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The Learning Curve in Prostate MRI Interpretation: Self-Directed Learning Versus Continual Reader Feedback

Rosenkrantz, Andrew B; Ayoola, Abimbola; Hoffman, David; Khasgiwala, Anunita; Prabhu, Vinay; Smereka, Paul; Somberg, Molly; Taneja, Samir S
OBJECTIVE: The purpose of this study is to evaluate the roles of self-directed learning and continual feedback in the learning curve for tumor detection by novice readers of prostate MRI. MATERIALS AND METHODS: A total of 124 prostate MRI examinations classified as positive (n = 52; single Prostate Imaging Reporting and Data System [PI-RADS] category 3 or higher lesion showing Gleason score >/= 7 tumor at MRI-targeted biopsy) or negative (n = 72; PI-RADS category 2 or lower and negative biopsy) for detectable tumor were included. These were divided into four equal-sized batches, each with matching numbers of positive and negative examinations. Six second-year radiology residents reviewed examinations to localize tumors. Three of the six readers received feedback after each examination showing the preceding case's solution. The learning curve, plotting accuracy over time, was assessed by the Akaike information criterion (AIC). Logistic regression and mixed-model ANOVA were performed. RESULTS: For readers with and without feedback, the learning curve exhibited an initial rapid improvement that slowed after 40 examinations (change in AIC > 0.2%). Accuracy improved from 58.1% (batch 1) to 71.0-75.3% (batches 2-4) without feedback and from 58.1% to 72.0-77.4% with feedback (p = 0.027-0.046), without a difference in the extent of improvement (p = 0.800). Specificity improved from 53.7% to 68.5-81.5% without feedback and from 55.6% to 74.1-81.5% with feedback (p = 0.006-0.010), without a difference in the extent of improvement (p = 0.891). Sensitivity improved from 59.0-61.5% (batches 1-2) to 71.8-76.9% (batches 3-4) with feedback (p = 0.052), though did not improve without feedback (p = 0.602). Sensitivity for transition zone tumors exhibited larger changes (p = 0.024) with feedback than without feedback. Sensitivity for peripheral zone tumors did not improve in either group (p > 0.3). Reader confidence increased only with feedback (p < 0.001). CONCLUSION: The learning curve in prostate tumor detection largely reflected self-directed learning. Continual feedback had a lesser effect. Clinical prostate MRI interpretation by novice radiologists warrants caution.
PMID: 28026201
ISSN: 1546-3141
CID: 2383542

Re: Study of Testosterone-Guided Androgen Deprivation Therapy in Management of Prostate Cancer

Taneja, Samir S
PMID: 28093144
ISSN: 1527-3792
CID: 2548422

Commentary regarding a recent collaborative consensus statement addressing prostate MRI and MRI-targeted biopsy in patients with a prior negative prostate biopsy [Letter]

Verma, Sadhna; Rosenkrantz, Andrew B; Choyke, Peter; Eberhardt, Steven C; Eggener, Scott E; Gaitonde, Krishnanath; Haider, Masoom A; Margolis, Daniel J; Marks, Leonard S; Pinto, Peter; Sonn, Geoffrey A; Taneja, Samir S
PMID: 27670878
ISSN: 2366-0058
CID: 2262272

Re: Predictive Parameters of Symptomatic Hematochezia following 5-Fraction Gantry-Based SABR in Prostate Cancer

Taneja, Samir S
PMID: 28093143
ISSN: 1527-3792
CID: 2548432

Re: Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer

Taneja, Samir S
PMID: 28093145
ISSN: 1527-3792
CID: 2548412

Re: Magnetic Resonance Imaging-Ultrasound Fusion Biopsy during Prostate Cancer Active Surveillance

Taneja, Samir S
PMID: 28093146
ISSN: 1527-3792
CID: 2548402

Re: Efficacy and Safety of Enzalutamide versus Bicalutamide for Patients with Metastatic Prostate Cancer (TERRAIN): A Randomised, Double-Blind, Phase 2 Study

Taneja, Samir S
PMID: 27979508
ISSN: 1527-3792
CID: 2548442

Detection of prostate cancer local recurrence following radical prostatectomy: assessment using a continuously acquired radial golden-angle compressed sensing acquisition

Rosenkrantz, Andrew B; Khasgiwala, Anunita; Doshi, Ankur M; Ream, Justin M; Taneja, Samir S; Lepor, Herbert
PURPOSE: To compare image quality and diagnostic performance for detecting local recurrence (LR) of prostate cancer after radical prostatectomy (RP) between standard dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and a high spatiotemporal resolution, continuously acquired Golden-angle RAdial Sparse Parallel acquisition employing compressed sensing reconstruction ("GRASP"). METHODS: A search was conducted for prostate MRI examinations performed in patients with PSA >/=0.2 ng/mL after RP in whom follow-up evaluation allowed classification as positive (>/=50% PSA reduction after pelvic radiation or positive biopsy) or negative (<50% PSA reduction after pelvic radiation; spontaneous PSA normalization) for LR, yielding 13 patients with standard DCE (11 LR+) and 12 with GRASP (10 LR+). Standard DCE had voxel size 3.0 x 1.9 x 1.9 mm and temporal resolution 5.5 s. GRASP had voxel size 1.0 x 1.1 x 1.1 cm and was retrospectively reconstructed at 2.3 s resolution. Two radiologists evaluated DCE sequences for image quality measures (1-5 scale) and the presence of LR. RESULTS: GRASP achieved higher scores than standard DCE from both readers (p < 0.001-0.136) for anatomic clarity (R1: 4.4 +/- 0.8 vs. 2.8 +/- 0.67 R2: 4.8 +/- 0.5 vs. 3.2 +/- 0.6), sharpness (3.6 +/- 0.9 vs. 2.5 +/- 0.7; 4.6 +/- 0.5 vs. 2.6 +/- 0.5), confidence in interpretation (3.8 +/- 0.8 vs. 3.1 +/- 0.9; 3.8 +/- 1.0 vs. 3.1 +/- 1.2), and conspicuity of detected lesions (4.7 +/- 0.5 vs. 3.8 +/- 1.1; 4.5 +/- 0.5 vs. 3.8 +/- 1.0). For detecting LR, GRASP also achieved higher sensitivity (70% vs. 36%; 80% vs. 45%), specificity (R1 and R2: 100% vs. 50%), and accuracy (75% vs. 38%; 83% vs. 46%) for both readers. CONCLUSION: Although requiring larger studies, high spatiotemporal resolution GRASP achieved substantially better image quality and diagnostic performance than standard DCE for detecting LR in patients with elevated PSA after prostatectomy.
PMCID:5538362
PMID: 27576605
ISSN: 2366-0058
CID: 2232502

Re: Robot-Assisted Laparoscopic Prostatectomy versus Open Radical Retropubic Prostatectomy: Early Outcomes from a Randomised Controlled Phase 3 Study

Taneja, Samir S
PMID: 27979507
ISSN: 1527-3792
CID: 2548452

Re: Five-Year Biochemical Results, Toxicity, and Patient-Reported Quality of Life after Delivery of Dose-Escalated Image Guided Proton Therapy for Prostate Cancer

Taneja, Samir S
PMID: 27979505
ISSN: 1527-3792
CID: 2548472