at the common femoral, superficial femoral, popliteal, and deep calf veins. Although a variety of protocols for CTVPA may be implemented, including a contiguous helical acquisition, obtaining 5- or 10-mm-thick images every 4 cm provides a high degree of accuracy and decreases overall radiation dose.

RATIONALE AND OBJECTIVES: The purpose of this study was to determine whether a simple rapid blood test can obviate computed tomography (CT) in a sizable percentage of patients suspected of having pulmonary embolism, based on the hypothesis that negative D-dimer results could eliminate any further search for pulmonary embolism. MATERIALS AND METHODS: At the authors' institution, 2,121 sequential patients underwent a whole-blood antibody agglutination test for cross-linked fibrin degradation products (D-dimer). Of these patients, 844 had positive test results and were not further considered. A retrospective review included reports of all multisection combined CT venographic and pulmonary angiographic studies obtained within 48 hours of the D-dimer assay for the 1,277 patients with negative D-dimer results; 229 (18%) of these 1,277 patients underwent combined CT venography and pulmonary angiography, usually within 24 hours. RESULTS: Retrospective review of the imaging examinations that were discrepant with the D-dimer results revealed only three false-negative D-dimer results. Of the 229 patients in whom combined CT venography and pulmonary angiography was performed for suspected pulmonary embolism, 226 (98.7%) had no evidence of acute pulmonary embolism or deep venous thrombosis. The negative predictive value of a negative D-dimer result was therefore 98.7% (confidence interval, 96.2%-99.7%). CONCLUSION: The D-dimer assay is a simple rapid blood test that is sensitive to the presence of acute thrombosis. Very few patients with negative results have acute deep venous thrombosis or pulmonary embolism, with combined CT venography and pulmonary angiography used as the reference standard.

Jackstone calculi are urinary tract stones that have a specific appearance resembling toy jacks. They are almost always composed of calcium oxalate dihydrate and may be found in the urinary bladder or rarely in the upper urinary tract. Their appearance on plain radiographs and computed tomography (CT) in human patients has been well described. They have also been imaged in several species of animals. However, our review of the English medical literature revealed no previous report in which a jackstone calculus had been identified on the sonographic examination of a human patient. We report a case in which a large jackstone calculus was incidentally detected during abdominal sonography in a 75-year-old man.