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Re: Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer

Taneja, Samir S
PMID: 28093145
ISSN: 1527-3792
CID: 2548412

Commentary regarding a recent collaborative consensus statement addressing prostate MRI and MRI-targeted biopsy in patients with a prior negative prostate biopsy [Letter]

Verma, Sadhna; Rosenkrantz, Andrew B; Choyke, Peter; Eberhardt, Steven C; Eggener, Scott E; Gaitonde, Krishnanath; Haider, Masoom A; Margolis, Daniel J; Marks, Leonard S; Pinto, Peter; Sonn, Geoffrey A; Taneja, Samir S
PMID: 27670878
ISSN: 2366-0058
CID: 2262272

Re: Predictive Parameters of Symptomatic Hematochezia following 5-Fraction Gantry-Based SABR in Prostate Cancer

Taneja, Samir S
PMID: 28093143
ISSN: 1527-3792
CID: 2548432

Re: Study of Testosterone-Guided Androgen Deprivation Therapy in Management of Prostate Cancer

Taneja, Samir S
PMID: 28093144
ISSN: 1527-3792
CID: 2548422

Re: Magnetic Resonance Imaging-Ultrasound Fusion Biopsy during Prostate Cancer Active Surveillance

Taneja, Samir S
PMID: 28093146
ISSN: 1527-3792
CID: 2548402

Re: Efficacy and Safety of Enzalutamide versus Bicalutamide for Patients with Metastatic Prostate Cancer (TERRAIN): A Randomised, Double-Blind, Phase 2 Study

Taneja, Samir S
PMID: 27979508
ISSN: 1527-3792
CID: 2548442

Risk Stratification by Urinary PCA3 Testing Prior to MRI-US Fusion-Targeted Prostate Biopsy among Men with No Previous History of Biopsy

Fenstermaker, Michael; Mendhiratta, Neil; Bjurlin, Marc A; Meng, Xiaosong; Rosenkrantz, Andrew B; Huang, Richard; Deng, Fang Ming; Zhou, Ming; Huang, William C; Lepor, Herbert; Taneja, Samir S
OBJECTIVES: To determine whether a combination of PCA3 and MRI suspicion score (mSS) could further optimize detection of prostate cancer on MRF-TB among men with no previous history of biopsy. MATERIALS AND METHODS: 187 men presenting to our institution between 6/12 and 8/14 who underwent multiparametric MRI and PCA3 prior to MRF-TB. Biopsy results, stratified by biopsy indication and PCA3 score, were recorded. Receiver operating characteristics (ROC) curves and multivariable logistic regressions were utilized to model the association of PCA3 and mSS with cancer detection on MRF-TB. RESULTS: PCA3 is associated with cancer detection on MRF-TB for men with no prior biopsies (AUC = 0.67, 95% CI 0.59-0.76). Using a cutoff of >/=35, PCA3 was associated with cancer risk among men with mSS 2-3 (p=0.004), but not among those with mSS 4-5 (p=0.340). The interaction of PCA3 and mSS demonstrated significantly higher discrimination for cancer than mSS alone (AUC: 0.83 vs. 0.79, p=0.0434). CONCLUSIONS: Urinary PCA3 is associated with mSS and the detection of cancer on MRF-TB for men with no prior biopsies. PCA3 notably demonstrates a high negative predictive value among mSS 2-3. However, in the case of high suspicion mpMRI, PCA3 is not associated with cancer detection on MRF-TB adding little to cancer diagnosis. Further studies are needed to evaluate the utility of PCA3 in predicting cancer among men with normal mpMRI.
PMID: 27562202
ISSN: 1527-9995
CID: 2221652

Detection of prostate cancer local recurrence following radical prostatectomy: assessment using a continuously acquired radial golden-angle compressed sensing acquisition

Rosenkrantz, Andrew B; Khasgiwala, Anunita; Doshi, Ankur M; Ream, Justin M; Taneja, Samir S; Lepor, Herbert
PURPOSE: To compare image quality and diagnostic performance for detecting local recurrence (LR) of prostate cancer after radical prostatectomy (RP) between standard dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and a high spatiotemporal resolution, continuously acquired Golden-angle RAdial Sparse Parallel acquisition employing compressed sensing reconstruction ("GRASP"). METHODS: A search was conducted for prostate MRI examinations performed in patients with PSA >/=0.2 ng/mL after RP in whom follow-up evaluation allowed classification as positive (>/=50% PSA reduction after pelvic radiation or positive biopsy) or negative (<50% PSA reduction after pelvic radiation; spontaneous PSA normalization) for LR, yielding 13 patients with standard DCE (11 LR+) and 12 with GRASP (10 LR+). Standard DCE had voxel size 3.0 x 1.9 x 1.9 mm and temporal resolution 5.5 s. GRASP had voxel size 1.0 x 1.1 x 1.1 cm and was retrospectively reconstructed at 2.3 s resolution. Two radiologists evaluated DCE sequences for image quality measures (1-5 scale) and the presence of LR. RESULTS: GRASP achieved higher scores than standard DCE from both readers (p < 0.001-0.136) for anatomic clarity (R1: 4.4 +/- 0.8 vs. 2.8 +/- 0.67 R2: 4.8 +/- 0.5 vs. 3.2 +/- 0.6), sharpness (3.6 +/- 0.9 vs. 2.5 +/- 0.7; 4.6 +/- 0.5 vs. 2.6 +/- 0.5), confidence in interpretation (3.8 +/- 0.8 vs. 3.1 +/- 0.9; 3.8 +/- 1.0 vs. 3.1 +/- 1.2), and conspicuity of detected lesions (4.7 +/- 0.5 vs. 3.8 +/- 1.1; 4.5 +/- 0.5 vs. 3.8 +/- 1.0). For detecting LR, GRASP also achieved higher sensitivity (70% vs. 36%; 80% vs. 45%), specificity (R1 and R2: 100% vs. 50%), and accuracy (75% vs. 38%; 83% vs. 46%) for both readers. CONCLUSION: Although requiring larger studies, high spatiotemporal resolution GRASP achieved substantially better image quality and diagnostic performance than standard DCE for detecting LR in patients with elevated PSA after prostatectomy.
PMCID:5538362
PMID: 27576605
ISSN: 2366-0058
CID: 2232502

Re: Robot-Assisted Laparoscopic Prostatectomy versus Open Radical Retropubic Prostatectomy: Early Outcomes from a Randomised Controlled Phase 3 Study

Taneja, Samir S
PMID: 27979507
ISSN: 1527-3792
CID: 2548452

Re: HSD3B1 and Resistance to Androgen-Deprivation Therapy in Prostate Cancer: A Retrospective, Multicohort Study

Taneja, Samir S
PMID: 27979506
ISSN: 1527-3792
CID: 2548462