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Anterolateral tibial osteotomy for accessing osteochondral lesions of the talus in autologous osteochondral transplantation: functional and t2 MRI analysis
Gianakos, Arianna L; Hannon, Charles P; Ross, Keir A; Newman, Hunter; Egan, Christopher J; Deyer, Timothy W; Kennedy, John G
BACKGROUND:Autologous osteochondral transplantation (AOT) is a primary treatment strategy for large or cystic osteochondral lesions of the talus (OLT) or a secondary replacement strategy after failed bone marrow stimulation. The technique requires perpendicular access to the talar dome, which is often difficult to obtain for posterior or lateral lesions. Traditional methods to access these areas have required disruption of the syndesmotic complex with concern over osteotomy reduction, malalignment, and ligament disruption. An alternate to these traditional methods of access is an anterolateral tibial osteotomy. The purpose of this study was to report functional and magnetic resonance imaging (MRI) outcomes in a series of patients that underwent AOT for treatment of an OLT via an anterolateral tibial osteotomy. METHODS:Records of patients that underwent an anterolateral tibial osteotomy for AOT were retrospectively reviewed. Pre- and postoperative Foot and Ankle Outcome Scores (FAOS) and demographic data were recorded. Magnetic resonance observation of cartilage repair tissue (MOCART) was used to assess morphologic state of tibial cartilage at the repair site of the osteotomy. Quantitative T2 mapping MRI was analyzed in the superficial and deep cartilage layers of the repair site of the osteotomy and in adjacent normal cartilage to serve as control tissue. Seventeen patients with a mean age of 36.9 (range, 17-76) years underwent anterolateral tibial osteotomy with a mean follow-up of 64 (range, 29 to 108) months. MOCART data were available in 9 of 17 patients, and quantitative T2 mapping was available in 6 patients. RESULTS:FAOS significantly improved from an average 39.2 (range, 14 to 66) out of 100 points preoperatively to 81.2 (range, 19 to 98) postoperatively (P < .01). The average MOCART score was 73.9 out of 100 points (range, 40 to 100). Quantitative T2 analysis demonstrated relaxation times that were not significantly different from the normal native cartilage in both the deep half and superficial half of interface repair tissue (P > .05). CONCLUSION/CONCLUSIONS:This study demonstrated that the anterolateral tibial osteotomy was a reasonable alternative for accessing centrolateral or posterolateral OLT for AOT with limited morbidity associated with the osteotomy. The evidence demonstrated adequate osteotomy and cartilaginous healing with improvement in functional outcome scores at medium-term follow-up. LEVEL OF EVIDENCE/METHODS:Level IV, retrospective case series.
PMID: 25576475
ISSN: 1944-7876
CID: 3524152
Investigating the relationship between ankle arthrodesis and adjacent-joint arthritis in the hindfoot: a systematic review
Ling, Jeffrey S; Smyth, Niall A; Fraser, Ethan J; Hogan, MaCalus V; Seaworth, Christine M; Ross, Keir A; Kennedy, John G
BACKGROUND:Ankle arthrodesis traditionally has been regarded as the treatment of choice for many patients with end-stage ankle arthritis. However, a major reported risk of ankle arthrodesis is adjacent-joint degeneration. There are conflicting views in the literature as to the causative link between ankle arthrodesis and progression to adjacent-joint arthritis. Recent studies have challenged the causative link between arthrodesis and adjacent-joint arthritis, purporting that preexisting adjacent-joint arthritis is present in many patients. The aim of the present study was to systematically review the available literature to determine if there is sufficient evidence to support either hypothesis. METHODS:A literature search of the EMBASE and PubMed/MEDLINE databases (1974 to present) was performed. A total of twenty-four studies were included for review. The studies were reviewed, and the relevant information was extracted, including research methodology, postoperative outcomes in the adjacent joints of the foot, and whether pre-arthrodesis radiographs and medical records were available for analysis. RESULTS:The twenty-four manuscripts included eighteen clinical studies, five biomechanical studies, and one gait-analysis study. The majority of biomechanical studies showed altered biomechanics in the fused ankle; however, there was no clear consensus as to whether these findings were causes of adjacent-joint arthritis. In studies assessing clinical outcomes, the reported prevalence of subtalar joint arthritis ranged from 24% to 100% and the prevalence of talonavicular and calcaneocuboid arthritis ranged from 18% to 77%. Correlation between imaging findings of arthritis in adjacent joints and patient symptoms was not established in a number of the clinical studies reviewed. CONCLUSIONS:There is no true consensus in the literature as to the effects of ankle arthrodesis on biomechanics or whether ankle arthrodesis leads to adjacent-joint arthritis. Similarly, a correlation between postoperative imaging findings and clinical presentation in this cohort of patients has not been conclusively demonstrated.
PMID: 25788309
ISSN: 1535-1386
CID: 3524162
Bone Marrow Stimulation and Biological Adjuncts for Treatment of Osteochondral Lesions of the Talus
Ross, Keir A.; Robbins, Justin; Easley, Mark E.; Kennedy, John G.
Osteochondral lesions of the talus (OLT) frequently occur after ankle sprain or fracture. Although there has been a growing interest in OLT treatment recently, the pathology has been recognized for hundreds of years. Yet there is a lack of consensus as to the most effective treatment strategy. Because of a lack of vasculature and the relative hypocellularity of articular cartilage, OLT are difficult to treat. Arthroscopic bone marrow stimulation (BMS) has become a commonly used method of treating smaller, primary OLT because of technical simplicity, the advantages of minimally invasive access, and cost-effectiveness. Results of BMS are good in the short-tomidterm with high overall success rates reported in the literature. However, the fibrocartilagenous repair tissue formed after BMS confers inferior biological and mechanical properties compared with native hyaline cartilage. Poorer outcomes have also been demonstrated in large and uncontained talar shoulder lesions. Subchondral bone compaction and thermal necrosis with drilling may be the cause for concern. There is also evidence of high rates of cracks and fissuring in fibrocartilage and inadequate integration with native cartilage postoperatively. Furthermore, there is a lack of long-term BMS outcome data available. Concerns with BMS have prompted investigation of biological adjuncts that could potentially improve the quality of BMS repair tissue and form a more hyaline-like repair. Arthroscopic BMS has much promise for the future but long-term, high-level studies are required. Enhancement of BMS with biological adjuncts and improved surgical instrumentation has the potential to improve cartilage repair and outcomes. ISI:000218261900009
ISSN: 1536-0644
CID: 3522712
Osteochondral Autologous Transfer and Bulk Allograft for Biological Resurfacing of Large Osteochondral Lesions of the Talus
Robbins, Justin; Ross, Keir A.; Kennedy, John G.; Easley, Mark E.
Osteochondral lesions of the talus that have previously undergone surgical management or involve the shoulder region of the talus require methods other than microfracture for treatment. For those lesions that have failed microfracture and do not involve the shoulder of the talus, osteochondral autologous transfer is our preferred treatment of choice. Perpendicular access to the lesion, often by osteotomy, is required for this technique. For those osteochondral lesions of the talus that involve the shoulder of the talus, structural allograft is indicated. This article describes our technique for osteochondral autologous transfer and structural allograft implantation. ISI:000218261900008
ISSN: 1536-0644
CID: 3522702
Lesser metatarsal osteotomies in metatarsalgia
Hodgkins, CW; O'Malley, MJ; Elliott, A; Kennedy, John G
Metatarsalgia is one of the most common forefoot pain presentations seen in orthopedics. Surgical management has often been suboptimal with more than 20 surgical methods reported, differing in indication, technique, fixation, and postoperative mobilization.The literature has not yet recorded a definitive surgical solution to this problem. Outcome parameters including patient satisfaction, pedobarographic, and radiologic measurements have indicated the relative success of the different surgical techniques and their adverse outcome trends.The current authors present their experience with the Weil, chevron, and oblique sliding diaphyseal techniques in the context of their indications, techniques, and outcomes, and review their success in the literature
ORIGINAL:0013332
ISSN: 1536-0644
CID: 3702472
An atraumatic case of extensive Achilles tendon ossification [Case Report]
Ross, Keir A; Smyth, Niall A; Hannon, Charles P; Seaworth, Christine M; DiCarlo, Edward F; Kennedy, John G
BACKGROUND:Ossification of the Achilles tendon is rare with most cases of ossification or calcification consisting of small, focal lesions. This pathology is usually predisposed by surgery, trauma, or other factors. CASE DESCRIPTION/METHODS:A case of extensive Achilles ossification and calcification, without prior surgery or trauma, is reported. Following removal of one of the largest ossific masses reported in the literature, measuring 11.0cm×2.5cm×2.0cm with additional 6.5cm calcifications, surgical reconstruction was required. PURPOSE AND CLINICAL RELEVANCE/CONCLUSIONS:The objective of this report was to describe an unusual case of Achilles tendon ossification and calcification that occurred without the presence of predisposing factors. When a large gap is present after removal of the ossification, direct repair may be impossible and V-Y lengthening plus flexor hallucis longus (FHL) transfer is a viable option for pain relief and return to function.
PMID: 25457673
ISSN: 1460-9584
CID: 3524132
Midfoot sprains in the National Football League
Osbahr, Daryl C; O'Loughlin, Padhraig F; Drakos, Mark C; Barnes, Ronnie P; Kennedy, John G; Warren, Russell F
Midfoot sprains in the National Football League (NFL) are uncommon. There are few studies on midfoot sprains in professional athletes, as most studies focus on severe traumatic injuries resulting in Lisfranc fracture-dislocations. We conducted a study to evaluate midfoot sprains in NFL players to allow for better identification and management of these injuries. All midfoot sprains from a single NFL team database were reviewed over a 15-year period, and 32 NFL team physicians completed a questionnaire detailing their management approach. A comparative analysis was performed analyzing several variables, including diagnosis, treatment methods, and time lost from participation. Fifteen NFL players sustained midfoot sprains. Most injuries occurred during games as opposed to practice, and the injury typically resulted from direct impact rather than torsion. Twelve players had nonoperative treatment, and 3 had operative treatment. Nonoperative management resulted in a mean of 11.7 days of time lost from participation. However, there was a significant (P=.047) difference in mean (SD) time lost between the grade 1 sprain group, 3.1 (1.9) days, and the grade 2 sprain group, 36 (26.1) days. Of the 3 operative grade 3 patients, 1 returned in 73 days, and 2 were injured late in the season and returned the next season. Eleven (92%) of the 12 players who had nonoperative treatment had a successful return to play, and 10 (83%) of the 12 played more games and seasons after their midfoot injury. Depending on the diastasis category, NFL team physicians vary treatment: no diastasis (84% cam walker), latent diastasis (47% surgery, 34% cam walker), and frank diastasis (94% surgery). In the NFL, midfoot sprains can be a source of significant disability. Successful return to play can be achieved with nonoperative management for grade 1 injuries within 1 week and grade 2 injuries within 5 weeks. However, severe injuries with frank diastasis that require operative management will necessitate a more significant delay in return to play. Either way, most NFL athletes will have a successful NFL career after their midfoot sprain injury.
PMID: 25490010
ISSN: 1934-3418
CID: 3524142
Functional and MRI outcomes after arthroscopic microfracture for treatment of osteochondral lesions of the distal tibial plafond
Ross, Keir A; Hannon, Charles P; Deyer, Timothy W; Smyth, Niall A; Hogan, MaCalus; Do, Huong T; Kennedy, John G
BACKGROUND:Osteochondral lesions of the distal tibial plafond are uncommon compared with talar lesions. The objective of this study was to assess functional and magnetic resonance imaging (MRI) outcomes following microfracture for tibial osteochondral lesions. METHODS:Thirty-one tibial osteochondral lesions in thirty-one ankles underwent arthroscopic microfracture. The Foot and Ankle Outcome Score (FAOS) and Short Form-12 (SF-12) general health questionnaire were used to obtain patient-reported functional outcome scores preoperatively and postoperatively. MRI scans were assessed postoperatively with use of the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score for twenty-three ankles. RESULTS:The average age was thirty-seven years (range, fifteen to sixty-eight years), and the average lesion area was 38 mm(2) (range, 7.1 to 113 mm(2)). Twelve ankles had a kissing lesion on the opposing surface of the talus, and two ankles had a concomitant osteochondral lesion elsewhere on the talus. FAOS and SF-12 scores were significantly improved (p < 0.01) at the time of follow-up, at an average of forty-four months. The average postoperative MOCART score was 69.4 (range, 10 to 95), with a lower score in the ankles with kissing lesions (62.8) than in the ankles with an isolated lesion (73.6). Increasing age negatively impacted improvement in SF-12 (p < 0.01) and MOCART (p = 0.04) scores. Increasing lesion area was negatively correlated with MOCART scores (p = 0.04) but was not associated with FAOS or SF-12 scores. Lesion location and the presence of kissing lesions showed no association with functional or MRI outcomes. CONCLUSIONS:Arthroscopic microfracture provided functional improvements, but the optimal treatment strategy for tibial osteochondral lesions remains unclear. The repair tissue assessed on MRI was inferior to normal hyaline cartilage. The MRI outcomes appeared to deteriorate with increasing lesion area, and both functional and MRI outcomes appeared to deteriorate with increasing age. LEVEL OF EVIDENCE/METHODS:Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
PMID: 25320197
ISSN: 1535-1386
CID: 3524122
A single platelet-rich plasma injection for chronic midsubstance achilles tendinopathy: a retrospective preliminary analysis
Murawski, Christopher D; Smyth, Niall A; Newman, Hunter; Kennedy, John G
UNLABELLED:The purpose of this study was to evaluate a series of patients undergoing a single platelet-rich plasma (PRP) injection for the treatment of chronic midsubstance Achilles tendinopathy, in whom conservative treatment had failed. Thirty-two patients underwent a single PRP injection for the treatment of chronic midsubstance Achilles tendinopathy and were evaluated at a 6-month final follow-up using the Foot and Ankle Outcome Score and Short Form 12 general health questionnaire. Magnetic resonance imaging was performed on all patients prior to and 6 months after injection. Twenty-five of 32 patients (78%) reported that they were asymptomatic at the 6-month follow-up visit and were able to participate in their respective sports and daily activities. The remaining 7 patients (22%) who reported symptoms that did not improve after 6 months ultimately required surgery. Four patients went on to have an Achilles tendoscopy, while the other 3 had an open debridement via a tendon splitting approach. A retrospective evaluation of patients receiving a single PRP injection for chronic midsubstance Achilles tendinopathy revealed that 78% had experienced clinical improvement and had avoided surgical intervention at 6-month follow-up. LEVELS OF EVIDENCE/METHODS:Therapeutic, Level IV: Retrospective case series.
PMID: 24771019
ISSN: 1938-7636
CID: 3524092
Osteochondral lesions of the talus: a current concepts review and evidence-based treatment paradigm
Savage-Elliott, Ian; Ross, Keir A; Smyth, Niall A; Murawski, Christopher D; Kennedy, John G
UNLABELLED:Osteochondral lesions of the talar dome are increasingly diagnosed and are a difficult pathology to treat. Conservative treatment yields best results in pediatric patients, often leaving surgical options for adult populations. There is a paucity of long-term data and comparisons of treatment options. Arthroscopic bone marrow stimulation is a common first-line treatment for smaller lesions. Despite promising short to medium term clinical results, bone marrow stimulation results in fibrocartilagenous tissue that incurs differing mechanical and biological properties compared with normal cartilage. Autologous osteochondral transplantation has demonstrated promising clinical results in the short to medium term for larger, cystic lesions and can restore the contact pressure of the joint. However, concerns remain over postoperative cyst formation and donor site morbidity. Recent developments have emphasized the usefulness of biological adjuncts such as platelet-rich plasma and concentrated bone marrow aspirate, as well as particulate juvenile cartilage, in augmenting reparative and replacement strategies in osteochondral lesion treatment. The purpose of this article is to review diagnosis and treatment of talar osteochondral lesions so that current practice guidelines can be more efficiently used given the available treatment strategies. A treatment paradigm based on current evidence is described. LEVELS OF EVIDENCE/METHODS:Therapeutic, Level V, Expert Opinion.
PMID: 25100765
ISSN: 1938-7636
CID: 3524112